CS199522B2 - Method of producing morphine derivatives - Google Patents

Method of producing morphine derivatives Download PDF

Info

Publication number
CS199522B2
CS199522B2 CS781847A CS184778A CS199522B2 CS 199522 B2 CS199522 B2 CS 199522B2 CS 781847 A CS781847 A CS 781847A CS 184778 A CS184778 A CS 184778A CS 199522 B2 CS199522 B2 CS 199522B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
alkyl
group
carbon atoms
solution
Prior art date
Application number
CS781847A
Other languages
Czech (cs)
English (en)
Inventor
Ryszard J Kobylecki
Ian G Guest
John W Lewis
Gordon W Kirby
Original Assignee
Reckitt & Colmann Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt & Colmann Prod Ltd filed Critical Reckitt & Colmann Prod Ltd
Publication of CS199522B2 publication Critical patent/CS199522B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CS781847A 1977-03-23 1978-03-22 Method of producing morphine derivatives CS199522B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB12342/77A GB1587831A (en) 1977-03-23 1977-03-23 Morphine derivatives

Publications (1)

Publication Number Publication Date
CS199522B2 true CS199522B2 (en) 1980-07-31

Family

ID=10002756

Family Applications (1)

Application Number Title Priority Date Filing Date
CS781847A CS199522B2 (en) 1977-03-23 1978-03-22 Method of producing morphine derivatives

Country Status (25)

Country Link
US (1) US4241067A (en, 2012)
JP (1) JPS53121798A (en, 2012)
AR (1) AR218296A1 (en, 2012)
AT (1) AT360664B (en, 2012)
AU (1) AU518614B2 (en, 2012)
BE (1) BE865182A (en, 2012)
CA (1) CA1089455A (en, 2012)
CH (1) CH630629A5 (en, 2012)
CS (1) CS199522B2 (en, 2012)
DD (1) DD135081A5 (en, 2012)
DE (1) DE2812581A1 (en, 2012)
DK (1) DK149753C (en, 2012)
ES (1) ES468170A1 (en, 2012)
FR (1) FR2384775A1 (en, 2012)
GB (1) GB1587831A (en, 2012)
HU (1) HU177722B (en, 2012)
IE (1) IE46442B1 (en, 2012)
IT (1) IT1105172B (en, 2012)
LU (1) LU79295A1 (en, 2012)
NL (1) NL7803084A (en, 2012)
NZ (1) NZ186693A (en, 2012)
PL (1) PL111722B1 (en, 2012)
SE (1) SE436132B (en, 2012)
SU (1) SU856381A3 (en, 2012)
ZA (1) ZA781525B (en, 2012)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362870A (en) * 1980-01-16 1982-12-07 Regents Of The University Of Minnesota Selective opioid receptor alkylating agents
US4401672A (en) * 1981-10-13 1983-08-30 Regents Of The University Of Minnesota Non-addictive narcotic antitussive preparation
EP0103636B1 (en) * 1982-03-16 1990-09-12 Rockefeller University Use of opium antagonists for the manufacture of medicaments for controlling gastrointestinal dysmotility
GB8711558D0 (en) * 1987-05-15 1987-06-17 Reckitt & Colmann Prod Ltd Derivative of codeine
DE69321525T2 (de) * 1992-01-23 1999-03-04 Toray Industries, Inc., Tokio/Tokyo Morphinan-derivate und medizinische verwendung
DE69414085T2 (de) * 1993-07-19 1999-03-18 Toray Industries, Inc., Tokio/Tokyo Wirkstoff zum schutze von gehirnzellen
DE69424853T2 (de) * 1993-07-23 2000-10-05 Toray Industries, Inc. Morphinan-derivate und ihre medizinische verwendung
US20060063792A1 (en) * 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use
US8067597B2 (en) 2005-06-16 2011-11-29 Mallinckrodt Llc Synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs
US9969746B2 (en) 2013-12-05 2018-05-15 The University Of Bath Opioid compounds and their uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
BE788478A (fr) * 1971-09-08 1973-03-06 Bristol Myers Co Procede de preparation de composes analgesiques
US4017497A (en) * 1975-11-18 1977-04-12 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives

Also Published As

Publication number Publication date
PL111722B1 (en) 1980-09-30
DK129978A (da) 1978-09-24
IE46442B1 (en) 1983-06-15
SU856381A3 (ru) 1981-08-15
LU79295A1 (fr) 1979-10-29
CH630629A5 (fr) 1982-06-30
DK149753C (da) 1987-07-06
CA1089455A (en) 1980-11-11
NZ186693A (en) 1979-10-25
SE436132B (sv) 1984-11-12
AU3435678A (en) 1979-09-27
ATA204378A (de) 1980-06-15
IT1105172B (it) 1985-10-28
JPS6259112B2 (en, 2012) 1987-12-09
HU177722B (en) 1981-12-28
ZA781525B (en) 1979-04-25
ES468170A1 (es) 1979-01-01
AR218296A1 (es) 1980-05-30
DE2812581A1 (de) 1978-09-28
PL205497A1 (pl) 1979-06-04
BE865182A (fr) 1978-09-22
GB1587831A (en) 1981-04-08
US4241067A (en) 1980-12-23
DK149753B (da) 1986-09-22
AT360664B (de) 1981-01-26
IE780514L (en) 1978-09-23
IT7848545A0 (it) 1978-03-22
DD135081A5 (de) 1979-04-11
AU518614B2 (en) 1981-10-08
FR2384775B1 (en, 2012) 1981-04-30
FR2384775A1 (fr) 1978-10-20
NL7803084A (nl) 1978-09-26
SE7803329L (sv) 1978-09-24
JPS53121798A (en) 1978-10-24

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