NO20021701L - Fremgangsmåte for fremstilling av et konjugat av polyglutamat og et terapeutisk middel - Google Patents
Fremgangsmåte for fremstilling av et konjugat av polyglutamat og et terapeutisk middelInfo
- Publication number
- NO20021701L NO20021701L NO20021701A NO20021701A NO20021701L NO 20021701 L NO20021701 L NO 20021701L NO 20021701 A NO20021701 A NO 20021701A NO 20021701 A NO20021701 A NO 20021701A NO 20021701 L NO20021701 L NO 20021701L
- Authority
- NO
- Norway
- Prior art keywords
- therapeutic agent
- preparation
- polyglutamate
- conjugate
- conjugates
- Prior art date
Links
- 108010020346 Polyglutamic Acid Proteins 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 229940124597 therapeutic agent Drugs 0.000 title abstract 3
- 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 title 1
- 229920002643 polyglutamic acid Polymers 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Polyamides (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15913599P | 1999-10-12 | 1999-10-12 | |
| PCT/US2000/028109 WO2001026693A2 (en) | 1999-10-12 | 2000-10-12 | Manufacture of polyglutamate-therapeutic agent conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20021701D0 NO20021701D0 (no) | 2002-04-11 |
| NO20021701L true NO20021701L (no) | 2002-05-23 |
Family
ID=22571222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20021701A NO20021701L (no) | 1999-10-12 | 2002-04-11 | Fremgangsmåte for fremstilling av et konjugat av polyglutamat og et terapeutisk middel |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20020077279A1 (https=) |
| EP (2) | EP1225917A2 (https=) |
| JP (1) | JP2003511423A (https=) |
| KR (1) | KR100821437B1 (https=) |
| CN (2) | CN1607962A (https=) |
| AU (1) | AU781735B2 (https=) |
| BR (1) | BRPI0014652B1 (https=) |
| CA (1) | CA2387611C (https=) |
| HU (1) | HUP0203123A3 (https=) |
| MX (1) | MXPA02003719A (https=) |
| NO (1) | NO20021701L (https=) |
| NZ (1) | NZ529789A (https=) |
| PL (1) | PL354623A1 (https=) |
| SG (1) | SG147286A1 (https=) |
| WO (1) | WO2001026693A2 (https=) |
| ZA (1) | ZA200202695B (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001266853B2 (en) * | 2000-06-14 | 2005-02-17 | Medarex, Inc. | Prodrug compounds with an oligopeptide having an isoleucine residue |
| US6872715B2 (en) | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| CN101791409A (zh) | 2003-04-22 | 2010-08-04 | 研究及应用科学协会股份有限公司 | 肽载体 |
| FR2855521B1 (fr) * | 2003-05-28 | 2005-08-05 | Flamel Tech Sa | Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques. |
| US7259156B2 (en) | 2004-05-20 | 2007-08-21 | Kosan Biosciences Incorporated | Geldanamycin compounds and method of use |
| EP1877097B1 (en) | 2004-08-11 | 2012-06-20 | Arqule, Inc. | Aminoacid conjugates of beta-lapachone for tumor targeting |
| US8614228B2 (en) | 2004-08-11 | 2013-12-24 | Arqule, Inc. | Quinone prodrug compositions and methods of use |
| JP4820758B2 (ja) | 2004-09-22 | 2011-11-24 | 日本化薬株式会社 | 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤 |
| CA2631704A1 (en) | 2005-12-05 | 2007-06-14 | Nitto Denko Corporation | Polyglutamate-amino acid conjugates and methods |
| WO2007067498A1 (en) * | 2005-12-06 | 2007-06-14 | Cell Therapeutics, Inc. | Estrogen cancer therapy |
| US7462627B2 (en) * | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
| US7671067B2 (en) * | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
| US8323669B2 (en) | 2006-03-28 | 2012-12-04 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of taxane |
| RU2447095C2 (ru) | 2006-05-18 | 2012-04-10 | Ниппон Каяку Кабусики Кайся | Высокомолекулярный конъюгат подофиллотоксинов |
| US8334364B2 (en) | 2006-11-06 | 2012-12-18 | Nipon Kayaku Kabushiki Kaisha | High-molecular weight derivative of nucleic acid antimetabolite |
| JP5548365B2 (ja) | 2006-11-08 | 2014-07-16 | 日本化薬株式会社 | 核酸系代謝拮抗剤の高分子誘導体 |
| CN101209350B (zh) * | 2006-12-30 | 2011-09-07 | 中国人民解放军军事医学科学院毒物药物研究所 | 以氨基酸为连接子的多聚谷氨酸-药物偶合物 |
| KR20090108082A (ko) * | 2007-02-09 | 2009-10-14 | 엔존 파마슈티컬즈, 인코포레이티드 | 7-에틸-10-하이드록시캄토테신 다분지형 고분자 접합체를 이용한 내성 또는 불응성 암의 치료방법 |
| CN101674852A (zh) * | 2007-04-10 | 2010-03-17 | 日东电工株式会社 | 多功能聚谷氨酸盐药物载体 |
| ES2532656T3 (es) | 2007-04-30 | 2015-03-30 | Arqule, Inc. | Compuestos de hidroxi sulfonato de quinona y sus usos |
| CA2683590A1 (en) * | 2007-05-09 | 2008-11-20 | Nitto Denko Corporation | Compositions that include a hydrophobic compound and a polyamino acid conjugate |
| CN101707869A (zh) * | 2007-05-09 | 2010-05-12 | 日东电工株式会社 | 具有多种药物的聚谷氨酸盐结合物和聚谷氨酸盐-氨基酸结合物 |
| JP2010528122A (ja) * | 2007-05-09 | 2010-08-19 | 日東電工株式会社 | 白金薬剤と結合されたポリマー |
| JP5349318B2 (ja) | 2007-09-28 | 2013-11-20 | 日本化薬株式会社 | ステロイド類の高分子結合体 |
| WO2009111271A1 (en) * | 2008-03-06 | 2009-09-11 | Nitto Denko Corporation | Polymer paclitaxel conjugates and methods for treating cancer |
| CN101977631A (zh) | 2008-03-18 | 2011-02-16 | 日本化药株式会社 | 生理活性物质的高分子量偶联物 |
| JP5366940B2 (ja) | 2008-05-08 | 2013-12-11 | 日本化薬株式会社 | 葉酸若しくは葉酸誘導体の高分子結合体 |
| TW201010732A (en) * | 2008-08-29 | 2010-03-16 | Enzon Pharmaceuticals Inc | Method of treating RAS associated cancer |
| CA2739757C (en) * | 2008-10-07 | 2016-07-05 | Rexahn Pharmaceuticals, Inc. | Hpma - docetaxel or gemcitabine conjugates and uses therefore |
| JP2012505906A (ja) * | 2008-10-15 | 2012-03-08 | 日東電工株式会社 | ポリグルタメートコンジュゲートの調製方法 |
| KR20110075029A (ko) * | 2008-10-21 | 2011-07-05 | 엔즌 파마슈티칼스, 인코포레이티드 | 7-에틸-10-하이드록시캄토테신의 다중-암 고분자 컨쥬게이트로 신경모세포종의 치료 |
| DE102008060549A1 (de) * | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
| JP5544357B2 (ja) | 2009-05-15 | 2014-07-09 | 日本化薬株式会社 | 水酸基を有する生理活性物質の高分子結合体 |
| CA2777397C (en) | 2009-10-13 | 2017-08-29 | Rexahn Pharmaceuticals, Inc. | Polymeric systems for the delivery of anticancer agents |
| BR112012022337A2 (pt) * | 2010-03-11 | 2016-07-05 | Nitto Denko Corp | composição e respectivos método de preparação e uso de quantidade eficaz |
| ES2993140T3 (en) | 2010-04-02 | 2024-12-23 | Amunix Pharmaceuticals Inc | Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same |
| KR20140024833A (ko) | 2010-11-17 | 2014-03-03 | 니폰 가야꾸 가부시끼가이샤 | 신규한 시티딘계 대사길항제의 고분자 유도체 |
| CN102649810A (zh) * | 2011-05-19 | 2012-08-29 | 东北林业大学 | 喜树碱衍生物、其制备方法和用途 |
| US8691284B2 (en) | 2011-07-07 | 2014-04-08 | Empire Technology Development Llc | Fluorinated block co-polymers |
| CN103874722B (zh) | 2011-09-11 | 2016-06-29 | 日本化药株式会社 | 嵌段共聚物的制造方法 |
| US8383093B1 (en) | 2011-11-01 | 2013-02-26 | Serina Therapeutics, Inc. | Subcutaneous delivery of poly(oxazoline) conjugates |
| WO2013151537A1 (en) | 2012-04-03 | 2013-10-10 | Empire Technology Development Llc | Biocompatible adhesive polymers |
| EP2989116A4 (en) * | 2013-04-26 | 2017-01-18 | Nitto Denko Corporation | Reduction of endotoxins from polyanionic polymer conjugates |
| KR101507119B1 (ko) * | 2013-05-31 | 2015-03-30 | 주식회사 바이오리더스 | 점막 점착성 폴리감마글루탐산 나노마이셀 및 이를 이용한 약물 전달체 |
| CN106267227A (zh) * | 2016-08-12 | 2017-01-04 | 北京蓝贝望生物医药科技股份有限公司 | 抗肿瘤药物 |
| CN106750272B (zh) * | 2016-12-05 | 2019-05-28 | 福建卫生职业技术学院 | 一种水溶性蛇葡萄素聚合物 |
| CN110123748A (zh) * | 2019-04-22 | 2019-08-16 | 南京师范大学 | 一种叶酸介导的靶向双载药聚合物胶束及其制备方法和应用 |
| CN113773282A (zh) * | 2021-09-22 | 2021-12-10 | 无锡紫杉药业有限公司 | 一种10-乙酰紫杉醇的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4356166A (en) * | 1978-12-08 | 1982-10-26 | University Of Utah | Time-release chemical delivery system |
| US5629433A (en) * | 1994-07-18 | 1997-05-13 | Hauser, Inc. | Selective process for the deacylation and deacetylation of taxol and taxanes |
| CA2192725C (en) * | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
| CN1304058C (zh) * | 1996-03-12 | 2007-03-14 | Pg－Txl有限公司 | 水溶性紫杉醇产品 |
| US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
| HUP0204562A2 (hu) * | 2000-03-17 | 2003-04-28 | Cell Therapeutics, Inc. | Poliglutaminsav-kamptotecin konjugátumok, eljárás előállításukra és ilyen konjugátumokat tartalmazó gyógyászati készítmények |
-
2000
- 2000-10-12 BR BRPI0014652A patent/BRPI0014652B1/pt not_active IP Right Cessation
- 2000-10-12 NZ NZ529789A patent/NZ529789A/en not_active IP Right Cessation
- 2000-10-12 WO PCT/US2000/028109 patent/WO2001026693A2/en not_active Ceased
- 2000-10-12 JP JP2001529754A patent/JP2003511423A/ja active Pending
- 2000-10-12 AU AU10793/01A patent/AU781735B2/en not_active Ceased
- 2000-10-12 EP EP00972079A patent/EP1225917A2/en not_active Withdrawn
- 2000-10-12 SG SG200401981-6A patent/SG147286A1/en unknown
- 2000-10-12 CA CA2387611A patent/CA2387611C/en not_active Expired - Fee Related
- 2000-10-12 CN CNA008170290A patent/CN1607962A/zh active Pending
- 2000-10-12 HU HU0203123A patent/HUP0203123A3/hu unknown
- 2000-10-12 CN CNA2009101276554A patent/CN101507820A/zh active Pending
- 2000-10-12 KR KR1020027004640A patent/KR100821437B1/ko not_active Expired - Fee Related
- 2000-10-12 PL PL00354623A patent/PL354623A1/xx not_active IP Right Cessation
- 2000-10-12 MX MXPA02003719A patent/MXPA02003719A/es active IP Right Grant
- 2000-10-12 EP EP04013703A patent/EP1466627A1/en not_active Withdrawn
-
2001
- 2001-10-09 US US09/971,657 patent/US20020077279A1/en not_active Abandoned
-
2002
- 2002-04-05 ZA ZA200202695A patent/ZA200202695B/en unknown
- 2002-04-11 NO NO20021701A patent/NO20021701L/no not_active Application Discontinuation
-
2003
- 2003-04-02 US US10/404,152 patent/US7399860B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR100821437B1 (ko) | 2008-04-10 |
| CN1607962A (zh) | 2005-04-20 |
| CA2387611A1 (en) | 2001-04-19 |
| ZA200202695B (en) | 2004-02-25 |
| MXPA02003719A (es) | 2002-08-30 |
| WO2001026693A2 (en) | 2001-04-19 |
| AU781735B2 (en) | 2005-06-09 |
| CN101507820A (zh) | 2009-08-19 |
| US20030224971A1 (en) | 2003-12-04 |
| WO2001026693A3 (en) | 2001-12-27 |
| CA2387611C (en) | 2011-03-29 |
| BRPI0014652B1 (pt) | 2016-08-09 |
| NO20021701D0 (no) | 2002-04-11 |
| AU1079301A (en) | 2001-04-23 |
| PL354623A1 (en) | 2004-02-09 |
| HUP0203123A2 (hu) | 2003-01-28 |
| BR0014652A (pt) | 2003-06-10 |
| US20020077279A1 (en) | 2002-06-20 |
| HUP0203123A3 (en) | 2004-12-28 |
| KR20020059616A (ko) | 2002-07-13 |
| EP1466627A1 (en) | 2004-10-13 |
| SG147286A1 (en) | 2008-11-28 |
| NZ529789A (en) | 2005-04-29 |
| JP2003511423A (ja) | 2003-03-25 |
| EP1225917A2 (en) | 2002-07-31 |
| US7399860B2 (en) | 2008-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |