CS210291A3 - Benzeneacetamide derivatives, process for their preparation and pharmaceuticals based on them - Google Patents

Benzeneacetamide derivatives, process for their preparation and pharmaceuticals based on them

Info

Publication number
CS210291A3
CS210291A3 CS912102A CS210291A CS210291A3 CS 210291 A3 CS210291 A3 CS 210291A3 CS 912102 A CS912102 A CS 912102A CS 210291 A CS210291 A CS 210291A CS 210291 A3 CS210291 A3 CS 210291A3
Authority
CS
Czechoslovakia
Prior art keywords
preparation
pharmaceuticals based
benzeneacetamide derivatives
benzeneacetamide
derivatives
Prior art date
Application number
CS912102A
Other languages
English (en)
Inventor
Daele Georges Henri Paul Van
Marc Gustaaf Celine Verdonck
Jean-Paul Rene Marie A Bosmans
Paul Adriaan Jan Janssen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CS210291A3 publication Critical patent/CS210291A3/cs
Publication of CZ279901B6 publication Critical patent/CZ279901B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/44—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
CS912102A 1990-07-10 1991-07-08 Benzenacetamidové deriváty, způsob jejich výroby a farmaceutické přípravky na jejich bázi CZ279901B6 (cs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90201857 1990-07-10
EP91200646 1991-03-22

Publications (2)

Publication Number Publication Date
CS210291A3 true CS210291A3 (en) 1992-02-19
CZ279901B6 CZ279901B6 (cs) 1995-08-16

Family

ID=26125946

Country Status (42)

Country Link
US (2) US5556886A (cs)
EP (1) EP0538301B1 (cs)
JP (1) JPH0819068B2 (cs)
KR (1) KR0183446B1 (cs)
CN (2) CN1028990C (cs)
AP (1) AP311A (cs)
AT (1) ATE144765T1 (cs)
AU (1) AU643056B2 (cs)
BG (1) BG61809B1 (cs)
CA (1) CA2084508A1 (cs)
CZ (1) CZ279901B6 (cs)
DE (1) DE69122963T2 (cs)
DK (1) DK0538301T3 (cs)
DZ (1) DZ1514A1 (cs)
ES (1) ES2095942T3 (cs)
FI (1) FI930070A0 (cs)
GR (1) GR3021829T3 (cs)
HR (1) HRP930485A2 (cs)
HU (2) HUT64013A (cs)
IE (1) IE75693B1 (cs)
IL (3) IL111924A (cs)
LT (1) LT3602B (cs)
LV (1) LV10086B (cs)
MA (1) MA22208A1 (cs)
MX (1) MX9100100A (cs)
MY (1) MY108580A (cs)
NO (1) NO303777B1 (cs)
NZ (1) NZ238763A (cs)
OA (1) OA09770A (cs)
PH (1) PH30977A (cs)
PL (1) PL167076B1 (cs)
PT (1) PT98259B (cs)
RO (1) RO112855B1 (cs)
RU (1) RU2087465C1 (cs)
SG (1) SG48829A1 (cs)
SI (1) SI9111204A (cs)
SK (1) SK279639B6 (cs)
TN (1) TNSN91056A1 (cs)
TW (1) TW204337B (cs)
WO (1) WO1992000952A1 (cs)
YU (1) YU120491A (cs)
ZA (1) ZA915334B (cs)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2125676A1 (en) * 1991-12-30 1993-07-08 Marcel August Constant Janssen .alpha.-substituted benzenemethanamine derivatives
US6177435B1 (en) 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
SG47553A1 (en) * 1992-07-06 1998-04-17 American Cyanamid Co Herbicide intermediate o-nitrophenyl cyclopropyl ketone and a method for the preparation thereof
EP0684818B1 (en) * 1993-02-22 1999-05-06 Janssen Pharmaceutica N.V. Method of reversing resistance of hiv-1 strains to zidovudine
US5767310A (en) * 1993-03-19 1998-06-16 Merck & Co., Inc. Phenoxyphenylacetic acid derivatives
US5686478A (en) * 1993-07-20 1997-11-11 Merck & Co. Inc. Endothelin antagonists
GB9403449D0 (en) * 1994-02-23 1994-04-13 Wellcome Found Therapeutic benzonitriles
GB9403408D0 (en) * 1994-02-23 1994-04-13 Wellcome Found Therapeutic benzonitriles
IL112739A0 (en) * 1994-02-23 1995-05-26 Wellcome Found Ayrlthiobenzonitrile compounds, their preparation and pharmaceutical compositions containing them
US5538991A (en) * 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides
US5559135A (en) * 1994-09-14 1996-09-24 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides
EP0872233A1 (en) * 1997-04-14 1998-10-21 Janssen Pharmaceutica N.V. Antiretroviral compositions with improved bioavailability
CN100369888C (zh) * 1997-08-22 2008-02-20 霍夫曼-拉罗奇有限公司 芳酰基苯丙氨酸衍生物
AU763729B2 (en) * 1998-06-19 2003-07-31 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Novel thiolesters and uses thereof
KR100820605B1 (ko) 1999-09-24 2008-04-08 얀센 파마슈티카 엔.브이. 항바이러스 조성물
US6916956B2 (en) 2000-08-11 2005-07-12 Japan Tobacco, Inc. Calcium receptor antagonist
JP4810529B2 (ja) * 2004-04-23 2011-11-09 エフ．ホフマン−ラ ロシュ アーゲー 非ヌクレオシド逆転写酵素インヒビター
US7625949B2 (en) 2004-04-23 2009-12-01 Roche Palo Alto Llc Methods for treating retroviral infections
CN101500993A (zh) * 2006-06-08 2009-08-05 百时美施贵宝公司 作为凝血因子Ⅶa抑制剂用作抗凝血药的2-氨基羰基苯基氨基-2-苯基乙酰胺
RU2449985C2 (ru) * 2010-03-31 2012-05-10 Федеральное государственное унитарное предприятие "Российский научный центр "Прикладная химия" Способ получения n,n-диметилацетамида
CN102675212B (zh) * 2012-05-09 2014-11-05 昆明理工大学 N-取代苯基-2-((1h-苯并咪唑-2-基)巯基)乙酰胺类衍生物及其用途
CN104000807B (zh) * 2014-05-28 2016-05-18 中山大学 苯基-酰胺类化合物在制备抗hiv-1病毒药物中的应用
CN105367437B (zh) * 2015-10-12 2017-08-01 湖北文理学院 一种2‑芳氨基乙酰胺类化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1423430A (en) * 1973-03-29 1976-02-04 Wyeth John & Brother Ltd Thioamides
US4246429A (en) * 1978-06-23 1981-01-20 Janssen Pharmaceutica, N.V. Novel α-amino-phenylacetic acid derivatives
CH637828A5 (en) * 1978-11-15 1983-08-31 Koehler Franz Dr Chemie Kg Cytostatics
CA2125676A1 (en) * 1991-12-30 1993-07-08 Marcel August Constant Janssen .alpha.-substituted benzenemethanamine derivatives

Also Published As

Publication number Publication date
FI930070A7 (fi) 1993-01-08
BG97265A (bg) 1994-03-24
PL167076B1 (pl) 1995-07-31
PT98259B (pt) 1998-12-31
RO112855B1 (ro) 1998-01-30
ATE144765T1 (de) 1996-11-15
AU643056B2 (en) 1993-11-04
IE912208A1 (en) 1992-01-15
US5556886A (en) 1996-09-17
AU8212091A (en) 1992-02-04
PL297608A1 (cs) 1992-07-13
BG61809B1 (bg) 1998-06-30
EP0538301B1 (en) 1996-10-30
ZA915334B (en) 1993-03-31
OA09770A (fr) 1993-11-30
NO930047L (no) 1993-01-07
US5684049A (en) 1997-11-04
RU2087465C1 (ru) 1997-08-20
LT3602B (en) 1995-12-27
KR0183446B1 (ko) 1999-05-15
NZ238763A (en) 1993-10-26
IE75693B1 (en) 1997-09-10
NO930047D0 (no) 1993-01-07
YU120491A (sh) 1994-06-10
CN1028990C (zh) 1995-06-21
IL98756A (en) 1996-06-18
GR3021829T3 (en) 1997-02-28
CN1058958A (zh) 1992-02-26
SK279639B6 (sk) 1999-01-11
CZ279901B6 (cs) 1995-08-16
LTIP848A (en) 1995-02-27
ES2095942T3 (es) 1997-03-01
IL111924A (en) 1996-12-05
EP0538301A1 (en) 1993-04-28
CN1107835A (zh) 1995-09-06
PT98259A (pt) 1992-04-30
SG48829A1 (en) 1998-05-18
MX9100100A (es) 1992-02-28
DE69122963T2 (de) 1997-03-13
PH30977A (en) 1997-12-23
CA2084508A1 (en) 1992-01-11
DE69122963D1 (de) 1996-12-05
MA22208A1 (fr) 1992-04-01
SI9111204A (en) 1995-04-30
LV10086B (en) 1995-02-20
AP9100288A0 (en) 1991-07-31
JPH05507931A (ja) 1993-11-11
HU211873A9 (en) 1995-12-28
FI930070A0 (fi) 1993-01-08
TW204337B (cs) 1993-04-21
IL98756A0 (en) 1992-07-15
DK0538301T3 (da) 1996-11-25
LV10086A (lv) 1994-05-10
WO1992000952A1 (en) 1992-01-23
JPH0819068B2 (ja) 1996-02-28
TNSN91056A1 (fr) 1992-10-25
SK210291A3 (en) 1995-07-11
CN1033142C (zh) 1996-10-30
MY108580A (en) 1996-10-31
HUT64013A (en) 1993-11-29
IL111924A0 (en) 1995-03-15
DZ1514A1 (fr) 2004-09-13
HRP930485A2 (en) 1996-06-30
NO303777B1 (no) 1998-08-31
HU9300032D0 (en) 1993-04-28
AP311A (en) 1994-02-01

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Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20000708