CR20120202A - Métodos y composiciones para tratar cáncer - Google Patents
Métodos y composiciones para tratar cáncerInfo
- Publication number
- CR20120202A CR20120202A CR20120202A CR20120202A CR20120202A CR 20120202 A CR20120202 A CR 20120202A CR 20120202 A CR20120202 A CR 20120202A CR 20120202 A CR20120202 A CR 20120202A CR 20120202 A CR20120202 A CR 20120202A
- Authority
- CR
- Costa Rica
- Prior art keywords
- methods
- compositions
- treat cancer
- equipment
- pharmaceutical compositions
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25666909P | 2009-10-30 | 2009-10-30 | |
| US25669009P | 2009-10-30 | 2009-10-30 | |
| US26101409P | 2009-11-13 | 2009-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20120202A true CR20120202A (es) | 2012-06-12 |
Family
ID=43922622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20120202A CR20120202A (es) | 2009-10-30 | 2012-04-25 | Métodos y composiciones para tratar cáncer |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20120316137A1 (enExample) |
| EP (2) | EP2493460A4 (enExample) |
| JP (1) | JP2013509444A (enExample) |
| KR (1) | KR20120115237A (enExample) |
| CN (1) | CN102770129A (enExample) |
| AU (1) | AU2010313152A1 (enExample) |
| CA (1) | CA2777128A1 (enExample) |
| CL (1) | CL2012001133A1 (enExample) |
| CR (1) | CR20120202A (enExample) |
| EA (1) | EA201290255A1 (enExample) |
| IL (1) | IL218987A0 (enExample) |
| MX (1) | MX2012005023A (enExample) |
| NI (1) | NI201200072A (enExample) |
| PH (1) | PH12012500809A1 (enExample) |
| WO (1) | WO2011053938A1 (enExample) |
| ZA (1) | ZA201202256B (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1973545B1 (en) | 2005-12-23 | 2013-01-30 | Ariad Pharmaceuticals, Inc. | Bicyclic heteroaryl compounds |
| JP6130391B2 (ja) | 2011-11-23 | 2017-05-17 | インテリカイン, エルエルシー | Mtor阻害剤を使用する強化された治療レジメン |
| CN103570724B (zh) * | 2012-07-27 | 2015-12-16 | 中国科学院广州生物医药与健康研究院 | ponatinib 的合成方法 |
| US10172796B2 (en) | 2012-12-03 | 2019-01-08 | Manli International Ltd. | Use of umirolimus and its derivatives for treating cancer |
| CA3167093A1 (en) | 2012-12-12 | 2014-06-12 | Ariad Pharmaceuticals, Inc. | Crystalline form c of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride |
| AU2013204506B2 (en) * | 2012-12-13 | 2016-05-05 | Takeda Pharmaceuticals U.S.A., Inc. | Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride |
| KR20150123250A (ko) | 2013-03-06 | 2015-11-03 | 제넨테크, 인크. | 암 약물 내성의 치료 및 예방 방법 |
| US20140343282A1 (en) | 2013-05-16 | 2014-11-20 | Apicore, Llc | Processes for making ponatinib and intermediates thereof |
| EP3016954B1 (en) * | 2013-07-04 | 2018-10-31 | Sandoz AG | Crystalline forms of ponatinib hydrochloride |
| WO2015014851A1 (en) * | 2013-07-30 | 2015-02-05 | Fresenius Kabi Deutschland Gmbh | Hydroxyalkyl starch for the treatment of hematological neoplasms |
| CN104650086A (zh) * | 2013-11-22 | 2015-05-27 | 天津市汉康医药生物技术有限公司 | 盐酸帕纳替尼化合物 |
| WO2015085973A1 (en) * | 2013-12-09 | 2015-06-18 | Zentiva, K.S. | Modifications of 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl] benzamide hydrochloride salt |
| WO2015085971A1 (en) * | 2013-12-09 | 2015-06-18 | Zentiva, K.S. | Hydrobromide salt of 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl] benzamide |
| WO2015085972A1 (en) * | 2013-12-09 | 2015-06-18 | Zentiva, K.S. | NOVEL SALTS OF 3-(2-IMIDAZO[1,2-b]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-[4-[(4-METHYL- 1-PIPERAZINYL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL] BENZAMIDE |
| CN110105340B (zh) | 2013-12-24 | 2022-10-25 | 昂康塔睿迪斯股份有限公司 | 苯甲酰胺和烟酰胺化合物及其使用方法 |
| CN104496994B (zh) * | 2014-01-06 | 2016-12-07 | 广东东阳光药业有限公司 | 一种炔类杂芳基化合物的新晶型 |
| JP2017517552A (ja) | 2014-06-13 | 2017-06-29 | ジェネンテック, インコーポレイテッド | 抗癌剤耐性の治療及び防止方法 |
| CN105267200A (zh) * | 2014-07-01 | 2016-01-27 | 中国科学院上海有机化学研究所 | 一种黄酮类化合物的应用 |
| US10202365B2 (en) | 2015-02-06 | 2019-02-12 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors |
| EA038890B1 (ru) | 2015-11-02 | 2021-11-03 | Блюпринт Медсинс Корпорейшн | Ингибиторы ret |
| AR107912A1 (es) | 2016-03-17 | 2018-06-28 | Blueprint Medicines Corp | Inhibidores de ret |
| WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| WO2018017983A1 (en) | 2016-07-22 | 2018-01-25 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to ret |
| CN106236732A (zh) * | 2016-08-31 | 2016-12-21 | 佛山市弘泰药物研发有限公司 | 一种依维莫司软胶囊的制备方法 |
| MA53150A (fr) * | 2016-12-15 | 2021-05-26 | Ariad Pharma Inc | Composés de benzimidazole en tant qu'inhibiteurs de c-kit |
| CN108047230B (zh) * | 2017-12-29 | 2020-04-17 | 深圳蓝新科技有限公司 | 帕纳替尼的制备方法 |
| CA3096043A1 (en) | 2018-04-03 | 2019-10-10 | Blueprint Medicines Corporation | Ret inhibitor for use in treating cancer having a ret alteration |
| CN109875999B (zh) * | 2018-05-29 | 2022-07-12 | 上海交通大学医学院附属第九人民医院 | 泊那替尼在kit突变型恶性黑色素瘤中的应用 |
| WO2019246479A1 (en) | 2018-06-22 | 2019-12-26 | Johnson Matthey Public Limited Company | Form of ponatinib |
| WO2020113210A1 (en) * | 2018-12-01 | 2020-06-04 | The Regents Of The University Of Colorado, A Body Corporate | Functional screen for small molecule and monoclonal antibody drug sensitivity in multiple myeloma patients |
| EP3861990A4 (en) * | 2019-12-09 | 2022-02-23 | Ascentage Pharma (Suzhou) Co., Ltd. | PHARMACEUTICAL COMPOSITION OF AN ALKYNYL-CONTAINING COMPOUND, ITS PREPARATION METHOD AND ITS APPLICATION |
| WO2021225980A1 (en) * | 2020-05-04 | 2021-11-11 | Dna-Seq, Inc. | Methods and systems for determination of an effective therapeutic regimen and drug discovery |
| KR20230017234A (ko) | 2020-05-29 | 2023-02-03 | 블루프린트 메디신즈 코포레이션 | 프랄세티닙의 고체 형태 |
| CN114533879B (zh) * | 2020-11-19 | 2023-09-29 | 广州顺健生物医药科技有限公司 | 治疗癌症的联合疗法 |
| CN114796227B (zh) * | 2022-05-30 | 2023-12-01 | 中山大学 | Ponatinib在制备预防或治疗血管退行性疾病药物中的应用及该药物 |
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| WO2008032077A1 (en) | 2006-09-14 | 2008-03-20 | Astrazeneca Ab | Pyrimidine derivatives |
| WO2008032060A1 (en) | 2006-09-14 | 2008-03-20 | Astrazeneca Ab | 4-benzimidaz0lyl-6-m0rph0lin0-2-piperazinylpyrimidine derivatives as p13k and mtor inhibitors for the treatment of proliferative disorders |
| WO2008032064A1 (en) | 2006-09-14 | 2008-03-20 | Astrazeneca Ab | Pyrimidine derivatives |
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| BRPI0814818A2 (pt) | 2007-07-09 | 2019-09-10 | Astrazeneca Ab | composto, uso de um composto, métodos para produzir um efeito anti-proliferativo e um efeito inibitório de mtor quinase em uma animal de sangue quente, método para tratar doenças, e, composição farmacêutica |
| CA2692725A1 (en) | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Compound - 946 |
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| WO2009076373A1 (en) * | 2007-12-10 | 2009-06-18 | Concert Pharmaceuticals Inc. | Heterocyclic kinase inhibitors |
| EP2611443A2 (en) * | 2010-09-01 | 2013-07-10 | ArQule, Inc. | Methods for treatment of non-small cell lung cancer |
-
2010
- 2010-11-01 US US13/504,251 patent/US20120316137A1/en not_active Abandoned
- 2010-11-01 PH PH1/2012/500809A patent/PH12012500809A1/en unknown
- 2010-11-01 CA CA2777128A patent/CA2777128A1/en not_active Abandoned
- 2010-11-01 EA EA201290255A patent/EA201290255A1/ru unknown
- 2010-11-01 MX MX2012005023A patent/MX2012005023A/es not_active Application Discontinuation
- 2010-11-01 WO PCT/US2010/055016 patent/WO2011053938A1/en not_active Ceased
- 2010-11-01 EP EP10827625.4A patent/EP2493460A4/en not_active Withdrawn
- 2010-11-01 JP JP2012537178A patent/JP2013509444A/ja active Pending
- 2010-11-01 CN CN2010800491501A patent/CN102770129A/zh active Pending
- 2010-11-01 EP EP13189355.4A patent/EP2762142A1/en not_active Withdrawn
- 2010-11-01 AU AU2010313152A patent/AU2010313152A1/en not_active Abandoned
- 2010-11-01 KR KR1020127014086A patent/KR20120115237A/ko not_active Withdrawn
-
2012
- 2012-03-28 ZA ZA2012/02256A patent/ZA201202256B/en unknown
- 2012-04-02 IL IL218987A patent/IL218987A0/en unknown
- 2012-04-25 CR CR20120202A patent/CR20120202A/es unknown
- 2012-04-27 NI NI201200072A patent/NI201200072A/es unknown
- 2012-04-30 CL CL2012001133A patent/CL2012001133A1/es unknown
-
2013
- 2013-03-13 US US13/802,039 patent/US20130178622A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20120115237A (ko) | 2012-10-17 |
| NI201200072A (es) | 2012-08-20 |
| JP2013509444A (ja) | 2013-03-14 |
| CL2012001133A1 (es) | 2013-08-02 |
| WO2011053938A8 (en) | 2011-08-11 |
| PH12012500809A1 (en) | 2012-11-26 |
| CA2777128A1 (en) | 2011-05-05 |
| WO2011053938A1 (en) | 2011-05-05 |
| ZA201202256B (en) | 2012-12-27 |
| AU2010313152A1 (en) | 2012-04-19 |
| CN102770129A (zh) | 2012-11-07 |
| EP2493460A1 (en) | 2012-09-05 |
| US20130178622A1 (en) | 2013-07-11 |
| IL218987A0 (en) | 2012-06-28 |
| US20120316137A1 (en) | 2012-12-13 |
| MX2012005023A (es) | 2012-06-19 |
| EP2493460A4 (en) | 2013-04-24 |
| EA201290255A1 (ru) | 2013-04-30 |
| EP2762142A1 (en) | 2014-08-06 |
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