CN1612938A - 去纤肽生物学活性的测定方法 - Google Patents
去纤肽生物学活性的测定方法 Download PDFInfo
- Publication number
- CN1612938A CN1612938A CNA028269799A CN02826979A CN1612938A CN 1612938 A CN1612938 A CN 1612938A CN A028269799 A CNA028269799 A CN A028269799A CN 02826979 A CN02826979 A CN 02826979A CN 1612938 A CN1612938 A CN 1612938A
- Authority
- CN
- China
- Prior art keywords
- fibrinolysin
- defibrotide
- substrate
- concentration
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/968—Plasmin, i.e. fibrinolysin
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
标准去纤肽 | 测试样品 | |||||||||||
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | |
A | - | - | - | - | - | - | - | - | - | - | - | - |
B | - | 0.5 | 8.0 | 4.0 | 2.0 | 1.0 | 1.0 | 2.0 | 4.0 | 8.0 | 0.5 | - |
C | - | 1.0 | 0.5 | 8.0 | 4.0 | 2.0 | 2.0 | 4.0 | 8.0 | 0.5 | 1.0 | - |
D | - | 2.0 | 1.0 | 0.5 | 8.0 | 4.0 | 4.0 | 8.0 | 0.5 | 1.0 | 2.0 | - |
E | - | 4.0 | 2.0 | 1.0 | 0.5 | 8.0 | 8.0 | 0.5 | 1.0 | 2.0 | 4.0 | - |
F | - | 8.0 | 4.0 | 2.0 | 1.0 | 0.5 | 0.5 | 1.0 | 2.0 | 4.0 | 8.0 | - |
G | - | - | - | - | - | - | - | - | - | - | - | - |
H | - | - | - | - | - | - | - | - | - | - | - | - |
Claims (14)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01830770.2 | 2001-12-17 | ||
EP01830770A EP1325962A1 (en) | 2001-12-17 | 2001-12-17 | A method for determining the biological activity of defibrotide |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1612938A true CN1612938A (zh) | 2005-05-04 |
CN100408690C CN100408690C (zh) | 2008-08-06 |
Family
ID=8184814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB028269799A Expired - Lifetime CN100408690C (zh) | 2001-12-17 | 2002-11-27 | 去纤肽生物学活性的测定方法 |
Country Status (27)
Country | Link |
---|---|
US (1) | US7338777B2 (zh) |
EP (2) | EP1325962A1 (zh) |
JP (1) | JP4348192B2 (zh) |
KR (1) | KR100912424B1 (zh) |
CN (1) | CN100408690C (zh) |
AR (1) | AR037870A1 (zh) |
AT (1) | ATE480637T1 (zh) |
AU (1) | AU2002360945B2 (zh) |
CA (1) | CA2468877C (zh) |
DE (1) | DE60237639D1 (zh) |
DK (1) | DK1456404T3 (zh) |
ES (1) | ES2349509T3 (zh) |
HK (1) | HK1077332A1 (zh) |
HR (1) | HRP20040548A2 (zh) |
HU (1) | HUP0402231A3 (zh) |
IL (2) | IL162511A0 (zh) |
IS (1) | IS7312A (zh) |
MX (1) | MXPA04005958A (zh) |
NO (1) | NO20042972L (zh) |
NZ (1) | NZ533594A (zh) |
PL (1) | PL373243A1 (zh) |
PT (1) | PT1456404E (zh) |
RS (1) | RS63104A (zh) |
RU (1) | RU2323979C2 (zh) |
UA (1) | UA80104C2 (zh) |
WO (1) | WO2003052130A2 (zh) |
ZA (1) | ZA200404656B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104619857A (zh) * | 2012-06-22 | 2015-05-13 | 真蒂奥姆有限公司 | 用于测定去纤维蛋白多核苷酸的生物活性的基于优球蛋白的方法 |
CN107109458A (zh) * | 2014-11-27 | 2017-08-29 | 真蒂奥姆责任有限公司 | 基于细胞的去纤维蛋白多核苷酸效力测定方法 |
TWI615473B (zh) * | 2013-11-26 | 2018-02-21 | 金提恩責任有限公司 | 用於測定去纖維蛋白多核苷酸的生物活性之基於優球蛋白的方法 |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1325962A1 (en) | 2001-12-17 | 2003-07-09 | Gentium S.p.A. | A method for determining the biological activity of defibrotide |
EP1872787A1 (en) * | 2006-06-27 | 2008-01-02 | Gentium S.p.A. | Use of defibrotide for the inhibition of heparanase |
EP1982722A1 (en) * | 2007-04-16 | 2008-10-22 | Gentium S.p.A. | Use of oligotide for the treatment of renal diseases |
EP2103689A1 (en) * | 2008-03-19 | 2009-09-23 | Gentium S.p.A. | Synthetic phosphodiester oligonucleotides and therapeutical uses thereof |
DK2637672T3 (en) | 2010-11-12 | 2018-10-22 | Gentium S R L | DEFIBROTID FOR USE IN PROPHYLAXY AND / OR TREATMENT OF GRAPHIC VERSUS HOST DISEASE (GVHD) |
US9655761B2 (en) | 2012-11-12 | 2017-05-23 | Djo, Llc | Orthopedic back brace |
RU2766143C2 (ru) * | 2017-07-26 | 2022-02-08 | Джентиум С.Р.Л. | Жидкая композиция дефибротида для лечения и профилактики веноокклюзионной болезни |
MX2020001337A (es) | 2017-08-03 | 2020-09-09 | Jazz Pharmaceuticals Ireland Ltd | Formulaciones que comprenden un acido nucleico en una alta concentracion. |
CA3095335A1 (en) | 2018-04-12 | 2019-10-17 | Jazz Pharmaceuticals, Inc. | Defibrotide for the prevention and treatment of cytokine release syndrome and neurotoxicity associated with immunodepletion |
US20220023533A1 (en) | 2018-12-07 | 2022-01-27 | Jazz Phrmaceticals Ireland Limited | Subcutaneous delivery of high concentration formulations |
WO2021174039A1 (en) | 2020-02-28 | 2021-09-02 | Jazz Pharmaceuticals Ireland Limited | Delivery of low viscosity formulations |
TW202308659A (zh) | 2021-05-06 | 2023-03-01 | 愛爾蘭商爵士製藥愛爾蘭有限責任公司 | 用於急性呼吸窘迫症候群之治療及預防的去纖維蛋白多核苷酸 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2154279A1 (de) * | 1970-11-03 | 1972-05-25 | Crinos Industria Farmaco | Medikamente für das fibrinolytische System |
DE2812943C3 (de) * | 1978-03-23 | 1981-05-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma |
IT1170215B (it) * | 1983-09-12 | 1987-06-03 | Crinos Industria Farmaco | Composizione farmaceutica per il trattamento di stati di insufficienza renale acuta |
IT1206341B (it) * | 1984-02-16 | 1989-04-14 | Crinos Industria Farmaco | Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio. |
US5231006A (en) * | 1986-10-16 | 1993-07-27 | Behringwerke Aktiengesellschaft | Method for the determination of plasminogen |
US5321006A (en) * | 1992-12-09 | 1994-06-14 | International Flavors & Fragrances Inc. | Flavor and fragrance compositions produced using process for quantitatively and qualitatively substantially continuously analyzing the aroma emitted from a living fruit |
CN1187201A (zh) * | 1995-05-05 | 1998-07-08 | 生物药物研究与发展有限公司 | 血纤维蛋白交联和/或转谷氨酰胺酶的抑制剂 |
GB9719161D0 (en) * | 1997-09-09 | 1997-11-12 | Glaxo Group Ltd | New therapeutic method |
EP1325962A1 (en) | 2001-12-17 | 2003-07-09 | Gentium S.p.A. | A method for determining the biological activity of defibrotide |
-
2001
- 2001-12-17 EP EP01830770A patent/EP1325962A1/en not_active Withdrawn
-
2002
- 2002-11-27 DK DK02795074.0T patent/DK1456404T3/da active
- 2002-11-27 AU AU2002360945A patent/AU2002360945B2/en not_active Expired
- 2002-11-27 RU RU2004121962/13A patent/RU2323979C2/ru not_active IP Right Cessation
- 2002-11-27 RS YU63104A patent/RS63104A/sr unknown
- 2002-11-27 KR KR1020047009476A patent/KR100912424B1/ko active IP Right Grant
- 2002-11-27 DE DE60237639T patent/DE60237639D1/de not_active Expired - Lifetime
- 2002-11-27 EP EP02795074A patent/EP1456404B1/en not_active Expired - Lifetime
- 2002-11-27 AT AT02795074T patent/ATE480637T1/de active
- 2002-11-27 WO PCT/EP2002/013371 patent/WO2003052130A2/en active Application Filing
- 2002-11-27 JP JP2003552997A patent/JP4348192B2/ja not_active Expired - Lifetime
- 2002-11-27 ES ES02795074T patent/ES2349509T3/es not_active Expired - Lifetime
- 2002-11-27 PT PT02795074T patent/PT1456404E/pt unknown
- 2002-11-27 PL PL02373243A patent/PL373243A1/xx not_active Application Discontinuation
- 2002-11-27 CN CNB028269799A patent/CN100408690C/zh not_active Expired - Lifetime
- 2002-11-27 UA UA20040705856A patent/UA80104C2/uk unknown
- 2002-11-27 HU HU0402231A patent/HUP0402231A3/hu unknown
- 2002-11-27 MX MXPA04005958A patent/MXPA04005958A/es unknown
- 2002-11-27 NZ NZ533594A patent/NZ533594A/xx unknown
- 2002-11-27 IL IL16251102A patent/IL162511A0/xx unknown
- 2002-11-27 CA CA2468877A patent/CA2468877C/en not_active Expired - Lifetime
- 2002-12-17 AR ARP020104901A patent/AR037870A1/es not_active Application Discontinuation
-
2004
- 2004-06-11 ZA ZA200404656A patent/ZA200404656B/en unknown
- 2004-06-14 IL IL162511A patent/IL162511A/en active IP Right Grant
- 2004-06-14 IS IS7312A patent/IS7312A/is unknown
- 2004-06-16 HR HR20040548A patent/HRP20040548A2/hr not_active Application Discontinuation
- 2004-06-17 US US10/868,798 patent/US7338777B2/en active Active
- 2004-07-14 NO NO20042972A patent/NO20042972L/no not_active Application Discontinuation
-
2005
- 2005-10-20 HK HK05109348.5A patent/HK1077332A1/xx not_active IP Right Cessation
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104619857A (zh) * | 2012-06-22 | 2015-05-13 | 真蒂奥姆有限公司 | 用于测定去纤维蛋白多核苷酸的生物活性的基于优球蛋白的方法 |
CN110079580A (zh) * | 2012-06-22 | 2019-08-02 | 真蒂奥姆责任有限公司 | 用于测定去纤维蛋白多核苷酸的生物活性的基于优球蛋白的方法 |
CN110079580B (zh) * | 2012-06-22 | 2022-12-06 | 真蒂奥姆责任有限公司 | 用于测定去纤维蛋白多核苷酸的生物活性的基于优球蛋白的方法 |
TWI615473B (zh) * | 2013-11-26 | 2018-02-21 | 金提恩責任有限公司 | 用於測定去纖維蛋白多核苷酸的生物活性之基於優球蛋白的方法 |
CN107109458A (zh) * | 2014-11-27 | 2017-08-29 | 真蒂奥姆责任有限公司 | 基于细胞的去纤维蛋白多核苷酸效力测定方法 |
CN107109458B (zh) * | 2014-11-27 | 2021-10-26 | 真蒂奥姆责任有限公司 | 基于细胞的去纤维蛋白多核苷酸效力测定方法 |
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