CN1976725B - 采用gpc和sec-mals进行的糖接合物尺度分析 - Google Patents

采用gpc和sec-mals进行的糖接合物尺度分析 Download PDF

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Publication number
CN1976725B
CN1976725B CN2005800204436A CN200580020443A CN1976725B CN 1976725 B CN1976725 B CN 1976725B CN 2005800204436 A CN2005800204436 A CN 2005800204436A CN 200580020443 A CN200580020443 A CN 200580020443A CN 1976725 B CN1976725 B CN 1976725B
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China
Prior art keywords
conjugate
serogroup
neisseria meningitidis
capsular saccharide
molar mass
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Expired - Lifetime
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CN2005800204436A
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Chinese (zh)
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CN1976725A (zh
Inventor
G·卡潘诺利
V·卡里奇
S·达申奇
C·马加诺利
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GlaxoSmithKline Biologicals SA
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Novartis Vaccines and Diagnostics SRL
Chiron SRL
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Spectrometry And Color Measurement (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CN2005800204436A 2004-06-21 2005-06-21 采用gpc和sec-mals进行的糖接合物尺度分析 Expired - Lifetime CN1976725B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0413868.1 2004-06-21
GBGB0413868.1A GB0413868D0 (en) 2004-06-21 2004-06-21 Dimensional anlaysis of saccharide conjugates
PCT/IB2005/002532 WO2006000920A2 (en) 2004-06-21 2005-06-21 Dimensional analysis of saccharide conjugates with gpc & sec-mals

Publications (2)

Publication Number Publication Date
CN1976725A CN1976725A (zh) 2007-06-06
CN1976725B true CN1976725B (zh) 2012-08-29

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CN2005800204436A Expired - Lifetime CN1976725B (zh) 2004-06-21 2005-06-21 采用gpc和sec-mals进行的糖接合物尺度分析

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Country Link
US (2) US8163296B2 (cg-RX-API-DMAC10.html)
EP (2) EP2374473B1 (cg-RX-API-DMAC10.html)
JP (5) JP2008503716A (cg-RX-API-DMAC10.html)
CN (1) CN1976725B (cg-RX-API-DMAC10.html)
AU (1) AU2005256961B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0512281A (cg-RX-API-DMAC10.html)
CA (1) CA2571565C (cg-RX-API-DMAC10.html)
ES (2) ES2443465T3 (cg-RX-API-DMAC10.html)
GB (1) GB0413868D0 (cg-RX-API-DMAC10.html)
MX (2) MXPA06015188A (cg-RX-API-DMAC10.html)
NZ (1) NZ552449A (cg-RX-API-DMAC10.html)
RU (1) RU2422156C2 (cg-RX-API-DMAC10.html)
WO (1) WO2006000920A2 (cg-RX-API-DMAC10.html)

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TW201009337A (en) * 2008-05-30 2010-03-01 Intervet Int Bv Analytical method to monitor vaccine potency and stability
EP2437882A4 (en) 2009-06-01 2016-11-23 Waters Technologies Corp HYBRID MATERIAL FOR CHROMATOGRAPHY SEPARATIONS
US8195405B2 (en) * 2009-06-30 2012-06-05 Wyatt Technology Corporation Method for characterizing reversible association of macromolecules at high concentration
PT2493498T (pt) 2009-10-30 2017-05-24 Glaxosmithkline Biologicals Sa Purificação de sacáridos capsulares de staphylococcus aureus tipo 5 e tipo 8
EP4023330A1 (en) * 2009-12-15 2022-07-06 Waters Technologies Corporation Device and methods for performing size exclusion chromatography
CN107029223A (zh) * 2010-05-26 2017-08-11 西莱克塔生物科技公司 合成纳米载体联合疫苗
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US12623205B2 (en) 2010-07-26 2026-05-12 Waters Technologies Corporation Superficially porous materials comprising a substantially nonporous hybrid core having narrow particle size distribution
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KR101584871B1 (ko) 2010-09-10 2016-01-22 와이어쓰 엘엘씨 네이세리아 메닝기티디스 orf2086 항원의 비-지질화된 변이체
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SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
US10481164B2 (en) 2012-03-26 2019-11-19 Amgen Inc. Method for using light scattering in real time to directly monitor and control impurity removal in purification processes
CA2903716C (en) 2013-03-08 2019-04-09 Pfizer Inc. Immunogenic fusion polypeptides
RU2662968C2 (ru) 2013-09-08 2018-07-31 Пфайзер Инк. Иммуногенная композиция против neisseria meningitidis (варианты)
KR20190049940A (ko) 2015-02-19 2019-05-09 화이자 인코포레이티드 나이세리아 메닌지티디스 조성물 및 그의 방법
CN109890413B (zh) 2016-09-02 2024-04-16 赛诺菲巴斯德股份有限公司 脑膜炎奈瑟氏菌疫苗
IL267709B2 (en) 2016-12-30 2025-04-01 Vaxcyte Inc Polypeptide-antigen conjugates with unnatural amino acids
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
SG11201906519RA (en) 2017-01-31 2019-08-27 Pfizer Neisseria meningitidis compositions and methods thereof
CN109459523B (zh) 2017-09-06 2022-11-08 上海绿谷制药有限公司 一种测定酸性糖可溶性盐重均分子量和含量的方法
CN109459504B (zh) * 2017-09-06 2022-05-27 绿谷(上海)医药科技有限公司 一种测定聚古罗糖醛酸硫酸酯盐重均分子量和含量的方法
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Also Published As

Publication number Publication date
US8163296B2 (en) 2012-04-24
RU2422156C2 (ru) 2011-06-27
CN1976725A (zh) 2007-06-06
JP6218327B2 (ja) 2017-10-25
JP6661568B2 (ja) 2020-03-11
JP2011246490A (ja) 2011-12-08
JP2015180707A (ja) 2015-10-15
EP2374473A1 (en) 2011-10-12
RU2007102016A (ru) 2008-07-27
MXPA06015188A (es) 2007-03-27
AU2005256961B2 (en) 2011-06-23
JP2014111654A (ja) 2014-06-19
WO2006000920A3 (en) 2006-03-30
JP2017134084A (ja) 2017-08-03
EP1778291B1 (en) 2013-10-30
WO2006000920A2 (en) 2006-01-05
ES2688796T3 (es) 2018-11-07
US20120207781A1 (en) 2012-08-16
US20080248059A1 (en) 2008-10-09
MX344621B (es) 2017-01-03
GB0413868D0 (en) 2004-07-21
CA2571565C (en) 2014-08-12
JP2008503716A (ja) 2008-02-07
EP2374473B1 (en) 2018-07-18
EP1778291A2 (en) 2007-05-02
CA2571565A1 (en) 2006-01-05
ES2443465T3 (es) 2014-02-19
BRPI0512281A (pt) 2008-02-26
NZ552449A (en) 2010-05-28
AU2005256961A1 (en) 2006-01-05

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