AU2002213409A1 - Galphaqproetin variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors - Google Patents

Galphaqproetin variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors

Info

Publication number
AU2002213409A1
AU2002213409A1 AU2002213409A AU1340902A AU2002213409A1 AU 2002213409 A1 AU2002213409 A1 AU 2002213409A1 AU 2002213409 A AU2002213409 A AU 2002213409A AU 1340902 A AU1340902 A AU 1340902A AU 2002213409 A1 AU2002213409 A1 AU 2002213409A1
Authority
AU
Australia
Prior art keywords
galphaqproetin
agonists
antagonists
discovery
variants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002213409A
Inventor
Hong Xu
Yong Yao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Firmenich Inc
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of AU2002213409A1 publication Critical patent/AU2002213409A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4722—G-proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2002213409A 2000-10-30 2001-10-24 Galphaqproetin variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors Abandoned AU2002213409A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24377000P 2000-10-30 2000-10-30
US60/243,770 2000-10-30
PCT/US2001/032619 WO2002036622A2 (en) 2000-10-30 2001-10-24 GαqPROETIN VARIANTS AND THEIR USE IN THE ANALYSIS AND DISCOVERY OF AGONISTS AND ANTAGONISTS OF CHEMOSENSORY RECEPTORS

Publications (1)

Publication Number Publication Date
AU2002213409A1 true AU2002213409A1 (en) 2002-05-15

Family

ID=22920062

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002213409A Abandoned AU2002213409A1 (en) 2000-10-30 2001-10-24 Galphaqproetin variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors

Country Status (4)

Country Link
US (3) US6818747B2 (en)
AU (1) AU2002213409A1 (en)
TW (1) TW200626612A (en)
WO (1) WO2002036622A2 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7364867B2 (en) 2000-04-17 2008-04-29 The Mount Sinai School Of Medicine Method of identifying bitter compounds by employing TRP8, a transient receptor potential channel expressed in taste receptor cells
WO2002036622A2 (en) * 2000-10-30 2002-05-10 Senomyx, Inc. GαqPROETIN VARIANTS AND THEIR USE IN THE ANALYSIS AND DISCOVERY OF AGONISTS AND ANTAGONISTS OF CHEMOSENSORY RECEPTORS
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US7208279B2 (en) * 2001-03-14 2007-04-24 Caden Biosciences, Inc. Method for identifying inhibitors of G protein coupled receptor signaling
US7803982B2 (en) 2001-04-20 2010-09-28 The Mount Sinai School Of Medicine Of New York University T1R3 transgenic animals, cells and related methods
US20040219632A1 (en) * 2001-04-20 2004-11-04 Robert Margolskee T1r3 a novel taste receptor
AU2002326315B2 (en) 2001-06-26 2007-07-05 Senomyx, Inc. T1R hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
US7314725B2 (en) 2001-07-20 2008-01-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Phenylthiocarbamide (PTC) taste receptor
ATE393778T1 (en) * 2002-12-18 2008-05-15 Givaudan Sa CHIMERA ALPHA Q-GUSTDUCIN G PROTEINS
WO2004076690A2 (en) * 2003-02-19 2004-09-10 Universit�T Duisburg-Essen Use of a mutation in the human gnas gene for predicting risks of disease, courses of diseases, and for predicting the response to treatments of disease
EP1644528A2 (en) 2003-06-19 2006-04-12 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services, Variants of human taste receptor genes
MXPA06001510A (en) 2003-08-06 2006-09-04 Senomyx Inc T1r hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds.
DE102004026330A1 (en) * 2004-05-26 2005-12-15 Universität Duisburg-Essen Use of gene modification in the human GNAQ gene to predict disease risks, disease trajectories and predict disease response
US20060045953A1 (en) * 2004-08-06 2006-03-02 Catherine Tachdjian Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers
GB0421693D0 (en) 2004-09-30 2004-11-03 Amersham Biosciences Uk Ltd Method for measuring binding of a test compound to a G-protein coupled receptor
WO2006068745A1 (en) 2004-12-22 2006-06-29 Cargill, Incorporated Methods for determining cellular response to stimuli
JP4734346B2 (en) 2005-02-04 2011-07-27 セノミックス インコーポレイテッド Compounds containing linked heteroaryl moieties, and novel umami flavor modifiers, tastants and taste enhancers for edible compositions
JP2008530017A (en) * 2005-02-04 2008-08-07 セノミックス インコーポレイテッド Molecules containing organic moieties linked as flavor modifiers for food compositions
TW200715993A (en) 2005-06-15 2007-05-01 Senomyx Inc Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers
WO2007065101A1 (en) * 2005-11-30 2007-06-07 Axitare, Inc. Compositions and methods of modulating the taste and smell receptors and screening methods therefore
DK3235811T3 (en) 2006-04-21 2018-11-12 Senomyx Inc PROCEDURE FOR THE PREPARATION OF OXALAMIDS
KR100852284B1 (en) 2006-07-07 2008-08-14 한국과학기술연구원 Cell-based high-throughput screening method of 5-HT6 receptors using fluorescence calcium imaging
US8697839B2 (en) 2008-08-11 2014-04-15 Xiaohui Li GQ protein competitive inhibitory polypeptides, preparation methods and uses thereof
US9128079B2 (en) 2011-08-08 2015-09-08 The Coca-Cola Company Methods of using lung or bronchial epithelial cells to identify bitter taste modulators
WO2014210585A2 (en) 2013-06-29 2014-12-31 Firmenich Sa Methods of identifying, isolating and using odorant and aroma receptors
JP6755640B2 (en) 2014-03-28 2020-09-16 味の素株式会社 Sweet receptor chimeric protein and its utilization
GB201601690D0 (en) * 2016-01-29 2016-03-16 Heptares Therapeutics Ltd G proteins

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004808A (en) * 1996-06-21 1999-12-21 Aurora Biosciences Corporation Promiscuous G-protein compositions and their use
WO1999005177A1 (en) * 1997-07-28 1999-02-04 The Regents Of The University Of California Methods and compositions for identifying modulators of g-protein-coupled receptors
DE10033353A1 (en) * 2000-07-08 2002-01-24 Aventis Pharma Gmbh Identifying compounds that modify activity of signal transduction pathways, useful potentially as therapeutic agents, by screening with cells that contain hybrid G proteins
WO2002036622A2 (en) * 2000-10-30 2002-05-10 Senomyx, Inc. GαqPROETIN VARIANTS AND THEIR USE IN THE ANALYSIS AND DISCOVERY OF AGONISTS AND ANTAGONISTS OF CHEMOSENSORY RECEPTORS

Also Published As

Publication number Publication date
US20050136512A1 (en) 2005-06-23
TW200626612A (en) 2006-08-01
US20020128433A1 (en) 2002-09-12
US6818747B2 (en) 2004-11-16
US20060084117A1 (en) 2006-04-20
WO2002036622A2 (en) 2002-05-10
WO2002036622A3 (en) 2003-09-25
US7291485B2 (en) 2007-11-06

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