CS208147B2 - Method of making the stabile low antigennous or the antigene of the plain insuline preparation of the protracted effect - Google Patents
Method of making the stabile low antigennous or the antigene of the plain insuline preparation of the protracted effect Download PDFInfo
- Publication number
- CS208147B2 CS208147B2 CS76270A CS27076A CS208147B2 CS 208147 B2 CS208147 B2 CS 208147B2 CS 76270 A CS76270 A CS 76270A CS 27076 A CS27076 A CS 27076A CS 208147 B2 CS208147 B2 CS 208147B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- insulin
- solution
- preparation
- bovine
- buffer
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 31
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- 230000000694 effects Effects 0.000 title claims description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims abstract description 208
- 229940125396 insulin Drugs 0.000 claims abstract description 101
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- IXIBAKNTJSCKJM-BUBXBXGNSA-N bovine insulin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 IXIBAKNTJSCKJM-BUBXBXGNSA-N 0.000 claims description 32
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- 125000003277 amino group Chemical group 0.000 claims 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK8375AA DK140801B (da) | 1975-01-15 | 1975-01-15 | Fremgangsmåde til fremstilling af et stabilt langtidsvirkende insulinpræparat. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS208147B2 true CS208147B2 (en) | 1981-08-31 |
Family
ID=8089535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS76270A CS208147B2 (en) | 1975-01-15 | 1976-01-15 | Method of making the stabile low antigennous or the antigene of the plain insuline preparation of the protracted effect |
Country Status (36)
| Country | Link |
|---|---|
| JP (1) | JPS5946939B2 (en0) |
| AR (1) | AR213088A1 (en0) |
| AT (1) | AT362492B (en0) |
| BE (1) | BE837600A (en0) |
| BR (1) | BR7600206A (en0) |
| CA (1) | CA1094549A (en0) |
| CH (1) | CH631625A5 (en0) |
| CS (1) | CS208147B2 (en0) |
| DD (1) | DD124379A5 (en0) |
| DE (1) | DE2600971C2 (en0) |
| DK (1) | DK140801B (en0) |
| EG (1) | EG11988A (en0) |
| ES (1) | ES444558A1 (en0) |
| FI (1) | FI66751C (en0) |
| FR (1) | FR2297634A1 (en0) |
| GB (1) | GB1524431A (en0) |
| GR (1) | GR58608B (en0) |
| HU (1) | HU175142B (en0) |
| IE (1) | IE42395B1 (en0) |
| IL (1) | IL48845A (en0) |
| IN (1) | IN143279B (en0) |
| IT (1) | IT1054211B (en0) |
| KE (1) | KE2919A (en0) |
| LU (1) | LU74175A1 (en0) |
| MX (1) | MX4052E (en0) |
| MY (1) | MY7900169A (en0) |
| NL (1) | NL166464C (en0) |
| NO (1) | NO146698C (en0) |
| NZ (1) | NZ179733A (en0) |
| OA (1) | OA05209A (en0) |
| PL (1) | PL99927B1 (en0) |
| PT (1) | PT64696B (en0) |
| RO (1) | RO71576A (en0) |
| SE (1) | SE437219B (en0) |
| YU (1) | YU8376A (en0) |
| ZA (1) | ZA7658B (en0) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK374579A (da) * | 1979-09-07 | 1981-03-08 | Nordisk Insulinlab | Fremgangsmaade til fremstilling af et injucerbart insulinpraeparat |
| US4459226A (en) * | 1982-02-26 | 1984-07-10 | Eli Lilly And Company | Process for recovering insulin |
| US4801575A (en) * | 1986-07-30 | 1989-01-31 | The Regents Of The University Of California | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| AU609769B2 (en) * | 1987-02-10 | 1991-05-09 | Drug Delivery Systems Inc. | Electrolytic transdermal delivery of proteins |
| US4878892A (en) * | 1987-02-10 | 1989-11-07 | Drug Delivery Systems Inc. | Electrolytic transdermal delivery of polypeptides |
| US5714167A (en) | 1992-06-15 | 1998-02-03 | Emisphere Technologies, Inc. | Active agent transport systems |
| US5629020A (en) * | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
| US5447728A (en) | 1992-06-15 | 1995-09-05 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
| US6221367B1 (en) | 1992-06-15 | 2001-04-24 | Emisphere Technologies, Inc. | Active agent transport systems |
| US5643957A (en) | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6051258A (en) | 1995-06-07 | 2000-04-18 | Emisphere Technologies, Inc. | Proteinoid emulsions and methods for preparation and use thereof |
| US5750147A (en) | 1995-06-07 | 1998-05-12 | Emisphere Technologies, Inc. | Method of solubilizing and encapsulating itraconazole |
| EP2077132A1 (en) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device, storage device and method for dispensing a formulation |
| EP2662472B1 (de) | 2009-03-31 | 2019-02-27 | Boehringer Ingelheim International Gmbh | Verfahren zur Beschichtung einer Oberfläche eines Bauteils |
| EP2432531B1 (de) | 2009-05-18 | 2019-03-06 | Boehringer Ingelheim International GmbH | Adapter, inhalationseinrichtung und zerstäuber |
| WO2011064164A1 (en) | 2009-11-25 | 2011-06-03 | Boehringer Ingelheim International Gmbh | Nebulizer |
| EP2504051B1 (en) | 2009-11-25 | 2019-09-04 | Boehringer Ingelheim International GmbH | Nebulizer |
| US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
| EP2585151B1 (en) | 2010-06-24 | 2018-04-04 | Boehringer Ingelheim International GmbH | Nebulizer |
| WO2012130757A1 (de) | 2011-04-01 | 2012-10-04 | Boehringer Ingelheim International Gmbh | Medizinisches gerät mit behälter |
| US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
| WO2013152894A1 (de) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Zerstäuber mit kodiermitteln |
| EP3030298B1 (en) | 2013-08-09 | 2017-10-11 | Boehringer Ingelheim International GmbH | Nebulizer |
| ES2836977T3 (es) | 2013-08-09 | 2021-06-28 | Boehringer Ingelheim Int | Nebulizador |
| US10722666B2 (en) | 2014-05-07 | 2020-07-28 | Boehringer Ingelheim International Gmbh | Nebulizer with axially movable and lockable container and indicator |
| ES2957901T3 (es) | 2014-05-07 | 2024-01-29 | Boehringer Ingelheim Int | Recipiente y dispositivo indicador y nebulizador |
| EP3139979B1 (en) | 2014-05-07 | 2023-07-05 | Boehringer Ingelheim International GmbH | Unit, nebulizer and method |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1285023A (en) * | 1968-08-09 | 1972-08-09 | Novo Terapeutisk Labor As | Improvements in or relating to injectable insulin preparations |
| US3758683A (en) * | 1971-04-30 | 1973-09-11 | R Jackson | Insulin product |
-
1975
- 1975-01-15 DK DK8375AA patent/DK140801B/da not_active IP Right Cessation
-
1976
- 1976-01-06 ZA ZA00760058A patent/ZA7658B/xx unknown
- 1976-01-07 GR GR49734A patent/GR58608B/el unknown
- 1976-01-07 IN IN41/CAL/76A patent/IN143279B/en unknown
- 1976-01-12 NZ NZ179733A patent/NZ179733A/xx unknown
- 1976-01-12 FI FI760058A patent/FI66751C/fi not_active IP Right Cessation
- 1976-01-12 CA CA243,587A patent/CA1094549A/en not_active Expired
- 1976-01-13 SE SE7600284A patent/SE437219B/xx not_active IP Right Cessation
- 1976-01-13 IT IT19221/76A patent/IT1054211B/it active
- 1976-01-13 LU LU74175A patent/LU74175A1/xx unknown
- 1976-01-13 IE IE62/76A patent/IE42395B1/en unknown
- 1976-01-13 DE DE2600971A patent/DE2600971C2/de not_active Expired
- 1976-01-14 FR FR7600854A patent/FR2297634A1/fr active Granted
- 1976-01-14 GB GB1309/76A patent/GB1524431A/en not_active Expired
- 1976-01-14 PL PL1976186526A patent/PL99927B1/pl unknown
- 1976-01-14 MX MX764822U patent/MX4052E/es unknown
- 1976-01-14 NL NL7600338.A patent/NL166464C/xx not_active IP Right Cessation
- 1976-01-14 AT AT21376A patent/AT362492B/de not_active IP Right Cessation
- 1976-01-14 NO NO760118A patent/NO146698C/no unknown
- 1976-01-14 DD DD190805A patent/DD124379A5/xx unknown
- 1976-01-14 PT PT64696A patent/PT64696B/pt unknown
- 1976-01-14 BR BR7600206A patent/BR7600206A/pt unknown
- 1976-01-14 RO RO7684491A patent/RO71576A/ro unknown
- 1976-01-14 OA OA55703A patent/OA05209A/xx unknown
- 1976-01-14 YU YU00083/76A patent/YU8376A/xx unknown
- 1976-01-15 BE BE163542A patent/BE837600A/xx not_active IP Right Cessation
- 1976-01-15 CH CH47076A patent/CH631625A5/de not_active IP Right Cessation
- 1976-01-15 ES ES444558A patent/ES444558A1/es not_active Expired
- 1976-01-15 CS CS76270A patent/CS208147B2/cs unknown
- 1976-01-15 IL IL48845A patent/IL48845A/xx unknown
- 1976-01-15 HU HU76NO198A patent/HU175142B/hu unknown
- 1976-01-16 JP JP51003293A patent/JPS5946939B2/ja not_active Expired
- 1976-01-17 EG EG16/76A patent/EG11988A/xx active
-
1978
- 1978-01-14 AR AR261924A patent/AR213088A1/es active
-
1979
- 1979-02-07 KE KE2919A patent/KE2919A/xx unknown
- 1979-12-30 MY MY169/79A patent/MY7900169A/xx unknown
Also Published As
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