CS199578B2 - Process for preparing new aryloxyaminobutanoles,stereoisomers thereof and non-toxic additive salts with acids - Google Patents

Process for preparing new aryloxyaminobutanoles,stereoisomers thereof and non-toxic additive salts with acids Download PDF

Info

Publication number
CS199578B2
CS199578B2 CS751129A CS112975A CS199578B2 CS 199578 B2 CS199578 B2 CS 199578B2 CS 751129 A CS751129 A CS 751129A CS 112975 A CS112975 A CS 112975A CS 199578 B2 CS199578 B2 CS 199578B2
Authority
CS
Czechoslovakia
Prior art keywords
compounds
general formula
formula
hydroxy
stereoisomers
Prior art date
Application number
CS751129A
Other languages
Czech (cs)
English (en)
Inventor
Kalman Harsanyi
Deszoe Korbonits
Erzsebet Molnar
Joszef Szegi
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Priority to CS774232A priority Critical patent/CS199579B2/cs
Publication of CS199578B2 publication Critical patent/CS199578B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/34—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS751129A 1974-02-20 1975-02-20 Process for preparing new aryloxyaminobutanoles,stereoisomers thereof and non-toxic additive salts with acids CS199578B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS774232A CS199579B2 (cs) 1974-02-20 1977-06-27 Způsob výroby nových aryloxyamlnobntanolů, Jejich stereoisomerů a netoxických adičních solí s kyselinami

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUCI1449A HU169464B (e) 1974-02-20 1974-02-20

Publications (1)

Publication Number Publication Date
CS199578B2 true CS199578B2 (en) 1980-07-31

Family

ID=10994508

Family Applications (1)

Application Number Title Priority Date Filing Date
CS751129A CS199578B2 (en) 1974-02-20 1975-02-20 Process for preparing new aryloxyaminobutanoles,stereoisomers thereof and non-toxic additive salts with acids

Country Status (22)

Country Link
JP (1) JPS5929063B2 (e)
AT (1) AT339281B (e)
BE (1) BE825745A (e)
BG (2) BG26366A3 (e)
CA (1) CA1074338A (e)
CH (1) CH619684A5 (e)
CS (1) CS199578B2 (e)
DD (1) DD119414A5 (e)
DE (1) DE2506355C2 (e)
DK (1) DK141935B (e)
ES (2) ES434784A1 (e)
FI (1) FI61304C (e)
FR (1) FR2261001B1 (e)
GB (1) GB1457086A (e)
HU (1) HU169464B (e)
IL (1) IL46634A (e)
NL (1) NL182698C (e)
NO (1) NO141754C (e)
PL (2) PL99025B1 (e)
SE (1) SE433935B (e)
SU (1) SU1025327A3 (e)
YU (2) YU36916B (e)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL48309A (en) * 1974-10-25 1980-01-31 Robins Co Inc A H 1-aryloxy-4-amino-2-butanols and pharmaceutical compositions containing them
EP0097000B1 (en) * 1982-06-10 1987-09-09 Beecham Wuelfing GmbH & Co KG Amine derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1957706C3 (de) * 1968-11-18 1978-06-29 Pfizer Corp., Colon (Panama) Kernsubstituierte 3-Phenoxy-l-phenoxyalkylamino-propan-2-ole und Arzneimittel auf deren Basis
GB1245148A (en) * 1968-11-18 1971-09-08 Pfizer Ltd Propanolamine derivatives
SE384853B (sv) * 1972-04-04 1976-05-24 Haessle Ab Forfarande for framstellning av nya aminer
CH556818A (de) * 1969-09-24 1974-12-13 Ici Ltd Verfahren zur herstellung von alkanolaminderivaten.

Also Published As

Publication number Publication date
YU167681A (en) 1983-04-27
FR2261001B1 (e) 1978-07-21
FR2261001A1 (e) 1975-09-12
IL46634A (en) 1979-01-31
JPS5929063B2 (ja) 1984-07-18
CH619684A5 (en) 1980-10-15
CA1074338A (en) 1980-03-25
IL46634A0 (en) 1975-04-25
JPS50117728A (e) 1975-09-16
SU1025327A3 (ru) 1983-06-23
ATA114075A (de) 1977-02-15
SE7501801L (e) 1975-08-21
DD119414A5 (e) 1976-04-20
FI61304C (fi) 1982-07-12
NO141754B (no) 1980-01-28
DK141935C (e) 1980-12-08
BG26367A4 (bg) 1979-03-15
ES453326A1 (es) 1977-11-16
PL99023B1 (pl) 1978-06-30
NO141754C (no) 1980-05-07
YU37116B (en) 1984-08-31
NO750566L (e) 1975-08-21
HU169464B (e) 1976-11-28
ES434784A1 (es) 1977-03-16
DK141935B (da) 1980-07-21
BG26366A3 (bg) 1979-03-15
FI750443A (e) 1975-08-21
DK60875A (e) 1975-10-20
NL7501951A (nl) 1975-08-22
FI61304B (fi) 1982-03-31
BE825745A (fr) 1975-06-16
NL182698C (nl) 1988-05-02
SE433935B (sv) 1984-06-25
DE2506355C2 (de) 1983-10-06
PL99025B1 (pl) 1978-06-30
DE2506355A1 (de) 1975-08-21
YU37375A (en) 1982-06-18
YU36916B (en) 1984-08-31
GB1457086A (en) 1976-12-01
AT339281B (de) 1977-10-10

Similar Documents

Publication Publication Date Title
US4387099A (en) Alkanolamine derivatives
US3836671A (en) Alkanolamine derivatives for producing beta-adrenergic blockade
US4081447A (en) 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
EP0004532B1 (de) 1-Aryloxy-3-nitratoalkylamino-2-propanole, Verfahren zu ihrer Herstellung und ihre pharmazeutischen Zubereitungen
US4059622A (en) Alkanolamine derivatives
US4308399A (en) O-(3-Amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
FR2496102A1 (fr) Benzopyranes 7-substitues, leur preparation et leur application en tant que medicaments
NO129792B (e)
US4115409A (en) Alkanolamine derivatives
CS199578B2 (en) Process for preparing new aryloxyaminobutanoles,stereoisomers thereof and non-toxic additive salts with acids
US3934032A (en) Alkanolamine derivatives for treating hypertension
NO792113L (no) Membranstabiliserende forbindelser som har beta-receptor blokkerende aktivitet, deres fremgangsmaate samt fremgangsmaate for behandling av arrhytmetiske tilstander, og farmasoeytiske preparater som inneholder disse
FI62060B (fi) Foerfarande foer framstaellning av beta-blockerande substituerad 2-hydroxi-3-(2-acyl-4-ureido-fenoxi)-propylaminderivat
US4141987A (en) 1-Aryloxy-3-thenamidoalkylamino-2-propanol derivatives
US3905990A (en) Basically substituted benzimidazole derivatives
US4086357A (en) Amide derivatives
US4101579A (en) Phenethanolamine ethers
US4171374A (en) Alkanolamine derivatives
DD153682A1 (de) Verfahren zur herstellung neuer alkanolamine
CS199579B2 (cs) Způsob výroby nových aryloxyamlnobntanolů, Jejich stereoisomerů a netoxických adičních solí s kyselinami
US3959486A (en) Method for producing β-adrenergic blockage with alkanolamine derivatives
EP0086256B1 (de) 1-(2,4-Dichlorphenoxy)-3-(3,4-dimethoxy-Beta-phenethylamino)-2-propanol, Verfahren zu seiner Herstellung und dieses enthaltende pharmazeutische Zusammensetzungen
US3799973A (en) 1-(phenoxy)-3-alkylamino-2-propanols and the salts thereof
US4200652A (en) Alkanolamine derivatives
US4172150A (en) Cardiac stimulants