CS205084B2 - Method of producing hydroxy-and oxoderivatives of aryloxy-and arylthio-perhydro-aza-heterocycles - Google Patents

Method of producing hydroxy-and oxoderivatives of aryloxy-and arylthio-perhydro-aza-heterocycles Download PDF

Info

Publication number
CS205084B2
CS205084B2 CS775690A CS569077A CS205084B2 CS 205084 B2 CS205084 B2 CS 205084B2 CS 775690 A CS775690 A CS 775690A CS 569077 A CS569077 A CS 569077A CS 205084 B2 CS205084 B2 CS 205084B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
optionally
hydroxy
compound
trans
Prior art date
Application number
CS775690A
Other languages
Czech (cs)
English (en)
Inventor
Romeo Paioni
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Priority to CS786732A priority Critical patent/CS205086B2/cs
Publication of CS205084B2 publication Critical patent/CS205084B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CS775690A 1976-09-01 1977-08-31 Method of producing hydroxy-and oxoderivatives of aryloxy-and arylthio-perhydro-aza-heterocycles CS205084B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS786732A CS205086B2 (cs) 1976-09-01 1978-10-16 Způsob výroby hydroxyderivátů aryloxy- a arylthioperhydroazaheterocyklů

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU75701 1976-09-01

Publications (1)

Publication Number Publication Date
CS205084B2 true CS205084B2 (en) 1981-04-30

Family

ID=19728341

Family Applications (3)

Application Number Title Priority Date Filing Date
CS775690A CS205087B2 (en) 1976-09-01 1977-08-31 Method of producing hydroxy-and oxoderivatives of aryloxy-and arylthio-perhydro-aza heterocycles
CS775690A CS205085B2 (en) 1976-09-01 1977-08-31 Method of producing hydroxy-and oxoderivatives of arylthio-perhydro-aza-heterocycles
CS775690A CS205084B2 (en) 1976-09-01 1977-08-31 Method of producing hydroxy-and oxoderivatives of aryloxy-and arylthio-perhydro-aza-heterocycles

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CS775690A CS205087B2 (en) 1976-09-01 1977-08-31 Method of producing hydroxy-and oxoderivatives of aryloxy-and arylthio-perhydro-aza heterocycles
CS775690A CS205085B2 (en) 1976-09-01 1977-08-31 Method of producing hydroxy-and oxoderivatives of arylthio-perhydro-aza-heterocycles

Country Status (29)

Country Link
US (3) US4160837A (nl)
JP (1) JPS5331659A (nl)
AT (1) AT361464B (nl)
AU (1) AU514675B2 (nl)
BE (1) BE858283A (nl)
CA (1) CA1112242A (nl)
CH (5) CH633776A5 (nl)
CS (3) CS205087B2 (nl)
CY (1) CY1212A (nl)
DD (1) DD132584A5 (nl)
DE (1) DE2738477A1 (nl)
DK (1) DK156301C (nl)
ES (6) ES462040A1 (nl)
FI (1) FI68229C (nl)
FR (1) FR2363559A1 (nl)
GB (1) GB1585133A (nl)
GR (1) GR72965B (nl)
HK (1) HK8884A (nl)
HU (1) HU179440B (nl)
IE (1) IE45511B1 (nl)
IL (1) IL52858A0 (nl)
MY (1) MY8500100A (nl)
NL (1) NL7709604A (nl)
NO (1) NO150081C (nl)
NZ (1) NZ185062A (nl)
PT (1) PT66955B (nl)
SE (1) SE437155B (nl)
SG (1) SG63783G (nl)
ZA (1) ZA775267B (nl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE45511B1 (en) * 1976-09-01 1982-09-08 Ciba Geigy Ag New derivatives of perhydro-aza-heterocycles and processesfor the production thereof
MX6634E (es) * 1979-01-09 1985-09-12 Robins Co Inc A H Procedimiento para preparar el isomero trans de 3-ariloxi-4-hidroxipirrolidinas
US4230718A (en) * 1979-01-09 1980-10-28 A. H. Robins Company, Inc. 1-Substituted-3,4-epoxypyrrolidines
US4251541A (en) * 1979-01-09 1981-02-17 A. H. Robins Company, Inc. 1-Substituted-3-arylthio-4-hydroxypyrrolidines
US4585785A (en) * 1979-01-09 1986-04-29 A. H. Robins Company, Inc. Cis and trans-3-aryloxy-4-hydroxypyrrolidines used as anti-arrhythmics
US4443462A (en) * 1979-08-06 1984-04-17 Merrell Dow Pharmaceuticals Inc. Antipsychotic 4-(naphthalenyloxy)piperidine derivatives
US4452809A (en) * 1980-03-10 1984-06-05 A. H. Robins Company, Inc. Trans-4-(2-chlorophenoxy)-1-ethyl-3-pyrrolidinol and anti-depressant use thereof
IL74140A (en) * 1984-04-10 1988-05-31 Robins Co Inc A H Substituted n-((amino)alkyl)-1-pyrrolidine,-1-piperidine and-1-homopiperidine-carboxamides and pharmaceutical compositions containing them
US4639528A (en) * 1985-02-21 1987-01-27 Bristol-Myers Company Crystalline form of 7-(dimethylaminomethylene-amino-9a-methoxymitosane
US4797397A (en) * 1987-07-31 1989-01-10 Warner-Lambert Company 2-nitroimidazole derivatives useful as radiosensitizers for hypoxic tumor cells
IE61631B1 (en) * 1988-05-20 1994-11-16 Zambon Spa Compounds with central analgesic activity, process for their preparation and pharmaceutical compositions containing them
FR2696445B1 (fr) * 1992-10-01 1994-12-16 Rennes Inst Nal Sciences Appli Composition pour l'obtention de produits à base de chaux pure, application de cette composition et procédé pour sa mise en Óoeuvre.
WO1997009311A1 (de) * 1995-09-07 1997-03-13 F. Hoffmann-La Roche Ag Neue 4-(oxyalkoxyphenyl)-3-oxy-piperidine zur behandlung von herz- und niereninsuffizienz
JP3064425B2 (ja) * 1995-09-15 2000-07-12 ノイロサーチ アクティーゼルスカブ カルシウムチャンネル・ブロッカーとしてのピペリジン化合物
WO2005023767A2 (en) 2003-09-10 2005-03-17 Brentwood Equities Ltd. Diastereomers of 4-aryloxy-3-hydroxypiperidines
US20070142389A1 (en) * 2005-12-20 2007-06-21 Pfizer Inc. Piperidine derivatives

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL202935A (nl) * 1954-12-23
US3117975A (en) * 1960-04-22 1964-01-14 Rohm & Haas Substituted pyrrolidinones and piperidinones
US3260723A (en) * 1963-08-27 1966-07-12 Parke Davis & Co 4-phenoxy piperidines; alpha4-phenoxy piperideines
US3360526A (en) * 1964-01-15 1967-12-26 Bristol Myers Co Heterocyclicamino methylene ethers of benzylphenols
US3446897A (en) * 1966-09-30 1969-05-27 Robins Co Inc A H Compositions and methods for the control of cardiac arrhythmia with o-substituted pyrrolidinols and s-substituted thiopyrrolidinols
DE1937459A1 (de) * 1968-08-02 1970-02-05 Ciba Geigy Neue Pyrimidinderivate und Verfahren zu ihrer Herstellung
CH511874A (de) 1968-08-02 1971-08-31 Ciba Geigy Ag Verfahren zur Herstellung von neuen 4,5,6,7-Tetrahydro-thieno(2,3-c)pyridinen
US3823151A (en) * 1968-08-02 1974-07-09 Ciba Geigy Corp 4,5,6,7-tetrahydrothieno(2,3-d)pyridines
US3577432A (en) * 1968-12-23 1971-05-04 Robins Co Inc A H 1-substituted-3-phenoxypyrrolidines
GB1280699A (en) * 1968-12-23 1972-07-05 Robins Co Inc A H 0-substituted-4-phenoxypiperidines
US3542794A (en) * 1969-11-07 1970-11-24 Grover Cleveland Helsley 1-carbamoyl-4-phenoxypiperidines
US3686169A (en) * 1970-07-20 1972-08-22 Monsanto Co Thiocycloamides
US3743645A (en) * 1970-10-19 1973-07-03 Robins Co Inc A H 1-substituted-4-phenoxypiperidines
JPS5119987B2 (nl) * 1973-02-05 1976-06-22
US4065290A (en) * 1975-07-03 1977-12-27 Eli Lilly And Company Herbicidal β-phenyl-4-piperidinones
IE45511B1 (en) * 1976-09-01 1982-09-08 Ciba Geigy Ag New derivatives of perhydro-aza-heterocycles and processesfor the production thereof
MX6634E (es) 1979-01-09 1985-09-12 Robins Co Inc A H Procedimiento para preparar el isomero trans de 3-ariloxi-4-hidroxipirrolidinas
US4251541A (en) 1979-01-09 1981-02-17 A. H. Robins Company, Inc. 1-Substituted-3-arylthio-4-hydroxypyrrolidines
US4230718A (en) 1979-01-09 1980-10-28 A. H. Robins Company, Inc. 1-Substituted-3,4-epoxypyrrolidines

Also Published As

Publication number Publication date
FI68229C (fi) 1985-08-12
SE437155B (sv) 1985-02-11
JPS5331659A (en) 1978-03-25
DK156301C (da) 1989-12-11
ES462040A1 (es) 1978-12-01
ES471740A1 (es) 1979-10-16
ES471738A1 (es) 1979-10-16
CA1112242A (en) 1981-11-10
FR2363559B1 (nl) 1982-03-26
US4320137A (en) 1982-03-16
CS205085B2 (en) 1981-04-30
DE2738477C2 (nl) 1989-11-09
ATA627977A (de) 1980-08-15
MY8500100A (en) 1985-12-31
HU179440B (en) 1982-10-28
BE858283A (fr) 1978-02-28
NL7709604A (nl) 1978-03-03
AU514675B2 (en) 1981-02-19
SE7709784L (sv) 1978-03-02
CY1212A (en) 1984-04-06
FI772566A (fi) 1978-03-02
CH637932A5 (de) 1983-08-31
ES471739A1 (es) 1979-10-16
NO773009L (no) 1978-03-02
CH637935A5 (de) 1983-08-31
CH633776A5 (de) 1982-12-31
NO150081C (no) 1984-08-15
SG63783G (en) 1984-07-27
US4246269A (en) 1981-01-20
AT361464B (de) 1981-03-10
DK156301B (da) 1989-07-31
CH637934A5 (de) 1983-08-31
PT66955A (en) 1977-09-01
AU2838577A (en) 1979-03-08
FR2363559A1 (fr) 1978-03-31
PT66955B (en) 1979-02-07
CH637933A5 (de) 1983-08-31
US4160837A (en) 1979-07-10
IE45511L (en) 1978-03-01
ES479112A1 (es) 1979-07-01
ES479190A1 (es) 1979-07-01
IE45511B1 (en) 1982-09-08
CS205087B2 (en) 1981-04-30
DK387177A (da) 1978-03-02
NZ185062A (en) 1980-10-08
DE2738477A1 (de) 1978-03-02
GB1585133A (en) 1981-02-25
IL52858A0 (en) 1977-10-31
GR72965B (nl) 1984-01-19
NO150081B (no) 1984-05-07
FI68229B (fi) 1985-04-30
DD132584A5 (de) 1978-10-11
HK8884A (en) 1984-02-10
JPS6340785B2 (nl) 1988-08-12
ZA775267B (en) 1978-07-26

Similar Documents

Publication Publication Date Title
CS205084B2 (en) Method of producing hydroxy-and oxoderivatives of aryloxy-and arylthio-perhydro-aza-heterocycles
SK282134B6 (sk) Derivát oxazolidinónu, spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahom a použitie
PL127036B1 (en) Method of obtaining new basic etheris
HU208005B (en) Process for producing optically active 8-methoxy-quinolone-carboxylic acid derivatives and pharmaceutical compositions containing them
US3531489A (en) Bis-basic esters and thioesters of fluoranthene
US3972994A (en) Disubstituted azabicycloalkanes
SK15572000A3 (sk) Spôsob prípravy enantiomérne čistého n-metyl-n-[(1s)-1-fenyl-2- -((3s)-s-hydroxypyrolidin-1-yl)etyl]-2,2-difenylacetamidu
NO174669B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzotiopyranylaminer
US4010280A (en) Phenoxyalkylamine derivatives and preparation thereof
US2980693A (en) Methods for producing same
US4833169A (en) Hydropyridine derivatives
US2642433A (en) Alpha-amino-alpha, alpha-diphenylacetic acid derivatives and method of preparing same
MXPA05004793A (es) Nuevos derivados de 2,3-dihidro-4(1h)-piridinonas, su metodo de preparacion y las composiciones farmaceuticas que lo contienen.
US4048321A (en) Disubstituted azabicycloalkanes
US4029786A (en) Morpholine derivatives for treating depression
CS205086B2 (cs) Způsob výroby hydroxyderivátů aryloxy- a arylthioperhydroazaheterocyklů
US4041038A (en) 1-(3-Phenylpropyl)-4-(beta-alkoxyacryloyl)piperazine derivatives
US4066662A (en) N-substituted-2-aminomethyl-3-azabicyclo(3,3,0)octane compounds
US4042598A (en) Disubstituted azabicycloalkanes
US4395416A (en) 1-Spiro isobenzofuranic and 1-spiro isobenzothiophenic derivatives the process for preparing the same and their use in therapeutics
US3882130A (en) 4-Phenylethynyl benzylamines
JPS638373A (ja) 水素化１−フェノキシアルキルピリジン−３−カルボン酸化合物
AT374175B (de) Verfahren zur herstellung von neuen pyrrolidin-, piperidin- und perhydroazepinderivaten und ihren saeureadditionssalzen
US3808217A (en) 1-cyclopropyl-3-mono-(and 2,3-di)substituted-1-propanones
JPH04211077A (ja) 光学活性な８−メトキシキノロンカルボン酸誘導体及びその製造方法並びにその中間体