CN1564820A - 用于治疗泌尿道疾病的杂环化合物 - Google Patents

用于治疗泌尿道疾病的杂环化合物 Download PDF

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Publication number
CN1564820A
CN1564820A CNA028197283A CN02819728A CN1564820A CN 1564820 A CN1564820 A CN 1564820A CN A028197283 A CNA028197283 A CN A028197283A CN 02819728 A CN02819728 A CN 02819728A CN 1564820 A CN1564820 A CN 1564820A
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ylmethyl
tetrahydroquinoline
piperazine
carbonyl
indyl
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CNA028197283A
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English (en)
Chinese (zh)
Inventor
A·利奥纳迪
G·莫塔
C·利瓦
R·泰斯塔
J·W·科贝特
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Recordati Ireland Ltd
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Recordati Industria Chimica e Farmaceutica SpA
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Publication of CN1564820A publication Critical patent/CN1564820A/zh
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
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  • Biomedical Technology (AREA)
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  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Quinoline Compounds (AREA)
CNA028197283A 2001-10-05 2002-10-07 用于治疗泌尿道疾病的杂环化合物 Pending CN1564820A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2001A002060 2001-10-05
IT2001MI002060A ITMI20012060A1 (it) 2001-10-05 2001-10-05 Nuovi eterocilcli n-acilati

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CN1564820A true CN1564820A (zh) 2005-01-12

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US (2) US20030181446A1 (https=)
EP (1) EP1432701B1 (https=)
JP (1) JP2005508952A (https=)
KR (1) KR20040048930A (https=)
CN (1) CN1564820A (https=)
AP (1) AP1705A (https=)
AR (1) AR036743A1 (https=)
AT (1) ATE313540T1 (https=)
AU (1) AU2002346979B9 (https=)
BR (1) BR0213067A (https=)
CA (1) CA2458456A1 (https=)
CO (1) CO5570679A2 (https=)
CY (1) CY1104991T1 (https=)
DE (1) DE60208221T2 (https=)
DK (1) DK1432701T3 (https=)
EA (1) EA200400507A1 (https=)
EC (1) ECSP045095A (https=)
ES (1) ES2253568T3 (https=)
HR (1) HRP20040392A2 (https=)
HU (1) HUP0401598A2 (https=)
IT (1) ITMI20012060A1 (https=)
MA (1) MA27067A1 (https=)
MX (1) MXPA04002962A (https=)
NO (1) NO20041833L (https=)
NZ (1) NZ532511A (https=)
OA (1) OA12663A (https=)
PL (1) PL369763A1 (https=)
SI (1) SI1432701T1 (https=)
TN (1) TNSN04053A1 (https=)
WO (1) WO2003031436A1 (https=)
YU (1) YU27204A (https=)
ZA (1) ZA200403356B (https=)

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Publication number Priority date Publication date Assignee Title
CN103249718A (zh) * 2010-12-17 2013-08-14 莱雅公司 4-氨基吲哚衍生物及其用于使角蛋白纤维氧化染色的用途
CN105555768A (zh) * 2013-09-20 2016-05-04 百时美施贵宝公司 RORγ调节剂
CN108299397A (zh) * 2018-03-21 2018-07-20 佳木斯大学附属第医院 一种用于降血压的活性药物及其制备方法
CN109069869A (zh) * 2015-12-09 2018-12-21 帕德罗科治疗公司 双环pad4抑制剂

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AR035521A1 (es) * 2000-12-22 2004-06-02 Lundbeck & Co As H Derivados de 3-indolina y composicion farmaceutica que los comprende
ATE424825T1 (de) 2001-07-20 2009-03-15 Psychogenics Inc Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
ITMI20012060A1 (it) * 2001-10-05 2003-04-05 Recordati Chem Pharm Nuovi eterocilcli n-acilati
US20040058962A1 (en) * 2002-06-14 2004-03-25 Amedeo Leonardi Phenylalkylamines and pyridylalkylamines
US20040215284A1 (en) * 2003-01-30 2004-10-28 Recordati S.A. Treatment of neuromuscular dysfunction of the lower urinary tract with selective mGlu5 antagonists
UY28538A1 (es) * 2003-09-26 2005-04-29 Vertex Pharma Derivados de fenil-piperazina como moduladores de receptores muscarínicos
RU2006124559A (ru) * 2003-12-09 2008-01-20 Вертекс Фармасьютикалз Инкорпорейтед (Us) Производные нафтиридина и применение указанных производныхых в качестве модуляторов мускариновых рецепторов
US20050165025A1 (en) * 2004-01-22 2005-07-28 Recordati Ireland Ltd. Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists
US7553967B2 (en) * 2004-03-12 2009-06-30 Wyeth 1,2-Dihydroquinoline derivatives and method for using the same to treat HIV infections
US7538113B2 (en) 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7534796B2 (en) 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US7582634B2 (en) 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7531542B2 (en) 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
DE102005027168A1 (de) * 2005-06-13 2006-12-14 Merck Patent Gmbh Tetrahydrochinoline
CA2651942A1 (en) 2006-05-11 2008-07-03 Janssen Pharmaceutica N.V. 1,2,3,4-tetrahydro-quinoline derivatives as cetp inhibitors
JP2009536954A (ja) 2006-05-11 2009-10-22 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｃｅｔｐ阻害剤としての３，４−ジヒドロ−２ｈ−ベンゾ［１，４］オキサジンおよびチアジン誘導体
FR2902790A1 (fr) * 2006-06-27 2007-12-28 Sanofi Aventis Sa Derives d'urees de piperidine ou pyrrolidine,leur preparation et leur application en therapeutique
PE20080212A1 (es) 2006-06-27 2008-04-25 Sanofi Aventis Derivados de ureas de piperidina o pirrolidina como moduladores de la 11b-hidroxiesteroide deshidrogenasa tipo 1 (11bhsd1)
TW200811170A (en) 2006-06-27 2008-03-01 Sanofi Aventis Urea derivatives of tropane, their preparation and their therapeutic application
CA2658098A1 (en) 2006-07-19 2008-01-24 Osurf Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof
CN101801965B (zh) * 2007-08-17 2014-07-30 株式会社Lg生命科学 作为细胞坏死抑制剂的吲哚化合物
CA2722340A1 (en) * 2008-04-24 2009-10-29 Marc Diamond Small-molecule inhibitors of the androgen receptor
JP6407285B2 (ja) 2013-09-09 2018-10-17 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ＲＯＲγ調節因子
US20250313569A1 (en) * 2024-04-09 2025-10-09 Enanta Pharmaceuticals, Inc. Pharmaceutical Compounds And Compositions As Modulators Of MAS-Related G-Protein Receptor X2

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CN103249718A (zh) * 2010-12-17 2013-08-14 莱雅公司 4-氨基吲哚衍生物及其用于使角蛋白纤维氧化染色的用途
CN103249718B (zh) * 2010-12-17 2017-01-18 莱雅公司 4‑氨基吲哚衍生物及其用于使角蛋白纤维氧化染色的用途
CN105555768A (zh) * 2013-09-20 2016-05-04 百时美施贵宝公司 RORγ调节剂
CN105555768B (zh) * 2013-09-20 2018-10-16 百时美施贵宝公司 RORγ调节剂
CN109069869A (zh) * 2015-12-09 2018-12-21 帕德罗科治疗公司 双环pad4抑制剂
CN108299397A (zh) * 2018-03-21 2018-07-20 佳木斯大学附属第医院 一种用于降血压的活性药物及其制备方法
CN108299397B (zh) * 2018-03-21 2019-01-29 佳木斯大学附属第一医院 一种用于降血压的活性药物及其制备方法

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