CO6210811A2 - Inhibidores de aldh-2 en el tratamiento de la adiccion - Google Patents
Inhibidores de aldh-2 en el tratamiento de la adiccionInfo
- Publication number
- CO6210811A2 CO6210811A2 CO08137618A CO08137618A CO6210811A2 CO 6210811 A2 CO6210811 A2 CO 6210811A2 CO 08137618 A CO08137618 A CO 08137618A CO 08137618 A CO08137618 A CO 08137618A CO 6210811 A2 CO6210811 A2 CO 6210811A2
- Authority
- CO
- Colombia
- Prior art keywords
- optionally substituted
- alkyl
- hydrogen
- heteroaryl
- cyano
- Prior art date
Links
- 206010012335 Dependence Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 150000002431 hydrogen Chemical group 0.000 abstract 5
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 2
- 101100516554 Caenorhabditis elegans nhr-5 gene Proteins 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 101100240527 Caenorhabditis elegans nhr-22 gene Proteins 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- -1 heteroaryl amide Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
- C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Addiction (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
1.- Un compuesto de la Fórmula I:en donde: R1 es fenilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, o heterociclilo opcionalmente sustituido; R2 es hidrógeno, hidroxi, halógeno, alcoxi inferior opcionalmente sustituido, alquilo inferior opcionalmente sustituido, ciano, heteroarilo opcionalmente sustituido, C(O)OR5, -C(O)R5, -SO2R15, -B(OH)2, OP(O)(OR5)2, -C(NR20)NHR22, -NHR4, o C(O)NHR5, en el cual, R4 es hidrógeno, -C(O)NHR5, o -SO2R15, o -C(O)R5; R5 es hidrógeno, alquilo inferior opcionalmente sustituido; R15 es alquilo inferior opcionalmente sustituido o fenilo opcionalmente sustituido; o R2 es -O-Q-R6, en el cual Q es un enlace covalente o alquileno inferior y R6 es heteroarilo opcionalmente sustituido; R3 es hidrógeno, ciano, amino opcionalmente sustituido, alquilo inferior, alcoxi inferior, o halo; X, Y y Z se eligen de -CR7- y -N-, en el cual R7 es hidrógeno, alquilo inferior, alcoxi inferior, o halo; V es oxígeno, azufre, o -NH-; y W es Q1-T-Q2, en donde Q1 es un enlace covalente o alquileno C1-6 lineal o ramificado opcionalmente sustituido con hidroxi, alcoxi inferior, amino, ciano, u =O; Q2 es alquileno C1-6 lineal o ramificado opcionalmente sustituido con hidroxi, alcoxi inferior, amino, ciano, u =O; yT es un enlace covalente, -O-, o -NH-, o T y Q1 pueden juntos formar un enlace covalente, R20 y R22 se seleccionan independientemente del grupo que consiste de hidrógeno, hidroxi, alquilo C1-15, alquenilo C2-15, alquinilo C2-15, cicloalquilo, heterociclilo, arilo, bencilo, y heteroarilo, en donde las mitades alquilo, alquenilo, alquinilo, cicloalquilo, heterociclilo, arilo, bencilo, y heteroarilo están opcionalmente sustituidas con de 1 a 3 sustituyentes seleccionados independientemente de halo, alquilo, mono o dialquilamino, alquilo o arilo o heteroaril amida, CN, O-alquilo C1-6, CF3, COOH, OCF3, B(OH)2, Si(CH3)3, ...
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83408306P | 2006-07-27 | 2006-07-27 | |
| US84642806P | 2006-09-21 | 2006-09-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6210811A2 true CO6210811A2 (es) | 2010-10-20 |
Family
ID=38792141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO08137618A CO6210811A2 (es) | 2006-07-27 | 2008-12-29 | Inhibidores de aldh-2 en el tratamiento de la adiccion |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20080032995A1 (es) |
| EP (1) | EP2046769A2 (es) |
| JP (1) | JP2009544742A (es) |
| KR (1) | KR20090033417A (es) |
| AU (1) | AU2007278877A1 (es) |
| CA (1) | CA2653056A1 (es) |
| CO (1) | CO6210811A2 (es) |
| EC (1) | ECSP088919A (es) |
| IL (1) | IL195400A0 (es) |
| MA (1) | MA30434B1 (es) |
| MX (1) | MX2008015765A (es) |
| NO (1) | NO20084971L (es) |
| RU (1) | RU2008151762A (es) |
| WO (1) | WO2008014497A2 (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080207610A1 (en) * | 2006-07-27 | 2008-08-28 | Jeff Zablocki | Aldh-2 inhibitors in the treatment of addiction |
| US8158810B2 (en) * | 2006-07-27 | 2012-04-17 | Gilead Sciences, Inc. | ALDH-2 inhibitors in the treatment of addiction |
| JO3598B1 (ar) | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
| AU2008226947B2 (en) | 2007-03-08 | 2014-07-17 | The Board Of Trustees Of The Leland Stanford Junior University | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
| US7951813B2 (en) | 2007-04-05 | 2011-05-31 | Gilead Sciences, Inc. | Quinazolinone derivatives as ALDH-2 inhibitors |
| AU2008323953A1 (en) * | 2007-11-06 | 2009-05-14 | Gilead Palo Alto, Inc. | ALDH-2 inhibitors in the treatment of psychiatric disorders |
| MX2010008111A (es) * | 2008-01-24 | 2010-11-30 | Endowment For Res In Human Biology Inc | Inhibidores de aldh-2 en el tratamiento de adicciones. |
| BRPI0908428A2 (pt) * | 2008-02-06 | 2015-12-08 | Gilead Sciences Inc | uso de ranozalina para tratar a dor. |
| PE20091838A1 (es) | 2008-04-09 | 2009-12-18 | Infinity Pharmaceuticals Inc | Inhibidores de amida hidrolasa de acido graso |
| US8354435B2 (en) | 2008-09-08 | 2013-01-15 | The Board Of Trustees Of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase activity and methods of use thereof |
| JP2012506856A (ja) | 2008-10-28 | 2012-03-22 | ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | アルデヒドデヒドロゲナーゼのモジュレーターおよびその使用方法 |
| CN102197109B (zh) * | 2008-10-29 | 2014-05-14 | 默克专利股份有限公司 | 液晶显示器 |
| US8541581B2 (en) | 2009-04-07 | 2013-09-24 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
| ES2493916T3 (es) | 2009-04-07 | 2014-09-12 | Infinity Pharmaceuticals, Inc. | Inhibidores de hidrolasa de amida de ácidos grasos |
| MX336742B (es) | 2010-02-03 | 2016-01-29 | Infinity Pharmaceuticals Inc | Inhibidores de amida hidrolasa de acido graso. |
| DK2533638T3 (en) * | 2010-02-12 | 2016-04-25 | Nivalis Therapeutics Inc | NOVEL S-nitrosoglutathione REDUCTASE |
| WO2012149106A1 (en) | 2011-04-29 | 2012-11-01 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
| TWI567061B (zh) | 2011-07-01 | 2017-01-21 | 吉李德科學股份有限公司 | 用於治療成癮之化合物 |
| EP2970124B1 (en) | 2013-03-14 | 2019-05-22 | The Board of Trustees of the Leland Stanford Junior University | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
| US9410016B2 (en) | 2013-07-16 | 2016-08-09 | Dow Global Technologies Llc | Aromatic polyacetals and articles comprising them |
| US8933239B1 (en) | 2013-07-16 | 2015-01-13 | Dow Global Technologies Llc | Bis(aryl)acetal compounds |
| US9063420B2 (en) | 2013-07-16 | 2015-06-23 | Rohm And Haas Electronic Materials Llc | Photoresist composition, coated substrate, and method of forming electronic device |
| US8962779B2 (en) | 2013-07-16 | 2015-02-24 | Dow Global Technologies Llc | Method of forming polyaryl polymers |
| AU2018352215A1 (en) * | 2017-10-16 | 2020-04-16 | Amygdala Neurosciences, Inc. | Combination therapy for preventing addiction |
| JP7204568B2 (ja) * | 2018-04-04 | 2023-01-16 | 株式会社Cics | アミロイドβ疾患のホウ素中性子捕捉療法用化合物 |
| CN109970738B (zh) * | 2019-02-27 | 2021-07-09 | 上海工程技术大学 | 一种金雀花碱n-异黄酮类化合物及其制备方法及应用 |
| WO2023244574A1 (en) | 2022-06-14 | 2023-12-21 | Amygdala Neurosciences, Inc. | Aldh-2 inhibitor compounds and methods of use |
| US20230399299A1 (en) | 2022-06-14 | 2023-12-14 | Amygdala Neurosciences, Inc. | Aldh-2 inhibitor compounds and methods of use |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3907830A (en) * | 1970-05-27 | 1975-09-23 | Chinoin Gyogyszer Es Vegyeszet | Isoflavone derivatives |
| US4166862A (en) * | 1971-05-25 | 1979-09-04 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | Animal feed containing anabolic isoflavones |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| DE2950135A1 (de) * | 1979-12-13 | 1981-06-19 | Merck Patent Gmbh, 6100 Darmstadt | Basischer aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung |
| US4326525A (en) | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
| US5364620A (en) | 1983-12-22 | 1994-11-15 | Elan Corporation, Plc | Controlled absorption diltiazem formulation for once daily administration |
| JPS62201882A (ja) * | 1985-11-18 | 1987-09-05 | Yamanouchi Pharmaceut Co Ltd | イソフラボン誘導体 |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| US4902514A (en) | 1988-07-21 | 1990-02-20 | Alza Corporation | Dosage form for administering nilvadipine for treating cardiovascular symptoms |
| US5204369A (en) * | 1991-07-01 | 1993-04-20 | The Endowment For Research In Human Biology | Method for the inhibition of aldh-i useful in the treatment of alcohol dependence or alcohol abuse |
| US5679806A (en) * | 1995-02-24 | 1997-10-21 | Hauser, Inc. | Process for the isolation and purification of isoflavones |
| US5783189A (en) * | 1996-04-23 | 1998-07-21 | Natural Pharmacia International, Inc. | Method for treating alcohol dependence |
| US6255497B1 (en) * | 1997-04-29 | 2001-07-03 | The Endowment For Research In Human Biology, Inc. | Method for the inhibition of ALDH-I useful in the treatment of alcohol dependence or alcohol abuse |
| DE69932427T2 (de) | 1998-05-12 | 2007-02-22 | The Endowment for Research in Human Biology, Inc., Boston | Verfahren und testen verwendbar bei der behandlung von alkoholabhängigkeit oder -missbrauch |
| JP4933730B2 (ja) * | 2001-05-04 | 2012-05-16 | パラテック ファーマシューティカルズ インコーポレイテッド | 転写因子調節化合物およびその使用法 |
| JP2006501180A (ja) * | 2002-06-27 | 2006-01-12 | ジ エンドウメント フォア リサーチ イン ヒューマン バイオロジー インコーポレイテッド | Ａｌｄｈの阻害に有効な化合物 |
| WO2006002422A2 (en) * | 2004-06-24 | 2006-01-05 | Novartis Vaccines And Diagnostics Inc. | Compounds for immunopotentiation |
| US20080207610A1 (en) * | 2006-07-27 | 2008-08-28 | Jeff Zablocki | Aldh-2 inhibitors in the treatment of addiction |
| US8158810B2 (en) * | 2006-07-27 | 2012-04-17 | Gilead Sciences, Inc. | ALDH-2 inhibitors in the treatment of addiction |
| US7951813B2 (en) * | 2007-04-05 | 2011-05-31 | Gilead Sciences, Inc. | Quinazolinone derivatives as ALDH-2 inhibitors |
| AU2008323953A1 (en) * | 2007-11-06 | 2009-05-14 | Gilead Palo Alto, Inc. | ALDH-2 inhibitors in the treatment of psychiatric disorders |
-
2007
- 2007-07-27 CA CA002653056A patent/CA2653056A1/en not_active Abandoned
- 2007-07-27 JP JP2009522029A patent/JP2009544742A/ja not_active Withdrawn
- 2007-07-27 EP EP07813501A patent/EP2046769A2/en not_active Withdrawn
- 2007-07-27 US US11/829,836 patent/US20080032995A1/en not_active Abandoned
- 2007-07-27 AU AU2007278877A patent/AU2007278877A1/en not_active Abandoned
- 2007-07-27 RU RU2008151762/04A patent/RU2008151762A/ru unknown
- 2007-07-27 KR KR1020087029279A patent/KR20090033417A/ko not_active Application Discontinuation
- 2007-07-27 WO PCT/US2007/074665 patent/WO2008014497A2/en active Application Filing
- 2007-07-27 MX MX2008015765A patent/MX2008015765A/es not_active Application Discontinuation
-
2008
- 2008-11-20 IL IL195400A patent/IL195400A0/en unknown
- 2008-11-26 NO NO20084971A patent/NO20084971L/no not_active Application Discontinuation
- 2008-11-27 MA MA31422A patent/MA30434B1/fr unknown
- 2008-11-28 EC EC2008008919A patent/ECSP088919A/es unknown
- 2008-12-29 CO CO08137618A patent/CO6210811A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009544742A (ja) | 2009-12-17 |
| US20080032995A1 (en) | 2008-02-07 |
| MA30434B1 (fr) | 2009-05-04 |
| WO2008014497A2 (en) | 2008-01-31 |
| CA2653056A1 (en) | 2008-01-31 |
| RU2008151762A (ru) | 2010-06-27 |
| EP2046769A2 (en) | 2009-04-15 |
| NO20084971L (no) | 2009-02-25 |
| MX2008015765A (es) | 2009-03-26 |
| KR20090033417A (ko) | 2009-04-03 |
| IL195400A0 (en) | 2009-08-03 |
| WO2008014497A3 (en) | 2008-04-10 |
| AU2007278877A1 (en) | 2008-01-31 |
| ECSP088919A (es) | 2009-01-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO6210811A2 (es) | Inhibidores de aldh-2 en el tratamiento de la adiccion | |
| EA200970493A1 (ru) | Макроциклические ингибиторы вируса гепатита с | |
| AR052458A1 (es) | Amino-imidazolonas para la inhibicion de beta-secretasa | |
| CO5611131A2 (es) | Derivados de 5-feniltiazol y su uso como inhibidores de pi3 cinasa | |
| CO6270320A2 (es) | Derivados de piperidina utiles como antagonistas del receptor orexina | |
| SV1999000119A (es) | Benzazoles consistentes en derivados de benzoxazol, benzthiazol y benzimidazol | |
| PE20060215A1 (es) | 4-fenilamino-quinazolin-6-il-amidas | |
| RS51776B (en) | MACROCYCLIC HEPATITIS VIRUS INHIBITORS C | |
| CO6241076A2 (es) | Compuestos de benzamida y aplicaciones de los mismos | |
| AR055360A1 (es) | Inhibidores macrociclicos del virus de la hepatitis c | |
| RS51101B (sr) | Inhibitori hcv ns3 proteaze | |
| AR064355A1 (es) | Herbicidas derivados de isoxazol | |
| EA200800476A1 (ru) | Макроциклические ингибиторы вируса гепатита с | |
| TW200716531A (en) | Cyclohexanesulfonyl derivatives as GLYT1 inhibitors to treat schizophrenia | |
| CO6140060A2 (es) | Derivados de aminocicloalquil 1,2,4-triazol como moduladores de mglur5 | |
| AR057433A1 (es) | Compuestos quimicos derivados de piridopirimidina, un metodo para su preparacion y composicion farmaceutica | |
| RS51654B (en) | DERIVATIVES OF THE SUBSTITUTED BICYCLIC PIRIMIDONE | |
| CO6220935A2 (es) | Derivados de 1,2,4-triazol como moduladores de mglur5 | |
| RS52520B (en) | ACT AND P70 S6 KINASE INHIBITORS | |
| RS51186B (sr) | Derivati oksadiazolona kao ppar delta agonisti | |
| MX2009012380A (es) | Compuestos de heteroarilamida pirimidona. | |
| ES2557477T3 (es) | Nuevos compuestos peptídicos cíclicos | |
| CO6251235A2 (es) | Compuestos derivados de azetidinas su preparacion y su aplicacion en terapeutica | |
| AR060379A1 (es) | Compuesto y composicion herbicida | |
| CO6260066A2 (es) | Derivados de azetidina y su uso como antagonistas de prostaglandina e2 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |