CO6440511A2 - Compuesto que contienen nitrogeno y composicion farmaceutica - Google Patents
Compuesto que contienen nitrogeno y composicion farmaceuticaInfo
- Publication number
- CO6440511A2 CO6440511A2 CO12046744A CO12046744A CO6440511A2 CO 6440511 A2 CO6440511 A2 CO 6440511A2 CO 12046744 A CO12046744 A CO 12046744A CO 12046744 A CO12046744 A CO 12046744A CO 6440511 A2 CO6440511 A2 CO 6440511A2
- Authority
- CO
- Colombia
- Prior art keywords
- group
- independently
- pharmaceutical composition
- compound containing
- containing nitrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Abstract
La presente invención provee un novedoso compuesto de diazepina que bloquea la corriente lKur o el canal Kv1.5 en forma potente y más selectiva que otros canales K+. La presente invención se refiere a un compuesto de diazepina representado por la Fórmula General (1) o una sal del mismo, en donde R1, R2, R3, y R4 son cada uno independientemente hidrógeno, alquilo inferior, cicloalquilo inferior o alcoxi inferior alquilo inferior; R2 y R3 pueden enlazarse para formar alquileno inferior; A1 es alquileno inferior sustituido opcionalmente con uno o más sustituyentes seleccionados del grupo conformado por hidroxilo y oxo; Y1 e Y2 son cada uno independientemente -N= o -CH= y R5 es un grupo representado por (2) en donde R6 y R7 son cada uno independientemente hidrógeno o un grupo orgánico; R6 y R7 pueden enlazarse para formar un anillo junto con el grupo adyacente -XA-N-XB-; XA y XB son cada uno independientemente un enlace, alquileno inferior, etc.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23598109P | 2009-08-21 | 2009-08-21 | |
US23597309P | 2009-08-21 | 2009-08-21 | |
US23598309P | 2009-08-21 | 2009-08-21 | |
US35968610P | 2010-06-29 | 2010-06-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6440511A2 true CO6440511A2 (es) | 2012-05-15 |
Family
ID=43014533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO12046744A CO6440511A2 (es) | 2009-08-21 | 2012-03-20 | Compuesto que contienen nitrogeno y composicion farmaceutica |
Country Status (25)
Country | Link |
---|---|
US (3) | US8822453B2 (es) |
EP (3) | EP2746272A1 (es) |
JP (2) | JP5769700B2 (es) |
KR (1) | KR20120081973A (es) |
CN (1) | CN102482234B (es) |
AR (1) | AR078098A1 (es) |
AU (2) | AU2010285621A1 (es) |
CA (1) | CA2771579A1 (es) |
CO (1) | CO6440511A2 (es) |
DK (1) | DK2467364T3 (es) |
ES (1) | ES2477221T3 (es) |
HK (1) | HK1167391A1 (es) |
HR (1) | HRP20140636T1 (es) |
IL (2) | IL217101A0 (es) |
IN (1) | IN2012DN01985A (es) |
MX (1) | MX2012002149A (es) |
NZ (1) | NZ598918A (es) |
PL (1) | PL2467364T3 (es) |
PT (1) | PT2467364E (es) |
RU (1) | RU2012110553A (es) |
SG (1) | SG177316A1 (es) |
SI (1) | SI2467364T1 (es) |
TW (1) | TWI481601B (es) |
WO (1) | WO2011021726A2 (es) |
ZA (1) | ZA201201025B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102639512B (zh) * | 2009-08-21 | 2015-12-09 | 大塚制药株式会社 | 苯并[b][1,4]二氮杂*-2,4-二酮化合物的制备方法 |
CA2871190C (en) * | 2011-06-03 | 2019-01-15 | Queen's University At Kingston | Substituted diarylamines and use of same as antioxidants |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CN102627597B (zh) * | 2012-04-25 | 2013-10-23 | 山东轻工业学院 | 吲哚-3-甲醛异丁酰腙类衍生物及其制备方法 |
EP2996692B1 (en) * | 2013-05-14 | 2021-06-30 | Medizinische Hochschule Hannover | Means and methods for treating cancer |
MY175778A (en) | 2013-10-04 | 2020-07-08 | Infinity Pharmaceuticals Inc | Heterocyclic compounds and uses thereof |
WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
SG11201607705XA (en) | 2014-03-19 | 2016-10-28 | Infinity Pharmaceuticals Inc | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
KR20180058741A (ko) | 2015-09-14 | 2018-06-01 | 인피니티 파마슈티칼스, 인코포레이티드 | 이소퀴놀리논의 고체형, 그의 제조 방법, 이를 포함하는 조성물 및 이를 사용하는 방법 |
US10759806B2 (en) | 2016-03-17 | 2020-09-01 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors |
WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2018112843A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3133056A (en) * | 1961-05-15 | 1964-05-12 | May & Baker Ltd | N-phenylpiperazine derivatives of tetrahydrobenzodiazepines |
BE707667A (es) | 1966-12-14 | 1968-06-07 | ||
US4001408A (en) | 1966-12-14 | 1977-01-04 | Roussel-Uclaf | Substituted heterocyclic compounds, processes and composition including those |
US3984398A (en) | 1966-12-14 | 1976-10-05 | Roussel-Uclaf | 1,5-Benzodiazepine-2,4-diones |
GB1460936A (en) | 1974-10-01 | 1977-01-06 | Beecham Group Ltd | Benzodiazepines |
JPS545981A (en) * | 1977-06-10 | 1979-01-17 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivatives |
IE46852B1 (en) | 1977-06-10 | 1983-10-05 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives |
JPS54163825A (en) * | 1978-06-15 | 1979-12-26 | Otsuka Pharma Co Ltd | Phosphoesterase inhibitor |
JPS5579372A (en) * | 1978-12-08 | 1980-06-14 | Otsuka Pharmaceut Co Ltd | Preparation of carbostyril derivative |
JPS56122356A (en) * | 1980-02-29 | 1981-09-25 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPS5780322A (en) * | 1980-11-05 | 1982-05-19 | Otsuka Pharmaceut Co Ltd | Cardiotonic agent |
JPS6010008B2 (ja) * | 1982-07-12 | 1985-03-14 | 大塚製薬株式会社 | 血小板凝集抑制剤 |
JP2753622B2 (ja) * | 1988-05-02 | 1998-05-20 | 大塚製薬株式会社 | カルボスチリル誘導体 |
DE68920797T2 (de) * | 1988-08-10 | 1995-06-29 | Otsuka Pharma Co Ltd | Herzmittel. |
JPH0296133A (ja) | 1988-10-01 | 1990-04-06 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
JPH03148223A (ja) * | 1989-11-02 | 1991-06-25 | Otsuka Pharmaceut Co Ltd | 血小板凝集抑制剤 |
BR9200951A (pt) * | 1991-03-21 | 1992-11-17 | Hoffmann La Roche | Compostos, processo para sua producao,preparacoes farmaceuticas e uso |
JPH05194405A (ja) * | 1991-08-23 | 1993-08-03 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体及び血小板凝集抑制剤 |
CA2093633A1 (en) * | 1991-08-23 | 1993-02-24 | Seiji Sato | Carbostyril derivative and platelets aggregation inhibitory agent |
PE27497A1 (es) | 1994-04-15 | 1997-08-07 | Glaxo Inc | Derivados de 1,5 benzodiazepina |
US5691331A (en) * | 1995-06-07 | 1997-11-25 | Merck & Co., Inc. | N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides |
US5700797A (en) | 1995-06-07 | 1997-12-23 | Merck & Co, Inc. | N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides |
TW338037B (en) | 1995-10-05 | 1998-08-11 | Otsuka Pharma Co Ltd | Carbostyril derivatives possessing platelet aggregation inhibitory activity, antithrombotic activity, intima thinkening, inhibitory activity and phosphoriesterase inhibitory activity, their preparation and pharmaceutical composition |
JP2964029B2 (ja) * | 1995-10-05 | 1999-10-18 | 大塚製薬株式会社 | カルボスチリル誘導体 |
GB0008179D0 (en) | 2000-04-05 | 2000-05-24 | Glaxo Group Ltd | Chemical process |
WO2001010216A1 (en) * | 1999-08-09 | 2001-02-15 | Merck & Co., Inc. | Antiarrhythmic compounds |
US6949542B2 (en) | 2002-02-06 | 2005-09-27 | Hoffman-La Roche Inc. | Dihydro-benzo[b][1,4]diazepin-2-one derivatives |
US7772433B2 (en) | 2002-02-28 | 2010-08-10 | University Of Tennessee Research Foundation | SARMS and method of use thereof |
CN100406007C (zh) * | 2002-12-20 | 2008-07-30 | 安姆根有限公司 | 哮喘和过敏性炎症调节剂 |
AR055203A1 (es) * | 2005-08-31 | 2007-08-08 | Otsuka Pharma Co Ltd | Derivados de benzotiofeno con propiedades antipsicoticas |
JP2007290984A (ja) * | 2006-04-21 | 2007-11-08 | Kowa Co | コフィリン結合剤、及びコフィリン結合剤を有効成分とする抗癌剤 |
JP4785881B2 (ja) | 2007-02-27 | 2011-10-05 | 大塚製薬株式会社 | 医薬 |
DK2254873T3 (da) | 2008-02-22 | 2014-06-30 | Otsuka Pharma Co Ltd | Benzodiazepinforbindelse og farmaceutisk sammensætning. |
-
2010
- 2010-08-19 TW TW099127738A patent/TWI481601B/zh active
- 2010-08-20 CA CA2771579A patent/CA2771579A1/en not_active Abandoned
- 2010-08-20 AR ARP100103052A patent/AR078098A1/es unknown
- 2010-08-20 DK DK10751720.3T patent/DK2467364T3/da active
- 2010-08-20 AU AU2010285621A patent/AU2010285621A1/en not_active Abandoned
- 2010-08-20 SI SI201030598T patent/SI2467364T1/sl unknown
- 2010-08-20 ES ES10751720.3T patent/ES2477221T3/es active Active
- 2010-08-20 KR KR1020127004471A patent/KR20120081973A/ko not_active Application Discontinuation
- 2010-08-20 SG SG2011095098A patent/SG177316A1/en unknown
- 2010-08-20 JP JP2012508284A patent/JP5769700B2/ja not_active Expired - Fee Related
- 2010-08-20 MX MX2012002149A patent/MX2012002149A/es active IP Right Grant
- 2010-08-20 WO PCT/JP2010/064545 patent/WO2011021726A2/en active Application Filing
- 2010-08-20 PT PT107517203T patent/PT2467364E/pt unknown
- 2010-08-20 EP EP14153418.0A patent/EP2746272A1/en not_active Withdrawn
- 2010-08-20 EP EP10751720.3A patent/EP2467364B9/en not_active Not-in-force
- 2010-08-20 US US13/388,442 patent/US8822453B2/en not_active Expired - Fee Related
- 2010-08-20 NZ NZ598918A patent/NZ598918A/en not_active IP Right Cessation
- 2010-08-20 RU RU2012110553/04A patent/RU2012110553A/ru unknown
- 2010-08-20 EP EP20140153417 patent/EP2727917A1/en not_active Withdrawn
- 2010-08-20 IN IN1985DEN2012 patent/IN2012DN01985A/en unknown
- 2010-08-20 PL PL10751720T patent/PL2467364T3/pl unknown
- 2010-08-20 CN CN201080037286.0A patent/CN102482234B/zh not_active Expired - Fee Related
-
2011
- 2011-12-20 IL IL217101A patent/IL217101A0/en unknown
-
2012
- 2012-02-13 ZA ZA2012/01025A patent/ZA201201025B/en unknown
- 2012-03-20 CO CO12046744A patent/CO6440511A2/es active IP Right Grant
- 2012-08-15 HK HK12108042.7A patent/HK1167391A1/xx not_active IP Right Cessation
-
2014
- 2014-06-25 US US14/314,189 patent/US9212187B2/en not_active Expired - Fee Related
- 2014-06-25 US US14/314,142 patent/US20140343277A1/en not_active Abandoned
- 2014-07-04 HR HRP20140636AT patent/HRP20140636T1/hr unknown
-
2015
- 2015-06-08 JP JP2015115391A patent/JP2015199748A/ja active Pending
-
2016
- 2016-08-03 IL IL247086A patent/IL247086A0/en unknown
- 2016-08-08 AU AU2016210778A patent/AU2016210778A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO6440511A2 (es) | Compuesto que contienen nitrogeno y composicion farmaceutica | |
AR070449A1 (es) | Compuesto de benzodiazepina y composicion farmaceutica | |
CO6321166A2 (es) | Compuestos de pirrol | |
IN2012DN01986A (es) | ||
CO6231035A2 (es) | Novedoso compuesto heteromonociclico que tiene propiedades superiores como agente farmaceutico | |
ECSP11011318A (es) | Derivados de benzofurano | |
AR082201A1 (es) | Bencenosulfonamidas utiles como inhibidores del canal de sodio | |
CO6781539A2 (es) | Derivado de diespiropirrolidina | |
MY186165A (en) | New bicyclic dihydroquinoline-2-one derivatives | |
MY169043A (en) | New dihydroquinoline-2-one derivatives | |
ES2653265T3 (es) | Morfinanos sustituidos y el uso de éstos | |
AR059905A1 (es) | Pirrolidina-3-ilaminas n-substituidas como antagonistas del receptor histamina-3, composicion farmaceutica y proceso para preparar el compuesto | |
PE20151781A1 (es) | Piridonamidas como moduladores de canales de sodio | |
ES2640911T3 (es) | Cicloalquilnitrilpirazolcarboxamidas como inhibidores de la quinasa Janus | |
PE20080150A1 (es) | Derivados de piridinona n-aril y n-heteroaril sustituidos como antagonistas del receptor de la hormona concentradora de melanina (mch) | |
CR20150221A (es) | Mezclas activas como plaguicidas que comprenden compuestos de antranilamida | |
MX343225B (es) | Nuevos derivados de aril-benzocicloalquil-amida. | |
MX2015001099A (es) | Nuevos derivados biciclicos de piridina. | |
MY169267A (en) | New aryl-quinoline derivatives | |
JO3143B1 (ar) | مركبات تتراهيدرو بيرولو ثيازين | |
CR20110348A (es) | Derivados de piperidina | |
AR068062A1 (es) | Sulfonas ciclicas sustituidas por amino- bencilo utiles como inhibidores de bace | |
AR069387A1 (es) | Compuestos de cicloalquiloxi -y heterocicloalquiloxipiridina como moduladores del receptor de histamina h3 | |
MX2015016400A (es) | Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona. | |
PE20141168A1 (es) | Derivados de pirazolidin-3-ona |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Application granted |