CN1802350A - 氮杂环丁烷羧酰胺衍生物以及它们在治疗cb1受体介导的病症中的应用 - Google Patents

氮杂环丁烷羧酰胺衍生物以及它们在治疗cb1受体介导的病症中的应用 Download PDF

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Publication number
CN1802350A
CN1802350A CNA2004800115989A CN200480011598A CN1802350A CN 1802350 A CN1802350 A CN 1802350A CN A2004800115989 A CNA2004800115989 A CN A2004800115989A CN 200480011598 A CN200480011598 A CN 200480011598A CN 1802350 A CN1802350 A CN 1802350A
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China
Prior art keywords
azetidine
trifluoromethyl
carboxylic acid
acid amides
butyl
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Pending
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CNA2004800115989A
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English (en)
Chinese (zh)
Inventor
J·E·P·戴维森
C·E·道森
K·哈里森
H·L·芒赛尔
R·M·普拉特
S·索哈尔
V·J·拉斯顿
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Ligand UK Research Ltd
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Vernalis Research Ltd
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Publication of CN1802350A publication Critical patent/CN1802350A/zh
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA2004800115989A 2003-05-01 2004-04-29 氮杂环丁烷羧酰胺衍生物以及它们在治疗cb1受体介导的病症中的应用 Pending CN1802350A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0310056 2003-05-01
GB0310056.7 2003-05-01

Publications (1)

Publication Number Publication Date
CN1802350A true CN1802350A (zh) 2006-07-12

Family

ID=33397041

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CNA2004800115989A Pending CN1802350A (zh) 2003-05-01 2004-04-29 氮杂环丁烷羧酰胺衍生物以及它们在治疗cb1受体介导的病症中的应用

Country Status (16)

Country Link
US (1) US7504522B2 (https=)
EP (1) EP1620395B1 (https=)
JP (1) JP2006525298A (https=)
KR (1) KR20060010770A (https=)
CN (1) CN1802350A (https=)
AT (1) ATE453620T1 (https=)
AU (1) AU2004234125A1 (https=)
BR (1) BRPI0409938A (https=)
CA (1) CA2524251A1 (https=)
DE (1) DE602004024880D1 (https=)
EA (1) EA010583B1 (https=)
MX (1) MXPA05011670A (https=)
NO (1) NO20055654L (https=)
NZ (1) NZ543016A (https=)
WO (1) WO2004096763A1 (https=)
ZA (1) ZA200508831B (https=)

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CN101945852B (zh) * 2007-12-18 2014-05-07 赛诺菲-安万特 氮杂环丁烷衍生物、其制备和其在治疗中的应用
CN105218474A (zh) * 2015-10-22 2016-01-06 山东国邦药业股份有限公司 (4r,5r)-2-二氯甲基-4,5-二氢-5-(4-甲砜基苯基)-4-恶唑甲醇的合成方法

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US20060025448A1 (en) 2004-07-22 2006-02-02 Cadila Healthcare Limited Hair growth stimulators
US7923465B2 (en) 2005-06-02 2011-04-12 Glenmark Pharmaceuticals S.A. Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
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US7906652B2 (en) 2005-11-28 2011-03-15 Merck Sharp & Dohme Corp. Heterocycle-substituted 3-alkyl azetidine derivatives
US20090264470A1 (en) * 2006-02-21 2009-10-22 Bennett Teresa A CB1 Antagonists and Inverse Agonists
EP2061767B1 (de) 2006-08-08 2014-12-17 Sanofi Arylaminoaryl-alkyl-substituierte Imidazolidin-2,4-dione, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und ihre Verwendung
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
FR2925051B1 (fr) * 2007-12-18 2010-05-21 Sanofi Aventis Derives d'azetidines,leur preparation et leur application en therapeutique
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UY31968A (es) 2008-07-09 2010-01-29 Sanofi Aventis Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
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US8329914B2 (en) 2008-10-31 2012-12-11 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
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JP2013520502A (ja) 2010-02-25 2013-06-06 メルク・シャープ・エンド・ドーム・コーポレイション 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体
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WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
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EP2683702B1 (de) 2011-03-08 2014-12-24 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683699B1 (de) 2011-03-08 2015-06-24 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
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US8895547B2 (en) 2011-03-08 2014-11-25 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
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KR20150118158A (ko) 2013-02-22 2015-10-21 머크 샤프 앤드 돔 코포레이션 항당뇨병 비시클릭 화합물
WO2014139388A1 (en) 2013-03-14 2014-09-18 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
US10077446B2 (en) 2013-06-25 2018-09-18 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Glucan-encapsulated siRNA for treating type 2 diabetes mellitus
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
CN109689045A (zh) 2016-05-04 2019-04-26 因美制药公司 大麻素的局部制剂在治疗大疱性表皮松解症和相关结缔组织病症中的用途
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
US12357604B2 (en) 2017-09-22 2025-07-15 Inmed Pharmaceuticals Inc. Topical formulations of cannabinoids and use thereof in the treatment of pain
WO2019134985A1 (en) 2018-01-08 2019-07-11 F. Hoffmann-La Roche Ag Octahydropyrido[1,2-alpha]pyrazines as magl inhibitors
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101945852B (zh) * 2007-12-18 2014-05-07 赛诺菲-安万特 氮杂环丁烷衍生物、其制备和其在治疗中的应用
CN105218474A (zh) * 2015-10-22 2016-01-06 山东国邦药业股份有限公司 (4r,5r)-2-二氯甲基-4,5-二氢-5-(4-甲砜基苯基)-4-恶唑甲醇的合成方法

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CA2524251A1 (en) 2004-11-11
NZ543016A (en) 2009-03-31
ATE453620T1 (de) 2010-01-15
AU2004234125A1 (en) 2004-11-11
US7504522B2 (en) 2009-03-17
DE602004024880D1 (de) 2010-02-11
JP2006525298A (ja) 2006-11-09
MXPA05011670A (es) 2005-12-15
EP1620395B1 (en) 2009-12-30
NO20055654L (no) 2006-01-31
EP1620395A1 (en) 2006-02-01
EA200501585A1 (ru) 2006-06-30
KR20060010770A (ko) 2006-02-02
BRPI0409938A (pt) 2006-04-25
EA010583B1 (ru) 2008-10-30
US20070054891A1 (en) 2007-03-08
NO20055654D0 (no) 2005-11-30
ZA200508831B (en) 2007-03-28
WO2004096763A1 (en) 2004-11-11

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