CO2021008995A2 - Proteínas de unión multiespecíficas con dominios fab mutantes - Google Patents
Proteínas de unión multiespecíficas con dominios fab mutantesInfo
- Publication number
- CO2021008995A2 CO2021008995A2 CONC2021/0008995A CO2021008995A CO2021008995A2 CO 2021008995 A2 CO2021008995 A2 CO 2021008995A2 CO 2021008995 A CO2021008995 A CO 2021008995A CO 2021008995 A2 CO2021008995 A2 CO 2021008995A2
- Authority
- CO
- Colombia
- Prior art keywords
- binding proteins
- region
- multispecific binding
- fab domains
- multispecific
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Se proporcionan proteínas de unión que comprenden una región VL emparejada con una región VH y una región CH1 emparejada con una región CL, en donde la región VL y la región VH comprenden mutaciones con carga opuesta para facilitar el emparejamiento y en donde la región CH1 y la región CL comprenden mutaciones para facilitar el emparejamiento. También se proporcionan proteínas de unión que comprenden uno o más restos de cisteína introducidos por ingeniería genética en el par VH/VL para formar uno o más enlaces disulfuro. También se proporcionan proteínas de unión multiespecíficas, ácidos nucleicos que codifican proteínas de unión y proteínas de unión multiespecíficas, vectores de expresión, células hospedadoras, composición farmacéutica y métodos de tratamiento que administran las proteínas de unión o proteínas de unión multiespecíficas descritas en la presente memoria.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18306843.6A EP3674316A1 (en) | 2018-12-24 | 2018-12-24 | Multispecific binding proteins with mutant fab domains |
EP19305812 | 2019-06-21 | ||
PCT/IB2019/061309 WO2020136566A1 (en) | 2018-12-24 | 2019-12-23 | Multispecific binding proteins with mutant fab domains |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2021008995A2 true CO2021008995A2 (es) | 2021-07-30 |
Family
ID=69167873
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2021/0008995A CO2021008995A2 (es) | 2018-12-24 | 2021-07-08 | Proteínas de unión multiespecíficas con dominios fab mutantes |
Country Status (14)
Country | Link |
---|---|
US (1) | US11965030B2 (es) |
EP (1) | EP3902823A1 (es) |
JP (1) | JP2022515424A (es) |
KR (1) | KR20210108421A (es) |
CN (1) | CN113795508A (es) |
AU (1) | AU2019412561A1 (es) |
BR (1) | BR112021012338A2 (es) |
CA (1) | CA3124796A1 (es) |
CO (1) | CO2021008995A2 (es) |
IL (1) | IL284140A (es) |
MX (1) | MX2021007672A (es) |
SG (1) | SG11202106525TA (es) |
TW (1) | TW202104257A (es) |
WO (1) | WO2020136566A1 (es) |
Families Citing this family (8)
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KR20230026621A (ko) | 2021-08-18 | 2023-02-27 | 주식회사 엘지에너지솔루션 | 비파괴 방식을 이용한 와이어 본딩 검사 방법 |
WO2023166098A1 (en) | 2022-03-02 | 2023-09-07 | Biomunex Pharmaceuticals | Bispecific antibodies binding to her-3 and to either her-2 or egfr |
WO2023178357A1 (en) * | 2022-03-18 | 2023-09-21 | Evolveimmune Therapeutics, Inc. | Bispecific antibody fusion molecules and methods of use thereof |
WO2024007013A2 (en) * | 2022-06-30 | 2024-01-04 | Modex Therapeutics, Inc. | Anti-sars-cov-2 antigen binding polypeptides, polypeptide complexes and methods of use thereof |
WO2024017371A1 (zh) * | 2022-07-22 | 2024-01-25 | 信达生物制药(苏州)有限公司 | 促进多特异性抗体的重链和轻链同源配对的突变体 |
CN116059361B (zh) * | 2023-02-27 | 2023-08-15 | 华中科技大学协和深圳医院 | 三价铬离子和/或金属铬在制备肿瘤免疫治疗药物中的应用 |
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CA3022143A1 (en) | 2016-03-25 | 2017-09-28 | Biomunex Pharmaceuticals | Binding molecules to cd38 and pd-l1 |
BR112018070998A2 (pt) | 2016-04-13 | 2019-02-26 | Sanofi | proteínas de ligação triespecíficas e/ou trivalentes |
KR102360742B1 (ko) | 2016-04-28 | 2022-02-08 | 바이오뮤넥스 파마슈티컬스 | Egfr 및 her2 를 표적하는 이특이적 항체 |
EP3487532A4 (en) | 2016-07-21 | 2020-03-18 | Development Center for Biotechnology | MODIFIED ANTI-BINDING FAB FRAGMENTS AND ANTI-BINDING MOLECULES THEREFOR |
US20190177439A1 (en) | 2016-08-16 | 2019-06-13 | Epimab Biotherapeutics, Inc. | Monovalent Asymmetric Tandem Fab Bispecific Antibodies |
CN109641949B (zh) | 2016-08-26 | 2023-09-15 | 赛诺菲 | 促进选择性轻链配对的多特异性抗体 |
JP7261158B2 (ja) | 2016-10-19 | 2023-04-19 | インベンラ, インコーポレイテッド | 抗体構築物 |
MX2019008241A (es) | 2017-01-09 | 2019-12-09 | Biomunex Pharmaceuticals | Un enlazador polipeptídico para preparar anticuerpos multispecíficos. |
US11685776B2 (en) * | 2017-03-02 | 2023-06-27 | Novartis Ag | Engineered heterodimeric proteins |
-
2019
- 2019-12-23 EP EP19836843.3A patent/EP3902823A1/en active Pending
- 2019-12-23 JP JP2021536775A patent/JP2022515424A/ja active Pending
- 2019-12-23 MX MX2021007672A patent/MX2021007672A/es unknown
- 2019-12-23 AU AU2019412561A patent/AU2019412561A1/en active Pending
- 2019-12-23 WO PCT/IB2019/061309 patent/WO2020136566A1/en unknown
- 2019-12-23 CN CN201980092139.4A patent/CN113795508A/zh active Pending
- 2019-12-23 US US16/725,228 patent/US11965030B2/en active Active
- 2019-12-23 BR BR112021012338-5A patent/BR112021012338A2/pt unknown
- 2019-12-23 KR KR1020217022722A patent/KR20210108421A/ko unknown
- 2019-12-23 CA CA3124796A patent/CA3124796A1/en active Pending
- 2019-12-23 SG SG11202106525TA patent/SG11202106525TA/en unknown
- 2019-12-24 TW TW108147272A patent/TW202104257A/zh unknown
-
2021
- 2021-06-17 IL IL284140A patent/IL284140A/en unknown
- 2021-07-08 CO CONC2021/0008995A patent/CO2021008995A2/es unknown
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MX2021007672A (es) | 2021-09-30 |
IL284140A (en) | 2021-08-31 |
BR112021012338A2 (pt) | 2021-09-14 |
JP2022515424A (ja) | 2022-02-18 |
US11965030B2 (en) | 2024-04-23 |
SG11202106525TA (en) | 2021-07-29 |
WO2020136566A1 (en) | 2020-07-02 |
CN113795508A (zh) | 2021-12-14 |
AU2019412561A1 (en) | 2021-08-12 |
US20200262926A1 (en) | 2020-08-20 |
EP3902823A1 (en) | 2021-11-03 |
AU2019412561A2 (en) | 2021-09-02 |
CA3124796A1 (en) | 2020-07-02 |
KR20210108421A (ko) | 2021-09-02 |
TW202104257A (zh) | 2021-02-01 |
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