CL2012001133A1 - Composicion farmaceutica oral que comprende ponatinib 3-(imidazo[1,2-b]piridazin-3-iletinil)-4-metil-n-(4-((4-metilpiperazin-1-il)-metil)-3-(trifluorometil)fenil)benzamida y al menos un excipiente farmaceuticamente aceptable; y su uso para el tratamiento de neoplasma, cancer o un trastorno hiperproliferativo. - Google Patents
Composicion farmaceutica oral que comprende ponatinib 3-(imidazo[1,2-b]piridazin-3-iletinil)-4-metil-n-(4-((4-metilpiperazin-1-il)-metil)-3-(trifluorometil)fenil)benzamida y al menos un excipiente farmaceuticamente aceptable; y su uso para el tratamiento de neoplasma, cancer o un trastorno hiperproliferativo.Info
- Publication number
- CL2012001133A1 CL2012001133A1 CL2012001133A CL2012001133A CL2012001133A1 CL 2012001133 A1 CL2012001133 A1 CL 2012001133A1 CL 2012001133 A CL2012001133 A CL 2012001133A CL 2012001133 A CL2012001133 A CL 2012001133A CL 2012001133 A1 CL2012001133 A1 CL 2012001133A1
- Authority
- CL
- Chile
- Prior art keywords
- methyl
- ylethynyl
- ponatinib
- pyridazin
- methylpiperazin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25666909P | 2009-10-30 | 2009-10-30 | |
US25669009P | 2009-10-30 | 2009-10-30 | |
US26101409P | 2009-11-13 | 2009-11-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2012001133A1 true CL2012001133A1 (es) | 2013-08-02 |
Family
ID=43922622
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2012001133A CL2012001133A1 (es) | 2009-10-30 | 2012-04-30 | Composicion farmaceutica oral que comprende ponatinib 3-(imidazo[1,2-b]piridazin-3-iletinil)-4-metil-n-(4-((4-metilpiperazin-1-il)-metil)-3-(trifluorometil)fenil)benzamida y al menos un excipiente farmaceuticamente aceptable; y su uso para el tratamiento de neoplasma, cancer o un trastorno hiperproliferativo. |
Country Status (15)
Country | Link |
---|---|
US (2) | US20120316137A1 (es) |
EP (2) | EP2762142A1 (es) |
JP (1) | JP2013509444A (es) |
KR (1) | KR20120115237A (es) |
CN (1) | CN102770129A (es) |
AU (1) | AU2010313152A1 (es) |
CA (1) | CA2777128A1 (es) |
CL (1) | CL2012001133A1 (es) |
CR (1) | CR20120202A (es) |
EA (1) | EA201290255A1 (es) |
IL (1) | IL218987A0 (es) |
MX (1) | MX2012005023A (es) |
NI (1) | NI201200072A (es) |
WO (1) | WO2011053938A1 (es) |
ZA (1) | ZA201202256B (es) |
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EP2793893A4 (en) | 2011-11-23 | 2015-07-08 | Intellikine Llc | IMPROVED TREATMENT REGIMES USING MTOR INHIBITORS |
CN103570724B (zh) * | 2012-07-27 | 2015-12-16 | 中国科学院广州生物医药与健康研究院 | ponatinib 的合成方法 |
US10172796B2 (en) | 2012-12-03 | 2019-01-08 | Manli International Ltd. | Use of umirolimus and its derivatives for treating cancer |
CA2815506C (en) | 2012-12-12 | 2018-12-11 | Ariad Pharmaceuticals, Inc. | Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride |
AU2013204506B2 (en) * | 2012-12-13 | 2016-05-05 | Ariad Pharmaceuticals, Inc. | Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride |
EP2964260A2 (en) | 2013-03-06 | 2016-01-13 | F. Hoffmann-La Roche AG | Methods of treating and preventing cancer drug resistance |
US20140343282A1 (en) | 2013-05-16 | 2014-11-20 | Apicore, Llc | Processes for making ponatinib and intermediates thereof |
CA2916329A1 (en) * | 2013-07-04 | 2015-01-08 | Sandoz Ag | Crystalline forms of ponatinib hydrochloride |
WO2015014851A1 (en) * | 2013-07-30 | 2015-02-05 | Fresenius Kabi Deutschland Gmbh | Hydroxyalkyl starch for the treatment of hematological neoplasms |
CN104650086A (zh) * | 2013-11-22 | 2015-05-27 | 天津市汉康医药生物技术有限公司 | 盐酸帕纳替尼化合物 |
WO2015085972A1 (en) * | 2013-12-09 | 2015-06-18 | Zentiva, K.S. | NOVEL SALTS OF 3-(2-IMIDAZO[1,2-b]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-[4-[(4-METHYL- 1-PIPERAZINYL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL] BENZAMIDE |
WO2015085973A1 (en) * | 2013-12-09 | 2015-06-18 | Zentiva, K.S. | Modifications of 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl] benzamide hydrochloride salt |
WO2015085971A1 (en) * | 2013-12-09 | 2015-06-18 | Zentiva, K.S. | Hydrobromide salt of 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl] benzamide |
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CN104496994B (zh) * | 2014-01-06 | 2016-12-07 | 广东东阳光药业有限公司 | 一种炔类杂芳基化合物的新晶型 |
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CN105267200A (zh) * | 2014-07-01 | 2016-01-27 | 中国科学院上海有机化学研究所 | 一种黄酮类化合物的应用 |
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-
2010
- 2010-11-01 WO PCT/US2010/055016 patent/WO2011053938A1/en active Application Filing
- 2010-11-01 MX MX2012005023A patent/MX2012005023A/es not_active Application Discontinuation
- 2010-11-01 CN CN2010800491501A patent/CN102770129A/zh active Pending
- 2010-11-01 EP EP13189355.4A patent/EP2762142A1/en not_active Withdrawn
- 2010-11-01 KR KR1020127014086A patent/KR20120115237A/ko not_active Application Discontinuation
- 2010-11-01 JP JP2012537178A patent/JP2013509444A/ja active Pending
- 2010-11-01 AU AU2010313152A patent/AU2010313152A1/en not_active Abandoned
- 2010-11-01 US US13/504,251 patent/US20120316137A1/en not_active Abandoned
- 2010-11-01 CA CA2777128A patent/CA2777128A1/en not_active Abandoned
- 2010-11-01 EA EA201290255A patent/EA201290255A1/ru unknown
- 2010-11-01 EP EP10827625.4A patent/EP2493460A4/en not_active Withdrawn
-
2012
- 2012-03-28 ZA ZA2012/02256A patent/ZA201202256B/en unknown
- 2012-04-02 IL IL218987A patent/IL218987A0/en unknown
- 2012-04-25 CR CR20120202A patent/CR20120202A/es unknown
- 2012-04-27 NI NI201200072A patent/NI201200072A/es unknown
- 2012-04-30 CL CL2012001133A patent/CL2012001133A1/es unknown
-
2013
- 2013-03-13 US US13/802,039 patent/US20130178622A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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US20130178622A1 (en) | 2013-07-11 |
IL218987A0 (en) | 2012-06-28 |
AU2010313152A1 (en) | 2012-04-19 |
EP2493460A1 (en) | 2012-09-05 |
EA201290255A1 (ru) | 2013-04-30 |
KR20120115237A (ko) | 2012-10-17 |
JP2013509444A (ja) | 2013-03-14 |
WO2011053938A8 (en) | 2011-08-11 |
ZA201202256B (en) | 2012-12-27 |
WO2011053938A1 (en) | 2011-05-05 |
US20120316137A1 (en) | 2012-12-13 |
EP2493460A4 (en) | 2013-04-24 |
CR20120202A (es) | 2012-06-12 |
NI201200072A (es) | 2012-08-20 |
MX2012005023A (es) | 2012-06-19 |
CA2777128A1 (en) | 2011-05-05 |
CN102770129A (zh) | 2012-11-07 |
EP2762142A1 (en) | 2014-08-06 |
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