CN1946692A - 作为丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的3,4－(环戊基)－稠合的脯氨酸化合物 - Google Patents

作为丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的3,4－(环戊基)－稠合的脯氨酸化合物 Download PDF

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Publication number
CN1946692A
CN1946692A CNA2005800128574A CN200580012857A CN1946692A CN 1946692 A CN1946692 A CN 1946692A CN A2005800128574 A CNA2005800128574 A CN A2005800128574A CN 200580012857 A CN200580012857 A CN 200580012857A CN 1946692 A CN1946692 A CN 1946692A
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China
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compound
alkyl
aryl
hcv
heterocyclic radical
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Pending
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CNA2005800128574A
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English (en)
Chinese (zh)
Inventor
F·G·恩裘洛吉
S·文卡特拉曼
A·阿拉萨潘
F·贝拉斯克斯
V·M·吉里加瓦拉布汉
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Merck Sharp and Dohme LLC
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
CNA2005800128574A 2004-02-27 2005-02-24 作为丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的3,4－(环戊基)－稠合的脯氨酸化合物 Pending CN1946692A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54865504P 2004-02-27 2004-02-27
US60/548,655 2004-02-27

Publications (1)

Publication Number Publication Date
CN1946692A true CN1946692A (zh) 2007-04-11

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CNA2005800128574A Pending CN1946692A (zh) 2004-02-27 2005-02-24 作为丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的3,4－(环戊基)－稠合的脯氨酸化合物

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US (1) US7342041B2 (https=)
EP (1) EP1737821B1 (https=)
JP (1) JP2007525512A (https=)
CN (1) CN1946692A (https=)
AR (1) AR048413A1 (https=)
AT (1) ATE438622T1 (https=)
CA (1) CA2557307A1 (https=)
DE (1) DE602005015834D1 (https=)
ES (1) ES2328589T3 (https=)
TW (1) TWI302835B (https=)
WO (1) WO2005087730A1 (https=)

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CN103387510A (zh) * 2013-08-08 2013-11-13 苏州永健生物医药有限公司 一种β-氨基-alpha-羟基环丁基丁酰胺盐酸盐的合成方法
CN103508918A (zh) * 2012-06-18 2014-01-15 上海医药工业研究院 带有环丁基的α-羟基β-氨基酯类化合物及其制备方法
CN103664739A (zh) * 2013-12-10 2014-03-26 湖南科源生物制品有限公司 一种特拉匹韦中间体的制备方法
CN103814001A (zh) * 2011-05-13 2014-05-21 弗特克斯药品有限公司 方法和中间体
CN102131813B (zh) * 2008-06-24 2014-07-30 科德克希思公司 用于制备基本上立体异构纯的稠合二环脯氨酸化合物的生物催化方法
CN104926712A (zh) * 2014-03-20 2015-09-23 上海医药工业研究院 合成特拉匹韦的中间体及其制备方法

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CN102131813B (zh) * 2008-06-24 2014-07-30 科德克希思公司 用于制备基本上立体异构纯的稠合二环脯氨酸化合物的生物催化方法
CN103814001A (zh) * 2011-05-13 2014-05-21 弗特克斯药品有限公司 方法和中间体
CN103508918A (zh) * 2012-06-18 2014-01-15 上海医药工业研究院 带有环丁基的α-羟基β-氨基酯类化合物及其制备方法
CN103508918B (zh) * 2012-06-18 2015-09-09 上海医药工业研究院 带有环丁基的α-羟基β-氨基酯类化合物及其制备方法
CN103387510A (zh) * 2013-08-08 2013-11-13 苏州永健生物医药有限公司 一种β-氨基-alpha-羟基环丁基丁酰胺盐酸盐的合成方法
CN103387510B (zh) * 2013-08-08 2015-09-09 苏州永健生物医药有限公司 一种β-氨基-alpha-羟基环丁基丁酰胺盐酸盐的合成方法
CN103664739A (zh) * 2013-12-10 2014-03-26 湖南科源生物制品有限公司 一种特拉匹韦中间体的制备方法
CN103664739B (zh) * 2013-12-10 2016-04-27 湖南科源生物制品有限公司 一种特拉匹韦中间体的制备方法
CN104926712A (zh) * 2014-03-20 2015-09-23 上海医药工业研究院 合成特拉匹韦的中间体及其制备方法
CN104926712B (zh) * 2014-03-20 2018-03-23 上海医药工业研究院 合成特拉匹韦的中间体及其制备方法

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EP1737821B1 (en) 2009-08-05
JP2007525512A (ja) 2007-09-06
TW200536530A (en) 2005-11-16
US7342041B2 (en) 2008-03-11
ATE438622T1 (de) 2009-08-15
AR048413A1 (es) 2006-04-26
DE602005015834D1 (de) 2009-09-17
EP1737821A1 (en) 2007-01-03
CA2557307A1 (en) 2005-09-22
WO2005087730A1 (en) 2005-09-22
HK1095820A1 (en) 2007-05-18
TWI302835B (en) 2008-11-11
ES2328589T3 (es) 2009-11-16
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