CS214767B2 - Method of preparation of pyrrolidine derivatives - Google Patents

Method of preparation of pyrrolidine derivatives Download PDF

Info

Publication number
CS214767B2
CS214767B2 CS78815A CS81578A CS214767B2 CS 214767 B2 CS214767 B2 CS 214767B2 CS 78815 A CS78815 A CS 78815A CS 81578 A CS81578 A CS 81578A CS 214767 B2 CS214767 B2 CS 214767B2
Authority
CS
Czechoslovakia
Prior art keywords
derivative
mixture
acid
general formula
silylating agent
Prior art date
Application number
CS78815A
Other languages
Czech (cs)
English (en)
Inventor
Riccardo Monguzzi
Giorgio Pifferi
Original Assignee
Isf Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isf Spa filed Critical Isf Spa
Publication of CS214767B2 publication Critical patent/CS214767B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
CS78815A 1977-02-11 1978-02-08 Method of preparation of pyrrolidine derivatives CS214767B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20226/77A IT1075564B (it) 1977-02-11 1977-02-11 Procedimento per la preparazione di derivati pirrolidinici

Publications (1)

Publication Number Publication Date
CS214767B2 true CS214767B2 (en) 1982-05-28

Family

ID=11164922

Family Applications (1)

Application Number Title Priority Date Filing Date
CS78815A CS214767B2 (en) 1977-02-11 1978-02-08 Method of preparation of pyrrolidine derivatives

Country Status (23)

Country Link
US (1) US4124594A (es)
JP (1) JPS53101368A (es)
AR (1) AR219734A1 (es)
AT (1) AT362781B (es)
CA (1) CA1083585A (es)
CH (1) CH631703A5 (es)
CS (1) CS214767B2 (es)
DE (1) DE2759033C2 (es)
DK (1) DK155279C (es)
ES (1) ES466857A1 (es)
FI (1) FI66847C (es)
GB (1) GB1588074A (es)
HU (1) HU178588B (es)
IN (1) IN147764B (es)
IT (1) IT1075564B (es)
MX (1) MX4988E (es)
NL (1) NL187207C (es)
NO (1) NO147751C (es)
PL (1) PL108024B1 (es)
PT (1) PT67641B (es)
SE (1) SE428208B (es)
SU (1) SU984407A3 (es)
YU (1) YU40322B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2858573A (en) * 1958-11-04 Fibers
IT1141287B (it) * 1979-06-13 1986-10-01 Nattermann A & Cie Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
IT1206699B (it) * 1984-02-27 1989-04-27 Isf Spa Procedimento per preparare derivati di pirrolidone.
IT1173768B (it) * 1984-04-02 1987-06-24 Isf Spa Procedimento di preparazione di derivati 1-carbamoilmetilici di 4-idrossi-2-osso-pirrolidina nonche' di intermedi per ottenere tali composti
CH666483A5 (de) * 1985-01-16 1988-07-29 Lonza Ag Verfahren zur herstellung von thiotetronsaeure.
IT1190378B (it) * 1985-06-21 1988-02-16 Isf Spa Derivati pirrolidonici
US4686296A (en) * 1985-07-26 1987-08-11 Denki Kagaku Kogyo Kabushiki Kaisha Process for producing oxiracetam
IL80071A0 (en) * 1985-09-24 1986-12-31 Lonza Ag Pyrrolidine acetamide derivatives
HU195773B (en) * 1985-09-24 1988-07-28 Lonza Ag Process for preparing alkyl esters of 4-alkoxy-3-pyrrolin-2-on-1-yl-acetic acid
CH668423A5 (de) * 1986-06-19 1988-12-30 Lonza Ag Verfahren zur herstellung von 4-alkoxy-3-pyrrolin-2-onen.
CH668424A5 (de) * 1986-06-26 1988-12-30 Lonza Ag 4-benzyloxy-3-pyrrolin-2-on-l-yl-acetamid, dessen herstellung und verwendung.
CH668422A5 (de) * 1986-06-26 1988-12-30 Lonza Ag 4-benzyloxy-3-pyrrolin-2-on, dessen herstellung und verwendung zur synthese von tetramsaeure.
CH667655A5 (de) * 1986-09-24 1988-10-31 Lonza Ag Verfahren zur herstellung von 4-alkoxy-2(5h)-thiophenonen.
CH670644A5 (es) * 1986-12-18 1989-06-30 Lonza Ag
DE58909320D1 (de) * 1988-09-06 1995-08-03 Lonza Ag Verfahren zur Herstellung von 5-Alkyltetramsäuren.
FI95034C (fi) * 1989-03-15 1995-12-11 Lonza Ag Menetelmä 1,3-substituoidun tetrahydro-1H-tieno/3,4-d/-imidatsol-2(3H)-on-4-ylideenipentaanihappoesterin valmistamiseksi
CH680293A5 (es) * 1990-06-26 1992-07-31 Lonza Ag
CN101704778B (zh) * 2009-09-30 2012-10-17 厦门市华兴化工有限公司 一种制备4-羟基吡咯烷酮-2-乙酰胺的方法
US9238622B2 (en) * 2010-05-21 2016-01-19 Chongqing Runze Pharmaceutical Co., Ltd. Crystal form I of (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide, preparing method and use thereof
JP2019531323A (ja) * 2016-10-24 2019-10-31 チョンキン ランゼ ファーマスーティカル カンパニー リミテッド （ｒ）−４−ヒドロキシ−２−オキソ−１−ピロリジンアセトアミドの結晶型、調製方法、用途
EP3530271A4 (en) 2016-10-24 2020-03-25 Chongqing Runze Pharmaceutical Company Limited CRYSTALLINE FORM II OF DEXTRAL-OXIRACETAM, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF
US10696629B2 (en) 2016-10-24 2020-06-30 Chongqing Runze Pharmaceutical Company Limited Crystalline form of dextral oxiracetam, preparation method therefor and use thereof
CN108299267A (zh) * 2017-01-12 2018-07-20 重庆润泽医药有限公司 (r)-4-羟基-2-氧-1-吡咯烷乙酰胺的晶型及其制备方法和用途
CN108299268A (zh) * 2017-01-12 2018-07-20 重庆润泽医药有限公司 一种(r)-4-羟基-2-氧-1-吡咯烷乙酰胺晶型的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1045043B (it) 1975-08-13 1980-04-21 Isf Spa Derivati pirrolidinici
AR211398Q (es) 1975-08-13 1977-12-15 Isf Spa Un procedimiento para preparar derivados de ( -pirrolin -2- on -1- il)-acilamida

Also Published As

Publication number Publication date
NO147751C (no) 1983-06-08
ATA88778A (de) 1980-11-15
ES466857A1 (es) 1978-10-01
YU40322B (en) 1985-12-31
PT67641B (de) 1980-03-03
PL204550A1 (pl) 1978-12-04
HU178588B (en) 1982-05-28
AT362781B (de) 1981-06-10
NO147751B (no) 1983-02-28
SE428208B (sv) 1983-06-13
AR219734A1 (es) 1980-09-15
PL108024B1 (pl) 1980-03-31
YU30378A (en) 1982-10-31
CA1083585A (en) 1980-08-12
PT67641A (de) 1978-03-01
NL7801501A (nl) 1978-08-15
DE2759033C2 (de) 1984-04-19
GB1588074A (en) 1981-04-15
FI780406A (fi) 1978-08-12
MX4988E (es) 1983-01-31
DE2759033A1 (de) 1978-08-17
FI66847C (fi) 1984-12-10
NO780463L (no) 1978-08-14
NL187207B (nl) 1991-02-01
JPS6338349B2 (es) 1988-07-29
SU984407A3 (ru) 1982-12-23
SE7801537L (sv) 1978-08-12
CH631703A5 (de) 1982-08-31
IT1075564B (it) 1985-04-22
IN147764B (es) 1980-06-21
NL187207C (nl) 1991-07-01
FI66847B (fi) 1984-08-31
US4124594A (en) 1978-11-07
DK63078A (da) 1978-08-12
JPS53101368A (en) 1978-09-04
DK155279C (da) 1989-07-24
DK155279B (da) 1989-03-20

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