AU781735B2 - Manufacture of polyglutamate-therapeutic agent conjugates - Google Patents

Manufacture of polyglutamate-therapeutic agent conjugates Download PDF

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Publication number
AU781735B2
AU781735B2 AU10793/01A AU1079301A AU781735B2 AU 781735 B2 AU781735 B2 AU 781735B2 AU 10793/01 A AU10793/01 A AU 10793/01A AU 1079301 A AU1079301 A AU 1079301A AU 781735 B2 AU781735 B2 AU 781735B2
Authority
AU
Australia
Prior art keywords
conjugate
camptothecin
polyglutamic acid
acid
conjugate according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU10793/01A
Other languages
English (en)
Other versions
AU1079301A (en
Inventor
Rama Bhatt
J. Peter Klein
Anil M. Kumar
Edward Vawter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CTI Biopharma Corp
Original Assignee
Cell Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Therapeutics Inc filed Critical Cell Therapeutics Inc
Publication of AU1079301A publication Critical patent/AU1079301A/en
Application granted granted Critical
Publication of AU781735B2 publication Critical patent/AU781735B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
AU10793/01A 1999-10-12 2000-10-12 Manufacture of polyglutamate-therapeutic agent conjugates Ceased AU781735B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15913599P 1999-10-12 1999-10-12
US60/159135 1999-10-12
PCT/US2000/028109 WO2001026693A2 (en) 1999-10-12 2000-10-12 Manufacture of polyglutamate-therapeutic agent conjugates

Publications (2)

Publication Number Publication Date
AU1079301A AU1079301A (en) 2001-04-23
AU781735B2 true AU781735B2 (en) 2005-06-09

Family

ID=22571222

Family Applications (1)

Application Number Title Priority Date Filing Date
AU10793/01A Ceased AU781735B2 (en) 1999-10-12 2000-10-12 Manufacture of polyglutamate-therapeutic agent conjugates

Country Status (16)

Country Link
US (2) US20020077279A1 (https=)
EP (2) EP1225917A2 (https=)
JP (1) JP2003511423A (https=)
KR (1) KR100821437B1 (https=)
CN (2) CN1607962A (https=)
AU (1) AU781735B2 (https=)
BR (1) BRPI0014652B1 (https=)
CA (1) CA2387611C (https=)
HU (1) HUP0203123A3 (https=)
MX (1) MXPA02003719A (https=)
NO (1) NO20021701L (https=)
NZ (1) NZ529789A (https=)
PL (1) PL354623A1 (https=)
SG (1) SG147286A1 (https=)
WO (1) WO2001026693A2 (https=)
ZA (1) ZA200202695B (https=)

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CN101791409A (zh) 2003-04-22 2010-08-04 研究及应用科学协会股份有限公司 肽载体
FR2855521B1 (fr) * 2003-05-28 2005-08-05 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques.
US7259156B2 (en) 2004-05-20 2007-08-21 Kosan Biosciences Incorporated Geldanamycin compounds and method of use
EP1877097B1 (en) 2004-08-11 2012-06-20 Arqule, Inc. Aminoacid conjugates of beta-lapachone for tumor targeting
US8614228B2 (en) 2004-08-11 2013-12-24 Arqule, Inc. Quinone prodrug compositions and methods of use
JP4820758B2 (ja) 2004-09-22 2011-11-24 日本化薬株式会社 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤
CA2631704A1 (en) 2005-12-05 2007-06-14 Nitto Denko Corporation Polyglutamate-amino acid conjugates and methods
WO2007067498A1 (en) * 2005-12-06 2007-06-14 Cell Therapeutics, Inc. Estrogen cancer therapy
US7462627B2 (en) * 2006-02-09 2008-12-09 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
US7671067B2 (en) * 2006-02-09 2010-03-02 Enzon Pharmaceuticals, Inc. Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
US8323669B2 (en) 2006-03-28 2012-12-04 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of taxane
RU2447095C2 (ru) 2006-05-18 2012-04-10 Ниппон Каяку Кабусики Кайся Высокомолекулярный конъюгат подофиллотоксинов
US8334364B2 (en) 2006-11-06 2012-12-18 Nipon Kayaku Kabushiki Kaisha High-molecular weight derivative of nucleic acid antimetabolite
JP5548365B2 (ja) 2006-11-08 2014-07-16 日本化薬株式会社 核酸系代謝拮抗剤の高分子誘導体
CN101209350B (zh) * 2006-12-30 2011-09-07 中国人民解放军军事医学科学院毒物药物研究所 以氨基酸为连接子的多聚谷氨酸-药物偶合物
KR20090108082A (ko) * 2007-02-09 2009-10-14 엔존 파마슈티컬즈, 인코포레이티드 7-에틸-10-하이드록시캄토테신 다분지형 고분자 접합체를 이용한 내성 또는 불응성 암의 치료방법
CN101674852A (zh) * 2007-04-10 2010-03-17 日东电工株式会社 多功能聚谷氨酸盐药物载体
ES2532656T3 (es) 2007-04-30 2015-03-30 Arqule, Inc. Compuestos de hidroxi sulfonato de quinona y sus usos
CA2683590A1 (en) * 2007-05-09 2008-11-20 Nitto Denko Corporation Compositions that include a hydrophobic compound and a polyamino acid conjugate
CN101707869A (zh) * 2007-05-09 2010-05-12 日东电工株式会社 具有多种药物的聚谷氨酸盐结合物和聚谷氨酸盐-氨基酸结合物
JP2010528122A (ja) * 2007-05-09 2010-08-19 日東電工株式会社 白金薬剤と結合されたポリマー
JP5349318B2 (ja) 2007-09-28 2013-11-20 日本化薬株式会社 ステロイド類の高分子結合体
WO2009111271A1 (en) * 2008-03-06 2009-09-11 Nitto Denko Corporation Polymer paclitaxel conjugates and methods for treating cancer
CN101977631A (zh) 2008-03-18 2011-02-16 日本化药株式会社 生理活性物质的高分子量偶联物
JP5366940B2 (ja) 2008-05-08 2013-12-11 日本化薬株式会社 葉酸若しくは葉酸誘導体の高分子結合体
TW201010732A (en) * 2008-08-29 2010-03-16 Enzon Pharmaceuticals Inc Method of treating RAS associated cancer
CA2739757C (en) * 2008-10-07 2016-07-05 Rexahn Pharmaceuticals, Inc. Hpma - docetaxel or gemcitabine conjugates and uses therefore
JP2012505906A (ja) * 2008-10-15 2012-03-08 日東電工株式会社 ポリグルタメートコンジュゲートの調製方法
KR20110075029A (ko) * 2008-10-21 2011-07-05 엔즌 파마슈티칼스, 인코포레이티드 7-에틸-10-하이드록시캄토테신의 다중-암 고분자 컨쥬게이트로 신경모세포종의 치료
DE102008060549A1 (de) * 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
JP5544357B2 (ja) 2009-05-15 2014-07-09 日本化薬株式会社 水酸基を有する生理活性物質の高分子結合体
CA2777397C (en) 2009-10-13 2017-08-29 Rexahn Pharmaceuticals, Inc. Polymeric systems for the delivery of anticancer agents
BR112012022337A2 (pt) * 2010-03-11 2016-07-05 Nitto Denko Corp composição e respectivos método de preparação e uso de quantidade eficaz
ES2993140T3 (en) 2010-04-02 2024-12-23 Amunix Pharmaceuticals Inc Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same
KR20140024833A (ko) 2010-11-17 2014-03-03 니폰 가야꾸 가부시끼가이샤 신규한 시티딘계 대사길항제의 고분자 유도체
CN102649810A (zh) * 2011-05-19 2012-08-29 东北林业大学 喜树碱衍生物、其制备方法和用途
US8691284B2 (en) 2011-07-07 2014-04-08 Empire Technology Development Llc Fluorinated block co-polymers
CN103874722B (zh) 2011-09-11 2016-06-29 日本化药株式会社 嵌段共聚物的制造方法
US8383093B1 (en) 2011-11-01 2013-02-26 Serina Therapeutics, Inc. Subcutaneous delivery of poly(oxazoline) conjugates
WO2013151537A1 (en) 2012-04-03 2013-10-10 Empire Technology Development Llc Biocompatible adhesive polymers
EP2989116A4 (en) * 2013-04-26 2017-01-18 Nitto Denko Corporation Reduction of endotoxins from polyanionic polymer conjugates
KR101507119B1 (ko) * 2013-05-31 2015-03-30 주식회사 바이오리더스 점막 점착성 폴리감마글루탐산 나노마이셀 및 이를 이용한 약물 전달체
CN106267227A (zh) * 2016-08-12 2017-01-04 北京蓝贝望生物医药科技股份有限公司 抗肿瘤药物
CN106750272B (zh) * 2016-12-05 2019-05-28 福建卫生职业技术学院 一种水溶性蛇葡萄素聚合物
CN110123748A (zh) * 2019-04-22 2019-08-16 南京师范大学 一种叶酸介导的靶向双载药聚合物胶束及其制备方法和应用
CN113773282A (zh) * 2021-09-22 2021-12-10 无锡紫杉药业有限公司 一种10-乙酰紫杉醇的制备方法

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WO1997033552A1 (en) * 1996-03-12 1997-09-18 Pg-Txl Company, L.P. Water soluble paclitaxel prodrugs
WO1999049901A1 (en) * 1998-03-30 1999-10-07 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives

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Patent Citations (2)

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WO1997033552A1 (en) * 1996-03-12 1997-09-18 Pg-Txl Company, L.P. Water soluble paclitaxel prodrugs
WO1999049901A1 (en) * 1998-03-30 1999-10-07 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives

Non-Patent Citations (1)

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Title
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Also Published As

Publication number Publication date
KR100821437B1 (ko) 2008-04-10
CN1607962A (zh) 2005-04-20
CA2387611A1 (en) 2001-04-19
ZA200202695B (en) 2004-02-25
MXPA02003719A (es) 2002-08-30
WO2001026693A2 (en) 2001-04-19
CN101507820A (zh) 2009-08-19
US20030224971A1 (en) 2003-12-04
WO2001026693A3 (en) 2001-12-27
CA2387611C (en) 2011-03-29
BRPI0014652B1 (pt) 2016-08-09
NO20021701D0 (no) 2002-04-11
AU1079301A (en) 2001-04-23
PL354623A1 (en) 2004-02-09
HUP0203123A2 (hu) 2003-01-28
BR0014652A (pt) 2003-06-10
US20020077279A1 (en) 2002-06-20
HUP0203123A3 (en) 2004-12-28
KR20020059616A (ko) 2002-07-13
NO20021701L (no) 2002-05-23
EP1466627A1 (en) 2004-10-13
SG147286A1 (en) 2008-11-28
NZ529789A (en) 2005-04-29
JP2003511423A (ja) 2003-03-25
EP1225917A2 (en) 2002-07-31
US7399860B2 (en) 2008-07-15

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