CO5611106A2 - Nuevos derivados de pirrolidinio - Google Patents
Nuevos derivados de pirrolidinioInfo
- Publication number
- CO5611106A2 CO5611106A2 CO04104136A CO04104136A CO5611106A2 CO 5611106 A2 CO5611106 A2 CO 5611106A2 CO 04104136 A CO04104136 A CO 04104136A CO 04104136 A CO04104136 A CO 04104136A CO 5611106 A2 CO5611106 A2 CO 5611106A2
- Authority
- CO
- Colombia
- Prior art keywords
- group
- lower alkyl
- alkyl group
- optionally substituted
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1.- Un compuesto de fórmula (I):en la queB es un grupo fenilo, naftalenilo, 5,6,7,8-tetrahidronaftalenilo, benzo[1,3]dioxolilo o bifenilo o un grupo heteroaromático de 5 a 10 miembros que contiene uno o más heteroátomos seleccionados de N, O o S;R1, R2 y R3 representan cada uno independientemente un átomo de hidrógeno o de halógeno, o un grupo hidroxi, fenilo, -OR5, -SR5, -NR5R6, -NHCOR5, -CONR5R6, -CN,-NO2, -COOR5 o -CF3 o un grupo alquilo inferior lineal o ramificado, opcionalmente sustituido;o R1 y R2 forman juntos un anillo aromático o alicíclico o un grupo heterocíclico;R5 y R6 representan cada uno independientemente un átomo de hidrógeno, un grupo alquilo inferior lineal o ramificado, opcionalmente sustituido o forman juntos un anillo alicíclico;n es un número entero de 0 a 4;A representa un grupo seleccionado de -CH2-, -CH=CR7-, -CR7=CH-, -CR7R8-, -CO-, -O-, -S-, -S(O)-, -S(O)2 y -NR7-, en la que R7 y R8 representan cada uno independientemente un átomo de hidrógeno, un grupo alquilo inferior lineal o ramificado, opcionalmente sustituido, o forman juntos un anillo alicíclico;m es un número entero de 0 a 8;R4 representa un grupo alquilo inferior; D representa un grupo de fórmula i) o ii) en las queR9 representa un grupo seleccionado de fenilo, 2-furilo, 3-furilo, 2-tienilo o 3-tienilo; ...
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200200889A ES2206021B1 (es) | 2002-04-16 | 2002-04-16 | Nuevos derivados de pirrolidinio. |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5611106A2 true CO5611106A2 (es) | 2006-02-28 |
Family
ID=29225796
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO04104136A CO5611106A2 (es) | 2002-04-16 | 2004-10-15 | Nuevos derivados de pirrolidinio |
Country Status (21)
Country | Link |
---|---|
US (2) | US7192978B2 (es) |
EP (1) | EP1497284A2 (es) |
CN (1) | CN100548978C (es) |
AR (1) | AR039412A1 (es) |
AU (1) | AU2003233967B2 (es) |
BR (1) | BR0309167A (es) |
CA (1) | CA2482536A1 (es) |
CO (1) | CO5611106A2 (es) |
ES (1) | ES2206021B1 (es) |
IL (1) | IL164522A0 (es) |
MX (1) | MXPA04010076A (es) |
MY (1) | MY137535A (es) |
NO (1) | NO20044826L (es) |
NZ (1) | NZ535884A (es) |
PE (1) | PE20040409A1 (es) |
RU (1) | RU2320657C2 (es) |
TW (1) | TW200403237A (es) |
UA (1) | UA79283C2 (es) |
UY (1) | UY27760A1 (es) |
WO (1) | WO2003087094A2 (es) |
ZA (1) | ZA200408335B (es) |
Families Citing this family (81)
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ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
TW200519106A (en) | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
AR044851A1 (es) | 2003-06-24 | 2005-10-05 | Novartis Ag | Compuestos heterociclicos, antagonistas del receptor m3 muscarinico |
US20050026887A1 (en) * | 2003-07-29 | 2005-02-03 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising an anticholinergic and a steroid |
GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
WO2005086873A2 (en) * | 2004-03-11 | 2005-09-22 | Glaxo Group Limited | Novel m3 muscarinic acetylcholine receptor antagonists |
TWI363759B (en) | 2004-04-27 | 2012-05-11 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
ES2257152B1 (es) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
ES2317245T3 (es) * | 2004-05-31 | 2009-04-16 | Laboratorios Almirall, S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
GT200500281A (es) | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
GB0428416D0 (en) * | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
GB0428418D0 (en) * | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
TW200722418A (en) * | 2005-04-20 | 2007-06-16 | Astrazeneca Ab | Novel compounds |
GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
BRPI0614290A2 (pt) * | 2005-08-08 | 2011-03-22 | Argenta Discovery Ltd | derivados de biciclo [ 2.2.1 ] hept-7-ilamina e seus usos |
AR058104A1 (es) | 2005-10-21 | 2008-01-23 | Novartis Ag | Compuestos organicos |
US20090182033A1 (en) * | 2005-12-16 | 2009-07-16 | Argenta Discovery Ltd. | Cyclic Amine Derivatives and Their Uses |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
JP5373599B2 (ja) | 2006-04-21 | 2013-12-18 | ノバルティス アーゲー | アデノシンa2a受容体アゴニストとして使用するためのプリン誘導体 |
ES2298049B1 (es) | 2006-07-21 | 2009-10-20 | Laboratorios Almirall S.A. | Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano. |
JP2010504933A (ja) | 2006-09-29 | 2010-02-18 | ノバルティス アーゲー | Pi3k脂質キナーゼ阻害剤としてのピラゾロピリミジン |
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BRPI0720799A2 (pt) | 2007-01-10 | 2014-03-11 | Irm Llc | Compostos e composições como inibidores de protease de ativação de canal. |
WO2008096094A1 (en) * | 2007-02-06 | 2008-08-14 | Argenta Discovery Ltd. | Bicyclor[2.2.1]hept-7-ylamine derivatives as muscarinic m3 receptor modulators |
ES2554646T3 (es) * | 2007-02-23 | 2015-12-22 | Theravance Biopharma R&D Ip, Llc | Compuestos de difenilmetilo de amonio cuaternario, de utilidad como antagonistas de receptores muscarínicos |
AU2008248598B2 (en) | 2007-05-07 | 2011-11-17 | Novartis Ag | Organic compounds |
PT2197841E (pt) * | 2007-09-07 | 2012-01-02 | Theravance Inc | Compostos contendo guanidina úteis como antagonistas do receptor muscarínico |
CA2608561A1 (en) * | 2007-10-29 | 2009-04-29 | Carl Paluszkiewicz | Motorcycle wind deflector accessory support |
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EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
UY34305A (es) | 2011-09-01 | 2013-04-30 | Novartis Ag | Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar |
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WO2013038378A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
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US9034879B2 (en) | 2011-09-16 | 2015-05-19 | Novartis Ag | Heterocyclic compounds for the treatment of CF |
WO2013038390A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | N-substituted heterocyclyl carboxamides |
WO2013038381A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine/pyrazine amide derivatives |
JP6130391B2 (ja) | 2011-11-23 | 2017-05-17 | インテリカイン, エルエルシー | Mtor阻害剤を使用する強化された治療レジメン |
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US9156833B2 (en) | 2012-07-16 | 2015-10-13 | Barry University, Inc. | Bitopic muscarinic agonists and antagonists and methods of synthesis and use thereof |
CN103965178B (zh) * | 2013-02-06 | 2018-03-02 | 中国药科大学 | 作为m3毒蕈碱性受体拮抗剂的吡咯烷鎓衍生物及其在制药中的用途 |
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JP6454727B2 (ja) | 2014-04-24 | 2019-01-16 | ノバルティス アーゲー | ホスファチジルイノシトール3−キナーゼ阻害薬としてのアミノピリジン誘導体 |
EP3134397A1 (en) | 2014-04-24 | 2017-03-01 | Novartis AG | Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors |
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EP3174869B1 (en) | 2014-07-31 | 2020-08-19 | Novartis AG | Combination therapy of a met inhibitor and an egfr inhibitor |
CN105085355B (zh) * | 2015-06-25 | 2017-11-14 | 御盛隆堂药业有限责任公司 | 一种取代的吡咯烷羧酸酯类化合物及其制备方法和应用 |
CN108698989B (zh) * | 2016-02-10 | 2021-05-11 | 住友化学株式会社 | 用于制备1-甲基吡咯烷-3-醇的方法 |
CA3030772A1 (en) | 2016-08-02 | 2018-02-08 | Dermira, Inc. | Processes for making, and methods of using, glycopyrronium compounds |
BR112021024668A2 (pt) | 2019-06-10 | 2022-05-31 | Novartis Ag | Derivado de piridina e pirazina para o tratamento de fc, dpoc e bronquiectasia |
JOP20220044A1 (ar) | 2019-08-28 | 2023-01-30 | Novartis Ag | مشتقات 1، 3- فينيل أريل غير متجانسة بها استبدال واستخدامها في معالجة مرض |
TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法 |
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2002
- 2002-04-16 ES ES200200889A patent/ES2206021B1/es not_active Expired - Fee Related
-
2003
- 2003-04-10 UY UY27760A patent/UY27760A1/es not_active Application Discontinuation
- 2003-04-11 BR BR0309167-8A patent/BR0309167A/pt not_active IP Right Cessation
- 2003-04-11 RU RU2004133371/04A patent/RU2320657C2/ru not_active IP Right Cessation
- 2003-04-11 EP EP03727294A patent/EP1497284A2/en not_active Withdrawn
- 2003-04-11 CN CNB038138921A patent/CN100548978C/zh not_active Expired - Fee Related
- 2003-04-11 US US10/510,680 patent/US7192978B2/en not_active Expired - Fee Related
- 2003-04-11 CA CA002482536A patent/CA2482536A1/en not_active Abandoned
- 2003-04-11 AU AU2003233967A patent/AU2003233967B2/en not_active Ceased
- 2003-04-11 NZ NZ535884A patent/NZ535884A/en unknown
- 2003-04-11 WO PCT/EP2003/003786 patent/WO2003087094A2/en not_active Application Discontinuation
- 2003-04-11 MX MXPA04010076A patent/MXPA04010076A/es active IP Right Grant
- 2003-04-14 AR ARP030101294A patent/AR039412A1/es unknown
- 2003-04-15 MY MYPI20031408A patent/MY137535A/en unknown
- 2003-04-15 PE PE2003000381A patent/PE20040409A1/es not_active Application Discontinuation
- 2003-04-16 TW TW092108810A patent/TW200403237A/zh unknown
- 2003-11-04 UA UA20041109322A patent/UA79283C2/uk unknown
-
2004
- 2004-10-12 IL IL16452204A patent/IL164522A0/xx unknown
- 2004-10-14 ZA ZA200408335A patent/ZA200408335B/xx unknown
- 2004-10-15 CO CO04104136A patent/CO5611106A2/es not_active Application Discontinuation
- 2004-11-05 NO NO20044826A patent/NO20044826L/no not_active Application Discontinuation
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2007
- 2007-01-03 US US11/648,581 patent/US20070129420A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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MXPA04010076A (es) | 2004-12-13 |
CN1662527A (zh) | 2005-08-31 |
ES2206021A1 (es) | 2004-05-01 |
US20070129420A1 (en) | 2007-06-07 |
UY27760A1 (es) | 2003-11-28 |
RU2320657C2 (ru) | 2008-03-27 |
AR039412A1 (es) | 2005-02-16 |
ES2206021B1 (es) | 2005-08-01 |
CN100548978C (zh) | 2009-10-14 |
EP1497284A2 (en) | 2005-01-19 |
AU2003233967A1 (en) | 2003-10-27 |
WO2003087094A3 (en) | 2004-03-18 |
US20050282875A1 (en) | 2005-12-22 |
TW200403237A (en) | 2004-03-01 |
RU2004133371A (ru) | 2005-08-10 |
US7192978B2 (en) | 2007-03-20 |
ZA200408335B (en) | 2005-11-02 |
NO20044826L (no) | 2005-01-14 |
NZ535884A (en) | 2007-11-30 |
IL164522A0 (en) | 2005-12-18 |
PE20040409A1 (es) | 2004-07-14 |
MY137535A (en) | 2009-02-27 |
CA2482536A1 (en) | 2003-10-23 |
UA79283C2 (en) | 2007-06-11 |
BR0309167A (pt) | 2005-01-25 |
WO2003087094A2 (en) | 2003-10-23 |
AU2003233967B2 (en) | 2009-08-06 |
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