CN87102167A - 具交叉保护作用的人单克隆抗体组合物 - Google Patents

具交叉保护作用的人单克隆抗体组合物 Download PDF

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Publication number
CN87102167A
CN87102167A CN198787102167A CN87102167A CN87102167A CN 87102167 A CN87102167 A CN 87102167A CN 198787102167 A CN198787102167 A CN 198787102167A CN 87102167 A CN87102167 A CN 87102167A CN 87102167 A CN87102167 A CN 87102167A
Authority
CN
China
Prior art keywords
antibody
monoclonal antibody
serotype
escherichia coli
serratia marcescens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN198787102167A
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English (en)
Chinese (zh)
Inventor
霍华德·V·拉夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetic Systems Corp
Original Assignee
Genetic Systems Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetic Systems Corp filed Critical Genetic Systems Corp
Publication of CN87102167A publication Critical patent/CN87102167A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN198787102167A 1986-02-07 1987-02-06 具交叉保护作用的人单克隆抗体组合物 Pending CN87102167A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US82800586A 1986-02-07 1986-02-07
US94449586A 1986-12-19 1986-12-19
US944495 1986-12-19
US828005 1997-03-27

Publications (1)

Publication Number Publication Date
CN87102167A true CN87102167A (zh) 1988-02-03

Family

ID=27125154

Family Applications (1)

Application Number Title Priority Date Filing Date
CN198787102167A Pending CN87102167A (zh) 1986-02-07 1987-02-06 具交叉保护作用的人单克隆抗体组合物

Country Status (28)

Country Link
US (2) US5717071A (https=)
JP (1) JP2645343B2 (https=)
KR (1) KR870007697A (https=)
CN (1) CN87102167A (https=)
AT (1) AT398781B (https=)
BE (1) BE1000967A5 (https=)
CA (1) CA1339013C (https=)
CH (1) CH672072A5 (https=)
DE (1) DE3703711A1 (https=)
DK (1) DK63187A (https=)
ES (1) ES2009140A6 (https=)
FI (1) FI94489C (https=)
FR (1) FR2595946B1 (https=)
GB (1) GB2186592B (https=)
GR (1) GR870194B (https=)
HK (1) HK21795A (https=)
HU (1) HU203583B (https=)
IE (1) IE59627B1 (https=)
IL (1) IL81370A (https=)
IT (1) IT1207589B (https=)
LU (1) LU86761A1 (https=)
MX (1) MX9203629A (https=)
NL (1) NL8700286A (https=)
NO (1) NO176924C (https=)
NZ (2) NZ233920A (https=)
OA (1) OA08477A (https=)
PT (1) PT84258B (https=)
SE (1) SE468747B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102378766A (zh) * 2009-03-23 2012-03-14 夸克医药公司 治疗癌症和纤维化疾病的化合物组合物和方法

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0256713A3 (en) * 1986-08-06 1989-02-15 Merck & Co. Inc. Therapeutic human antipseudomonas aeruginosa antibodies
CA1341375C (en) * 1988-10-12 2002-07-09 Baxter International Inc. Compositions and methods for the treatment and prevention of gram-negative bacterial infections
DE3925161A1 (de) * 1989-03-15 1990-09-27 Boehringer Mannheim Gmbh Monoklonale, gegen eca gerichtete antikoerper und ihre verwendung
AU5675790A (en) * 1989-05-09 1990-11-29 Cetus Corporation Human monoclonal antibodies to sero-specific determinants of gram-negative bacteria
GB8918232D0 (en) * 1989-08-10 1989-09-20 Opal Stephen M Pharmaceutical product for the treatment of septic shock
US6315999B1 (en) 1989-08-10 2001-11-13 Solvay, S.A. Pharmaceutical product for the treatment of sepsis
US20080139789A1 (en) * 1990-10-22 2008-06-12 Henry M. Jackson Foundation For The Advancement Of Military Medicine Isolated Broadly Reactive Opsonic Immunoglobulin for Treating a Pathogenic Coagulase-Negative Staphylococcus Infection
DK0635132T4 (da) * 1992-03-19 2008-08-25 Jackson H M Found Military Med Bredt reaktive opsoniske antistoffer, som reagerer med fælles stafylokok-antigener
WO1994015640A1 (en) * 1993-01-12 1994-07-21 Anthony George Gristina Methods and compositions for the direct concentrated delivery of passive immunity
US5510264A (en) * 1993-09-28 1996-04-23 Insight Biotech Inc. Antibodies which bind meningitis related homologous antigenic sequences
WO1999054357A1 (en) * 1998-04-14 1999-10-28 Chugai Research Institute For Molecular Medicine, Inc. Novel cytokine-like protein
BRPI0814127A2 (pt) * 2007-07-23 2015-02-03 Sanofi Pasteur Ltd Polipeptídeos imunegênicos e anticorpos monoclonais
KR20140009281A (ko) 2010-12-03 2014-01-22 사노피 파스퇴르 리미티드 / 사노피 파스퇴르 리미떼 스트렙토코커스 뉴모니애에 대한 면역화를 위한 조성물
AU2016353073A1 (en) 2015-11-10 2018-06-07 Visterra, Inc. Antibody molecule-drug conjugates that specifically binds to lipopolysaccharide and uses thereof
CN110431150A (zh) 2017-01-18 2019-11-08 威特拉公司 抗体分子-药物偶联物及其用途
AU2021248643A1 (en) 2020-04-03 2022-10-27 Visterra, Inc. Antibody molecule-drug conjugates and uses thereof
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
US12537071B1 (en) 2020-07-22 2026-01-27 David Gordon Bermudes Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464465A (en) * 1982-04-05 1984-08-07 Genetic Systems Corporation Cell-driven viral transfer in eukaryotes
CA1262238A (en) * 1982-09-30 1989-10-10 Richard Insel Human monoclonal antibodies against bacterial toxins
US4587121A (en) * 1983-06-14 1986-05-06 Miles Laboratories, Inc. High titer Pseudomonas immune serum globulin
US5179018A (en) * 1983-10-14 1993-01-12 Centocor, Inc. Mamalian monoclonal antibodies against endotoxin of gram-negative bacteria
US4834975A (en) * 1984-05-25 1989-05-30 Genetics Corporation Human monoclonal antibodies to serotypic lipopolysaccharide determinants on gram-negative bacteria and their production
DE3426903A1 (de) * 1984-07-20 1986-01-23 Biotest Pharma GmbH, 6000 Frankfurt Eine immunglobulinpraeparation in kombination mit einer anderen pharmakologisch wirksamen praeparation zur verwendung bei der behandlung von krankheiten
US4675287A (en) * 1984-07-26 1987-06-23 Scripps Clinic And Research Foundation Monoclonal antibody directed to human ganglioside GD2
US4677070A (en) * 1985-04-26 1987-06-30 Cetus Corporation Pseudomonas aeruginosa exotoxin A antibodies, their preparation and use
US4772464A (en) * 1985-08-01 1988-09-20 Miles Laboratories, Inc. Protective antibodies to serotypic determinants of flagellar antigens
US4918163A (en) * 1985-09-27 1990-04-17 Pfizer Inc. Monoclonal antibodies specific for lipid-A determinants of gram negative bacteria
US4777136A (en) * 1985-09-27 1988-10-11 The Regents Of The University Of California Monoclonal antibody reactive with Pseudomonas Aeruginosa
NZ218499A (en) * 1985-12-10 1990-04-26 Genetic Systems Corp Monoclonal antibodies against pseudomonas aeruginosa, pharmaceutical compositions and detection methods
US4970070A (en) * 1986-02-07 1990-11-13 Genetic Systems Corporation Protective monoclonal antibody compositions for infections due to group B streptococcus

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102378766A (zh) * 2009-03-23 2012-03-14 夸克医药公司 治疗癌症和纤维化疾病的化合物组合物和方法

Also Published As

Publication number Publication date
MX9203629A (es) 1992-07-01
CH672072A5 (https=) 1989-10-31
IL81370A0 (en) 1987-08-31
FI870502L (fi) 1987-08-08
GR870194B (en) 1987-06-10
NZ219187A (en) 1990-12-21
NZ233920A (en) 1990-12-21
DE3703711A1 (de) 1987-09-24
US5717071A (en) 1998-02-10
ATA26287A (de) 1994-06-15
FR2595946B1 (fr) 1991-10-04
HU203583B (en) 1991-08-28
JPS62270535A (ja) 1987-11-24
FI94489C (fi) 1995-09-25
KR870007697A (ko) 1987-09-21
DK63187A (da) 1987-08-08
FI94489B (fi) 1995-06-15
IL81370A (en) 1991-06-30
IT1207589B (it) 1989-05-25
FI870502A0 (fi) 1987-02-06
AT398781B (de) 1995-01-25
FR2595946A1 (fr) 1987-09-25
NO870476D0 (no) 1987-02-06
NO870476L (no) 1987-08-10
NL8700286A (nl) 1987-09-01
OA08477A (fr) 1988-07-29
GB2186592A (en) 1987-08-19
BE1000967A5 (fr) 1989-05-30
ES2009140A6 (es) 1989-09-01
IE870320L (en) 1987-08-07
IT8719292A0 (it) 1987-02-06
HK21795A (en) 1995-02-24
SE8700467L (sv) 1987-08-08
PT84258A (en) 1987-03-01
US5837541A (en) 1998-11-17
LU86761A1 (fr) 1987-09-15
DK63187D0 (da) 1987-02-06
JP2645343B2 (ja) 1997-08-25
SE8700467D0 (sv) 1987-02-06
NO176924C (no) 1995-06-21
PT84258B (pt) 1989-09-14
CA1339013C (en) 1997-03-25
NO176924B (no) 1995-03-13
SE468747B (sv) 1993-03-15
DE3703711C2 (https=) 1993-06-24
GB2186592B (en) 1990-08-01
HUT46062A (en) 1988-09-28
IE59627B1 (en) 1994-03-09
GB8702689D0 (en) 1987-03-11

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