CN1788018A - 铜绿假单胞菌血清型iats o6的脂多糖(lps)特异性的人单克隆抗体 - Google Patents
铜绿假单胞菌血清型iats o6的脂多糖(lps)特异性的人单克隆抗体 Download PDFInfo
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- CN1788018A CN1788018A CNA200480013138XA CN200480013138A CN1788018A CN 1788018 A CN1788018 A CN 1788018A CN A200480013138X A CNA200480013138X A CN A200480013138XA CN 200480013138 A CN200480013138 A CN 200480013138A CN 1788018 A CN1788018 A CN 1788018A
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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Abstract
Description
IATS血清型 | 规格 |
O1O2O3O4O6O7O10O11O16 | PA53(IT4)E576(IT3)6510(Habs3)6511(Habs4)PA220(IT1)Fisher6(IT6)Fisher5(IT5)Fisher2(IT2)Fisher7(IT7) |
#分离株 | 分离株来源 |
2310_152310_192310_11V04 1297V05 1573V07 2215V07 2420V10 11941V103328V10 9205V12 3799 | 囊性纤维化囊性纤维化Broncho-catheter阴道感染囊性纤维化导管伤口伤口肺移植痰气管分泌 |
引物 | 序列 | 应用 |
ConμConκμ序列κ序列 | 5′-GCC ACG CTG CTC GTA TCC GAC G-3′(SEQ ID NO:11)5′-AGC AGG CAC ACA ACA GAG GCA GTT CC-3′(SEQ ID NO:12)5′-GCT GCT CGT ATC CGA CGG-3′(SEQ ID NO:13)5′-CAC AAC AGA GGC AGT TCC-3′(SEQ ID NO:14) | PCRPCR序列测定序列测定 |
重链 | 轻链 | |||
种系 | R∶S | 种系 | R∶S | |
310BO6 | DP-75 | 11∶5 | L12a | 2∶4 |
抗体克隆 | 血清特异性 | LD50(cfu) | 保护倍数 | |
对照 | 治疗 | |||
310BO6 | IATS O6 | 24 | 35′541 | 1476 |
Claims (21)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03010836.9 | 2003-05-14 | ||
EP03010836A EP1479695B1 (en) | 2003-05-14 | 2003-05-14 | Human monoclonal antibody specific for lipopolysaccharides (LPS) of serotype IATS O6 of Pseudomonas aeruginosa |
PCT/EP2004/004485 WO2004101622A1 (en) | 2003-05-14 | 2004-04-28 | Human monoclonal antibody specific for lipopolysaccharides (lps) of serotype iats 06 of pseudomonas aeruginosa |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1788018A true CN1788018A (zh) | 2006-06-14 |
CN1788018B CN1788018B (zh) | 2012-04-25 |
Family
ID=33040937
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200480013138XA Expired - Fee Related CN1788018B (zh) | 2003-05-14 | 2004-04-28 | 铜绿假单胞菌血清型iats o6的脂多糖(lps)特异性的人单克隆抗体 |
Country Status (9)
Country | Link |
---|---|
US (1) | US7597893B2 (zh) |
EP (1) | EP1479695B1 (zh) |
KR (1) | KR100910097B1 (zh) |
CN (1) | CN1788018B (zh) |
AT (1) | ATE458006T1 (zh) |
CA (1) | CA2525657C (zh) |
DE (1) | DE60331292D1 (zh) |
ES (1) | ES2338105T3 (zh) |
WO (1) | WO2004101622A1 (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102858976A (zh) * | 2010-02-18 | 2013-01-02 | 明治制果药业株式会社 | 铜绿假单胞菌b血清型脂多糖的抗体 |
CN101910197B (zh) * | 2007-11-30 | 2014-09-24 | 卡罗拜奥斯制药公司 | 针对铜绿假单胞菌pcrv抗原的抗体 |
CN105424929A (zh) * | 2015-11-24 | 2016-03-23 | 四川夹金山逢春养殖科技有限公司 | 一种铜绿假单胞菌抗体检测试剂盒及检测方法 |
CN105517573A (zh) * | 2013-07-03 | 2016-04-20 | 辛格利科医药品有限公司 | 合成用于绿脓杆菌疫苗的低聚糖 |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102639562A (zh) * | 2009-04-09 | 2012-08-15 | 肯塔生物技术有限公司 | 对绿脓假单胞菌的血清型iats o1的脂多糖类(lps)具有特异性的人单克隆抗体 |
ITFI20090230A1 (it) * | 2009-11-04 | 2011-05-05 | Azienda Ospedaliero Universitaria C Areggi | Glicoconiugato sintetico immunogeno utile per l'immunoterapia del melanoma. |
EP2361989A1 (en) * | 2010-02-26 | 2011-08-31 | Kenta Biotech AG | Assays and kits for serotyping Pseudomonas aeruginosa and oligonucleotide sequences useful in such methods and kits |
SI2673373T1 (sl) * | 2011-02-08 | 2019-03-29 | Medimmune, Llc | Protitelesa, ki specifično vežejo alfa toksin Staphylococcus aureus in postopki uporabe |
WO2017083515A2 (en) | 2015-11-10 | 2017-05-18 | Visterra, Inc. | Antibody molecule-drug conjugates and uses thereof |
EP3571223A1 (en) | 2017-01-18 | 2019-11-27 | Visterra, Inc. | Antibody molecule-drug conjugates and uses thereof |
TW202019956A (zh) | 2018-07-24 | 2020-06-01 | 美商麥迪紐有限責任公司 | 抗金黃色葡萄球菌凝集因子a(clfa)之抗體 |
CN113164602A (zh) | 2018-10-09 | 2021-07-23 | 免疫医疗有限责任公司 | 抗金黄色葡萄球菌抗体的组合 |
AU2021248643A1 (en) | 2020-04-03 | 2022-10-27 | Visterra, Inc. | Antibody molecule-drug conjugates and uses thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4834975A (en) * | 1984-05-25 | 1989-05-30 | Genetics Corporation | Human monoclonal antibodies to serotypic lipopolysaccharide determinants on gram-negative bacteria and their production |
JPH04211393A (ja) * | 1990-02-08 | 1992-08-03 | Sumitomo Pharmaceut Co Ltd | ヒトモノクローナル抗体及びそれを有効成分とする緑膿菌感染症治療剤 |
WO2002020619A2 (en) * | 2000-09-07 | 2002-03-14 | Schreiber John R | HUMAN ANTIBODIES AGAINST PSEUDOMONAS AERUGINOSA LPS DERIVED FROM TRANSGENIC XENOMOUSE$m(3) |
SV2007000775A (es) * | 2001-01-05 | 2007-03-15 | Pfizer | Anticuerpos contra el receptor del factor de crecimiento similar a insulina |
DK2270052T3 (en) * | 2001-06-26 | 2018-07-02 | Amgen Inc | Antibodies to OPGL |
-
2003
- 2003-05-14 ES ES03010836T patent/ES2338105T3/es not_active Expired - Lifetime
- 2003-05-14 EP EP03010836A patent/EP1479695B1/en not_active Expired - Lifetime
- 2003-05-14 DE DE60331292T patent/DE60331292D1/de not_active Expired - Lifetime
- 2003-05-14 AT AT03010836T patent/ATE458006T1/de active
-
2004
- 2004-04-28 KR KR1020057021656A patent/KR100910097B1/ko not_active IP Right Cessation
- 2004-04-28 WO PCT/EP2004/004485 patent/WO2004101622A1/en active Application Filing
- 2004-04-28 CA CA2525657A patent/CA2525657C/en not_active Expired - Fee Related
- 2004-04-28 CN CN200480013138XA patent/CN1788018B/zh not_active Expired - Fee Related
-
2005
- 2005-11-10 US US11/271,008 patent/US7597893B2/en not_active Expired - Fee Related
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101910197B (zh) * | 2007-11-30 | 2014-09-24 | 卡罗拜奥斯制药公司 | 针对铜绿假单胞菌pcrv抗原的抗体 |
CN102858976A (zh) * | 2010-02-18 | 2013-01-02 | 明治制果药业株式会社 | 铜绿假单胞菌b血清型脂多糖的抗体 |
CN102858977A (zh) * | 2010-02-18 | 2013-01-02 | 明治制果药业株式会社 | 铜绿假单胞菌g血清型脂多糖抗体 |
CN102858974A (zh) * | 2010-02-18 | 2013-01-02 | 明治制果药业株式会社 | 抗铜绿假单胞菌e血清型脂多糖的抗体 |
CN102858799A (zh) * | 2010-02-18 | 2013-01-02 | 明治制果药业株式会社 | 抗铜绿假单胞菌的i血清型脂多糖的抗体 |
CN105517573A (zh) * | 2013-07-03 | 2016-04-20 | 辛格利科医药品有限公司 | 合成用于绿脓杆菌疫苗的低聚糖 |
CN105424929A (zh) * | 2015-11-24 | 2016-03-23 | 四川夹金山逢春养殖科技有限公司 | 一种铜绿假单胞菌抗体检测试剂盒及检测方法 |
CN105424929B (zh) * | 2015-11-24 | 2017-08-08 | 四川夹金山逢春养殖科技有限公司 | 一种铜绿假单胞菌抗体检测试剂盒及检测方法 |
Also Published As
Publication number | Publication date |
---|---|
KR20060006967A (ko) | 2006-01-20 |
CN1788018B (zh) | 2012-04-25 |
US7597893B2 (en) | 2009-10-06 |
KR100910097B1 (ko) | 2009-07-30 |
CA2525657C (en) | 2011-11-29 |
US20060093610A1 (en) | 2006-05-04 |
WO2004101622A1 (en) | 2004-11-25 |
ATE458006T1 (de) | 2010-03-15 |
ES2338105T3 (es) | 2010-05-04 |
CA2525657A1 (en) | 2004-11-25 |
EP1479695A1 (en) | 2004-11-24 |
DE60331292D1 (de) | 2010-04-01 |
EP1479695B1 (en) | 2010-02-17 |
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