CN1646154A - 与白蛋白融合的抗-血管生成肽 - Google Patents
与白蛋白融合的抗-血管生成肽 Download PDFInfo
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- CN1646154A CN1646154A CNA038076411A CN03807641A CN1646154A CN 1646154 A CN1646154 A CN 1646154A CN A038076411 A CNA038076411 A CN A038076411A CN 03807641 A CN03807641 A CN 03807641A CN 1646154 A CN1646154 A CN 1646154A
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Abstract
Description
治疗性蛋白质X | PCT/专利参考文献 | 生物活性 | 相关出版物 | 优选适应症Y |
内皮他丁 | US5854205,WO9715666 | 它们是抑制肿瘤生长的抗血管生成肽 | Sim等,(2000)Cancer and Metastasis Reviews19:181-190,Dhanabal(1999)Cancer Research59:189-197 | 实体瘤和癌症 |
制管张素 | US5885795,US5792845 | 它们是抑制肿瘤生长的抗血管生成肽 | Sim等,(2000)Cancer and Metastasis Reviews19:181-190 | 实体瘤和癌症 |
Kringle 5 | US5854221 | 它们是抑制肿瘤生长的抗血管生成肽 | Cao等,(1996)J.Biological Chemistry 271,46:29461-29467;Cao等,(1997)J.BiologicalChemistry 272,36:22924-22928;Lu等,(1999)Biochem.Biophysical ResearchCommunications,258,668-673 | 实体瘤和癌症 |
泳道 | 样品 | 加载量 |
1 | - | - |
2 | Magic Marker | - |
3 | - | - |
4 | C末端内皮他丁 | 1μg |
5 | N末端内皮他丁 | 1μg |
6 | HSA | 1μg |
7 | 内皮他丁标准品 | 1μg |
C-末端融合体 | N-末端融合体 | |
通过SDS-PAGE和胶体蓝染色测定的%纯度 | 95 | 99 |
翻译后修饰的ESMS指示 | 未检测到校正理论质量=86512的种类。主要种类与损失CT赖氨酸残基一致。1 | 检测到一类校正理论质量。存在一些分子量较高的组分。2 |
N-末端序列 | rHA的校正NT序列 | 内皮他丁的校正NT序列 |
内毒素(EU.mL-1) | 4.3 | 5.7 |
融合体浓度(mg.mL-1) | 5 | 5 |
内皮他丁 CT-内皮他丁 NT-内皮他丁10mg/kg | 内皮他丁1.25mg/kg |
吸收半衰期(hr) 0.09 1.61 8.84终末半衰期(hr) 4.5 55.7 28.4AUC(hr.ng/mL) 3,010 142,183 175,272Cmax(ng/mL) 229 1,785 2,198 | 0.052.0a2,682b44 |
a由高达24小时的值计算b区域包括24小时后的增加水平 |
内皮他丁1.25mg/kg | CT-内皮他丁 NT-内皮他丁 |
起始半衰期(hr) -终末半衰期(hr) 1.9AUC(hr.ng/mL) 1,723Cmax(ng/mL) 126 | 6.39 2.4050.0 23.7456,139 658,46924,252 24,127 |
Claims (50)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35554702P | 2002-02-07 | 2002-02-07 | |
US60/355,547 | 2002-02-07 | ||
PCT/IB2003/000433 WO2003066085A1 (en) | 2002-02-07 | 2003-02-07 | Albumin-fused anti-angiogenesis peptides |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1646154A true CN1646154A (zh) | 2005-07-27 |
CN1646154B CN1646154B (zh) | 2010-12-01 |
Family
ID=27734531
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA038075164A Pending CN101166762A (zh) | 2002-02-07 | 2003-02-07 | 白蛋白融合的Kunitz结构域肽 |
CNA038069687A Pending CN1642567A (zh) | 2002-02-07 | 2003-02-07 | Hiv抑制蛋白 |
CN038076411A Expired - Fee Related CN1646154B (zh) | 2002-02-07 | 2003-02-07 | 与白蛋白融合的抗-血管生成肽 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA038075164A Pending CN101166762A (zh) | 2002-02-07 | 2003-02-07 | 白蛋白融合的Kunitz结构域肽 |
CNA038069687A Pending CN1642567A (zh) | 2002-02-07 | 2003-02-07 | Hiv抑制蛋白 |
Country Status (10)
Country | Link |
---|---|
US (4) | US20060122374A1 (zh) |
EP (4) | EP2090589A1 (zh) |
JP (4) | JP2005538932A (zh) |
KR (4) | KR20110014661A (zh) |
CN (3) | CN101166762A (zh) |
AU (5) | AU2003244516A1 (zh) |
CA (3) | CA2485064A1 (zh) |
NZ (3) | NZ534310A (zh) |
WO (3) | WO2003066824A2 (zh) |
ZA (3) | ZA200406124B (zh) |
Cited By (6)
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CN102939304A (zh) * | 2010-04-09 | 2013-02-20 | 诺维信生物制药丹麦公司 | 白蛋白衍生物和变体 |
CN104926946A (zh) * | 2015-07-13 | 2015-09-23 | 中国科学院广州生物医药与健康研究院 | 具有延长体内半衰期的adamts13-mdtcs融合蛋白及其应用 |
CN105440138A (zh) * | 2014-09-30 | 2016-03-30 | 复旦大学 | 一种长效内皮抑素融合蛋白的制备方法和用途 |
CN106674352A (zh) * | 2015-11-10 | 2017-05-17 | 孙嘉琳 | 抗肿瘤蛋白内皮抑素的衍生物及应用 |
CN111995686A (zh) * | 2019-05-27 | 2020-11-27 | 兰州大学 | 一种具有抗血管生成活性的药物及其制备方法 |
CN117924430A (zh) * | 2024-03-22 | 2024-04-26 | 中国人民解放军军事科学院军事医学研究院 | 促进血小板生成的tpor结合肽 |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0737207B1 (en) | 1994-01-11 | 2004-09-22 | Dyax Corporation | Inhibitors of human plasmin derived from the kunitz domains |
US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
WO2005003296A2 (en) * | 2003-01-22 | 2005-01-13 | Human Genome Sciences, Inc. | Albumin fusion proteins |
DK2311432T3 (en) | 2002-06-07 | 2015-02-02 | Dyax Corp | Modified Kunitz domain polypeptides and their use in reducing ischemia or the onset of a systemic inflammatory response associated with a surgical procedure |
US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
GB0217033D0 (en) | 2002-07-23 | 2002-08-28 | Delta Biotechnology Ltd | Gene and polypeptide sequences |
JP2005537006A (ja) * | 2002-08-28 | 2005-12-08 | ダイアックス、コープ | 臓器及び組織の保存方法 |
ATE425767T1 (de) | 2002-12-19 | 2009-04-15 | Nektar Therapeutics Al Corp | Konjugate von cyanovirin-varianten und einem polyalkylenoxid |
US6989369B2 (en) | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
US7524811B2 (en) * | 2003-08-29 | 2009-04-28 | Children's Medical Center Corporation | Anti-angiogenic peptides from the N-terminus of endostatin |
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