CN1726224A - 嵌合αQ－Gustducin G－蛋白 - Google Patents

嵌合αQ－Gustducin G－蛋白 Download PDF

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Publication number
CN1726224A
CN1726224A CNA2003801065075A CN200380106507A CN1726224A CN 1726224 A CN1726224 A CN 1726224A CN A2003801065075 A CNA2003801065075 A CN A2003801065075A CN 200380106507 A CN200380106507 A CN 200380106507A CN 1726224 A CN1726224 A CN 1726224A
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CN
China
Prior art keywords
protein
chimeric
cell
albumen
gustducin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CNA2003801065075A
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English (en)
Chinese (zh)
Inventor
J·P·斯莱克
T·S·麦克拉斯基
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Givaudan SA
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Givaudan SA
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Application filed by Givaudan SA filed Critical Givaudan SA
Publication of CN1726224A publication Critical patent/CN1726224A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4722—G-proteins

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2003801065075A 2002-12-18 2003-12-17 嵌合αQ－Gustducin G－蛋白 Pending CN1726224A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43479002P 2002-12-18 2002-12-18
US60/434,790 2002-12-18

Publications (1)

Publication Number Publication Date
CN1726224A true CN1726224A (zh) 2006-01-25

Family

ID=32595305

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2003801065075A Pending CN1726224A (zh) 2002-12-18 2003-12-17 嵌合αQ－Gustducin G－蛋白

Country Status (10)

Country Link
US (2) US7919236B2 (enExample)
EP (1) EP1581555B1 (enExample)
JP (2) JP4654038B2 (enExample)
CN (1) CN1726224A (enExample)
AT (1) ATE393778T1 (enExample)
AU (1) AU2003286069A1 (enExample)
CA (1) CA2507387A1 (enExample)
DE (1) DE60320682T2 (enExample)
ES (1) ES2305536T3 (enExample)
WO (1) WO2004055048A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105339384A (zh) * 2013-05-10 2016-02-17 百事可乐公司 作为鉴别潜在味觉调节剂的模型的细胞
CN108611324A (zh) * 2018-05-07 2018-10-02 云南中烟工业有限责任公司 一种稳定共表达重组人源甜味受体蛋白的真核细胞系及其制备方法
CN119193656A (zh) * 2024-09-24 2024-12-27 上海交通大学 一种响应鲜味信号的酵母细胞模型及其制备方法与应用

Families Citing this family (36)

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US7368285B2 (en) 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
DK2327985T3 (en) 2001-06-26 2016-09-05 Senomyx Inc H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds
CN1726224A (zh) * 2002-12-18 2006-01-25 吉万奥丹股份有限公司 嵌合αQ－Gustducin G－蛋白
WO2006046854A2 (en) 2004-10-29 2006-05-04 Quest International B.V. Flavour modulating substances
BRPI0518075B8 (pt) 2004-10-29 2017-05-16 Quest Int Services B V composição flavorizante, produto, e, processo de melhorar o flavor de um alimento, de uma bebida ou de um produto farmacêutico
ATE438310T1 (de) 2005-09-02 2009-08-15 Givaudan Nederland Services B Geschmackverstärker
JP2009533065A (ja) * 2006-04-20 2009-09-17 ジボダン エス エー 味覚物質同定のための機能的方法
EP2995950B1 (en) 2006-04-20 2024-01-17 Givaudan SA Method relating to sweetness enhancement
US20110097741A1 (en) * 2006-04-20 2011-04-28 Jay Patrick Slack Partial t1r2 nucleic acid sequence, receptor protein and its use in screening assays
DE602006009484D1 (de) 2006-05-05 2009-11-12 Givaudan Nederland Services B Zusammensetzung zur Verbesserung von Geschmack
US8039233B2 (en) 2007-01-18 2011-10-18 Givaudan S.A. Nucleic acid sequences and their use in methods to identify umami modulatiors
EP1975611A1 (en) 2007-03-29 2008-10-01 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Agonists of bitter taste receptors and uses thereof
US8187822B2 (en) 2007-03-30 2012-05-29 Givaudan S.A. Methods to identify modulators
US20100137449A1 (en) * 2007-12-10 2010-06-03 Metaproteomics, Llc Substituted 1,3-cyclopentadione multi-target protein kinase modulators of cancer, angiogenesis and the inflammatory pathways associated therewith
EP2108954A1 (en) 2008-04-10 2009-10-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. A test system for detecting intracellular cyclic nucleotide level and methods and uses thereof
WO2009149577A1 (en) * 2008-06-13 2009-12-17 Givaudan Sa Methods of identifying modulators of the bitter taste receptor tas2r44
JP5576653B2 (ja) * 2008-12-26 2014-08-20 サントリー食品インターナショナル株式会社 環状ジペプチド含有飲料
EP2391711B1 (en) * 2009-02-02 2015-04-08 Chromocell Corporation Novel cell lines and methods
SG184962A1 (en) 2010-05-07 2012-11-29 Givaudan Sa Methods to identify modulators of tas2r4s receptors
EP2567229A1 (en) 2010-05-07 2013-03-13 Givaudan SA Methods to identify modulators
JP5906013B2 (ja) * 2010-12-10 2016-04-20 花王株式会社 苦味抑制剤の評価・選択方法
WO2014011926A1 (en) 2012-07-11 2014-01-16 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
PT2661266T (pt) 2011-01-07 2020-11-30 Anji Pharma Us Llc Terapias com base em ligandos do recetor quimiossensorial
US9795792B2 (en) 2011-02-25 2017-10-24 Medtronic, Inc. Emergency mode switching for non-pacing modes
US9128079B2 (en) 2011-08-08 2015-09-08 The Coca-Cola Company Methods of using lung or bronchial epithelial cells to identify bitter taste modulators
WO2013072332A1 (en) 2011-11-14 2013-05-23 Givaudan Sa Methods of using antagonists of bitter taste receptors
CN104349773A (zh) 2012-01-06 2015-02-11 埃尔舍利克斯治疗公司 用于治疗代谢性病症的组合物和方法
CN110693868A (zh) 2012-01-06 2020-01-17 埃尔舍利克斯治疗公司 双胍组合物和治疗代谢性病症的方法
EP4410380A3 (en) 2013-01-05 2024-10-23 Anji Pharmaceuticals Inc. Delayed-release composition comprising biguanide
WO2014149829A1 (en) 2013-03-15 2014-09-25 Afb International Feline bitter taste receptors and methods
US9804157B1 (en) 2013-03-15 2017-10-31 Senomyx, Inc. Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives
CN105377885B (zh) 2013-05-10 2019-11-05 百事可乐公司 味觉受体内化试验
JP6755640B2 (ja) 2014-03-28 2020-09-16 味の素株式会社 甘味受容体キメラタンパク質及びその利用
WO2017066799A1 (en) * 2015-10-16 2017-04-20 Cornell University Sweeteners having enhanced organoleptic properties
JP6924590B2 (ja) * 2016-03-14 2021-08-25 サントリーホールディングス株式会社 苦味評価のための融合タンパク質および苦味評価方法
WO2025183058A1 (ja) * 2024-02-29 2025-09-04 味の素株式会社 植物由来タンパク質含有食品における異味・異風味をマスキングする物質のスクリーニング方法および異味・異風味のマスキング用の組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817759A (en) * 1992-04-09 1998-10-06 Linguagen Corporation Gustducin polypeptides and fragments
WO2001018050A2 (en) 1999-09-10 2001-03-15 The Regents Of The University Of California T2r taste receptor family
US6462178B1 (en) * 1999-11-17 2002-10-08 Yong Hou Wong G protein
US7041457B2 (en) * 2000-10-30 2006-05-09 Senomyx, Inc. Gαq protein variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors
WO2002036622A2 (en) 2000-10-30 2002-05-10 Senomyx, Inc. GαqPROETIN VARIANTS AND THEIR USE IN THE ANALYSIS AND DISCOVERY OF AGONISTS AND ANTAGONISTS OF CHEMOSENSORY RECEPTORS
CN1726224A (zh) * 2002-12-18 2006-01-25 吉万奥丹股份有限公司 嵌合αQ－Gustducin G－蛋白

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105339384A (zh) * 2013-05-10 2016-02-17 百事可乐公司 作为鉴别潜在味觉调节剂的模型的细胞
CN108611324A (zh) * 2018-05-07 2018-10-02 云南中烟工业有限责任公司 一种稳定共表达重组人源甜味受体蛋白的真核细胞系及其制备方法
CN119193656A (zh) * 2024-09-24 2024-12-27 上海交通大学 一种响应鲜味信号的酵母细胞模型及其制备方法与应用

Also Published As

Publication number Publication date
ES2305536T3 (es) 2008-11-01
EP1581555B1 (en) 2008-04-30
WO2004055048A2 (en) 2004-07-01
JP2010187666A (ja) 2010-09-02
US20060275765A1 (en) 2006-12-07
JP2006524483A (ja) 2006-11-02
US8609362B2 (en) 2013-12-17
ATE393778T1 (de) 2008-05-15
US7919236B2 (en) 2011-04-05
JP5425651B2 (ja) 2014-02-26
DE60320682D1 (de) 2008-06-12
WO2004055048A3 (en) 2004-09-16
US20110177545A1 (en) 2011-07-21
AU2003286069A1 (en) 2004-07-09
DE60320682T2 (de) 2009-06-10
AU2003286069A8 (en) 2004-07-09
CA2507387A1 (en) 2004-07-01
EP1581555A2 (en) 2005-10-05
JP4654038B2 (ja) 2011-03-16

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