CS207774B2 - Method of making the new substituted 2-phenyliminoimidazolines - Google Patents

Method of making the new substituted 2-phenyliminoimidazolines Download PDF

Info

Publication number
CS207774B2
CS207774B2 CS798500A CS850079A CS207774B2 CS 207774 B2 CS207774 B2 CS 207774B2 CS 798500 A CS798500 A CS 798500A CS 850079 A CS850079 A CS 850079A CS 207774 B2 CS207774 B2 CS 207774B2
Authority
CS
Czechoslovakia
Prior art keywords
acid
chloro
bromo
formula
dihydroxyphenyl
Prior art date
Application number
CS798500A
Other languages
Czech (cs)
English (en)
Inventor
Helmut Staehle
Herbert Koeppe
Werner Kummer
Wolfgang Hoefke
Wolfram Gaida
Ludwig Pichler
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of CS207774B2 publication Critical patent/CS207774B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
CS798500A 1978-02-17 1979-02-19 Method of making the new substituted 2-phenyliminoimidazolines CS207774B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782806775 DE2806775A1 (de) 1978-02-17 1978-02-17 Neue substituierte 2-phenylimino- imidazolidine deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben

Publications (1)

Publication Number Publication Date
CS207774B2 true CS207774B2 (en) 1981-08-31

Family

ID=6032231

Family Applications (2)

Application Number Title Priority Date Filing Date
CS791092A CS207773B2 (en) 1978-02-17 1979-02-19 Method of making the new substituted 2-phenyl-iminoimidazolines
CS798500A CS207774B2 (en) 1978-02-17 1979-02-19 Method of making the new substituted 2-phenyliminoimidazolines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CS791092A CS207773B2 (en) 1978-02-17 1979-02-19 Method of making the new substituted 2-phenyl-iminoimidazolines

Country Status (32)

Country Link
US (2) US4250186A (no)
JP (1) JPS54122273A (no)
AT (1) AT370093B (no)
AU (1) AU519356B2 (no)
BE (1) BE874252A (no)
CA (1) CA1115717A (no)
CH (1) CH640230A5 (no)
CS (2) CS207773B2 (no)
DD (1) DD142048A5 (no)
DE (1) DE2806775A1 (no)
DK (1) DK69479A (no)
ES (2) ES477784A1 (no)
FI (1) FI69301C (no)
FR (1) FR2417502A1 (no)
GB (1) GB2014575B (no)
GR (2) GR67626B (no)
HU (1) HU180430B (no)
IE (1) IE48073B1 (no)
IL (1) IL56678A (no)
IT (1) IT1113469B (no)
LU (1) LU80924A1 (no)
NL (1) NL7901241A (no)
NO (1) NO151239C (no)
NZ (1) NZ189684A (no)
PH (1) PH16188A (no)
PL (2) PL116527B1 (no)
PT (1) PT69239A (no)
RO (2) RO81504B (no)
SE (1) SE7901405L (no)
SU (2) SU812175A3 (no)
YU (1) YU36779A (no)
ZA (1) ZA79709B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2854659A1 (de) * 1978-12-18 1980-07-10 Boehringer Sohn Ingelheim Neue 3,4-disubstituierte 2-phenylimino-imidazolidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung
DE3168754D1 (en) * 1980-07-09 1985-03-21 Beecham Group Plc Clonidine derivatives useful in the treatment of diarrhoea
EP0070084A3 (en) * 1981-04-24 1983-02-16 Beecham Group Plc Imidazoline derivatives
US4517199A (en) * 1981-11-20 1985-05-14 Alcon Laboratories, Inc. Method for lowering intraocular pressure using phenylimino-imidazoles
CA1201066A (en) * 1981-11-20 1986-02-25 Alcon Laboratories, Inc. N-¬3,5-dichloro-4-(2-imidazolidinylideneamino)- phenyl|-acetamide solutions for lowering intraocular pressure
US4515800A (en) * 1981-11-20 1985-05-07 Icilio Cavero Method of lowering intraocular pressure using phenylimino-imidazoles
US4644007A (en) * 1981-11-20 1987-02-17 Alcon Laboratories, Inc. 3-chloro-4-(4,5-dihydro-1H-imidazo-2-yl)-amino-5-alkylbenzoic acids, esters, salts, compositions and methods
US4461904A (en) * 1981-11-20 1984-07-24 Alcon Laboratories, Inc. 2-(Trisubstituted phenylimino)-imidazolines
FR2521140A1 (fr) * 1982-02-05 1983-08-12 Synthelabo Derives d'imidazolidine, leur preparation et leur application en therapeutique
GB2137191A (en) * 1983-02-28 1984-10-03 Sumitomo Chemical Co Fungicidal N-phenylimidates
DE19514579A1 (de) * 1995-04-20 1996-10-24 Boehringer Ingelheim Kg Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz
JP2003166617A (ja) 2001-11-28 2003-06-13 Honda Motor Co Ltd トルクコンバータ付き内燃機関
JP2007308392A (ja) * 2006-05-16 2007-11-29 Bayer Cropscience Ag 殺虫性ベンズアミジン類

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2938038A (en) * 1960-05-24 X-dihydroxyphenylamino
US2899426A (en) * 1959-08-11 Synthesis of l
FR1211341A (fr) * 1955-12-19 1960-03-15 A Wander Dr Procédé pour la préparation de 2-amino-imidazolines
US3595961A (en) * 1965-10-01 1971-07-27 Boehringer Sohn Ingelheim Hypotensive compositions containing 2-(2' - halo-anilino) - 1,3 -diazacyclopentenes-(2) and methods of using the same
DE1670274A1 (de) * 1966-10-31 1970-07-16 Boehringer Sohn Ingelheim Neues Verfahren zur Herstellung von 2-Arylamino-1,3-diazacycloalkenen-(2)
AT285599B (de) * 1968-06-21 1970-11-10 Boehringer Sohn Ingelheim Verfahren zur Herstellung von neuen trisubstituierten 2-Arylaminoimidazolinen und ihren Salzen
DE2446758C3 (de) * 1974-10-01 1979-01-04 C.H. Boehringer Sohn, 6507 Ingelheim 2-(2-Fluor-6-trifluormethylphenylimino)-imidazolidin, dessen Säureadditionssalze, Verfahren zur Herstellung dieser Verbindungen und deren Verwendung bei der Bekämpfung der Hypertonie
DE2523103C3 (de) * 1975-05-24 1979-11-29 C.H. Boehringer Sohn, 6507 Ingelheim Substituierte 2-[N-Progargyl-N-(2-chlorphenyl)amino] -imidazoline-^), deren Säureadditionssalze, Verfahren zu ihrer Herstellung und deren Verwendung
DE2630060C2 (de) * 1976-07-03 1984-04-19 C.H. Boehringer Sohn, 6507 Ingelheim 2-(2-Brom-6-fluor-phenylimino)-imidazolidin, dessen Säureadditionssalze, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung

Also Published As

Publication number Publication date
CS207773B2 (en) 1981-08-31
ATA101579A (de) 1982-07-15
GB2014575B (en) 1982-11-10
DE2806775A1 (de) 1979-08-30
PL213475A1 (no) 1980-03-10
NO151239B (no) 1984-11-26
SE7901405L (sv) 1979-08-18
RO76799A (ro) 1981-05-30
GR67626B (no) 1981-09-01
HU180430B (en) 1983-03-28
IT7948010A0 (it) 1979-02-15
ES485043A1 (es) 1980-05-16
IT1113469B (it) 1986-01-20
DK69479A (da) 1979-08-18
GB2014575A (en) 1979-08-30
IE48073B1 (en) 1984-09-19
RO81504B (ro) 1983-04-30
AU4432579A (en) 1979-08-23
NL7901241A (nl) 1979-08-21
AU519356B2 (en) 1981-11-26
NZ189684A (en) 1981-01-23
CA1115717A (en) 1982-01-05
JPS54122273A (en) 1979-09-21
SU828964A3 (ru) 1981-05-07
FI69301B (fi) 1985-09-30
PL116527B1 (en) 1981-06-30
RO81504A (ro) 1983-04-29
GR69232B (no) 1982-05-10
ZA79709B (en) 1980-10-29
DD142048A5 (de) 1980-06-04
FI790510A (fi) 1979-08-18
NO790523L (no) 1979-08-20
US4250186A (en) 1981-02-10
FR2417502B1 (no) 1981-06-26
CH640230A5 (de) 1983-12-30
PL115759B1 (en) 1981-04-30
YU36779A (en) 1983-04-30
PH16188A (en) 1983-07-28
BE874252A (fr) 1979-08-16
IL56678A0 (en) 1979-05-31
FR2417502A1 (fr) 1979-09-14
PT69239A (de) 1979-03-01
ES477784A1 (es) 1980-04-01
AT370093B (de) 1983-02-25
NO151239C (no) 1985-03-06
IL56678A (en) 1982-01-31
FI69301C (fi) 1986-01-10
LU80924A1 (de) 1980-04-21
IE790311L (en) 1979-08-17
US4293564A (en) 1981-10-06
SU812175A3 (ru) 1981-03-07

Similar Documents

Publication Publication Date Title
US4125620A (en) 2-[(2',6'-Disubstituted-phenyl)-imino]-imidazolidines and salts thereof
CS207774B2 (en) Method of making the new substituted 2-phenyliminoimidazolines
RU2162081C2 (ru) Способ получения ламотриджина и промежуточное соединение, используемое при его получении
HU191895B (en) Process for producing 2-guanidino-4-imidazolyl-thiazoles
US4166859A (en) 2-Bromo-6-fluoro-N-(2-imidazolidinylidene)-benzamine and salts thereof and the use to treat hypertension
US4213995A (en) 2-Phenylimino-imidazolidines and salts thereof
JPS6026112B2 (ja) ２−フエニルアミノ−イミダゾリン−（２）化合物
US6538012B2 (en) Amlodipine hemimaleate
US3740401A (en) 2-(n-cycloalkyl-phenylamino)-2-imidazolines-(2) and salts thereof
US4277487A (en) Substituted 2-phenylamino-2-imidazolines as bradycardiacs
US4263300A (en) Substituted 2-phenylamino-1,3-tetrahydro-2-pyrimidines and salts thereof
JP2004002376A (ja) ５−ヒドロキシ−１−メチルヒダントイン新規結晶形
US4215133A (en) 2-[N-(2'-Chloro-4'-methyl-thienyl-3')-N-(cyclopropyl-methyl)-amino]-2-imidazoline and salts thereof
KR820001714B1 (ko) 치환된 2-페닐이미노-이미다졸리딘의 제조방법
HU192501B (en) Process for producing /2-methyl-propoxy/-methyl-n-phenyl-n-/phenyl-methyl/-1-pyrrolidin-ethanamine
JPS6410512B2 (no)
US4036972A (en) 2-(N-thienylmethyl-phenylamino)-imidazolines-(2) and salts thereof
US3534142A (en) Methods of treating tapeworm infections with naphthamidines
KR810000631B1 (ko) 치환된 2-페닐아미노-이미다졸린-(2)유도체의 제조방법
US4327106A (en) 2-(Phenyl-amino)-2-imidazolines and salts
KR820001715B1 (ko) 치환된 2-페닐이미노-이미다졸리딘의 제조방법
US4239764A (en) Substituted 2-phenylamino-2-imidazolines and salts thereof
US5011974A (en) Process for the preparation of derivative of 2-diethylamino-1-methylethyl-1-hydroxy-(bicyclohexyl)-2-carboxylate
KR830001441B1 (ko) 치환된 2-페닐아미노-이미다졸린-(2)의 제조방법
EP0367944A2 (en) Ether derivative of 4-[3H] -quinazolinone, a process for the preparation thereof, and pharmaceutical compositions