CR7317A - Derivados de 3-azabiciclo [3.1.0] hexano como antagonistas de un receptor de opioide - Google Patents

Derivados de 3-azabiciclo [3.1.0] hexano como antagonistas de un receptor de opioide

Info

Publication number
CR7317A
CR7317A CR7317A CR7317A CR7317A CR 7317 A CR7317 A CR 7317A CR 7317 A CR7317 A CR 7317A CR 7317 A CR7317 A CR 7317A CR 7317 A CR7317 A CR 7317A
Authority
CR
Costa Rica
Prior art keywords
antagonists
azabiciclo
hexano
derivatives
opioid
Prior art date
Application number
CR7317A
Other languages
English (en)
Spanish (es)
Inventor
Furst Mchardy Stanton
Liras Spiros
Donald Heck Steven
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of CR7317A publication Critical patent/CR7317A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/04Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CR7317A 2001-10-22 2004-04-20 Derivados de 3-azabiciclo [3.1.0] hexano como antagonistas de un receptor de opioide CR7317A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33851101P 2001-10-22 2001-10-22

Publications (1)

Publication Number Publication Date
CR7317A true CR7317A (es) 2006-08-09

Family

ID=23325099

Family Applications (1)

Application Number Title Priority Date Filing Date
CR7317A CR7317A (es) 2001-10-22 2004-04-20 Derivados de 3-azabiciclo [3.1.0] hexano como antagonistas de un receptor de opioide

Country Status (41)

Country Link
US (3) US7049335B2 (OSRAM)
EP (1) EP1440059B1 (OSRAM)
JP (2) JP4155522B2 (OSRAM)
KR (1) KR100621292B1 (OSRAM)
CN (1) CN100368398C (OSRAM)
AP (1) AP1816A (OSRAM)
AR (1) AR036905A1 (OSRAM)
AT (1) ATE392415T1 (OSRAM)
AU (1) AU2002329557B2 (OSRAM)
BR (1) BR0213464A (OSRAM)
CA (1) CA2463264C (OSRAM)
CR (1) CR7317A (OSRAM)
DE (1) DE60226161T2 (OSRAM)
DK (1) DK1440059T3 (OSRAM)
EA (1) EA006708B1 (OSRAM)
EC (1) ECSP045077A (OSRAM)
ES (1) ES2302839T3 (OSRAM)
GE (1) GEP20084300B (OSRAM)
GT (1) GT200200216A (OSRAM)
HN (1) HN2002000299A (OSRAM)
HR (1) HRP20040288A2 (OSRAM)
HU (1) HUP0401884A2 (OSRAM)
IL (2) IL161157A0 (OSRAM)
IS (1) IS7187A (OSRAM)
MA (1) MA27141A1 (OSRAM)
MX (1) MXPA04003730A (OSRAM)
MY (1) MY136580A (OSRAM)
NO (1) NO329092B1 (OSRAM)
NZ (1) NZ531807A (OSRAM)
OA (1) OA12711A (OSRAM)
PA (1) PA8556701A1 (OSRAM)
PE (1) PE20030610A1 (OSRAM)
PL (1) PL368919A1 (OSRAM)
PT (1) PT1440059E (OSRAM)
RS (1) RS25104A (OSRAM)
SI (1) SI1440059T1 (OSRAM)
SV (1) SV2004001363A (OSRAM)
TN (1) TNSN04071A1 (OSRAM)
UA (1) UA75714C2 (OSRAM)
WO (1) WO2003035622A1 (OSRAM)
ZA (1) ZA200402172B (OSRAM)

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ATE434607T1 (de) 2001-04-18 2009-07-15 Euro Celtique Sa 1-(4-amino-cyclohexyl)-1,3-dihydro-2h- benzimidazole-2-on derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz
SI1440059T1 (sl) * 2001-10-22 2008-08-31 Pfizer Prod Inc Derivati 3-azabiciklo(3.1.0)heksana kot antagonisti opioidnega receptorja
CA2522323C (en) * 2003-04-14 2009-09-15 Pfizer Products Inc. 3-azabicyclo[3.2.1]octane derivatives as opioid receptor ligands
US20050043327A1 (en) * 2003-08-21 2005-02-24 Pfizer Inc Pharmaceutical composition for the prevention and treatment of addiction in a mammal
US7153976B2 (en) * 2003-10-06 2006-12-26 Pfizer Inc. Purification process for an azabicyclo[3.1.0]hexane compound
AU2004281794B2 (en) * 2003-10-14 2010-04-22 Pfizer Products Inc. Bicyclic [3.1.0] derivatives as glycine transporter inhibitors
KR20060096038A (ko) * 2003-10-16 2006-09-05 화이자 프로덕츠 인크. 3-아자비시클로〔3.1.0〕헥산 유도체의 제조법
CA2557115C (en) 2004-02-23 2012-10-02 Glaxo Group Limited Azabicyclo (3.1.0) hexane derivatives useful as modulators of dopamine d3 receptors
EP1726590A4 (en) * 2004-03-05 2009-07-15 Banyu Pharma Co Ltd CYCLOALKANOPYRIDINDERIVAT
CA2590182A1 (en) * 2004-12-14 2006-06-22 Shionogi & Co., Ltd. Indolomorphinan derivatives having carboxy at the 6'-position
GB0512099D0 (en) * 2005-06-14 2005-07-20 Glaxo Group Ltd Compounds
GB0517191D0 (en) * 2005-08-22 2005-09-28 Glaxo Group Ltd Compounds
US7592461B2 (en) * 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
MY145633A (en) 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
WO2008075162A2 (en) * 2006-12-15 2008-06-26 Pfizer Limited Selective mu opioid receptor antagonists for the treatment of female sexual dysfunction
TWI409067B (zh) * 2007-02-28 2013-09-21 Theravance Inc 8-氮雜雙環〔3.2.1〕辛烷化合物之結晶型
WO2009029253A1 (en) * 2007-08-27 2009-03-05 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
WO2009029252A1 (en) * 2007-08-27 2009-03-05 Theravance, Inc. Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
ATE502939T1 (de) * 2007-08-27 2011-04-15 Theravance Inc Disubstituierte alkyl-8-azabicycloä3.2.1üoktan- verbindungen als mu-opioid-rezeptorantagonisten
TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之8-氮雜雙環〔3.2.1〕辛基-2-羥基苯甲醯胺化合物
US9133116B2 (en) 2010-09-28 2015-09-15 Panacea Biotec Ltd. Bicyclic compounds
WO2015076310A1 (ja) 2013-11-20 2015-05-28 株式会社 三和化学研究所 新規3-アザビシクロ[3.1.0]ヘキサン誘導体及びその医薬用途
WO2016186184A1 (ja) * 2015-05-20 2016-11-24 株式会社 三和化学研究所 新規3-アザビシクロ[3.1.0]ヘキサン誘導体の塩の結晶及びその医薬用途
AU2018229062A1 (en) 2017-03-02 2019-09-26 Ube Industries, Ltd. Therapeutic agent for alcohol use disorders

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GB9912415D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
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US20020025948A1 (en) * 2000-06-23 2002-02-28 Banks Bernard Joseph 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
US20030207876A1 (en) * 2000-06-23 2003-11-06 Banks Bernard Joseph 3-Azabicyclo[3.1.0]hexane derivatives useful in therapy
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SI1440059T1 (sl) 2001-10-22 2008-08-31 Pfizer Prod Inc Derivati 3-azabiciklo(3.1.0)heksana kot antagonisti opioidnega receptorja
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US20040204453A1 (en) 2003-04-14 2004-10-14 Pfizer Inc 4-Phenyl-piperidine compounds and their use as modulators of opioid receptors
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US20050043327A1 (en) 2003-08-21 2005-02-24 Pfizer Inc Pharmaceutical composition for the prevention and treatment of addiction in a mammal
US7153976B2 (en) 2003-10-06 2006-12-26 Pfizer Inc. Purification process for an azabicyclo[3.1.0]hexane compound

Also Published As

Publication number Publication date
MY136580A (en) 2008-10-31
US7049335B2 (en) 2006-05-23
WO2003035622A1 (en) 2003-05-01
CN1610664A (zh) 2005-04-27
BR0213464A (pt) 2004-11-09
UA75714C2 (en) 2006-05-15
SV2004001363A (es) 2004-02-24
US20030087898A1 (en) 2003-05-08
PE20030610A1 (es) 2003-07-12
JP4155522B2 (ja) 2008-09-24
JP2005511545A (ja) 2005-04-28
SI1440059T1 (sl) 2008-08-31
EA200400467A1 (ru) 2004-08-26
GT200200216A (es) 2003-05-23
US20050171178A1 (en) 2005-08-04
IS7187A (is) 2004-03-18
AP1816A (en) 2008-01-04
HN2002000299A (es) 2002-11-21
DE60226161D1 (de) 2008-05-29
DE60226161T2 (de) 2009-07-02
ECSP045077A (es) 2004-05-28
IL161157A0 (en) 2004-08-31
TNSN04071A1 (fr) 2006-06-01
MXPA04003730A (es) 2004-07-23
ES2302839T3 (es) 2008-08-01
PA8556701A1 (es) 2003-07-28
OA12711A (en) 2006-06-27
RS25104A (sr) 2007-02-05
HUP0401884A2 (hu) 2005-01-28
CA2463264A1 (en) 2003-05-01
EA006708B1 (ru) 2006-02-24
CA2463264C (en) 2009-05-26
NZ531807A (en) 2006-03-31
GEP20084300B (en) 2008-02-11
PT1440059E (pt) 2008-05-16
HK1072052A1 (zh) 2005-08-12
EP1440059B1 (en) 2008-04-16
MA27141A1 (fr) 2005-01-03
PL368919A1 (en) 2005-04-04
AU2002329557B2 (en) 2008-07-31
AP2004003007A0 (en) 2004-06-30
CN100368398C (zh) 2008-02-13
KR100621292B1 (ko) 2006-09-13
ZA200402172B (en) 2006-09-27
JP2008069169A (ja) 2008-03-27
NO329092B1 (no) 2010-08-23
ATE392415T1 (de) 2008-05-15
HRP20040288A2 (en) 2004-12-31
AR036905A1 (es) 2004-10-13
EP1440059A1 (en) 2004-07-28
KR20040048984A (ko) 2004-06-10
NO20041626L (no) 2004-05-26
IL161157A (en) 2009-09-01
DK1440059T3 (da) 2008-07-14
US20070054950A1 (en) 2007-03-08

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