KR100821437B1 - 폴리글루타메이트-치료제 접합체의 제조 방법 - Google Patents

폴리글루타메이트-치료제 접합체의 제조 방법

Info

Publication number
KR100821437B1
KR100821437B1 KR1020027004640A KR20027004640A KR100821437B1 KR 100821437 B1 KR100821437 B1 KR 100821437B1 KR 1020027004640 A KR1020027004640 A KR 1020027004640A KR 20027004640 A KR20027004640 A KR 20027004640A KR 100821437 B1 KR100821437 B1 KR 100821437B1
Authority
KR
South Korea
Prior art keywords
camptothecin
conjugate
delete delete
polyglutamic acid
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020027004640A
Other languages
English (en)
Korean (ko)
Other versions
KR20020059616A (ko
Inventor
아닐 엠. 쿠마
제이. 피터 클레인
라마 바트
에드워드 버터
Original Assignee
쎌세러퓨틱스,인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 쎌세러퓨틱스,인코포레이티드 filed Critical 쎌세러퓨틱스,인코포레이티드
Publication of KR20020059616A publication Critical patent/KR20020059616A/ko
Application granted granted Critical
Publication of KR100821437B1 publication Critical patent/KR100821437B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
KR1020027004640A 1999-10-12 2000-10-12 폴리글루타메이트-치료제 접합체의 제조 방법 Expired - Fee Related KR100821437B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15913599P 1999-10-12 1999-10-12
US60/159,135 1999-10-12

Publications (2)

Publication Number Publication Date
KR20020059616A KR20020059616A (ko) 2002-07-13
KR100821437B1 true KR100821437B1 (ko) 2008-04-10

Family

ID=22571222

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027004640A Expired - Fee Related KR100821437B1 (ko) 1999-10-12 2000-10-12 폴리글루타메이트-치료제 접합체의 제조 방법

Country Status (16)

Country Link
US (2) US20020077279A1 (https=)
EP (2) EP1225917A2 (https=)
JP (1) JP2003511423A (https=)
KR (1) KR100821437B1 (https=)
CN (2) CN1607962A (https=)
AU (1) AU781735B2 (https=)
BR (1) BRPI0014652B1 (https=)
CA (1) CA2387611C (https=)
HU (1) HUP0203123A3 (https=)
MX (1) MXPA02003719A (https=)
NO (1) NO20021701L (https=)
NZ (1) NZ529789A (https=)
PL (1) PL354623A1 (https=)
SG (1) SG147286A1 (https=)
WO (1) WO2001026693A2 (https=)
ZA (1) ZA200202695B (https=)

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US8614228B2 (en) 2004-08-11 2013-12-24 Arqule, Inc. Quinone prodrug compositions and methods of use
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CA2631704A1 (en) 2005-12-05 2007-06-14 Nitto Denko Corporation Polyglutamate-amino acid conjugates and methods
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US7462627B2 (en) * 2006-02-09 2008-12-09 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
US7671067B2 (en) * 2006-02-09 2010-03-02 Enzon Pharmaceuticals, Inc. Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
US8323669B2 (en) 2006-03-28 2012-12-04 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of taxane
RU2447095C2 (ru) 2006-05-18 2012-04-10 Ниппон Каяку Кабусики Кайся Высокомолекулярный конъюгат подофиллотоксинов
US8334364B2 (en) 2006-11-06 2012-12-18 Nipon Kayaku Kabushiki Kaisha High-molecular weight derivative of nucleic acid antimetabolite
JP5548365B2 (ja) 2006-11-08 2014-07-16 日本化薬株式会社 核酸系代謝拮抗剤の高分子誘導体
CN101209350B (zh) * 2006-12-30 2011-09-07 中国人民解放军军事医学科学院毒物药物研究所 以氨基酸为连接子的多聚谷氨酸-药物偶合物
KR20090108082A (ko) * 2007-02-09 2009-10-14 엔존 파마슈티컬즈, 인코포레이티드 7-에틸-10-하이드록시캄토테신 다분지형 고분자 접합체를 이용한 내성 또는 불응성 암의 치료방법
CN101674852A (zh) * 2007-04-10 2010-03-17 日东电工株式会社 多功能聚谷氨酸盐药物载体
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CA2683590A1 (en) * 2007-05-09 2008-11-20 Nitto Denko Corporation Compositions that include a hydrophobic compound and a polyamino acid conjugate
CN101707869A (zh) * 2007-05-09 2010-05-12 日东电工株式会社 具有多种药物的聚谷氨酸盐结合物和聚谷氨酸盐-氨基酸结合物
JP2010528122A (ja) * 2007-05-09 2010-08-19 日東電工株式会社 白金薬剤と結合されたポリマー
JP5349318B2 (ja) 2007-09-28 2013-11-20 日本化薬株式会社 ステロイド類の高分子結合体
WO2009111271A1 (en) * 2008-03-06 2009-09-11 Nitto Denko Corporation Polymer paclitaxel conjugates and methods for treating cancer
CN101977631A (zh) 2008-03-18 2011-02-16 日本化药株式会社 生理活性物质的高分子量偶联物
JP5366940B2 (ja) 2008-05-08 2013-12-11 日本化薬株式会社 葉酸若しくは葉酸誘導体の高分子結合体
TW201010732A (en) * 2008-08-29 2010-03-16 Enzon Pharmaceuticals Inc Method of treating RAS associated cancer
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JP2012505906A (ja) * 2008-10-15 2012-03-08 日東電工株式会社 ポリグルタメートコンジュゲートの調製方法
KR20110075029A (ko) * 2008-10-21 2011-07-05 엔즌 파마슈티칼스, 인코포레이티드 7-에틸-10-하이드록시캄토테신의 다중-암 고분자 컨쥬게이트로 신경모세포종의 치료
DE102008060549A1 (de) * 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
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Also Published As

Publication number Publication date
CN1607962A (zh) 2005-04-20
CA2387611A1 (en) 2001-04-19
ZA200202695B (en) 2004-02-25
MXPA02003719A (es) 2002-08-30
WO2001026693A2 (en) 2001-04-19
AU781735B2 (en) 2005-06-09
CN101507820A (zh) 2009-08-19
US20030224971A1 (en) 2003-12-04
WO2001026693A3 (en) 2001-12-27
CA2387611C (en) 2011-03-29
BRPI0014652B1 (pt) 2016-08-09
NO20021701D0 (no) 2002-04-11
AU1079301A (en) 2001-04-23
PL354623A1 (en) 2004-02-09
HUP0203123A2 (hu) 2003-01-28
BR0014652A (pt) 2003-06-10
US20020077279A1 (en) 2002-06-20
HUP0203123A3 (en) 2004-12-28
KR20020059616A (ko) 2002-07-13
NO20021701L (no) 2002-05-23
EP1466627A1 (en) 2004-10-13
SG147286A1 (en) 2008-11-28
NZ529789A (en) 2005-04-29
JP2003511423A (ja) 2003-03-25
EP1225917A2 (en) 2002-07-31
US7399860B2 (en) 2008-07-15

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