CN1607962A - 聚谷氨酸－治疗剂结合物的生产方法 - Google Patents

聚谷氨酸－治疗剂结合物的生产方法 Download PDF

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Publication number
CN1607962A
CN1607962A CNA008170290A CN00817029A CN1607962A CN 1607962 A CN1607962 A CN 1607962A CN A008170290 A CNA008170290 A CN A008170290A CN 00817029 A CN00817029 A CN 00817029A CN 1607962 A CN1607962 A CN 1607962A
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CN
China
Prior art keywords
conjugate
therapeutic agent
poly
acid
solution
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Pending
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CNA008170290A
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English (en)
Chinese (zh)
Inventor
A·M·库马
J·P·克莱恩
R·巴特
E·沃特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CTI Biopharma Corp
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Cell Therapeutics Inc
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Application filed by Cell Therapeutics Inc filed Critical Cell Therapeutics Inc
Publication of CN1607962A publication Critical patent/CN1607962A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
CNA008170290A 1999-10-12 2000-10-12 聚谷氨酸－治疗剂结合物的生产方法 Pending CN1607962A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15913599P 1999-10-12 1999-10-12
US60/159,135 1999-10-12

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2009101276554A Division CN101507820A (zh) 1999-10-12 2000-10-12 聚谷氨酸-治疗剂结合物的生产方法

Publications (1)

Publication Number Publication Date
CN1607962A true CN1607962A (zh) 2005-04-20

Family

ID=22571222

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA008170290A Pending CN1607962A (zh) 1999-10-12 2000-10-12 聚谷氨酸－治疗剂结合物的生产方法
CNA2009101276554A Pending CN101507820A (zh) 1999-10-12 2000-10-12 聚谷氨酸-治疗剂结合物的生产方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2009101276554A Pending CN101507820A (zh) 1999-10-12 2000-10-12 聚谷氨酸-治疗剂结合物的生产方法

Country Status (16)

Country Link
US (2) US20020077279A1 (https=)
EP (2) EP1225917A2 (https=)
JP (1) JP2003511423A (https=)
KR (1) KR100821437B1 (https=)
CN (2) CN1607962A (https=)
AU (1) AU781735B2 (https=)
BR (1) BRPI0014652B1 (https=)
CA (1) CA2387611C (https=)
HU (1) HUP0203123A3 (https=)
MX (1) MXPA02003719A (https=)
NO (1) NO20021701L (https=)
NZ (1) NZ529789A (https=)
PL (1) PL354623A1 (https=)
SG (1) SG147286A1 (https=)
WO (1) WO2001026693A2 (https=)
ZA (1) ZA200202695B (https=)

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CN106750272A (zh) * 2016-12-05 2017-05-31 福建卫生职业技术学院 一种水溶性蛇葡萄素聚合物

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CN101707869A (zh) * 2007-05-09 2010-05-12 日东电工株式会社 具有多种药物的聚谷氨酸盐结合物和聚谷氨酸盐-氨基酸结合物
JP2010528122A (ja) * 2007-05-09 2010-08-19 日東電工株式会社 白金薬剤と結合されたポリマー
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Cited By (2)

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Publication number Priority date Publication date Assignee Title
CN106750272A (zh) * 2016-12-05 2017-05-31 福建卫生职业技术学院 一种水溶性蛇葡萄素聚合物
CN106750272B (zh) * 2016-12-05 2019-05-28 福建卫生职业技术学院 一种水溶性蛇葡萄素聚合物

Also Published As

Publication number Publication date
KR100821437B1 (ko) 2008-04-10
CA2387611A1 (en) 2001-04-19
ZA200202695B (en) 2004-02-25
MXPA02003719A (es) 2002-08-30
WO2001026693A2 (en) 2001-04-19
AU781735B2 (en) 2005-06-09
CN101507820A (zh) 2009-08-19
US20030224971A1 (en) 2003-12-04
WO2001026693A3 (en) 2001-12-27
CA2387611C (en) 2011-03-29
BRPI0014652B1 (pt) 2016-08-09
NO20021701D0 (no) 2002-04-11
AU1079301A (en) 2001-04-23
PL354623A1 (en) 2004-02-09
HUP0203123A2 (hu) 2003-01-28
BR0014652A (pt) 2003-06-10
US20020077279A1 (en) 2002-06-20
HUP0203123A3 (en) 2004-12-28
KR20020059616A (ko) 2002-07-13
NO20021701L (no) 2002-05-23
EP1466627A1 (en) 2004-10-13
SG147286A1 (en) 2008-11-28
NZ529789A (en) 2005-04-29
JP2003511423A (ja) 2003-03-25
EP1225917A2 (en) 2002-07-31
US7399860B2 (en) 2008-07-15

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