CN1649848A - 作为促肾上腺皮质激素释放因子(crf)拮抗剂的稠合嘧啶衍生物 - Google Patents
作为促肾上腺皮质激素释放因子(crf)拮抗剂的稠合嘧啶衍生物 Download PDFInfo
- Publication number
- CN1649848A CN1649848A CNA028107462A CN02810746A CN1649848A CN 1649848 A CN1649848 A CN 1649848A CN A028107462 A CNA028107462 A CN A028107462A CN 02810746 A CN02810746 A CN 02810746A CN 1649848 A CN1649848 A CN 1649848A
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- China
- Prior art keywords
- methyl
- pyrimidine
- dihydro
- pyrrolo
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
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- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0463—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0465—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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- C07D239/72—Quinazolines; Hydrogenated quinazolines
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Applications Claiming Priority (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0110567.5 | 2001-04-30 | ||
GB0110569A GB0110569D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
GB0110569.1 | 2001-04-30 | ||
GB0110570.9 | 2001-04-30 | ||
GB0110567A GB0110567D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
GB0110570A GB0110570D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
GB0117399.6 | 2001-07-17 | ||
GB0117401.0 | 2001-07-17 | ||
GB0117399A GB0117399D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
GB0117401A GB0117401D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
GB0117420A GB0117420D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
GB0117420.0 | 2001-07-17 | ||
GB0203201.9 | 2002-02-11 | ||
GB0203201A GB0203201D0 (en) | 2002-02-11 | 2002-02-11 | Chemical compounds |
GB0206834.4 | 2002-03-22 | ||
GB0206834A GB0206834D0 (en) | 2002-03-22 | 2002-03-22 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1649848A true CN1649848A (zh) | 2005-08-03 |
Family
ID=27571152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA028107462A Pending CN1649848A (zh) | 2001-04-30 | 2002-04-30 | 作为促肾上腺皮质激素释放因子(crf)拮抗剂的稠合嘧啶衍生物 |
Country Status (19)
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104193745A (zh) * | 2014-07-30 | 2014-12-10 | 天津市斯芬克司药物研发有限公司 | 一种咪唑并嘧啶羧酸类化合物及其制备方法 |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004533465A (ja) * | 2001-06-12 | 2004-11-04 | グラクソ グループ リミテッド | コルチコトロピン放出因子アンタゴニスト |
GB0117396D0 (en) * | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
EP1583531B1 (en) * | 2003-01-16 | 2007-04-18 | SB Pharmco Puerto Rico Inc | Heteroaryl-substituted pyrrolo[2, 3- b]pyridine derivatives as crf receptor antagonists |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
GB0308208D0 (en) * | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
AU2004235907B2 (en) * | 2003-05-05 | 2007-08-30 | F. Hoffmann La-Roche Ag | Fused pyrimidine derivatives with CRF activity |
WO2005013997A1 (en) | 2003-08-12 | 2005-02-17 | F. Hoffmann-La Roche Ag | Spiro-substituted tetrahydroquinazolines as corticotropin releasing factor (cfr) antagonists |
DE602004009200T2 (de) * | 2003-08-12 | 2008-07-10 | F. Hoffmann-La Roche Ag | Tetrahydrochinazolinderivate als cfr-antagonisten |
RU2394035C2 (ru) * | 2003-12-22 | 2010-07-10 | Эс Би ФАРМКО ПУЭРТО РИКО ИНК. | Антагонисты crf-рецепторов и способы, относящиеся к ним |
RU2006128580A (ru) * | 2004-01-06 | 2008-02-20 | Тайсо Фармасьютикал Ко., Лтд. (Jp) | Производные тиенопиримидина и тиенопиридина, замещенные циклической аминогруппой |
CA2556946A1 (en) * | 2004-03-05 | 2005-09-15 | Taisho Pharmaceutical Co., Ltd. | Pyrrolopyrimidine derivatives |
GEP20105024B (en) | 2004-06-02 | 2010-06-25 | Takeda Pharmaceuticals Co | Fused heterocyclic compound |
JP2008503443A (ja) * | 2004-06-25 | 2008-02-07 | 大正製薬株式会社 | テトラヒドロピリジンで置換されたピロロピリミジン及びピロロピリジンの誘導体 |
DE602005014375D1 (de) * | 2004-10-19 | 2009-06-18 | Neurocrine Biosciences Inc | Crf-rezeptor-antagonisten und zugehörige verfahren |
GB0519957D0 (en) * | 2005-09-30 | 2005-11-09 | Sb Pharmco Inc | Chemical compound |
US8088779B2 (en) * | 2005-09-30 | 2012-01-03 | Smithkline Beecham (Cork) Limited | Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as corticotropin-releasing factor (CRF) receptor antagonists |
JP5231410B2 (ja) | 2006-07-06 | 2013-07-10 | アレイ バイオファーマ、インコーポレイテッド | Aktプロテインキナーゼ阻害剤としてのジヒドロフロピリミジン |
BRPI0713555A2 (pt) | 2006-07-06 | 2012-03-20 | Array Biopharma, Inc. | ciclopenta [d] pirimidinas como inibidores de akt protéina cinase |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104193745A (zh) * | 2014-07-30 | 2014-12-10 | 天津市斯芬克司药物研发有限公司 | 一种咪唑并嘧啶羧酸类化合物及其制备方法 |
CN104193745B (zh) * | 2014-07-30 | 2016-09-28 | 斯芬克司药物研发(天津)股份有限公司 | 一种咪唑并嘧啶羧酸类化合物及其制备方法 |
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KR20040015206A (ko) | 2004-02-18 |
CA2446514A1 (en) | 2002-11-07 |
NO20034836L (no) | 2003-10-29 |
NO20034836D0 (no) | 2003-10-29 |
CZ20032946A3 (en) | 2004-05-12 |
BR0209267A (pt) | 2004-06-15 |
AU2002253357B2 (en) | 2006-08-24 |
US20040176400A1 (en) | 2004-09-09 |
ATE386727T1 (de) | 2008-03-15 |
ES2301633T3 (es) | 2008-07-01 |
AR033295A1 (es) | 2003-12-10 |
JP2004528349A (ja) | 2004-09-16 |
MXPA03009938A (es) | 2005-09-07 |
WO2002088095A1 (en) | 2002-11-07 |
PL366934A1 (en) | 2005-02-07 |
DE60225127T2 (de) | 2009-02-19 |
US7279474B2 (en) | 2007-10-09 |
EP1383747A1 (en) | 2004-01-28 |
DE60225127D1 (en) | 2008-04-03 |
IL158062A0 (en) | 2004-03-28 |
EP1383747B1 (en) | 2008-02-20 |
HUP0304054A2 (hu) | 2004-04-28 |
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