AR078098A1 - Compuesto que contiene nitrogeno y composicion farmaceutica - Google Patents
Compuesto que contiene nitrogeno y composicion farmaceuticaInfo
- Publication number
- AR078098A1 AR078098A1 ARP100103052A ARP100103052A AR078098A1 AR 078098 A1 AR078098 A1 AR 078098A1 AR P100103052 A ARP100103052 A AR P100103052A AR P100103052 A ARP100103052 A AR P100103052A AR 078098 A1 AR078098 A1 AR 078098A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- lower alkyl
- phenyl
- alkylene
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Quinoline Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Reivindicacion 1: Un compuesto de diazepina representado por la formula general (1) o una sal del mismo, caracterizado porque R1, R2, R3, y R4 son cada uno independientemente hidrogeno, alquilo inferior, ciclo alquilo inferior o alcoxi inferior alquilo inferior; R2 y R3 pueden ser ligados para formar alquileno inferior; A1 es alquileno inferior opcionalmente substituido con uno o más substituyentes seleccionados entre el grupo que consiste en hidroxilo y oxo; Y1 e Y2 son cada uno independientemente -N= o -CH=; R5 es un grupo representado por (R6-XA)(R7-XB)-N- en donde: R6 y R7 son cada uno independientemente hidrogeno o un grupo orgánico; R6 y R7 pueden ser ligados para formar un anillo junto con el grupo adyacente -XA-N-XB-; XA y XB son cada uno independientemente un enlace, alquileno, alquenileno, -CO-, -SO2- o -CONH-, en donde cada una de las cadenas de alquileno y alquenileno pueden contener opcionalmente uno o más substituyentes seleccionados entre el grupo que consiste en -S-, -C(=S)-, -SO2-, -CO-, -O-, -NH-, -CONH- y -SO2NH-, y el átomo de hidrogeno (H) unido al átomo de nitrogeno (N) en XA y XB es opcionalmente substituido con un substituyente seleccionado entre el grupo que consiste en alquilo inferior, fenilo alquilo inferior y fenilo. Reivindicacion 8: Un compuesto amino representado por la formula general (R1-XA)(R2-XB)-N-A1-O-R3 o una sal del mismo, caracterizado porque R1 y R2 son cada uno independientemente hidrogeno o un grupo orgánico; XA y XB son cada uno independientemente un enlace, alquileno, alquenileno, -CO-, -SO2- o -CONH-, en donde cada una de las cadenas de alquileno y alquenileno pueden contener opcionalmente uno o más substituyentes seleccionados entre el grupo que consiste en -S-, -C(=S)-, -SO2-, -CO-, -O-, -NH-, -CONH- y -SO2NH-, y el átomo de hidrogeno (H) unido al átomo de nitrogeno (N) en XA y XB es substituido opcionalmente con un substituyente seleccionado entre el grupo que consiste en alquilo inferior, fenilo alquilo inferior y fenilo; A1 es alquileno inferior substituido opcionalmente con uno o más substituyentes seleccionados entre el grupo que consiste en hidroxilo y oxo; R3 es (i) un grupo heterocíclico que es substituido opcionalmente con uno o más substituyentes, o (ii) un grupo arilo substituido con uno o más substituyentes seleccionados entre el grupo que consiste en oxo, alquilo inferior, carboxilo, halo-alquilo inferior, alcanoilo inferior alquilo inferior, fenilo alquilo inferior, ciclo alquilo inferior, alcoxi inferior, halo alcoxi inferior, fenilo alcoxi inferior, fenoxi, ciano, hidroxilo, halogeno, nitro, alquiltio inferior, alcanoilo inferior, alcoxi inferior carbonilo, alquenilo inferior, fenilo, triazolilo, isoxazolilo, imidazolilo, pirrolilo, benzo[d]oxazolilo, benzo[d]tiazolilo y el grupo representado por la formula general -Y-N(R4)(R5) en donde Y es un enlace, alquileno inferior o -CO-; R4 y R5 son cada uno independientemente hidrogeno, alquilo inferior, ciclo alquilo inferior, fenilo o alcanoilo inferior; o R4 y R5 pueden ser ligados para formar un anillo junto con el nitrogeno adyacente, y el anillo puede tener opcionalmente uno o más substituyentes.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23598109P | 2009-08-21 | 2009-08-21 | |
US23598309P | 2009-08-21 | 2009-08-21 | |
US23597309P | 2009-08-21 | 2009-08-21 | |
US35968610P | 2010-06-29 | 2010-06-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR078098A1 true AR078098A1 (es) | 2011-10-12 |
Family
ID=43014533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100103052A AR078098A1 (es) | 2009-08-21 | 2010-08-20 | Compuesto que contiene nitrogeno y composicion farmaceutica |
Country Status (25)
Country | Link |
---|---|
US (3) | US8822453B2 (es) |
EP (3) | EP2727917A1 (es) |
JP (2) | JP5769700B2 (es) |
KR (1) | KR20120081973A (es) |
CN (1) | CN102482234B (es) |
AR (1) | AR078098A1 (es) |
AU (2) | AU2010285621A1 (es) |
CA (1) | CA2771579A1 (es) |
CO (1) | CO6440511A2 (es) |
DK (1) | DK2467364T3 (es) |
ES (1) | ES2477221T3 (es) |
HK (1) | HK1167391A1 (es) |
HR (1) | HRP20140636T1 (es) |
IL (2) | IL217101A0 (es) |
IN (1) | IN2012DN01985A (es) |
MX (1) | MX2012002149A (es) |
NZ (1) | NZ598918A (es) |
PL (1) | PL2467364T3 (es) |
PT (1) | PT2467364E (es) |
RU (1) | RU2012110553A (es) |
SG (1) | SG177316A1 (es) |
SI (1) | SI2467364T1 (es) |
TW (1) | TWI481601B (es) |
WO (1) | WO2011021726A2 (es) |
ZA (1) | ZA201201025B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2553676C2 (ru) * | 2009-08-21 | 2015-06-20 | Оцука Фармасьютикал Ко., Лтд. | СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНОГО БЕНЗО[b][1,4]ДИАЗЕПИН-2,4-ДИОНА |
WO2012162818A1 (en) * | 2011-06-03 | 2012-12-06 | Queen's University At Kingston | Substituted diarylamines and use of same as antioxidants |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CN102627597B (zh) * | 2012-04-25 | 2013-10-23 | 山东轻工业学院 | 吲哚-3-甲醛异丁酰腙类衍生物及其制备方法 |
US9849127B2 (en) | 2013-05-14 | 2017-12-26 | Medizinisch Hochschule Hannover | Means and methods for treating cancer |
JP6466924B2 (ja) | 2013-10-04 | 2019-02-06 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | 複素環式化合物及びその使用 |
US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
DK3119397T3 (da) | 2014-03-19 | 2022-03-28 | Infinity Pharmaceuticals Inc | Heterocykliske forbindelser til anvendelse i behandling af PI3K-gamma-medierede lidelser |
WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
KR20180058741A (ko) | 2015-09-14 | 2018-06-01 | 인피니티 파마슈티칼스, 인코포레이티드 | 이소퀴놀리논의 고체형, 그의 제조 방법, 이를 포함하는 조성물 및 이를 사용하는 방법 |
WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2018112843A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3133056A (en) * | 1961-05-15 | 1964-05-12 | May & Baker Ltd | N-phenylpiperazine derivatives of tetrahydrobenzodiazepines |
US4001408A (en) | 1966-12-14 | 1977-01-04 | Roussel-Uclaf | Substituted heterocyclic compounds, processes and composition including those |
US3984398A (en) | 1966-12-14 | 1976-10-05 | Roussel-Uclaf | 1,5-Benzodiazepine-2,4-diones |
BE707667A (es) | 1966-12-14 | 1968-06-07 | ||
GB1460936A (en) | 1974-10-01 | 1977-01-06 | Beecham Group Ltd | Benzodiazepines |
JPS545981A (en) * | 1977-06-10 | 1979-01-17 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivatives |
NZ187452A (en) | 1977-06-10 | 1980-05-27 | Otsuka Pharma Co Ltd | N- substituted-aminocarbonylpropoxy-carbostyrils and their preparation |
JPS54163825A (en) * | 1978-06-15 | 1979-12-26 | Otsuka Pharma Co Ltd | Phosphoesterase inhibitor |
JPS5579372A (en) * | 1978-12-08 | 1980-06-14 | Otsuka Pharmaceut Co Ltd | Preparation of carbostyril derivative |
JPS56122356A (en) | 1980-02-29 | 1981-09-25 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPS5780322A (en) * | 1980-11-05 | 1982-05-19 | Otsuka Pharmaceut Co Ltd | Cardiotonic agent |
JPS6010008B2 (ja) * | 1982-07-12 | 1985-03-14 | 大塚製薬株式会社 | 血小板凝集抑制剤 |
JP2753622B2 (ja) * | 1988-05-02 | 1998-05-20 | 大塚製薬株式会社 | カルボスチリル誘導体 |
DE68920797T2 (de) * | 1988-08-10 | 1995-06-29 | Otsuka Pharma Co Ltd | Herzmittel. |
JPH0296133A (ja) | 1988-10-01 | 1990-04-06 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
JPH03148223A (ja) * | 1989-11-02 | 1991-06-25 | Otsuka Pharmaceut Co Ltd | 血小板凝集抑制剤 |
BR9200951A (pt) * | 1991-03-21 | 1992-11-17 | Hoffmann La Roche | Compostos, processo para sua producao,preparacoes farmaceuticas e uso |
JPH05194405A (ja) * | 1991-08-23 | 1993-08-03 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体及び血小板凝集抑制剤 |
CA2093633A1 (en) | 1991-08-23 | 1993-02-24 | Seiji Sato | Carbostyril derivative and platelets aggregation inhibitory agent |
PE27497A1 (es) | 1994-04-15 | 1997-08-07 | Glaxo Inc | Derivados de 1,5 benzodiazepina |
US5691331A (en) * | 1995-06-07 | 1997-11-25 | Merck & Co., Inc. | N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides |
US5700797A (en) | 1995-06-07 | 1997-12-23 | Merck & Co, Inc. | N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides |
JP2964029B2 (ja) * | 1995-10-05 | 1999-10-18 | 大塚製薬株式会社 | カルボスチリル誘導体 |
TW338037B (en) | 1995-10-05 | 1998-08-11 | Otsuka Pharma Co Ltd | Carbostyril derivatives possessing platelet aggregation inhibitory activity, antithrombotic activity, intima thinkening, inhibitory activity and phosphoriesterase inhibitory activity, their preparation and pharmaceutical composition |
GB0008179D0 (en) | 2000-04-05 | 2000-05-24 | Glaxo Group Ltd | Chemical process |
WO2001010216A1 (en) | 1999-08-09 | 2001-02-15 | Merck & Co., Inc. | Antiarrhythmic compounds |
US6949542B2 (en) | 2002-02-06 | 2005-09-27 | Hoffman-La Roche Inc. | Dihydro-benzo[b][1,4]diazepin-2-one derivatives |
US7772433B2 (en) | 2002-02-28 | 2010-08-10 | University Of Tennessee Research Foundation | SARMS and method of use thereof |
ES2401079T3 (es) * | 2002-12-20 | 2013-04-16 | Amgen Inc. | Moduladores del asma y de la inflamación alérgica |
AR055203A1 (es) * | 2005-08-31 | 2007-08-08 | Otsuka Pharma Co Ltd | Derivados de benzotiofeno con propiedades antipsicoticas |
JP2007290984A (ja) * | 2006-04-21 | 2007-11-08 | Kowa Co | コフィリン結合剤、及びコフィリン結合剤を有効成分とする抗癌剤 |
JP4785881B2 (ja) | 2007-02-27 | 2011-10-05 | 大塚製薬株式会社 | 医薬 |
MX2010009269A (es) * | 2008-02-22 | 2010-09-14 | Otsuka Pharma Co Ltd | Compuesto de benzodiazepina y composicion farmaceutica. |
-
2010
- 2010-08-19 TW TW099127738A patent/TWI481601B/zh active
- 2010-08-20 AU AU2010285621A patent/AU2010285621A1/en not_active Abandoned
- 2010-08-20 CA CA2771579A patent/CA2771579A1/en not_active Abandoned
- 2010-08-20 PL PL10751720T patent/PL2467364T3/pl unknown
- 2010-08-20 PT PT107517203T patent/PT2467364E/pt unknown
- 2010-08-20 SG SG2011095098A patent/SG177316A1/en unknown
- 2010-08-20 NZ NZ598918A patent/NZ598918A/en not_active IP Right Cessation
- 2010-08-20 IN IN1985DEN2012 patent/IN2012DN01985A/en unknown
- 2010-08-20 WO PCT/JP2010/064545 patent/WO2011021726A2/en active Application Filing
- 2010-08-20 EP EP20140153417 patent/EP2727917A1/en not_active Withdrawn
- 2010-08-20 ES ES10751720.3T patent/ES2477221T3/es active Active
- 2010-08-20 EP EP10751720.3A patent/EP2467364B9/en not_active Not-in-force
- 2010-08-20 KR KR1020127004471A patent/KR20120081973A/ko not_active Application Discontinuation
- 2010-08-20 RU RU2012110553/04A patent/RU2012110553A/ru unknown
- 2010-08-20 DK DK10751720.3T patent/DK2467364T3/da active
- 2010-08-20 AR ARP100103052A patent/AR078098A1/es unknown
- 2010-08-20 SI SI201030598T patent/SI2467364T1/sl unknown
- 2010-08-20 EP EP14153418.0A patent/EP2746272A1/en not_active Withdrawn
- 2010-08-20 JP JP2012508284A patent/JP5769700B2/ja not_active Expired - Fee Related
- 2010-08-20 MX MX2012002149A patent/MX2012002149A/es active IP Right Grant
- 2010-08-20 US US13/388,442 patent/US8822453B2/en not_active Expired - Fee Related
- 2010-08-20 CN CN201080037286.0A patent/CN102482234B/zh not_active Expired - Fee Related
-
2011
- 2011-12-20 IL IL217101A patent/IL217101A0/en unknown
-
2012
- 2012-02-13 ZA ZA2012/01025A patent/ZA201201025B/en unknown
- 2012-03-20 CO CO12046744A patent/CO6440511A2/es active IP Right Grant
- 2012-08-15 HK HK12108042.7A patent/HK1167391A1/xx not_active IP Right Cessation
-
2014
- 2014-06-25 US US14/314,189 patent/US9212187B2/en not_active Expired - Fee Related
- 2014-06-25 US US14/314,142 patent/US20140343277A1/en not_active Abandoned
- 2014-07-04 HR HRP20140636AT patent/HRP20140636T1/hr unknown
-
2015
- 2015-06-08 JP JP2015115391A patent/JP2015199748A/ja active Pending
-
2016
- 2016-08-03 IL IL247086A patent/IL247086A0/en unknown
- 2016-08-08 AU AU2016210778A patent/AU2016210778A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR078098A1 (es) | Compuesto que contiene nitrogeno y composicion farmaceutica | |
PE20140863A1 (es) | Compuestos de benceno sustituidos con arilo o heteroarilo | |
PE20120992A1 (es) | Conjugados de dimeros de pirrolo[1,4] benzodiazepina como agentes anticancerosos | |
CO6321166A2 (es) | Compuestos de pirrol | |
AR111811A2 (es) | Compuestos derivados de 1,2,4-oxadiazol y composiciones para el control de nematodos | |
PE20130647A1 (es) | Indoles | |
ES2600636T3 (es) | Spiro-[1,3]-oxazinas y spiro-[1,4]-oxazepinas como inhibidores de BACE1 y/o BACE2 | |
AR087452A1 (es) | Composiciones de combustible | |
AR085615A1 (es) | Derivados de fluoropiridinona utiles como agentes antibacterianos y composiciones farmaceuticas que los contienen | |
UY32547A (es) | Piperidinas sustituidas como antagonistas de ccr3 | |
AR080057A1 (es) | Piridinas disustituidas como anticancerigenos | |
UY32606A (es) | Sulfonamidas nematocidas | |
CO6140056A2 (es) | Compuestos amino -5-4(difluorometoxi)fenil sustituido-5-fenilimidazolona como inhibidores de beta -secretasa | |
AR074435A1 (es) | Derivados de 1,3-benzotiazol, medicamentos que los contienen y uso de los mismos en el tratamiento del cancer. | |
AR070558A1 (es) | Derivados de 7-fenil-7h-pirrolo-[2,3d]-pirimidin-2-il-amino,proceso para prepararlos, composiciones farmaceuticas que los comprenden y uso de los mismos para el tratamiento de enfermedades dependientes de tirosinquinasas,tales como enfermedades proliferativas. | |
CO6321232A2 (es) | Compuesto de tropano como inhibidores de hsp90 | |
PE20091343A1 (es) | Compuestos derivados de heterociclo biciclicos como moduladores de gpr119 | |
CR9459A (es) | Derivados benzodioxano y benzodioxolano y usos de los mismos | |
PA8809001A1 (es) | Compuestos organicos | |
DOP2011000281A (es) | Derivados de benzofurano | |
AR077977A1 (es) | Compuestos y composiciones como inhibidores de cinasa de proteina | |
ES2630079T3 (es) | Moduladores de la ruta del complemento y usos de los mismos | |
CO6190626A2 (es) | Compuestos y composiciones como inhibidores de proteasa activadora de canal | |
AR065583A1 (es) | Compuestos macrociclicos y composicion farmaceutica | |
PE20141940A1 (es) | Compuestos triciclicos, composiciones que los comprenden y usos de los mismos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |