DE60320682T2 - Chimäre alpha q-gustducin g-proteine - Google Patents

Chimäre alpha q-gustducin g-proteine Download PDF

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Publication number
DE60320682T2
DE60320682T2 DE60320682T DE60320682T DE60320682T2 DE 60320682 T2 DE60320682 T2 DE 60320682T2 DE 60320682 T DE60320682 T DE 60320682T DE 60320682 T DE60320682 T DE 60320682T DE 60320682 T2 DE60320682 T2 DE 60320682T2
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DE
Germany
Prior art keywords
protein
chimeric
taste
cells
gustducin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60320682T
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German (de)
English (en)
Other versions
DE60320682D1 (de
Inventor
Jay Patrick Loveland SLACK
Thomas Scott Amelia MCCLUSKEY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Givaudan SA
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Givaudan SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Givaudan SA filed Critical Givaudan SA
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Publication of DE60320682D1 publication Critical patent/DE60320682D1/de
Publication of DE60320682T2 publication Critical patent/DE60320682T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4722G-proteins

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60320682T 2002-12-18 2003-12-17 Chimäre alpha q-gustducin g-proteine Expired - Lifetime DE60320682T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43479002P 2002-12-18 2002-12-18
US434790P 2002-12-18
PCT/CH2003/000830 WO2004055048A2 (en) 2002-12-18 2003-12-17 Chimeric alpha q-gustducin g-proteins

Publications (2)

Publication Number Publication Date
DE60320682D1 DE60320682D1 (de) 2008-06-12
DE60320682T2 true DE60320682T2 (de) 2009-06-10

Family

ID=32595305

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60320682T Expired - Lifetime DE60320682T2 (de) 2002-12-18 2003-12-17 Chimäre alpha q-gustducin g-proteine

Country Status (10)

Country Link
US (2) US7919236B2 (enExample)
EP (1) EP1581555B1 (enExample)
JP (2) JP4654038B2 (enExample)
CN (1) CN1726224A (enExample)
AT (1) ATE393778T1 (enExample)
AU (1) AU2003286069A1 (enExample)
CA (1) CA2507387A1 (enExample)
DE (1) DE60320682T2 (enExample)
ES (1) ES2305536T3 (enExample)
WO (1) WO2004055048A2 (enExample)

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US7368285B2 (en) 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
DK2327985T3 (en) 2001-06-26 2016-09-05 Senomyx Inc H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds
WO2004055048A2 (en) * 2002-12-18 2004-07-01 Givaudan Sa Chimeric alpha q-gustducin g-proteins
BRPI0518075B8 (pt) 2004-10-29 2017-05-16 Quest Int Services B V composição flavorizante, produto, e, processo de melhorar o flavor de um alimento, de uma bebida ou de um produto farmacêutico
ATE535508T1 (de) 2004-10-29 2011-12-15 Givaudan Nederland Services Bv Geschmacksmodulierende substanzen
EP1759595B1 (en) 2005-09-02 2009-08-05 Givaudan Nederland Services B.V. Flavour modulating substance
US8124360B2 (en) 2006-04-20 2012-02-28 Givaudan S.A. Use of a T1R2 nucleic acid sequence to identify tastants
US20110097741A1 (en) * 2006-04-20 2011-04-28 Jay Patrick Slack Partial t1r2 nucleic acid sequence, receptor protein and its use in screening assays
KR101356914B1 (ko) 2006-04-20 2014-01-28 지보당 에스아 단맛 강화 방법
PL1854782T3 (pl) 2006-05-05 2010-02-26 Givaudan Nederland Services Bv Kompozycja ulepszająca smak
KR101511394B1 (ko) * 2007-01-18 2015-04-10 지보당 에스아 키메라 우마미 미각 수용체, 이를 코딩하는 핵산 및 이의 용도
EP1975611A1 (en) 2007-03-29 2008-10-01 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Agonists of bitter taste receptors and uses thereof
US8187822B2 (en) 2007-03-30 2012-05-29 Givaudan S.A. Methods to identify modulators
WO2009076428A1 (en) * 2007-12-10 2009-06-18 Metaproteomics, Llc Substituted 1,3-cyclopentadione multi-target protein kinase modulators of cancer, angiogenesis and the inflammatory pathways associated therewith
EP2108954A1 (en) 2008-04-10 2009-10-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. A test system for detecting intracellular cyclic nucleotide level and methods and uses thereof
WO2009149577A1 (en) * 2008-06-13 2009-12-17 Givaudan Sa Methods of identifying modulators of the bitter taste receptor tas2r44
JP5576653B2 (ja) * 2008-12-26 2014-08-20 サントリー食品インターナショナル株式会社 環状ジペプチド含有飲料
EP2924112A1 (en) * 2009-02-02 2015-09-30 Chromocell Corporation Novel cell lines and methods
EP2567229A1 (en) 2010-05-07 2013-03-13 Givaudan SA Methods to identify modulators
US20130123135A1 (en) 2010-05-07 2013-05-16 Jay Patrick Slack Methods To Identify Modulators of TAS2R48 Receptors
JP5906013B2 (ja) * 2010-12-10 2016-04-20 花王株式会社 苦味抑制剤の評価・選択方法
WO2013103384A1 (en) 2012-01-06 2013-07-11 Elcelyx Therapeutics, Inc. Biguanide compositions and methods of treating metabolic disorders
WO2012094636A2 (en) 2011-01-07 2012-07-12 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
US9795792B2 (en) 2011-02-25 2017-10-24 Medtronic, Inc. Emergency mode switching for non-pacing modes
WO2013022948A1 (en) 2011-08-08 2013-02-14 The Coca-Cola Company Cell lines comprising endogenous taste receptors and their uses
WO2013072332A1 (en) 2011-11-14 2013-05-23 Givaudan Sa Methods of using antagonists of bitter taste receptors
SG10201901922VA (en) 2012-01-06 2019-04-29 Elcelyx Therapeutics Inc Compositions and methods for treating metabolic disorders
AU2013290100A1 (en) 2012-07-11 2015-01-29 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
CN110051638B (zh) 2013-01-05 2022-02-01 安济药业(美国)有限责任公司 包含双胍的延迟释放组合物
CA2903208C (en) 2013-03-15 2021-05-18 Applied Food Biotechnology, Inc. Feline bitter taste receptors and methods
US9804157B1 (en) 2013-03-15 2017-10-31 Senomyx, Inc. Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives
US9766236B2 (en) 2013-05-10 2017-09-19 Pepsico, Inc. Taste receptor internalization assay
US10107794B2 (en) 2013-05-10 2018-10-23 Pepsico, Inc. Methods of using U2-OS cells to identify potential sweet taste modulators
JP6755640B2 (ja) 2014-03-28 2020-09-16 味の素株式会社 甘味受容体キメラタンパク質及びその利用
WO2017066799A1 (en) * 2015-10-16 2017-04-20 Cornell University Sweeteners having enhanced organoleptic properties
JP6924590B2 (ja) * 2016-03-14 2021-08-25 サントリーホールディングス株式会社 苦味評価のための融合タンパク質および苦味評価方法
CN108611324A (zh) * 2018-05-07 2018-10-02 云南中烟工业有限责任公司 一种稳定共表达重组人源甜味受体蛋白的真核细胞系及其制备方法
WO2025183058A1 (ja) * 2024-02-29 2025-09-04 味の素株式会社 植物由来タンパク質含有食品における異味・異風味をマスキングする物質のスクリーニング方法および異味・異風味のマスキング用の組成物
CN119193656A (zh) * 2024-09-24 2024-12-27 上海交通大学 一种响应鲜味信号的酵母细胞模型及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817759A (en) * 1992-04-09 1998-10-06 Linguagen Corporation Gustducin polypeptides and fragments
CN1289525C (zh) 1999-09-10 2006-12-13 加利福尼亚大学董事会 T2r,一类味觉受体
US6462178B1 (en) * 1999-11-17 2002-10-08 Yong Hou Wong G protein
US7041457B2 (en) * 2000-10-30 2006-05-09 Senomyx, Inc. Gαq protein variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors
AU2002213409A1 (en) 2000-10-30 2002-05-15 Senomyx, Inc. Galphaqproetin variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors
WO2004055048A2 (en) * 2002-12-18 2004-07-01 Givaudan Sa Chimeric alpha q-gustducin g-proteins

Also Published As

Publication number Publication date
ES2305536T3 (es) 2008-11-01
AU2003286069A1 (en) 2004-07-09
WO2004055048A2 (en) 2004-07-01
AU2003286069A8 (en) 2004-07-09
CN1726224A (zh) 2006-01-25
WO2004055048A3 (en) 2004-09-16
US8609362B2 (en) 2013-12-17
JP2010187666A (ja) 2010-09-02
DE60320682D1 (de) 2008-06-12
CA2507387A1 (en) 2004-07-01
JP4654038B2 (ja) 2011-03-16
EP1581555A2 (en) 2005-10-05
ATE393778T1 (de) 2008-05-15
US7919236B2 (en) 2011-04-05
US20060275765A1 (en) 2006-12-07
EP1581555B1 (en) 2008-04-30
JP5425651B2 (ja) 2014-02-26
US20110177545A1 (en) 2011-07-21
JP2006524483A (ja) 2006-11-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN