CO4900061A1 - Piridinas y bifenilos substituidos - Google Patents
Piridinas y bifenilos substituidosInfo
- Publication number
- CO4900061A1 CO4900061A1 CO97043316A CO97043316A CO4900061A1 CO 4900061 A1 CO4900061 A1 CO 4900061A1 CO 97043316 A CO97043316 A CO 97043316A CO 97043316 A CO97043316 A CO 97043316A CO 4900061 A1 CO4900061 A1 CO 4900061A1
- Authority
- CO
- Colombia
- Prior art keywords
- carbon atoms
- straight
- alkyl
- chain
- hydroxy
- Prior art date
Links
- 150000004074 biphenyls Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 18
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 125000003545 alkoxy group Chemical group 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 150000002367 halogens Chemical class 0.000 abstract 6
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 5
- 125000002252 acyl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- -1 hydroxy, carboxyl Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000000660 7-membered heterocyclic compounds Chemical class 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 150000003222 pyridines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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- C07D213/34—Sulfur atoms to which a second hetero atom is attached
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- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D213/80—Acids; Esters in position 3
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
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- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract
Piridinas substituidas que tienen la fórmula (1A).en la cual A representa arilo con 6 a 10 átomos de carbono, que está opcionalmente substituido hasta 3 veces de manera idéntica o diferente con halógeno, hidroxi, triflúormetilo, triflúormetoxi, o alquilo, acilo o alcoxi de cadena recta o ramificada con hasta 7 átomos de carbono cada uno, o con un grupo que tiene la fórmula NR1 R2 , donde R1 y R2 son idénticos o diferentes y representan hidrógeno, fenilo, o alquilo de cadena recta o ramificada con hasta 6 átomos de carbono, D representa alquilo de cadena recta o ramificada con hasta 8 átomos de carbono que está substituido con hidroxi, E y L son idénticos o diferentes y representan alquilo de cadena recta o ramificada con hasta 8 átomos de carbono, que está opcionalmente substituido con cicloalquilo con 3 a 8 átomos de carbono,orepresentan cicloalquilo con 3 a 8 átomos de carbono, E tiene el significado previamente indicado yL representa en este caso arilo con 6 a 10 átomos de carbono, que está opcionalmente substituido hasta 3 veces de manera idéntica o diferente con halógeno, hidroxi, triflúormetilo, triflúormetoxi, o con alquilo, acilo o alcoxi de cadena recta o ramificada con hasta 7 átomos de carbono cada uno, o con un grupo que tiene la fórmula NR3 R4 - 2 -dondeR3 y R4 son idénticos o diferentes y tienen el significado indicado más arriba para R1 y R2 , oE representa alquilo de cadena recta o ramificada con hasta 8 átomos de carbono,orepresenta arilo con 6 a 10 átomos de carbono, que está opcionalmente substituido hasta 3 veces de manera idéntica o diferente con halógeno, hidroxi, triflúormetilo, triflúormetoxi, o con alquilo, acilo o alcoxi de cadena recta o ramificada con hasta 7 átomos de carbono cada uno, o con un grupo que tiene la fórmula NR5 R6 donde R5 y R6 son idénticos o diferentes y tienen el significado indicado más arriba para R1 y R2 , yL representa en este caso alcoxi de cadena recta o ramificada con hasta 8 átomos de carbono o cicloalquiloxi con 3 a 8 átomos de carbono, T representa un radical que tiene la fórmula donde R7 y R8 son idénticos o diferentes y representan cicloalquilo con 3 a 8 átomos de carbono o arilo con 6 a 10 átomos de carbono, o representan un compuesto heterocíclico de 5 a 7 miembros, aromático, opcionalmente benzo-condensado con hasta 3 átomos heterocíclicos de las series de S, N y/o O, que están opcionalmente substituidos hasta 3 veces de manera idéntica o diferente con triflúormetilo, triflúormetoxi, halógeno, hidroxi, carboxilo, con alquilo, acilo, alcoxi o alcoxicarbonilo de cadena recta o ramificada con hasta 6 átomos de carbono cada uno, o con fenilo, fenoxi o tiofenilo que puede ser a su vez substituido con halógeno, triflúormetilo o triflúormetoxi, y/o los anillos están substituidos con un grupo que tiene la fórmula -NR11 y R12 R11 y R12 son idénticos o diferentes y tienen el significado indicado más arriba para R1 y R2 , X representa una cadena alquilo o una cadena alquilo recta o ramificada con 2 a 10 átomos de carbono cada una que están opcionalmente substituidas hasta 2 veces con hidroxi, R9 representa hidrógeno,yR10 representa hidrógeno, halógeno, azido, tiflúormetilo, hidroxi, mercapto, trifluormetoxi, alcoxi de cadena recta o ramificada con hasta 5 átomos de carbono o un radical que tiene la fórmula -NR13 R14 , dondeR13 y R14 son idénticos o diferentes y tienen el significado indicado mas arriba para R1 y R2 ,oR9 y R10 forman un grupo carbonilo conjuntamente con el atomo de carbono y las sales del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69011196A | 1996-07-31 | 1996-07-31 |
Publications (1)
Publication Number | Publication Date |
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CO4900061A1 true CO4900061A1 (es) | 2000-03-27 |
Family
ID=24771137
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO97043316A CO4900061A1 (es) | 1996-07-31 | 1997-07-29 | Piridinas y bifenilos substituidos |
Country Status (24)
Country | Link |
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US (1) | US6218431B1 (es) |
EP (1) | EP0934274A1 (es) |
JP (1) | JP2001512416A (es) |
KR (1) | KR20000029723A (es) |
CN (1) | CN1239474A (es) |
AR (2) | AR008789A1 (es) |
AU (1) | AU3897197A (es) |
BG (1) | BG103200A (es) |
BR (1) | BR9710637A (es) |
CA (1) | CA2262434A1 (es) |
CO (1) | CO4900061A1 (es) |
CZ (1) | CZ30899A3 (es) |
HR (1) | HRP970425A2 (es) |
HU (1) | HUP0100324A3 (es) |
ID (1) | ID19422A (es) |
IL (1) | IL128251A0 (es) |
NO (1) | NO314143B1 (es) |
NZ (1) | NZ333951A (es) |
PL (1) | PL333465A1 (es) |
RU (1) | RU2195443C2 (es) |
TR (3) | TR199902326T2 (es) |
TW (1) | TW520360B (es) |
WO (1) | WO1998004528A2 (es) |
ZA (1) | ZA976730B (es) |
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- 1997-07-28 AR ARP970103411A patent/AR008789A1/es unknown
- 1997-07-29 PL PL97333465A patent/PL333465A1/xx unknown
- 1997-07-29 TR TR1999/02326T patent/TR199902326T2/xx unknown
- 1997-07-29 WO PCT/US1997/013248 patent/WO1998004528A2/en not_active Application Discontinuation
- 1997-07-29 RU RU99104527/04A patent/RU2195443C2/ru not_active IP Right Cessation
- 1997-07-29 JP JP50906898A patent/JP2001512416A/ja not_active Ceased
- 1997-07-29 TR TR1999/02325T patent/TR199902325T2/xx unknown
- 1997-07-29 TW TW086110851A patent/TW520360B/zh not_active IP Right Cessation
- 1997-07-29 EP EP97936259A patent/EP0934274A1/en not_active Withdrawn
- 1997-07-29 BR BR9710637-2A patent/BR9710637A/pt not_active IP Right Cessation
- 1997-07-29 ZA ZA9706730A patent/ZA976730B/xx unknown
- 1997-07-29 HR HR08/690,111A patent/HRP970425A2/hr not_active Application Discontinuation
- 1997-07-29 CN CN97198258A patent/CN1239474A/zh active Pending
- 1997-07-29 CO CO97043316A patent/CO4900061A1/es unknown
- 1997-07-29 HU HU0100324A patent/HUP0100324A3/hu unknown
- 1997-07-29 AU AU38971/97A patent/AU3897197A/en not_active Abandoned
- 1997-07-29 NZ NZ333951A patent/NZ333951A/xx unknown
- 1997-07-29 TR TR1999/00163T patent/TR199900163T2/xx unknown
- 1997-07-29 IL IL12825197A patent/IL128251A0/xx unknown
- 1997-07-29 CA CA002262434A patent/CA2262434A1/en not_active Abandoned
- 1997-07-29 CZ CZ99308A patent/CZ30899A3/cs unknown
- 1997-07-29 KR KR1019997000826A patent/KR20000029723A/ko not_active Application Discontinuation
- 1997-07-31 ID IDP972662A patent/ID19422A/id unknown
- 1997-07-31 US US08/904,119 patent/US6218431B1/en not_active Expired - Fee Related
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1999
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- 1999-02-23 BG BG103200A patent/BG103200A/xx unknown
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2002
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EP0934274A1 (en) | 1999-08-11 |
BG103200A (en) | 1999-11-30 |
NZ333951A (en) | 2000-09-29 |
CZ30899A3 (cs) | 1999-05-12 |
WO1998004528A3 (en) | 1999-11-11 |
TW520360B (en) | 2003-02-11 |
HUP0100324A2 (hu) | 2001-05-28 |
ZA976730B (en) | 1999-07-29 |
NO314143B1 (no) | 2003-02-03 |
HUP0100324A3 (en) | 2001-06-28 |
PL333465A1 (en) | 1999-12-20 |
TR199902325T2 (xx) | 2000-02-21 |
US6218431B1 (en) | 2001-04-17 |
HRP970425A2 (en) | 1998-08-31 |
CN1239474A (zh) | 1999-12-22 |
AU3897197A (en) | 1998-02-20 |
TR199902326T2 (xx) | 2000-05-22 |
AR037300A2 (es) | 2004-11-03 |
KR20000029723A (ko) | 2000-05-25 |
TR199900163T2 (xx) | 1999-04-21 |
BR9710637A (pt) | 2000-10-31 |
NO990399D0 (no) | 1999-01-28 |
AR008789A1 (es) | 2000-02-23 |
IL128251A0 (en) | 1999-11-30 |
RU2195443C2 (ru) | 2002-12-27 |
NO990399L (no) | 1999-03-29 |
CA2262434A1 (en) | 1998-02-05 |
ID19422A (id) | 1998-07-09 |
WO1998004528A2 (en) | 1998-02-05 |
JP2001512416A (ja) | 2001-08-21 |
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