CO6400219A2 - Derivados de ciclopropilamida dirigidos al receptor h3 de la histamina - Google Patents
Derivados de ciclopropilamida dirigidos al receptor h3 de la histaminaInfo
- Publication number
- CO6400219A2 CO6400219A2 CO11095921A CO11095921A CO6400219A2 CO 6400219 A2 CO6400219 A2 CO 6400219A2 CO 11095921 A CO11095921 A CO 11095921A CO 11095921 A CO11095921 A CO 11095921A CO 6400219 A2 CO6400219 A2 CO 6400219A2
- Authority
- CO
- Colombia
- Prior art keywords
- cyclopropilamide
- derivatives directed
- histamine
- receiver
- histamine receiver
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
Abstract
En la presente se divulga al menos un derivado de ciclopropilamida, al menos una composición farmacéutica que comprende al menos un derivado de ciclopropilamida de los aquí divulgados y al menos un método para utilizar al menos un derivado de ciclopropilamida aquí divulgado para el tratamiento de al menos una afección vinculada al receptor H3 de la histamina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15406709P | 2009-02-20 | 2009-02-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6400219A2 true CO6400219A2 (es) | 2012-03-15 |
Family
ID=42631518
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO11095921A CO6400219A2 (es) | 2009-02-20 | 2011-07-29 | Derivados de ciclopropilamida dirigidos al receptor h3 de la histamina |
Country Status (39)
Country | Link |
---|---|
US (3) | US8993577B2 (es) |
EP (1) | EP2398780B1 (es) |
JP (2) | JP5666480B2 (es) |
KR (1) | KR20110126628A (es) |
CN (2) | CN102405213B (es) |
AR (1) | AR075531A1 (es) |
AU (1) | AU2010216454B2 (es) |
BR (1) | BRPI1007817A2 (es) |
CA (1) | CA2752796A1 (es) |
CO (1) | CO6400219A2 (es) |
CR (1) | CR20110447A (es) |
CU (2) | CU20110161A7 (es) |
DK (1) | DK2398780T3 (es) |
DO (1) | DOP2011000270A (es) |
EA (2) | EA201490268A1 (es) |
EC (1) | ECSP11011280A (es) |
ES (1) | ES2416464T3 (es) |
HK (2) | HK1164863A1 (es) |
HN (1) | HN2011002261A (es) |
HR (1) | HRP20130579T1 (es) |
IL (1) | IL214277A (es) |
ME (1) | ME01619B (es) |
MX (1) | MX2011008280A (es) |
NI (1) | NI201100160A (es) |
NZ (1) | NZ595248A (es) |
PE (2) | PE20151281A1 (es) |
PL (1) | PL2398780T3 (es) |
PT (1) | PT2398780E (es) |
RS (1) | RS52851B (es) |
SA (1) | SA110310136B1 (es) |
SG (1) | SG173449A1 (es) |
SI (1) | SI2398780T1 (es) |
SM (1) | SMT201300077B (es) |
SV (1) | SV2011004008A (es) |
TW (1) | TW201039825A (es) |
UA (1) | UA108841C2 (es) |
UY (1) | UY32460A (es) |
WO (1) | WO2010096011A1 (es) |
ZA (1) | ZA201106821B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9108948B2 (en) * | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
SG173312A1 (en) * | 2006-06-23 | 2011-08-29 | Abbott Lab | Cyclopropyl amine derivatives as histamin h3 receptor modulators |
AU2008290329B2 (en) | 2007-08-22 | 2011-12-22 | Astrazeneca Ab | Cyclopropyl amide derivatives |
TW201039825A (en) | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
AU2011218490B9 (en) * | 2010-02-18 | 2014-12-18 | Astrazeneca Ab | Solid forms comprising a cyclopropyl amide derivative |
CA2788444A1 (en) * | 2010-02-18 | 2011-08-25 | Astrazeneca Ab | New crystalline form of a cyclopropyl benzamide derivative |
WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
HUE057460T2 (hu) | 2016-03-22 | 2022-05-28 | Merck Sharp & Dohme | Nikotinos acetilkolin receptorok alloszterikus modulátorai |
US20230365589A1 (en) | 2020-09-18 | 2023-11-16 | Sumitomo Pharma Co., Ltd. | Novel amine derivatives |
Family Cites Families (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE637271A (es) | 1963-04-04 | 1900-01-01 | ||
NL128365C (es) | 1963-11-05 | |||
US3449427A (en) | 1965-06-03 | 1969-06-10 | Smithkline Corp | Aminocyclopropane derivatives of 5h-dibenzo(a,d)cycloheptenes |
US3697506A (en) | 1970-08-07 | 1972-10-10 | Pfizer | Crystalline alkali metal salts of {60 -carboxybenzylpenicillin and process therefor |
US3686335A (en) | 1970-12-21 | 1972-08-22 | Smith Kline French Lab | 5-vinyl-5h-di benzo(a,d)cycloheptenes |
US4432987A (en) | 1982-04-23 | 1984-02-21 | Pfizer Inc. | Crystalline benzenesulfonate salts of sultamicillin |
US4547505A (en) | 1983-03-25 | 1985-10-15 | Degussa Aktiengesellschaft | N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production |
CS244821B2 (en) * | 1983-06-16 | 1986-08-14 | Boehringer Ingelheim Ltd | Production method of new substituted phenylalkyl(piperazinyl or homopiperazinyle)-prpylureas or thioureas |
DE3418167A1 (de) | 1984-05-16 | 1985-11-21 | Bayer Ag, 5090 Leverkusen | Verwendung von amiden zur verbesserung der kulturpflanzen-vertraeglichkeit von herbizid wirksamen heteroaryloxyacetamiden |
DE3600288A1 (de) | 1986-01-08 | 1987-07-16 | Bayer Ag | Verwendung von amiden zur verbesserung der kulturpflanzen-vertraeglichkeit von herbizid wirksamen sulfonylharnstoff-derivaten |
DE3618004A1 (de) | 1986-05-28 | 1987-12-03 | Bayer Ag | Verwendung von amiden zur verbesserung der kulturpflanzen-vertraeglichkeit von herbizid wirksamen sulfonyliso(thio)-harnstoff-derivaten |
JPH05503517A (ja) | 1989-12-18 | 1993-06-10 | バージニア・コモンウェルス・ユニバーシティ | シグマレセプターリガンド及びその用途 |
US5112818A (en) | 1989-12-29 | 1992-05-12 | Banyu Pharmaceutical Co., Ltd. | 2-(2-cyclopropylpyrrolidin-4-ylthio)carbapenhem derivatives |
HUT66301A (en) | 1991-08-22 | 1994-11-28 | Monsanto Co | Safening herbicidal pyrazolylsufonylureas |
DE4131139A1 (de) | 1991-09-19 | 1993-03-25 | Bayer Ag | Verfahren zur herstellung von 1-fluor-cyclopropan-1-carbonsaeure |
DE69427469T2 (de) | 1993-03-12 | 2001-10-31 | Upjohn Co | Kristallines ceftiofur (freie säure) |
JP2941950B2 (ja) | 1994-11-23 | 1999-08-30 | ニューロゲン コーポレイション | 或る種の4−アミノメチル−2−置換イミダゾール誘導体および2−アミノメチル−4−置換イミダゾール誘導体;新規な種類のドーパミン リセプタ亜型特異性リガンド |
US5604253A (en) | 1995-05-22 | 1997-02-18 | Merck Frosst Canada, Inc. | N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors |
US5859246A (en) | 1997-01-30 | 1999-01-12 | Neurogen Corporation | 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands |
JP3476203B2 (ja) | 1997-02-24 | 2003-12-10 | ザイモジュネティックス インコーポレイテッド | カルシトニン擬似体 |
US6160134A (en) | 1997-12-24 | 2000-12-12 | Bristol-Myers Squibb Co. | Process for preparing chiral cyclopropane carboxylic acids and acyl guanidines |
HUP0101810A3 (en) | 1998-01-27 | 2002-05-28 | Aventis Pharm Prod Inc | Substituted oxoazaheterocyclyl factor xa inhibitors and pharmaceutical compositions containing them |
US6268367B1 (en) | 1998-02-23 | 2001-07-31 | Zymogenetics, Inc. | Piperazine derivatives for treating bone deficit conditions |
WO2000000492A1 (fr) | 1998-06-26 | 2000-01-06 | Chugai Seiyaku Kabushiki Kaisha | DERIVE D'ACIDE L-α-AMINOADIPIQUE EN POUDRE FINE, PREPARATIONS SOLIDES ORALES CONTENANT LEDIT DERIVE ET PROCEDE DE TRAITEMENT DE POUDRES EN VRAC |
EP1140879A1 (en) | 1999-01-08 | 2001-10-10 | Neurogen Corporation | 1-phenyl-4-(1- 2-aryl]cyclopropyl) methylpiperazines: dopamine receptor ligands |
US6284761B1 (en) | 1999-01-08 | 2001-09-04 | Neurogen Corporation | 1-phenyl-4-(1-[2-aryl]cyclopropyl)methylpiperazines: dopamine receptor ligands |
CA2380860A1 (en) | 1999-06-16 | 2000-12-21 | Takeda Chemical Industries, Ltd. | Benzazepine derivative, production and use thereof |
WO2001022963A1 (en) | 1999-09-27 | 2001-04-05 | Merck & Co., Inc. | Method of preventing osteoporosis |
WO2001051919A2 (en) | 2000-01-07 | 2001-07-19 | Transform Pharmaceuticals, Inc. | High-throughput formation, identification, and analysis of diverse solid-forms |
CN1242989C (zh) | 2000-06-29 | 2006-02-22 | 艾伯特公司 | 芳基苯基环丙基硫醚衍生物及其作为抑制细胞粘附的抗炎和免疫抑制剂的用途 |
US6521619B2 (en) | 2000-06-29 | 2003-02-18 | Icos Corporation | Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents |
WO2002008221A2 (en) | 2000-07-20 | 2002-01-31 | Neurogen Corporation | Capsaicin receptor ligands |
WO2002051781A1 (fr) | 2000-12-25 | 2002-07-04 | Ajinomoto Co., Inc. | Procede permettant de preparer un compose d'halohydrine optiquement actif |
WO2002068409A1 (en) | 2001-02-23 | 2002-09-06 | Merck & Co., Inc. | N-substituted nonaryl-heterocyclic nmda/nr2b antagonists |
ATE449090T1 (de) | 2001-07-02 | 2009-12-15 | High Point Pharmaceuticals Llc | Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren |
EP1422228A1 (en) | 2001-08-08 | 2004-05-26 | Takeda Chemical Industries, Ltd. | BENZAZEPINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE |
USRE40794E1 (en) | 2001-09-26 | 2009-06-23 | Merck & Co., Inc. | Crystalline forms of carbapenem antibiotics and methods of preparation |
US20050143372A1 (en) | 2001-10-30 | 2005-06-30 | Shomir Ghosh | Compounds, pharmaceutical compositions and methods of use therefor |
US6861432B2 (en) | 2001-11-23 | 2005-03-01 | Schering Aktiengesellschaft | Piperazine derivatives that destabilize androgen receptors |
WO2003080601A1 (en) | 2002-03-22 | 2003-10-02 | Lg Life Sciences Ltd. | New crystalline forms of (2s)-n-5-[amino(imino)methyl]-2-thienylmethyl-1-(2r)-2-[(carboxymethyl)amino]-3,3-diphenylpropanoyl-2-pyrrolidinecarboxamide nh2o |
AU2003236686A1 (en) | 2002-06-07 | 2003-12-22 | Altana Pharma Ag | 4,5-dihydro-imidazo(4,5,1-j) quinolin-6-ones as parp inhibitors |
US20040077618A1 (en) | 2002-10-22 | 2004-04-22 | Bennani Youssef L. | Cycloalkylamides and their therapeutic applications |
US20040209858A1 (en) | 2002-10-22 | 2004-10-21 | Bennani Youssef L. | Cycloalkylamides and their therapeutic applications |
AU2003284402A1 (en) | 2002-11-15 | 2004-06-15 | Yamanouchi Pharmaceutical Co., Ltd. | Antagonist to melanin-concentrating hormone receptor |
AU2003296993A1 (en) | 2002-12-13 | 2004-07-09 | Smithkline Beecham Corporation | Cyclopropyl compounds as ccr5 antagonists |
RU2005136368A (ru) | 2003-04-23 | 2006-06-10 | Глэксо Груп Лимитед (GB) | Производные пиперазина и их применение для лечения неврологических и психиатрических заболеваний |
ATE482200T1 (de) | 2003-05-01 | 2010-10-15 | Bristol Myers Squibb Co | Als kinaseinhibitoren geeignete arylsubstituierte pyrazolamidverbindungen |
TWI339206B (en) | 2003-09-04 | 2011-03-21 | Vertex Pharma | Compositions useful as inhibitors of protein kinases |
CN1901971A (zh) | 2003-12-15 | 2007-01-24 | 日本烟草产业株式会社 | 环丙烷化合物及其药物应用 |
BRPI0418939A (pt) | 2004-07-06 | 2008-04-08 | Xenon Pharmaceuticals Inc | derivados de nicotinamida e sua utilização como agentes terapêuticos |
TW200621760A (en) | 2004-09-09 | 2006-07-01 | Mitsubishi Pharma Corp | 2-morpholino-4-pyrimidone compound |
BRPI0515851A (pt) | 2004-09-29 | 2008-08-12 | Mitsubishi Pharma Corp | composto de pirimidona |
DE602005005080T2 (de) | 2004-10-15 | 2009-02-26 | Glaxo Group Ltd., Greenford | Pyrrolidinderivate als histaminrezeptor-liganden |
EP1833800A1 (en) | 2004-12-27 | 2007-09-19 | AstraZeneca AB | Pyrazolone compounds as metabotropic glutamate receptor agonists for the treatment of neurological and psychiatric disorders |
CA2595882A1 (en) | 2005-01-26 | 2006-08-03 | Pharmacia & Upjohn Company Llc | Thieno [2,3-d] pyrimidine compounds as inhibitors of adp-mediated platelets aggregation |
EP1848695B1 (en) | 2005-02-15 | 2011-07-27 | Glaxo Group Limited | Compounds which potentiate glutamate receptor and uses thereof in medicine |
KR101065979B1 (ko) | 2005-02-17 | 2011-09-19 | 아스텔라스세이야쿠 가부시키가이샤 | 피리딜 비방향족 질소 함유 헤테로환-1-카르복실산에스테르 유도체 |
WO2006100591A1 (en) | 2005-03-25 | 2006-09-28 | Pharmacia & Upjohn Company Llc | 4-piperazinnylthieno [2,3-d] pyrimidine compounds as platelet aggregation inhibitors |
CA2603041A1 (en) | 2005-03-28 | 2006-10-05 | Pharmacia & Upjohn Company Llc | 4-piperazinylthieno [2, 3-d] pyrimidine compounds as platelet aggregation inhibitors |
JP2008534573A (ja) | 2005-03-28 | 2008-08-28 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 血小板凝集阻害剤としての4−ピペラジノチエノ[2,3−d]ピリミジン化合物 |
JP2008534571A (ja) | 2005-03-28 | 2008-08-28 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 血小板凝集阻害物質としての4−ピペラジニルチエノ[2,3−d]ピリミジン化合物 |
JP2009501235A (ja) | 2005-07-15 | 2009-01-15 | シェーリング コーポレイション | 癌処置において有用なキナゾリン誘導体 |
TW200740779A (en) | 2005-07-22 | 2007-11-01 | Mitsubishi Pharma Corp | Intermediate compound for synthesizing pharmaceutical agent and production method thereof |
EP1909797A4 (en) | 2005-08-02 | 2013-02-27 | Neurogen Corp | DIPIPERAZINYL KETONE AND RELATED ANALOG |
KR101336106B1 (ko) * | 2005-09-16 | 2013-12-05 | 얀센 파마슈티카 엔.브이. | 히스타민 h3 수용체의 조절제로서 사이클로프로필 아민 |
US8158673B2 (en) | 2005-10-27 | 2012-04-17 | Pfizer Inc. | Histamine-3 receptor antagonists |
RS52569B (sr) | 2005-10-31 | 2013-04-30 | Janssen Pharmaceutica N.V. | Proces pripreme derivata ciklopropilamina |
CA2633653A1 (en) | 2005-12-21 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives as modulators of ion channels |
WO2007076140A2 (en) | 2005-12-23 | 2007-07-05 | University Of Cincinnati | Treatment methods employing histamine h3 receptor antagonists, including betahistine |
EP1976840A1 (en) | 2006-01-13 | 2008-10-08 | F.Hoffmann-La Roche Ag | Cyclohexyl piperazinyl methanone derivatives and their use as histamine h3 receptor modulators |
CN101384581B (zh) | 2006-02-17 | 2013-09-18 | 弗·哈夫曼-拉罗切有限公司 | 作为5ht2/d3调节剂的苯甲酰基-哌啶衍生物 |
MX2008011133A (es) | 2006-03-01 | 2008-12-18 | Cementech Pty Ltd | Matriz para elementos de albañileria y metodo de fabricacion de la misma. |
JP2009132621A (ja) | 2006-03-13 | 2009-06-18 | Ajinomoto Co Inc | シクロプロピルアミド化合物の製造方法 |
US7524848B2 (en) | 2006-03-23 | 2009-04-28 | Amgen Inc. | Diaza heterocyclic amide compounds and their uses |
US7834190B2 (en) | 2006-05-26 | 2010-11-16 | Kaneka Corporation | Process for production of optically active-3-amino-2-hydroxypropionic cyclopropylamide derivatives and salts thereof |
SG173312A1 (en) | 2006-06-23 | 2011-08-29 | Abbott Lab | Cyclopropyl amine derivatives as histamin h3 receptor modulators |
US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
EP2044027A2 (en) | 2006-07-03 | 2009-04-08 | Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patiëntenzorg | Fused bicyclic compounds interacting with the histamine h4 receptor |
EP2056828A4 (en) | 2006-08-21 | 2010-06-23 | Merck Sharp & Dohme | SULFONYLATED PIPERAZINES AS CANNABINOID-1 RECEPTOR MODULATORS |
TW200828371A (en) | 2006-09-21 | 2008-07-01 | Matsushita Electric Ind Co Ltd | Chip-type filter |
DE102006056526A1 (de) | 2006-11-30 | 2008-06-05 | Archimica Gmbh | Verfahren zur stereoselektiven Synthese von chiralen Epoxiden durch ADH-Reduktion von alpha-Abgangsgruppen-substituierten Ketonen und Cyclisierung |
US7737149B2 (en) | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
WO2008147864A2 (en) * | 2007-05-22 | 2008-12-04 | Xenon Pharmaceuticals Inc. | Methods of using piperazine compounds in treating sodium channel-mediated diseases or conditions |
US8030495B2 (en) | 2007-05-23 | 2011-10-04 | Coleman Paul J | Cyclopropyl pyrrolidine orexin receptor antagonists |
DE602008002598D1 (en) | 2007-06-11 | 2010-10-28 | Hoffmann La Roche | Cyclohexylderivate |
AU2008290329B2 (en) * | 2007-08-22 | 2011-12-22 | Astrazeneca Ab | Cyclopropyl amide derivatives |
MX2010003155A (es) | 2007-10-04 | 2010-04-01 | Hoffmann La Roche | Derivados de ciclopropil aril amida y uso de los mismos. |
AR070107A1 (es) | 2008-01-15 | 2010-03-17 | Lilly Co Eli | R-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida en forma cristalina, composicion farmaceutica que la comprende y su uso para la manufactura de un medicamento util para la prevencion o tratamiento de hiperglicemia |
DE102008049371A1 (de) | 2008-03-06 | 2009-09-10 | Mühlbauer Ag | Einrichtung mit einem RFID-Transponder in einem elektrisch leitfähigen Gegenstand und Herstellungsverfahren hierfür |
BRPI0913057A2 (pt) | 2008-05-08 | 2015-10-13 | Evotec Ag | azetidinas e ciclobutanos como antagonistas de receptor de histamina h3 |
US8586607B2 (en) | 2008-07-28 | 2013-11-19 | Syddansk Universitet | Compounds for the treatment of metabolic diseases |
CN101462980B (zh) | 2009-01-05 | 2013-01-09 | 扬州天辰精细化工有限公司 | 2,6—二氟苯甲酰胺的工业化生产方法 |
TW201039825A (en) | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
AU2011218490B9 (en) * | 2010-02-18 | 2014-12-18 | Astrazeneca Ab | Solid forms comprising a cyclopropyl amide derivative |
CA2788444A1 (en) | 2010-02-18 | 2011-08-25 | Astrazeneca Ab | New crystalline form of a cyclopropyl benzamide derivative |
-
2010
- 2010-02-12 TW TW099104778A patent/TW201039825A/zh unknown
- 2010-02-17 SA SA110310136A patent/SA110310136B1/ar unknown
- 2010-02-19 US US12/708,550 patent/US8993577B2/en not_active Expired - Fee Related
- 2010-02-19 JP JP2011551039A patent/JP5666480B2/ja not_active Expired - Fee Related
- 2010-02-19 AU AU2010216454A patent/AU2010216454B2/en not_active Ceased
- 2010-02-19 PL PL10744028T patent/PL2398780T3/pl unknown
- 2010-02-19 MX MX2011008280A patent/MX2011008280A/es active IP Right Grant
- 2010-02-19 RS RS20130280A patent/RS52851B/en unknown
- 2010-02-19 SI SI201030257T patent/SI2398780T1/sl unknown
- 2010-02-19 CN CN201080017452.0A patent/CN102405213B/zh not_active Expired - Fee Related
- 2010-02-19 PE PE2015001189A patent/PE20151281A1/es not_active Application Discontinuation
- 2010-02-19 DK DK10744028.1T patent/DK2398780T3/da active
- 2010-02-19 EA EA201490268A patent/EA201490268A1/ru unknown
- 2010-02-19 ME MEP-2013-74A patent/ME01619B/me unknown
- 2010-02-19 BR BRPI1007817A patent/BRPI1007817A2/pt not_active IP Right Cessation
- 2010-02-19 CA CA2752796A patent/CA2752796A1/en not_active Abandoned
- 2010-02-19 WO PCT/SE2010/050191 patent/WO2010096011A1/en active Application Filing
- 2010-02-19 ES ES10744028T patent/ES2416464T3/es active Active
- 2010-02-19 EP EP10744028.1A patent/EP2398780B1/en active Active
- 2010-02-19 PE PE2011001527A patent/PE20120063A1/es not_active Application Discontinuation
- 2010-02-19 NZ NZ595248A patent/NZ595248A/en not_active IP Right Cessation
- 2010-02-19 SG SG2011053477A patent/SG173449A1/en unknown
- 2010-02-19 AR ARP100100499A patent/AR075531A1/es unknown
- 2010-02-19 KR KR1020117019311A patent/KR20110126628A/ko not_active Application Discontinuation
- 2010-02-19 UA UAA201109215A patent/UA108841C2/ru unknown
- 2010-02-19 EA EA201190140A patent/EA020093B1/ru not_active IP Right Cessation
- 2010-02-19 PT PT107440281T patent/PT2398780E/pt unknown
- 2010-02-19 CN CN201410557796.0A patent/CN104398516A/zh active Pending
- 2010-02-19 UY UY0001032460A patent/UY32460A/es not_active Application Discontinuation
-
2011
- 2011-07-25 IL IL214277A patent/IL214277A/en not_active IP Right Cessation
- 2011-07-29 CO CO11095921A patent/CO6400219A2/es active IP Right Grant
- 2011-08-19 EC EC2011011280A patent/ECSP11011280A/es unknown
- 2011-08-19 HN HN2011002261A patent/HN2011002261A/es unknown
- 2011-08-19 CR CR20110447A patent/CR20110447A/es unknown
- 2011-08-19 CU CU20110161A patent/CU20110161A7/es unknown
- 2011-08-19 DO DO2011000270A patent/DOP2011000270A/es unknown
- 2011-08-19 NI NI201100160A patent/NI201100160A/es unknown
- 2011-08-19 SV SV2011004008A patent/SV2011004008A/es unknown
- 2011-09-19 ZA ZA2011/06821A patent/ZA201106821B/en unknown
-
2012
- 2012-06-07 HK HK12105548.2A patent/HK1164863A1/xx not_active IP Right Cessation
-
2013
- 2013-06-21 HR HRP20130579AT patent/HRP20130579T1/hr unknown
- 2013-07-04 SM SM201300077T patent/SMT201300077B/xx unknown
-
2014
- 2014-02-06 CU CU2014000013A patent/CU20140013A7/es unknown
- 2014-12-09 JP JP2014248499A patent/JP2015071634A/ja active Pending
-
2015
- 2015-02-24 US US14/630,514 patent/US20150164888A1/en not_active Abandoned
- 2015-02-24 US US14/630,530 patent/US20150164889A1/en not_active Abandoned
- 2015-09-11 HK HK15108903.2A patent/HK1208348A1/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO6400219A2 (es) | Derivados de ciclopropilamida dirigidos al receptor h3 de la histamina | |
NI201000031A (es) | Derivados de ciclopropilamida. | |
CR11684A (es) | Dihidropirazolonas sustituidas de hif-propil-4- como inhibidores hidroxilasa | |
ECSP11011387A (es) | Anticuerpos biespecíficos anti-erbb-3/anti-c-met | |
UY32640A (es) | Aril-pirimidinas como inhibidoras de sintasa dfe aldosterona | |
CO6430459A2 (es) | Derivados de prolina como inhibidores de catepsina | |
ECSP12011799A (es) | Compuestos de espiropiperidina y uso farmacéutico de los mismos | |
DK2411395T3 (da) | Furopyrimidindionderivater som modulatorer for TRPA1 | |
CO6410298A2 (es) | Pirimidinas fusionadas | |
UY33075A (es) | Derivados de ciclohexano y usos de los mismos | |
CO6362012A2 (es) | Clohidarto de nalmefeno dihidratado | |
MX2011011733A (es) | Inhiibidores de dihidroorotato deshidrogenasa como compuestos virostaticos. | |
PA8846201A1 (es) | Derivados de anilina-pirimidina sustituidos con sulfoximina como inhibidores de quinasas dependientes de ciclina (cdk), producción y uso de los mismos como productos medicinales | |
NI201100096A (es) | Lactamas como inhibidores de beta secretasa. | |
CL2012000278A1 (es) | Proceso para la obtencion de derivados de 5-trifluorometil-pirimidinas; y uno de los compuestos intermediarios considerados. | |
ECSP099754A (es) | Derivados de la espirociclopropil piperidina | |
SV2010003773A (es) | 7-sulfanilmetil-, 7-sulfinilmetil- y 7-sulfonilmetilindoles sustituidos y el uso de los mismos | |
UY32258A (es) | Derivados de la espirociclobutilpiperidina | |
ATE481395T1 (de) | Cyclohexylderivate | |
ECSP11011150A (es) | Derivados de arilciclopropilacetamida útiles como activadores de glucoquinasa | |
UY31303A1 (es) | Derivados de ciclopropil amida 978 | |
GT200800195A (es) | Procedimiento para la preparación de derivados de ciclopropilamida | |
CY1114176T1 (el) | Παραγωγα κυκλοπροπυλαμιδιου που στοχευουν τον υποδοχεα η3 της ισταμινης | |
CL2010000497A1 (es) | Uso de compuestos derivados de indol para el tratamiento del dolor visceral; compuestos específicos derivados de indol; procedimiento de preparación de un compuesto; composición farmacéutica y uso para el tratamiento de una condición causada por la acción de nos. | |
UY35348A (es) | Derivados de carbazol inhibidores del bromodominio y composiciones que los contienen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Application granted |