MXPA04005958A - Un metodo para determinar la actividad biologica de defibrotida. - Google Patents
Un metodo para determinar la actividad biologica de defibrotida.Info
- Publication number
- MXPA04005958A MXPA04005958A MXPA04005958A MXPA04005958A MXPA04005958A MX PA04005958 A MXPA04005958 A MX PA04005958A MX PA04005958 A MXPA04005958 A MX PA04005958A MX PA04005958 A MXPA04005958 A MX PA04005958A MX PA04005958 A MXPA04005958 A MX PA04005958A
- Authority
- MX
- Mexico
- Prior art keywords
- defibrotide
- plasmin
- determining
- biological activity
- enzymatic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/968—Plasmin, i.e. fibrinolysin
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Se describe un metodo enzimatico para determinar la actividad biologica de defibrotida. El metodo, el cual se basa en la capacidad de defribrotida para potenciar la actividad enzimatica de plasmido, comprende las etapas de: a) conducir en contacto la defibrotida, plasmido y un sustrato especifico para el plasmido el cual, mediante reaccion con plasmina, proporciona un producto medible y b) medir la cantidad de producto formado en tiempos sucesivos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01830770A EP1325962A1 (en) | 2001-12-17 | 2001-12-17 | A method for determining the biological activity of defibrotide |
| PCT/EP2002/013371 WO2003052130A2 (en) | 2001-12-17 | 2002-11-27 | A method for determining the biological activity of defibrotide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04005958A true MXPA04005958A (es) | 2004-11-01 |
Family
ID=8184814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04005958A MXPA04005958A (es) | 2001-12-17 | 2002-11-27 | Un metodo para determinar la actividad biologica de defibrotida. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7338777B2 (es) |
| EP (2) | EP1325962A1 (es) |
| JP (1) | JP4348192B2 (es) |
| KR (1) | KR100912424B1 (es) |
| CN (1) | CN100408690C (es) |
| AR (1) | AR037870A1 (es) |
| AT (1) | ATE480637T1 (es) |
| AU (1) | AU2002360945B2 (es) |
| CA (1) | CA2468877C (es) |
| DE (1) | DE60237639D1 (es) |
| DK (1) | DK1456404T3 (es) |
| ES (1) | ES2349509T3 (es) |
| HK (1) | HK1077332A1 (es) |
| HR (1) | HRP20040548A2 (es) |
| HU (1) | HUP0402231A3 (es) |
| IL (2) | IL162511A0 (es) |
| IS (1) | IS7312A (es) |
| MX (1) | MXPA04005958A (es) |
| NO (1) | NO20042972L (es) |
| NZ (1) | NZ533594A (es) |
| PL (1) | PL373243A1 (es) |
| PT (1) | PT1456404E (es) |
| RS (1) | RS63104A (es) |
| RU (1) | RU2323979C2 (es) |
| UA (1) | UA80104C2 (es) |
| WO (1) | WO2003052130A2 (es) |
| ZA (1) | ZA200404656B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1325962A1 (en) | 2001-12-17 | 2003-07-09 | Gentium S.p.A. | A method for determining the biological activity of defibrotide |
| EP1872787A1 (en) * | 2006-06-27 | 2008-01-02 | Gentium S.p.A. | Use of defibrotide for the inhibition of heparanase |
| EP1982722A1 (en) * | 2007-04-16 | 2008-10-22 | Gentium S.p.A. | Use of oligotide for the treatment of renal diseases |
| EP2103689A1 (en) * | 2008-03-19 | 2009-09-23 | Gentium S.p.A. | Synthetic phosphodiester oligonucleotides and therapeutical uses thereof |
| JP6069209B2 (ja) | 2010-11-12 | 2017-02-01 | ジェンティウム ソシエタ ア レスポンサビリタ リミタータ | 移植片対宿主病（ｇｖｈｄ）の予防および／または治療に使用するためのデフィブロタイド |
| RU2627177C2 (ru) * | 2012-06-22 | 2017-08-03 | Джентиум С.Р.Л. | Способ определения биологической активности дефибротида, основанный на применении эуглобулина |
| US9655761B2 (en) | 2012-11-12 | 2017-05-23 | Djo, Llc | Orthopedic back brace |
| TWI615473B (zh) * | 2013-11-26 | 2018-02-21 | 金提恩責任有限公司 | 用於測定去纖維蛋白多核苷酸的生物活性之基於優球蛋白的方法 |
| EP3026122A1 (en) | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Cellular-based method for determining the potency of defibrotide |
| RU2766143C2 (ru) * | 2017-07-26 | 2022-02-08 | Джентиум С.Р.Л. | Жидкая композиция дефибротида для лечения и профилактики веноокклюзионной болезни |
| KR20200121780A (ko) | 2017-08-03 | 2020-10-26 | 재즈 파마슈티칼즈 아일랜드 리미티드 | 높은 농도에서 핵산을 포함하는 제제 |
| KR20210008478A (ko) | 2018-04-12 | 2021-01-22 | 재즈 파마슈티칼즈, 인코포레이티드 | 면역고갈과 관련된 사이토카인 방출 증후군 및 신경독성의 예방 및 치료를 위한 데피브로타이드 |
| US20220023533A1 (en) | 2018-12-07 | 2022-01-27 | Jazz Phrmaceticals Ireland Limited | Subcutaneous delivery of high concentration formulations |
| US20230190783A1 (en) | 2020-02-28 | 2023-06-22 | Jazz Pharmaceuticals Ireland Limited | Delivery of low viscosity formulations |
| TW202308659A (zh) | 2021-05-06 | 2023-03-01 | 愛爾蘭商爵士製藥愛爾蘭有限責任公司 | 用於急性呼吸窘迫症候群之治療及預防的去纖維蛋白多核苷酸 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2154279A1 (de) * | 1970-11-03 | 1972-05-25 | Crinos Industria Farmaco | Medikamente für das fibrinolytische System |
| DE2812943C3 (de) * | 1978-03-23 | 1981-05-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma |
| IT1170215B (it) * | 1983-09-12 | 1987-06-03 | Crinos Industria Farmaco | Composizione farmaceutica per il trattamento di stati di insufficienza renale acuta |
| IT1206341B (it) * | 1984-02-16 | 1989-04-14 | Crinos Industria Farmaco | Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio. |
| US5231006A (en) * | 1986-10-16 | 1993-07-27 | Behringwerke Aktiengesellschaft | Method for the determination of plasminogen |
| US5321006A (en) * | 1992-12-09 | 1994-06-14 | International Flavors & Fragrances Inc. | Flavor and fragrance compositions produced using process for quantitatively and qualitatively substantially continuously analyzing the aroma emitted from a living fruit |
| CN1187201A (zh) * | 1995-05-05 | 1998-07-08 | 生物药物研究与发展有限公司 | 血纤维蛋白交联和/或转谷氨酰胺酶的抑制剂 |
| GB9719161D0 (en) * | 1997-09-09 | 1997-11-12 | Glaxo Group Ltd | New therapeutic method |
| EP1325962A1 (en) | 2001-12-17 | 2003-07-09 | Gentium S.p.A. | A method for determining the biological activity of defibrotide |
-
2001
- 2001-12-17 EP EP01830770A patent/EP1325962A1/en not_active Withdrawn
-
2002
- 2002-11-27 MX MXPA04005958A patent/MXPA04005958A/es unknown
- 2002-11-27 JP JP2003552997A patent/JP4348192B2/ja not_active Expired - Lifetime
- 2002-11-27 EP EP02795074A patent/EP1456404B1/en not_active Expired - Lifetime
- 2002-11-27 CN CNB028269799A patent/CN100408690C/zh not_active Expired - Lifetime
- 2002-11-27 NZ NZ533594A patent/NZ533594A/xx unknown
- 2002-11-27 KR KR1020047009476A patent/KR100912424B1/ko active IP Right Grant
- 2002-11-27 ES ES02795074T patent/ES2349509T3/es not_active Expired - Lifetime
- 2002-11-27 RS YU63104A patent/RS63104A/sr unknown
- 2002-11-27 AU AU2002360945A patent/AU2002360945B2/en not_active Expired
- 2002-11-27 UA UA20040705856A patent/UA80104C2/uk unknown
- 2002-11-27 PL PL02373243A patent/PL373243A1/xx not_active Application Discontinuation
- 2002-11-27 RU RU2004121962/13A patent/RU2323979C2/ru not_active IP Right Cessation
- 2002-11-27 HU HU0402231A patent/HUP0402231A3/hu unknown
- 2002-11-27 DE DE60237639T patent/DE60237639D1/de not_active Expired - Lifetime
- 2002-11-27 AT AT02795074T patent/ATE480637T1/de active
- 2002-11-27 IL IL16251102A patent/IL162511A0/xx unknown
- 2002-11-27 CA CA2468877A patent/CA2468877C/en not_active Expired - Lifetime
- 2002-11-27 PT PT02795074T patent/PT1456404E/pt unknown
- 2002-11-27 DK DK02795074.0T patent/DK1456404T3/da active
- 2002-11-27 WO PCT/EP2002/013371 patent/WO2003052130A2/en active Application Filing
- 2002-12-17 AR ARP020104901A patent/AR037870A1/es not_active Application Discontinuation
-
2004
- 2004-06-11 ZA ZA200404656A patent/ZA200404656B/en unknown
- 2004-06-14 IS IS7312A patent/IS7312A/is unknown
- 2004-06-14 IL IL162511A patent/IL162511A/en active IP Right Grant
- 2004-06-16 HR HR20040548A patent/HRP20040548A2/hr not_active Application Discontinuation
- 2004-06-17 US US10/868,798 patent/US7338777B2/en active Active
- 2004-07-14 NO NO20042972A patent/NO20042972L/no not_active Application Discontinuation
-
2005
- 2005-10-20 HK HK05109348.5A patent/HK1077332A1/xx not_active IP Right Cessation
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