NO773009L - Fremgangsmaate til fremstilling av nye derivater av perhydro-aza-heterocykler - Google Patents

Fremgangsmaate til fremstilling av nye derivater av perhydro-aza-heterocykler

Info

Publication number
NO773009L
NO773009L NO773009A NO773009A NO773009L NO 773009 L NO773009 L NO 773009L NO 773009 A NO773009 A NO 773009A NO 773009 A NO773009 A NO 773009A NO 773009 L NO773009 L NO 773009L
Authority
NO
Norway
Prior art keywords
perhydro
procedure
preparing new
aza heterocycles
heterocycles derivatives
Prior art date
Application number
NO773009A
Other languages
English (en)
Other versions
NO150081C (no
NO150081B (no
Inventor
Romeo Paioni
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of NO773009L publication Critical patent/NO773009L/no
Publication of NO150081B publication Critical patent/NO150081B/no
Publication of NO150081C publication Critical patent/NO150081C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
NO773009A 1976-09-01 1977-08-31 Analogifremgangsmaate til fremstilling av terapeutisk virksomme derivater av perhydro-aza-heterocykler NO150081C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU75701 1976-09-01

Publications (3)

Publication Number Publication Date
NO773009L true NO773009L (no) 1978-03-02
NO150081B NO150081B (no) 1984-05-07
NO150081C NO150081C (no) 1984-08-15

Family

ID=19728341

Family Applications (1)

Application Number Title Priority Date Filing Date
NO773009A NO150081C (no) 1976-09-01 1977-08-31 Analogifremgangsmaate til fremstilling av terapeutisk virksomme derivater av perhydro-aza-heterocykler

Country Status (29)

Country Link
US (3) US4160837A (no)
JP (1) JPS5331659A (no)
AT (1) AT361464B (no)
AU (1) AU514675B2 (no)
BE (1) BE858283A (no)
CA (1) CA1112242A (no)
CH (5) CH633776A5 (no)
CS (3) CS205087B2 (no)
CY (1) CY1212A (no)
DD (1) DD132584A5 (no)
DE (1) DE2738477A1 (no)
DK (1) DK156301C (no)
ES (6) ES462040A1 (no)
FI (1) FI68229C (no)
FR (1) FR2363559A1 (no)
GB (1) GB1585133A (no)
GR (1) GR72965B (no)
HK (1) HK8884A (no)
HU (1) HU179440B (no)
IE (1) IE45511B1 (no)
IL (1) IL52858A0 (no)
MY (1) MY8500100A (no)
NL (1) NL7709604A (no)
NO (1) NO150081C (no)
NZ (1) NZ185062A (no)
PT (1) PT66955B (no)
SE (1) SE437155B (no)
SG (1) SG63783G (no)
ZA (1) ZA775267B (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE45511B1 (en) * 1976-09-01 1982-09-08 Ciba Geigy Ag New derivatives of perhydro-aza-heterocycles and processesfor the production thereof
MX6634E (es) * 1979-01-09 1985-09-12 Robins Co Inc A H Procedimiento para preparar el isomero trans de 3-ariloxi-4-hidroxipirrolidinas
US4251541A (en) * 1979-01-09 1981-02-17 A. H. Robins Company, Inc. 1-Substituted-3-arylthio-4-hydroxypyrrolidines
US4585785A (en) * 1979-01-09 1986-04-29 A. H. Robins Company, Inc. Cis and trans-3-aryloxy-4-hydroxypyrrolidines used as anti-arrhythmics
US4230718A (en) * 1979-01-09 1980-10-28 A. H. Robins Company, Inc. 1-Substituted-3,4-epoxypyrrolidines
US4443462A (en) * 1979-08-06 1984-04-17 Merrell Dow Pharmaceuticals Inc. Antipsychotic 4-(naphthalenyloxy)piperidine derivatives
US4452809A (en) * 1980-03-10 1984-06-05 A. H. Robins Company, Inc. Trans-4-(2-chlorophenoxy)-1-ethyl-3-pyrrolidinol and anti-depressant use thereof
IL74140A (en) * 1984-04-10 1988-05-31 Robins Co Inc A H Substituted n-((amino)alkyl)-1-pyrrolidine,-1-piperidine and-1-homopiperidine-carboxamides and pharmaceutical compositions containing them
US4639528A (en) * 1985-02-21 1987-01-27 Bristol-Myers Company Crystalline form of 7-(dimethylaminomethylene-amino-9a-methoxymitosane
US4797397A (en) * 1987-07-31 1989-01-10 Warner-Lambert Company 2-nitroimidazole derivatives useful as radiosensitizers for hypoxic tumor cells
IE61631B1 (en) * 1988-05-20 1994-11-16 Zambon Spa Compounds with central analgesic activity, process for their preparation and pharmaceutical compositions containing them
FR2696445B1 (fr) * 1992-10-01 1994-12-16 Rennes Inst Nal Sciences Appli Composition pour l'obtention de produits à base de chaux pure, application de cette composition et procédé pour sa mise en Óoeuvre.
DE59610509D1 (de) * 1995-09-07 2003-07-10 Hoffmann La Roche Neue 4-(oxyalkoxyphenyl)-3-oxy-piperidine zur behandlung von herz- und niereninsuffizienz
DE69631058T2 (de) * 1995-09-15 2004-06-03 Neurosearch A/S Piperindinverbindungen als calcium-kanal-blocker
WO2005023767A2 (en) 2003-09-10 2005-03-17 Brentwood Equities Ltd. Diastereomers of 4-aryloxy-3-hydroxypiperidines
US20070142389A1 (en) * 2005-12-20 2007-06-21 Pfizer Inc. Piperidine derivatives

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL92955C (no) * 1954-12-23
US3117975A (en) * 1960-04-22 1964-01-14 Rohm & Haas Substituted pyrrolidinones and piperidinones
US3260723A (en) * 1963-08-27 1966-07-12 Parke Davis & Co 4-phenoxy piperidines; alpha4-phenoxy piperideines
US3381013A (en) * 1964-01-15 1968-04-30 Bristol Myers Co Heterocyclicamino ethers of benzylphenols
US3446897A (en) * 1966-09-30 1969-05-27 Robins Co Inc A H Compositions and methods for the control of cardiac arrhythmia with o-substituted pyrrolidinols and s-substituted thiopyrrolidinols
CH500226A (de) 1968-08-02 1970-12-15 Ciba Geigy Ag Verfahren zur Herstellung neuer Pyrimidinderivate
DE1937459A1 (de) * 1968-08-02 1970-02-05 Ciba Geigy Neue Pyrimidinderivate und Verfahren zu ihrer Herstellung
US3823151A (en) * 1968-08-02 1974-07-09 Ciba Geigy Corp 4,5,6,7-tetrahydrothieno(2,3-d)pyridines
US3577432A (en) * 1968-12-23 1971-05-04 Robins Co Inc A H 1-substituted-3-phenoxypyrrolidines
GB1280699A (en) * 1968-12-23 1972-07-05 Robins Co Inc A H 0-substituted-4-phenoxypiperidines
US3542794A (en) * 1969-11-07 1970-11-24 Grover Cleveland Helsley 1-carbamoyl-4-phenoxypiperidines
US3686169A (en) * 1970-07-20 1972-08-22 Monsanto Co Thiocycloamides
US3743645A (en) * 1970-10-19 1973-07-03 Robins Co Inc A H 1-substituted-4-phenoxypiperidines
JPS5119987B2 (no) * 1973-02-05 1976-06-22
US4065290A (en) * 1975-07-03 1977-12-27 Eli Lilly And Company Herbicidal β-phenyl-4-piperidinones
IE45511B1 (en) * 1976-09-01 1982-09-08 Ciba Geigy Ag New derivatives of perhydro-aza-heterocycles and processesfor the production thereof
US4230718A (en) 1979-01-09 1980-10-28 A. H. Robins Company, Inc. 1-Substituted-3,4-epoxypyrrolidines
MX6634E (es) 1979-01-09 1985-09-12 Robins Co Inc A H Procedimiento para preparar el isomero trans de 3-ariloxi-4-hidroxipirrolidinas
US4251541A (en) * 1979-01-09 1981-02-17 A. H. Robins Company, Inc. 1-Substituted-3-arylthio-4-hydroxypyrrolidines

Also Published As

Publication number Publication date
HU179440B (en) 1982-10-28
AT361464B (de) 1981-03-10
GR72965B (no) 1984-01-19
JPS5331659A (en) 1978-03-25
HK8884A (en) 1984-02-10
US4246269A (en) 1981-01-20
IE45511L (en) 1978-03-01
JPS6340785B2 (no) 1988-08-12
DK387177A (da) 1978-03-02
IL52858A0 (en) 1977-10-31
CH633776A5 (de) 1982-12-31
BE858283A (fr) 1978-02-28
CS205084B2 (en) 1981-04-30
US4320137A (en) 1982-03-16
NO150081C (no) 1984-08-15
PT66955A (en) 1977-09-01
US4160837A (en) 1979-07-10
AU2838577A (en) 1979-03-08
FR2363559A1 (fr) 1978-03-31
NL7709604A (nl) 1978-03-03
CH637935A5 (de) 1983-08-31
SE7709784L (sv) 1978-03-02
NZ185062A (en) 1980-10-08
FI772566A (fi) 1978-03-02
CY1212A (en) 1984-04-06
ZA775267B (en) 1978-07-26
ES479190A1 (es) 1979-07-01
CH637933A5 (de) 1983-08-31
AU514675B2 (en) 1981-02-19
PT66955B (en) 1979-02-07
SG63783G (en) 1984-07-27
ES471739A1 (es) 1979-10-16
SE437155B (sv) 1985-02-11
DE2738477A1 (de) 1978-03-02
ES471738A1 (es) 1979-10-16
MY8500100A (en) 1985-12-31
DK156301C (da) 1989-12-11
ES462040A1 (es) 1978-12-01
ES479112A1 (es) 1979-07-01
ATA627977A (de) 1980-08-15
CA1112242A (en) 1981-11-10
FI68229B (fi) 1985-04-30
IE45511B1 (en) 1982-09-08
FI68229C (fi) 1985-08-12
CH637934A5 (de) 1983-08-31
ES471740A1 (es) 1979-10-16
CS205085B2 (en) 1981-04-30
DE2738477C2 (no) 1989-11-09
DK156301B (da) 1989-07-31
DD132584A5 (de) 1978-10-11
CS205087B2 (en) 1981-04-30
NO150081B (no) 1984-05-07
CH637932A5 (de) 1983-08-31
FR2363559B1 (no) 1982-03-26
GB1585133A (en) 1981-02-25

Similar Documents

Publication Publication Date Title
RO76589A (ro) Procedeu pentru prepararea alchilaminelor heterociclice
NO782768L (no) Fremgangsmaate for fremstilling av alkenderivater
SE440501B (sv) Forfarande for framstellning av substituerade fenylamidoximer
SE432595B (sv) Analogiforfarande for framstellning av piperidyl-indolderivat
NO773548L (no) Fremgangsmaate for fremstilling av spiro-hydantoinderivater
SE440772B (sv) Forfarande for framstellning av nya 1-naftylmetyl-cinnamyl-aminderivat
NO773009L (no) Fremgangsmaate til fremstilling av nye derivater av perhydro-aza-heterocykler
NO770841L (no) Fremgangsm}te for fremstilling av nye imidazo-tiazol-derivater
NO784281L (no) Fremgangsmaate til fremstilling av nye 2alfa-cyano-3-okso-steroider
NO791228L (no) Fremgangsmaate til fremstilling av nye mercaptoimidazolderivater
SE428684B (sv) Analogiforfarande for framstellning av substituerade (3-lagalkylamino-2-hydroxi-propoxi)pyridiner
SE438856B (sv) Analogiforfarande for framstellning av 1-acyloximetyl-3-fluoruracilderivat
SE433212B (sv) Forfarande for framstellning av 4-hydroxi-aporfin-derivat
SE433745B (sv) Forfarande for framstellning av tetrahydroisokinolinderivat
NO783958L (no) Fremgangsmaate for fremstilling av nye indolokinolizidiner
SE431871B (sv) Forfarande for framstellning av 2-brom-6-fluor-n-2-imidazolidinylidenbensamin
NO772997L (no) Fremgangsmaate til fremstilling av nye benzopyranderivater
SE423390B (sv) Foerfarande foer framstaellning av eburnameninderivat
SE443140B (sv) Forfarande for framstellning av karbostyrilderivat
SE433220B (sv) Forfarande for framstellning av nya pregnan-derivat
SE423902B (sv) Forfarande for framstellning av purinderivat
SE439631B (sv) Forfarande for framstellning av 3,4-dihydrokarbostyrilderivat
SE431336B (sv) Analogiforfarande for framstellning av substituerade 8-azapurinderivat
SE421125B (sv) Forfarande for framstellning av 5-m-tolyloxiuracil
NO773472L (no) Fremgangsmaate ved fremstilling av nye piperidylidenderivater