CA2507387A1 - Chimeric alpha q-gustducin g-proteins - Google Patents

Chimeric alpha q-gustducin g-proteins Download PDF

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Publication number
CA2507387A1
CA2507387A1 CA002507387A CA2507387A CA2507387A1 CA 2507387 A1 CA2507387 A1 CA 2507387A1 CA 002507387 A CA002507387 A CA 002507387A CA 2507387 A CA2507387 A CA 2507387A CA 2507387 A1 CA2507387 A1 CA 2507387A1
Authority
CA
Canada
Prior art keywords
protein
chimeric
receptor
cells
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002507387A
Other languages
English (en)
French (fr)
Inventor
Jay Patrick Slack
Thomas Scott Mccluskey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Givaudan SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2507387A1 publication Critical patent/CA2507387A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4722—G-proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002507387A 2002-12-18 2003-12-17 Chimeric alpha q-gustducin g-proteins Abandoned CA2507387A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43479002P 2002-12-18 2002-12-18
US60/434,790 2002-12-18
PCT/CH2003/000830 WO2004055048A2 (en) 2002-12-18 2003-12-17 Chimeric alpha q-gustducin g-proteins

Publications (1)

Publication Number Publication Date
CA2507387A1 true CA2507387A1 (en) 2004-07-01

Family

ID=32595305

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002507387A Abandoned CA2507387A1 (en) 2002-12-18 2003-12-17 Chimeric alpha q-gustducin g-proteins

Country Status (10)

Country Link
US (2) US7919236B2 (enExample)
EP (1) EP1581555B1 (enExample)
JP (2) JP4654038B2 (enExample)
CN (1) CN1726224A (enExample)
AT (1) ATE393778T1 (enExample)
AU (1) AU2003286069A1 (enExample)
CA (1) CA2507387A1 (enExample)
DE (1) DE60320682T2 (enExample)
ES (1) ES2305536T3 (enExample)
WO (1) WO2004055048A2 (enExample)

Families Citing this family (39)

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US7368285B2 (en) 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
DK2327985T3 (en) 2001-06-26 2016-09-05 Senomyx Inc H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds
AU2003286069A1 (en) * 2002-12-18 2004-07-09 Givaudan Sa Chimeric alpha q-gustducin g-proteins
BRPI0518075B8 (pt) 2004-10-29 2017-05-16 Quest Int Services B V composição flavorizante, produto, e, processo de melhorar o flavor de um alimento, de uma bebida ou de um produto farmacêutico
WO2006046854A2 (en) 2004-10-29 2006-05-04 Quest International B.V. Flavour modulating substances
DE602005015849D1 (de) 2005-09-02 2009-09-17 Givaudan Nederland Services B Geschmackverstärker
US8124360B2 (en) 2006-04-20 2012-02-28 Givaudan S.A. Use of a T1R2 nucleic acid sequence to identify tastants
US20110097741A1 (en) * 2006-04-20 2011-04-28 Jay Patrick Slack Partial t1r2 nucleic acid sequence, receptor protein and its use in screening assays
EP2995950B1 (en) 2006-04-20 2024-01-17 Givaudan SA Method relating to sweetness enhancement
PL1854782T3 (pl) 2006-05-05 2010-02-26 Givaudan Nederland Services Bv Kompozycja ulepszająca smak
KR101511394B1 (ko) * 2007-01-18 2015-04-10 지보당 에스아 키메라 우마미 미각 수용체, 이를 코딩하는 핵산 및 이의 용도
EP1975611A1 (en) 2007-03-29 2008-10-01 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Agonists of bitter taste receptors and uses thereof
WO2008119195A1 (en) * 2007-03-30 2008-10-09 Givaudan Sa Methods to identify modulators
AU2008335156A1 (en) * 2007-12-10 2009-06-18 Metaproteomics, Llc Substituted 1,3-cyclopentadione multi-target protein kinase modulators of cancer, angiogenesis and the inflammatory pathways associated therewith
EP2108954A1 (en) 2008-04-10 2009-10-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. A test system for detecting intracellular cyclic nucleotide level and methods and uses thereof
US8546085B2 (en) * 2008-06-13 2013-10-01 Givaudan Sa Methods of identifying modulators of the bitter taste receptor TAS2R44
JP5576653B2 (ja) * 2008-12-26 2014-08-20 サントリー食品インターナショナル株式会社 環状ジペプチド含有飲料
WO2010088633A2 (en) * 2009-02-02 2010-08-05 Chromocell Corporation Novel cell lines and methods
US20130123135A1 (en) 2010-05-07 2013-05-16 Jay Patrick Slack Methods To Identify Modulators of TAS2R48 Receptors
US20130115624A1 (en) 2010-05-07 2013-05-09 Givaudan S.A. Methods To Identify Modulators
JP5906013B2 (ja) * 2010-12-10 2016-04-20 花王株式会社 苦味抑制剤の評価・選択方法
HRP20201731T1 (hr) 2011-01-07 2020-12-25 Anji Pharma (Us) Llc Terapije na bazi liganda kemozensoričkog receptora
US9795792B2 (en) 2011-02-25 2017-10-24 Medtronic, Inc. Emergency mode switching for non-pacing modes
US9128079B2 (en) 2011-08-08 2015-09-08 The Coca-Cola Company Methods of using lung or bronchial epithelial cells to identify bitter taste modulators
WO2013072332A1 (en) 2011-11-14 2013-05-23 Givaudan Sa Methods of using antagonists of bitter taste receptors
AU2013207329B2 (en) 2012-01-06 2017-10-26 Anji Pharmaceuticals Inc. Compositions and methods for treating metabolic disorders
KR20230095124A (ko) 2012-01-06 2023-06-28 앤지 파마 유에스 엘엘씨 바이구아나이드 조성물 및 대사 장애를 치료하는 방법
JP2015522080A (ja) 2012-07-11 2015-08-03 エルセリクス セラピューティクス インコーポレイテッド スタチン、ビグアナイド、およびさらなる薬剤を含む心血管代謝性リスクを減少させるための組成物
EP2941245B1 (en) 2013-01-05 2024-06-26 Anji Pharmaceuticals Inc. Delayed-release composition comprising biguanide
US9804157B1 (en) 2013-03-15 2017-10-31 Senomyx, Inc. Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives
ES2797547T3 (es) 2013-03-15 2020-12-02 Applied Food Biotech Inc Receptores del sabor amargo felino y métodos.
PL2994482T3 (pl) 2013-05-10 2020-06-01 Pepsico, Inc. Test internalizacji receptora smaku
HK1218301A1 (zh) * 2013-05-10 2017-02-10 百事可乐公司 作為鑒別潛在味覺調節劑的模型的細胞
JP6755640B2 (ja) 2014-03-28 2020-09-16 味の素株式会社 甘味受容体キメラタンパク質及びその利用
WO2017066799A1 (en) * 2015-10-16 2017-04-20 Cornell University Sweeteners having enhanced organoleptic properties
JP6924590B2 (ja) * 2016-03-14 2021-08-25 サントリーホールディングス株式会社 苦味評価のための融合タンパク質および苦味評価方法
CN108611324A (zh) * 2018-05-07 2018-10-02 云南中烟工业有限责任公司 一种稳定共表达重组人源甜味受体蛋白的真核细胞系及其制备方法
WO2025183058A1 (ja) * 2024-02-29 2025-09-04 味の素株式会社 植物由来タンパク質含有食品における異味・異風味をマスキングする物質のスクリーニング方法および異味・異風味のマスキング用の組成物
CN119193656A (zh) * 2024-09-24 2024-12-27 上海交通大学 一种响应鲜味信号的酵母细胞模型及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817759A (en) * 1992-04-09 1998-10-06 Linguagen Corporation Gustducin polypeptides and fragments
IL148593A0 (en) 1999-09-10 2002-09-12 Univ California T2r, a novel family of taste receptors
US6462178B1 (en) * 1999-11-17 2002-10-08 Yong Hou Wong G protein
US7041457B2 (en) * 2000-10-30 2006-05-09 Senomyx, Inc. Gαq protein variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors
WO2002036622A2 (en) 2000-10-30 2002-05-10 Senomyx, Inc. GαqPROETIN VARIANTS AND THEIR USE IN THE ANALYSIS AND DISCOVERY OF AGONISTS AND ANTAGONISTS OF CHEMOSENSORY RECEPTORS
AU2003286069A1 (en) * 2002-12-18 2004-07-09 Givaudan Sa Chimeric alpha q-gustducin g-proteins

Also Published As

Publication number Publication date
JP2010187666A (ja) 2010-09-02
DE60320682T2 (de) 2009-06-10
EP1581555A2 (en) 2005-10-05
JP5425651B2 (ja) 2014-02-26
JP2006524483A (ja) 2006-11-02
AU2003286069A1 (en) 2004-07-09
AU2003286069A8 (en) 2004-07-09
US8609362B2 (en) 2013-12-17
JP4654038B2 (ja) 2011-03-16
CN1726224A (zh) 2006-01-25
WO2004055048A2 (en) 2004-07-01
ES2305536T3 (es) 2008-11-01
US20060275765A1 (en) 2006-12-07
US7919236B2 (en) 2011-04-05
DE60320682D1 (de) 2008-06-12
WO2004055048A3 (en) 2004-09-16
US20110177545A1 (en) 2011-07-21
EP1581555B1 (en) 2008-04-30
ATE393778T1 (de) 2008-05-15

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US8124360B2 (en) Use of a T1R2 nucleic acid sequence to identify tastants
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KR101511394B1 (ko) 키메라 우마미 미각 수용체, 이를 코딩하는 핵산 및 이의 용도

Legal Events

Date Code Title Description
FZDE Discontinued