CN1649848A - 作为促肾上腺皮质激素释放因子(crf)拮抗剂的稠合嘧啶衍生物 - Google Patents

作为促肾上腺皮质激素释放因子(crf)拮抗剂的稠合嘧啶衍生物 Download PDF

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Publication number
CN1649848A
CN1649848A CNA028107462A CN02810746A CN1649848A CN 1649848 A CN1649848 A CN 1649848A CN A028107462 A CNA028107462 A CN A028107462A CN 02810746 A CN02810746 A CN 02810746A CN 1649848 A CN1649848 A CN 1649848A
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China
Prior art keywords
methyl
pyrimidine
dihydro
pyrrolo
compound
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Pending
Application number
CNA028107462A
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Chinese (zh)
Inventor
罗马诺·迪法比奥
安娜·M·卡佩利
恰拉·马奇奥尼
法布里齐奥·米歇利
亚历山德拉·帕斯奎里洛
贝尼德塔·佩里尼
伊维斯·圣丹尼斯
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Glaxo Group Ltd
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Glaxo Group Ltd
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Priority claimed from GB0110569A external-priority patent/GB0110569D0/en
Priority claimed from GB0110567A external-priority patent/GB0110567D0/en
Priority claimed from GB0110570A external-priority patent/GB0110570D0/en
Priority claimed from GB0117399A external-priority patent/GB0117399D0/en
Priority claimed from GB0117401A external-priority patent/GB0117401D0/en
Priority claimed from GB0117420A external-priority patent/GB0117420D0/en
Priority claimed from GB0203201A external-priority patent/GB0203201D0/en
Priority claimed from GB0206834A external-priority patent/GB0206834D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CN1649848A publication Critical patent/CN1649848A/zh
Pending legal-status Critical Current

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    • C07D471/04Ortho-condensed systems
CNA028107462A 2001-04-30 2002-04-30 作为促肾上腺皮质激素释放因子(crf)拮抗剂的稠合嘧啶衍生物 Pending CN1649848A (zh)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
GB0110567.5 2001-04-30
GB0110569A GB0110569D0 (en) 2001-04-30 2001-04-30 Chemical compounds
GB0110569.1 2001-04-30
GB0110570.9 2001-04-30
GB0110567A GB0110567D0 (en) 2001-04-30 2001-04-30 Chemical compounds
GB0110570A GB0110570D0 (en) 2001-04-30 2001-04-30 Chemical compounds
GB0117399.6 2001-07-17
GB0117401.0 2001-07-17
GB0117399A GB0117399D0 (en) 2001-07-17 2001-07-17 Chemical compounds
GB0117401A GB0117401D0 (en) 2001-07-17 2001-07-17 Chemical compounds
GB0117420A GB0117420D0 (en) 2001-07-17 2001-07-17 Chemical compounds
GB0117420.0 2001-07-17
GB0203201.9 2002-02-11
GB0203201A GB0203201D0 (en) 2002-02-11 2002-02-11 Chemical compounds
GB0206834.4 2002-03-22
GB0206834A GB0206834D0 (en) 2002-03-22 2002-03-22 Chemical compounds

Publications (1)

Publication Number Publication Date
CN1649848A true CN1649848A (zh) 2005-08-03

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CNA028107462A Pending CN1649848A (zh) 2001-04-30 2002-04-30 作为促肾上腺皮质激素释放因子(crf)拮抗剂的稠合嘧啶衍生物

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104193745A (zh) * 2014-07-30 2014-12-10 天津市斯芬克司药物研发有限公司 一种咪唑并嘧啶羧酸类化合物及其制备方法

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004533465A (ja) * 2001-06-12 2004-11-04 グラクソ グループ リミテッド コルチコトロピン放出因子アンタゴニスト
GB0117396D0 (en) * 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
EP1583531B1 (en) * 2003-01-16 2007-04-18 SB Pharmco Puerto Rico Inc Heteroaryl-substituted pyrrolo[2, 3- b]pyridine derivatives as crf receptor antagonists
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
GB0308208D0 (en) * 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
AU2004235907B2 (en) * 2003-05-05 2007-08-30 F. Hoffmann La-Roche Ag Fused pyrimidine derivatives with CRF activity
WO2005013997A1 (en) 2003-08-12 2005-02-17 F. Hoffmann-La Roche Ag Spiro-substituted tetrahydroquinazolines as corticotropin releasing factor (cfr) antagonists
DE602004009200T2 (de) * 2003-08-12 2008-07-10 F. Hoffmann-La Roche Ag Tetrahydrochinazolinderivate als cfr-antagonisten
RU2394035C2 (ru) * 2003-12-22 2010-07-10 Эс Би ФАРМКО ПУЭРТО РИКО ИНК. Антагонисты crf-рецепторов и способы, относящиеся к ним
RU2006128580A (ru) * 2004-01-06 2008-02-20 Тайсо Фармасьютикал Ко., Лтд. (Jp) Производные тиенопиримидина и тиенопиридина, замещенные циклической аминогруппой
CA2556946A1 (en) * 2004-03-05 2005-09-15 Taisho Pharmaceutical Co., Ltd. Pyrrolopyrimidine derivatives
GEP20105024B (en) 2004-06-02 2010-06-25 Takeda Pharmaceuticals Co Fused heterocyclic compound
JP2008503443A (ja) * 2004-06-25 2008-02-07 大正製薬株式会社 テトラヒドロピリジンで置換されたピロロピリミジン及びピロロピリジンの誘導体
DE602005014375D1 (de) * 2004-10-19 2009-06-18 Neurocrine Biosciences Inc Crf-rezeptor-antagonisten und zugehörige verfahren
GB0519957D0 (en) * 2005-09-30 2005-11-09 Sb Pharmco Inc Chemical compound
US8088779B2 (en) * 2005-09-30 2012-01-03 Smithkline Beecham (Cork) Limited Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as corticotropin-releasing factor (CRF) receptor antagonists
JP5231410B2 (ja) 2006-07-06 2013-07-10 アレイ バイオファーマ、インコーポレイテッド Aktプロテインキナーゼ阻害剤としてのジヒドロフロピリミジン
BRPI0713555A2 (pt) 2006-07-06 2012-03-20 Array Biopharma, Inc. ciclopenta [d] pirimidinas como inibidores de akt protéina cinase
US9303040B2 (en) 2006-07-06 2016-04-05 Array Biopharma Inc. Substituted piperazines as AKT inhibitors
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
WO2008008895A1 (en) * 2006-07-13 2008-01-17 Smithkline Beecham Corporation Gpr119 agonists for the treatment of diabetes and related disorders
DE102007004303A1 (de) 2006-08-04 2008-02-07 Osram Opto Semiconductors Gmbh Dünnfilm-Halbleiterbauelement und Bauelement-Verbund
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN101772513B (zh) 2007-06-04 2013-11-13 协同医药品公司 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
JP5542282B2 (ja) * 2007-07-05 2014-07-09 アレイ バイオファーマ、インコーポレイテッド Aktプロテインキナーゼ阻害剤としてのピリミジルシクロペンタン
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8618097B2 (en) 2007-07-05 2013-12-31 Array Biopharma, Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
ES2401685T3 (es) * 2008-01-09 2013-04-23 Array Biopharma, Inc. Pirimidil ciclopentano hidroxilado como inhibidor de la proteína quinasa AKT
US8835434B2 (en) * 2008-01-09 2014-09-16 Array Biopharma, Inc. Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
WO2009107767A1 (ja) * 2008-02-29 2009-09-03 大日本住友製薬株式会社 H4受容体アンタゴニスト作用を有する新規2環性ピリミジン誘導体
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
EP2694073B1 (en) 2011-04-01 2018-08-08 Genentech, Inc. Combinations of akt and mek inhibitors for treating cancer
TR201802093T4 (tr) 2011-04-01 2018-03-21 Genentech Inc Terapötik terapilerde kullanım için akt inhibitör bileşiği ve abirateron kombinasyonu.
DK3392252T3 (da) 2011-08-23 2024-01-08 Libertas Bio Inc Pyrimido-pyridazinonforbindelser og deres anvendelse
LT3495367T (lt) 2012-06-13 2021-02-25 Incyte Holdings Corporation Pakeistieji tricikliniai junginiai, kaip fgfr inhibitoriai
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
WO2014145576A2 (en) 2013-03-15 2014-09-18 Northwestern University Substituted pyrrolo(2,3-d)pyrimidines for the treatment of cancer
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
MY181497A (en) 2013-04-19 2020-12-23 Incyte Holdings Corp Bicyclic heterocycles as fgfr inhibitors
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
WO2016134320A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
ES2917634T3 (es) 2018-04-09 2022-07-11 Raqualia Pharma Inc Derivados de urea cíclica fusionados como antagonista de CRHR2
EP3788046A1 (en) 2018-05-04 2021-03-10 Incyte Corporation Salts of an fgfr inhibitor
MA52494A (fr) 2018-05-04 2021-03-10 Incyte Corp Formes solides d'un inhibiteur de fgfr et leurs procédés de préparation
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
EP4045151A1 (en) 2019-10-14 2022-08-24 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CA3162010A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Derivatives of an fgfr inhibitor
WO2021113479A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
EP4161523A1 (en) * 2020-06-03 2023-04-12 Yumanity Therapeutics, Inc. Bicyclic heteroarenes and methods of their use
TW202313611A (zh) 2021-06-09 2023-04-01 美商英塞特公司 作為fgfr抑制劑之三環雜環

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9022644D0 (en) 1990-10-18 1990-11-28 Ici Plc Heterocyclic compounds
TW530047B (en) * 1994-06-08 2003-05-01 Pfizer Corticotropin releasing factor antagonists
US6403599B1 (en) 1995-11-08 2002-06-11 Pfizer Inc Corticotropin releasing factor antagonists
TW477787B (en) * 1996-08-27 2002-03-01 Pfizer Pyrido six-membered nitrogen-containing cyclic ring derivatives having corticotropin releasing factor antagonist activity and pharmaceutical composition containing same
JP2000038350A (ja) 1998-05-18 2000-02-08 Yoshitomi Pharmaceut Ind Ltd 糖尿病治療薬
EP1040831A3 (en) 1999-04-02 2003-05-02 Pfizer Products Inc. Use of corticotropin releasing factor (CRF) antagonists to prevent sudden death
US6387894B1 (en) 1999-06-11 2002-05-14 Pfizer Inc. Use of CRF antagonists and renin-angiotensin system inhibitors
US6432989B1 (en) * 1999-08-27 2002-08-13 Pfizer Inc Use of CRF antagonists to treat circadian rhythm disorders
CN1390219A (zh) 1999-09-17 2003-01-08 艾博特股份有限两合公司 作为治疗剂的吡唑并嘧啶类
DE60026155T2 (de) 1999-09-30 2006-08-10 Neurogen Corp., Branford Einige alkylendiamin-substituierte heterocyclen
IL139197A0 (en) * 1999-10-29 2001-11-25 Pfizer Prod Inc Use of corticotropin releasing factor antagonists and related compositions
EP1149583A3 (en) * 2000-04-13 2001-11-14 Pfizer Products Inc. Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104193745A (zh) * 2014-07-30 2014-12-10 天津市斯芬克司药物研发有限公司 一种咪唑并嘧啶羧酸类化合物及其制备方法
CN104193745B (zh) * 2014-07-30 2016-09-28 斯芬克司药物研发(天津)股份有限公司 一种咪唑并嘧啶羧酸类化合物及其制备方法

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