ITMI20012060A1 - Nuovi eterocilcli n-acilati - Google Patents

Nuovi eterocilcli n-acilati Download PDF

Info

Publication number
ITMI20012060A1
ITMI20012060A1 IT2001MI002060A ITMI20012060A ITMI20012060A1 IT MI20012060 A1 ITMI20012060 A1 IT MI20012060A1 IT 2001MI002060 A IT2001MI002060 A IT 2001MI002060A IT MI20012060 A ITMI20012060 A IT MI20012060A IT MI20012060 A1 ITMI20012060 A1 IT MI20012060A1
Authority
IT
Italy
Prior art keywords
compounds
substituted
compound
group
piperazine
Prior art date
Application number
IT2001MI002060A
Other languages
English (en)
Italian (it)
Inventor
Amedeo Leonardi
Daniela Barlocco
Gianni Motta
Carlo Riva
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Priority to IT2001MI002060A priority Critical patent/ITMI20012060A1/it
Priority to ARP020103760A priority patent/AR036743A1/es
Priority to EA200400507A priority patent/EA200400507A1/ru
Priority to APAP/P/2004/002997A priority patent/AP1705A/en
Priority to HU0401598A priority patent/HUP0401598A2/hu
Priority to CA002458456A priority patent/CA2458456A1/en
Priority to SI200230244T priority patent/SI1432701T1/sl
Priority to DK02782863T priority patent/DK1432701T3/da
Priority to AT02782863T priority patent/ATE313540T1/de
Priority to MXPA04002962A priority patent/MXPA04002962A/es
Priority to PCT/EP2002/011282 priority patent/WO2003031436A1/en
Priority to KR10-2004-7004948A priority patent/KR20040048930A/ko
Priority to PL02369763A priority patent/PL369763A1/xx
Priority to YU27204A priority patent/YU27204A/sh
Priority to OA1200400088A priority patent/OA12663A/en
Priority to EP02782863A priority patent/EP1432701B1/en
Priority to US10/266,088 priority patent/US20030181446A1/en
Priority to HR20040392A priority patent/HRP20040392A2/hr
Priority to CNA028197283A priority patent/CN1564820A/zh
Priority to HK04107812.7A priority patent/HK1067362B/en
Priority to US10/266,104 priority patent/US20030162777A1/en
Priority to BR0213067-0A priority patent/BR0213067A/pt
Priority to NZ532511A priority patent/NZ532511A/en
Priority to ES02782863T priority patent/ES2253568T3/es
Priority to AU2002346979A priority patent/AU2002346979B9/en
Priority to DE60208221T priority patent/DE60208221T2/de
Priority to JP2003534419A priority patent/JP2005508952A/ja
Publication of ITMI20012060A1 publication Critical patent/ITMI20012060A1/it
Priority to MA27571A priority patent/MA27067A1/fr
Priority to TNP2004000053A priority patent/TNSN04053A1/en
Priority to CO04040886A priority patent/CO5570679A2/es
Priority to NO20041833A priority patent/NO20041833L/no
Priority to ZA200403356A priority patent/ZA200403356B/en
Priority to EC2004005095A priority patent/ECSP045095A/es
Priority to CY20061100304T priority patent/CY1104991T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IT2001MI002060A 2001-10-05 2001-10-05 Nuovi eterocilcli n-acilati ITMI20012060A1 (it)

Priority Applications (34)

Application Number Priority Date Filing Date Title
IT2001MI002060A ITMI20012060A1 (it) 2001-10-05 2001-10-05 Nuovi eterocilcli n-acilati
ARP020103760A AR036743A1 (es) 2001-10-05 2002-10-04 Compuestos heterociclicos para el uso en el tratamiento de los trastornos de las vias urinarias
HR20040392A HRP20040392A2 (en) 2001-10-05 2002-10-07 Heterocyclic compounds for use in the treatment of disorders of the urinary tract
CNA028197283A CN1564820A (zh) 2001-10-05 2002-10-07 用于治疗泌尿道疾病的杂环化合物
HU0401598A HUP0401598A2 (hu) 2001-10-05 2002-10-07 Heterogyűrűs vegyületek a vizeletvezető rendszer rendellenességeinek kezelésében való használatra, és ezeket tartalmazó gyógyszerkészítmények
CA002458456A CA2458456A1 (en) 2001-10-05 2002-10-07 Heterocyclic compounds for use in the treatment of disorders of the urinary tract
SI200230244T SI1432701T1 (sl) 2001-10-05 2002-10-07 Uporaba heterociklicnih spojin pri zdravljenju bolezni urinarnega trakta
DK02782863T DK1432701T3 (da) 2001-10-05 2002-10-07 Heterocycliske forbindelser til anvendelse ved behandlingen af lidelser i urinvejene
AT02782863T ATE313540T1 (de) 2001-10-05 2002-10-07 Heterozyklische verbindungen zur behandlung von harnwegserkrankungen
MXPA04002962A MXPA04002962A (es) 2001-10-05 2002-10-07 Compuestos heterociclicos para el uso en el tratamiento de los trastornos de las vias urinarias.
PCT/EP2002/011282 WO2003031436A1 (en) 2001-10-05 2002-10-07 Heterocyclic compounds for use in the treatment of disorders of the urinary tract
KR10-2004-7004948A KR20040048930A (ko) 2001-10-05 2002-10-07 요로장애 치료 용도를 위한 헤테로시클릭 화합물
PL02369763A PL369763A1 (en) 2001-10-05 2002-10-07 Heterocyclic compounds for use in the treatment of disorders of the urinary tract
YU27204A YU27204A (sh) 2001-10-05 2002-10-07 Heterociklična jedinjenja koja se upotrebljavaju u tretmanu poremećaja urinarnog trakta
OA1200400088A OA12663A (en) 2001-10-05 2002-10-07 Heterocyclic compounds for use in the treatment ofdisorders of the urinary tract.
EP02782863A EP1432701B1 (en) 2001-10-05 2002-10-07 Heterocyclic compounds for use in the treatment of disorders of the urinary tract
US10/266,088 US20030181446A1 (en) 2001-10-05 2002-10-07 Novel N-acylated heterocycles
EA200400507A EA200400507A1 (ru) 2001-10-05 2002-10-07 Гетероциклические соединения для лечения заболеваний мочевых путей
US10/266,104 US20030162777A1 (en) 2001-10-05 2002-10-07 Novel N-acylated heterocycles
APAP/P/2004/002997A AP1705A (en) 2001-10-05 2002-10-07 Heterocyclic compounds for use in the treatment of disorders of the urinary tract
HK04107812.7A HK1067362B (en) 2001-10-05 2002-10-07 Heterocyclic compounds for use in the treatment of disorders of the urinary tract
BR0213067-0A BR0213067A (pt) 2001-10-05 2002-10-07 Compostos heterocìclicos para uso no tratamento de desordens do trato urinário
NZ532511A NZ532511A (en) 2001-10-05 2002-10-07 Heterocyclic compounds for use in the treatment of disorders of the urinary tract
ES02782863T ES2253568T3 (es) 2001-10-05 2002-10-07 Compuestos heterociclicos para el uso en el tratamiento de los trastornos de las vias urinarias.
AU2002346979A AU2002346979B9 (en) 2001-10-05 2002-10-07 Heterocyclic compounds for use in the treatment of disorders of the urinary tract
DE60208221T DE60208221T2 (de) 2001-10-05 2002-10-07 Heterozyklische verbindungen zur behandlung von harnwegserkrankungen
JP2003534419A JP2005508952A (ja) 2001-10-05 2002-10-07 尿路障害の処置における使用のためのヘテロ環式化合物
MA27571A MA27067A1 (fr) 2001-10-05 2004-03-11 Composes heterocycliques pour l'utilisation dans le traitement des maladies de l'appareil urinaire
TNP2004000053A TNSN04053A1 (en) 2001-10-05 2004-04-02 Heterocyclic compounds for use in the treatment of disorders of the urinary tract
CO04040886A CO5570679A2 (es) 2001-10-05 2004-05-04 Compuestos heterociclicos para el uso en el tratamiento de los transtornos de las vias urinarias
NO20041833A NO20041833L (no) 2001-10-05 2004-05-04 Heterocykliske forbindelser for anvendelse i behandlingen av forstyrrelser i urinveissystemet
ZA200403356A ZA200403356B (en) 2001-10-05 2004-05-04 Heterocyclic compounds for use in the treatment of disorders of the urinary tract.
EC2004005095A ECSP045095A (es) 2001-10-05 2004-05-05 COMPUESTOS HETEROCÍCLICOS PARA EL USO EN EL TRATAMIENTO DE LOS TRASTORNOS DE LAS VíAS URINARIAS
CY20061100304T CY1104991T1 (el) 2001-10-05 2006-03-03 Ετεροκυκλικες ενωσεις για χρηση στην αγωγη διαταραχων της ουροποιητικης οδου

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2001MI002060A ITMI20012060A1 (it) 2001-10-05 2001-10-05 Nuovi eterocilcli n-acilati

Publications (1)

Publication Number Publication Date
ITMI20012060A1 true ITMI20012060A1 (it) 2003-04-05

Family

ID=11448476

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2001MI002060A ITMI20012060A1 (it) 2001-10-05 2001-10-05 Nuovi eterocilcli n-acilati

Country Status (32)

Country Link
US (2) US20030181446A1 (https=)
EP (1) EP1432701B1 (https=)
JP (1) JP2005508952A (https=)
KR (1) KR20040048930A (https=)
CN (1) CN1564820A (https=)
AP (1) AP1705A (https=)
AR (1) AR036743A1 (https=)
AT (1) ATE313540T1 (https=)
AU (1) AU2002346979B9 (https=)
BR (1) BR0213067A (https=)
CA (1) CA2458456A1 (https=)
CO (1) CO5570679A2 (https=)
CY (1) CY1104991T1 (https=)
DE (1) DE60208221T2 (https=)
DK (1) DK1432701T3 (https=)
EA (1) EA200400507A1 (https=)
EC (1) ECSP045095A (https=)
ES (1) ES2253568T3 (https=)
HR (1) HRP20040392A2 (https=)
HU (1) HUP0401598A2 (https=)
IT (1) ITMI20012060A1 (https=)
MA (1) MA27067A1 (https=)
MX (1) MXPA04002962A (https=)
NO (1) NO20041833L (https=)
NZ (1) NZ532511A (https=)
OA (1) OA12663A (https=)
PL (1) PL369763A1 (https=)
SI (1) SI1432701T1 (https=)
TN (1) TNSN04053A1 (https=)
WO (1) WO2003031436A1 (https=)
YU (1) YU27204A (https=)
ZA (1) ZA200403356B (https=)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR035521A1 (es) * 2000-12-22 2004-06-02 Lundbeck & Co As H Derivados de 3-indolina y composicion farmaceutica que los comprende
ES2323451T7 (es) 2001-07-20 2011-08-01 Psychogenics Inc. Tratamiento para el trastorno de hiperactividad con deficit de atencion.
ITMI20012060A1 (it) * 2001-10-05 2003-04-05 Recordati Chem Pharm Nuovi eterocilcli n-acilati
US20040058962A1 (en) * 2002-06-14 2004-03-25 Amedeo Leonardi Phenylalkylamines and pyridylalkylamines
US20040215284A1 (en) * 2003-01-30 2004-10-28 Recordati S.A. Treatment of neuromuscular dysfunction of the lower urinary tract with selective mGlu5 antagonists
AR047759A1 (es) * 2003-09-26 2006-02-22 Vertex Pharma Derivados de fenil - piperazina como moduladores de receptores muscarnicos
CN1914204A (zh) * 2003-12-09 2007-02-14 弗特克斯药品有限公司 萘啶衍生物及其作为毒蕈碱性受体调节剂的用途
US20050165025A1 (en) * 2004-01-22 2005-07-28 Recordati Ireland Ltd. Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists
US7553967B2 (en) * 2004-03-12 2009-06-30 Wyeth 1,2-Dihydroquinoline derivatives and method for using the same to treat HIV infections
US7534796B2 (en) 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US7538113B2 (en) 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7582634B2 (en) 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7531542B2 (en) 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
DE102005027168A1 (de) * 2005-06-13 2006-12-14 Merck Patent Gmbh Tetrahydrochinoline
US7749995B2 (en) 2006-05-11 2010-07-06 Janssen Pharmaceutica Nv 3,4-dihydro-2h-benzo[1,4]oxazine and thiazine derivatives as CETP inhibitors
EP2034998A1 (en) 2006-05-11 2009-03-18 Janssen Pharmaceutica, N.V. 1,2,3,4-tetrahydro-quinoline derivatives as cetp inhibitors
TW200811158A (en) * 2006-06-27 2008-03-01 Sanofi Aventis Piperidine or pyrrolidine urea derivatives, their preparation and their therapeutic application
TW200811170A (en) 2006-06-27 2008-03-01 Sanofi Aventis Urea derivatives of tropane, their preparation and their therapeutic application
FR2902790A1 (fr) * 2006-06-27 2007-12-28 Sanofi Aventis Sa Derives d'urees de piperidine ou pyrrolidine,leur preparation et leur application en therapeutique
BRPI0713198A2 (pt) 2006-07-19 2012-10-16 Osurf Ohio State University Res Foundation modulares seletivos de receptores de androgênio, seus análogos e derivados, e seus usos
DK2178870T3 (en) * 2007-08-17 2018-10-22 Lg Chemical Ltd INDOLE AND INDAZOLIC COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSE
CA2722340A1 (en) * 2008-04-24 2009-10-29 Marc Diamond Small-molecule inhibitors of the androgen receptor
FR2969151B1 (fr) * 2010-12-17 2016-11-04 Oreal Derives du 4-amino et leur utilisation pour la coloration d'oxydation des fibres keratiniques.
JP6407285B2 (ja) 2013-09-09 2018-10-17 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ＲＯＲγ調節因子
JP6397488B2 (ja) 2013-09-20 2018-09-26 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ＲＯＲγ調節因子
AR107032A1 (es) * 2015-12-09 2018-03-14 Padlock Therapeutics Inc Inhibidores bicíclicos de pad4
CN108299397B (zh) * 2018-03-21 2019-01-29 佳木斯大学附属第一医院 一种用于降血压的活性药物及其制备方法
WO2025217141A1 (en) * 2024-04-09 2025-10-16 Enanta Pharmaceuticals, Inc. Pharmaceutical compounds and compositions as modulators of mas-related g-protein receptor x2

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1027611A (en) * 1962-01-04 1966-04-27 May & Baker Ltd Phenoxy- and phenylthio-alkylamines and acid addition salts thereof
GB1166538A (en) * 1967-06-10 1969-10-08 Pfizer Ltd Substituted Tetrahydroquinolines
US3983121A (en) * 1974-07-01 1976-09-28 Council Of Scientific And Industrial Research 1-Substituted 4-(β-2-quinolylethyl)piperazines and 1,2,3,4-tetrahydroquinolyl-ethyl analogues thereof
US4011324A (en) * 1976-01-20 1977-03-08 Pfizer Inc. Esters and amides of pyrimido[4,5-b]quinolin-4(3H)-one-2-carboxylic acids as antiulcer agents
US4461896A (en) * 1979-02-07 1984-07-24 Norwich Eaton Pharmaceuticals, Inc. 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids
CH653021A5 (fr) * 1981-04-24 1985-12-13 Delalande Sa Derives piperidino, piperazino et homopiperazino, n-substitues par un groupe heterocyclique aromatique, leur procede de preparation et composition therapeutique les contenant.
US4585773A (en) * 1984-07-11 1986-04-29 Bristol-Myers Company Isoindolinyl-alkyl-piperazines
EP0189612B1 (en) * 1984-12-21 1992-11-04 Duphar International Research B.V New pharmaceutical compositions having a psychotropic activity
US4831031A (en) * 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
US5641504A (en) * 1988-06-09 1997-06-24 Alza Corporation Skin permeation enhancer compositions using glycerol monolinoleate
IE920040A1 (en) * 1991-01-09 1992-07-15 Alza Corp Bioerodible devices and compositions for diffusional release¹of agents
US5443459A (en) * 1991-01-30 1995-08-22 Alza Corporation Osmotic device for delayed delivery of agent
JPH05117276A (ja) * 1991-10-23 1993-05-14 Sumitomo Pharmaceut Co Ltd 新規な３環性キノキサリンジオン誘導体
US5629019A (en) * 1992-02-27 1997-05-13 Alza Corporation Formulations with hydrophobic permeation enhancers
ZA933349B (en) * 1992-05-13 1994-06-15 Alza Corp Transdermal administration of oxybutynin
US5512293A (en) * 1992-07-23 1996-04-30 Alza Corporation Oral sustained release drug delivery device
US5573776A (en) * 1992-12-02 1996-11-12 Alza Corporation Oral osmotic device with hydrogel driving member
US5533971A (en) * 1993-09-03 1996-07-09 Alza Corporation Reduction of skin irritation during electrotransport
IT1270993B (it) * 1994-03-18 1997-05-26 Recordati Chem Pharm Derivati chinzolilamminici attivi come alfa-antagonisti
FR2729144A1 (fr) * 1995-01-06 1996-07-12 Smithkline Beecham Lab Nouvelles diamines, leur procede de preparation et leur utilisation en tant que medicaments et notamment en tant qu' agents anti-arythmiques
US5859014A (en) * 1995-06-09 1999-01-12 Syntex (U.S.A.) Inc. Pyrimidinedione, pyrimidinetrione, triazinedione and tetrahydroquinazolinedione derivatives as α1 -adrenergic receptor antagonists
US5780058A (en) * 1995-07-21 1998-07-14 Alza Corporation Oral delivery of discrete units
US6096339A (en) * 1997-04-04 2000-08-01 Alza Corporation Dosage form, process of making and using same
EP0882717B1 (en) * 1996-10-01 2010-09-08 Kyowa Hakko Kirin Co., Ltd. Nitrogenous heterocyclic compounds
CA2220649C (en) * 1996-12-03 2007-02-13 F. Hoffmann-La Roche Ag 4-hydroxy-piperidine derivatives
EP0846683B1 (en) * 1996-12-03 2001-09-19 F. Hoffmann-La Roche Ag 4-Hydroxy-piperidine derivatives
US6281227B1 (en) * 1996-12-13 2001-08-28 Aventis Pharma Deutschland Gmbh Sulfonic acid sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds
JP4642946B2 (ja) * 1996-12-20 2011-03-02 アルザ コーポレイション ゲル組成物および方法
US6169086B1 (en) * 1997-01-27 2001-01-02 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivatives
IT1293804B1 (it) * 1997-08-01 1999-03-10 Recordati Chem Pharm Diarilalchilpiperazine attive sulle basse vie urinarie
JP2001512110A (ja) * 1997-08-01 2001-08-21 レコルダチ エッセ．ア．，ケミカル アンド ファーマシューティカル カンパニー １，４−ジ置換ピペラジン
US6039977A (en) * 1997-12-09 2000-03-21 Alza Corporation Pharmaceutical hydrogel formulations, and associated drug delivery devices and methods
BR9909146A (pt) * 1998-03-26 2000-12-05 Shionogi & Co Derivados de indol apresentando uma atividade antiviral
US6174547B1 (en) * 1999-07-14 2001-01-16 Alza Corporation Dosage form comprising liquid formulation
US6306861B1 (en) * 1999-07-30 2001-10-23 Recordati S.A. Chemical And Pharmaceutical Company Thienopyrancecarboxamide derivatives
US6365591B1 (en) * 1999-10-18 2002-04-02 Recordati, S.A., Chemical And Pharmacueticals Company Isoxazolecarboxamide derivatives
US6403594B1 (en) * 1999-10-18 2002-06-11 Recordati, S.A. Chemical And Pharmaceutical Company Benzopyran derivatives
AR035521A1 (es) * 2000-12-22 2004-06-02 Lundbeck & Co As H Derivados de 3-indolina y composicion farmaceutica que los comprende
US20030060513A1 (en) * 2001-09-27 2003-03-27 Arneric Stephen P. Pharmaceutical composition
ITMI20012060A1 (it) * 2001-10-05 2003-04-05 Recordati Chem Pharm Nuovi eterocilcli n-acilati

Also Published As

Publication number Publication date
AR036743A1 (es) 2004-09-29
ZA200403356B (en) 2004-11-08
AU2002346979B9 (en) 2006-03-02
DE60208221T2 (de) 2006-08-03
EP1432701B1 (en) 2005-12-21
MXPA04002962A (es) 2005-06-20
CA2458456A1 (en) 2003-04-17
OA12663A (en) 2006-06-19
JP2005508952A (ja) 2005-04-07
NO20041833L (no) 2004-07-05
ATE313540T1 (de) 2006-01-15
DE60208221D1 (de) 2006-01-26
EA200400507A1 (ru) 2004-10-28
NZ532511A (en) 2005-10-28
HUP0401598A2 (hu) 2004-12-28
HK1067362A1 (en) 2005-04-08
ECSP045095A (es) 2004-08-27
ES2253568T3 (es) 2006-06-01
CY1104991T1 (el) 2010-03-03
US20030162777A1 (en) 2003-08-28
DK1432701T3 (da) 2006-05-08
CN1564820A (zh) 2005-01-12
MA27067A1 (fr) 2004-12-20
YU27204A (sh) 2006-08-17
US20030181446A1 (en) 2003-09-25
HRP20040392A2 (en) 2004-10-31
WO2003031436A1 (en) 2003-04-17
AP1705A (en) 2007-01-02
TNSN04053A1 (en) 2006-06-01
AU2002346979B2 (en) 2005-09-29
KR20040048930A (ko) 2004-06-10
WO2003031436A8 (en) 2004-05-27
BR0213067A (pt) 2004-09-28
EP1432701A1 (en) 2004-06-30
PL369763A1 (en) 2005-05-02
AP2004002997A0 (en) 2004-03-31
CO5570679A2 (es) 2005-10-31
SI1432701T1 (sl) 2006-04-30

Similar Documents

Publication Publication Date Title
ITMI20012060A1 (it) Nuovi eterocilcli n-acilati
US5804588A (en) Quinoline carboxanides and their therapeutic use
US7166617B2 (en) Cyclic amide derivatives
DE60212841T2 (de) 4 piperazinylindolderivate mit affinität zum 5-ht6-rezeptor
US8173639B2 (en) Isoquinolinone derivatives as NK3 antagonists
AU2002346979A1 (en) Heterocyclic compounds for use in the treatment of disorders of the urinary tract
JPH08109169A (ja) 非ペプチドタキキニン受容体拮抗物質
WO1999048492A1 (en) Amide derivatives and nociceptin antagonists
WO1996011929A1 (en) Biheteroaryl-carbonyl and carboxamide derivatives with 5ht 2c/2b antagonists activity
KR20190130573A (ko) 칼슘 채널 억제제
US5576336A (en) Indole derivatives as dopamine D4 antagonists
KR20030022421A (ko) 알파-1 아드레날린성 길항제로서 퀴나졸린 유도체
CA2367681A1 (en) Azaindole derivatives for the treatment of depression
JP2004525967A (ja) Ｏｒｌ−１受容体介在障害の治療に有用な１，３，８−トリアザスピロ［４．５］デカン−４−オン誘導体
KR101463190B1 (ko) ５­ｈｔ６ 수용체 리간드인 술폰 화합물
JP5747910B2 (ja) ベンゾアゼピン化合物
US7998981B2 (en) Aminoaryl sulphonamide derivatives as functional 5-HT6 ligands
JPWO2006082872A1 (ja) １−（ピペリジン−４−イル）−１ｈ−インドール誘導体
EP2150534B1 (en) Isoquinolinone derivatives as nk3 antagonists
WO2009034581A1 (en) Substituted indolyl compounds and their use as 5-ht6 ligands
KR20080044273A (ko) 아실구아니딘 유도체 또는 그의 염
US20020193383A1 (en) 1-(N-phenylalkylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
WO2003106421A2 (en) Phenylalkylamines and pyridylalkylamines
SK137597A3 (en) 1-£'omega'-(3,4-dihydro-2-naphthalenyl)alkyl| cyclic amine derivatives, process for producing the same, and medicinal composition containing the same
US20040058962A1 (en) Phenylalkylamines and pyridylalkylamines