CN1483466A - 头花蓼提取物及其药物组合物制剂 - Google Patents
头花蓼提取物及其药物组合物制剂 Download PDFInfo
- Publication number
- CN1483466A CN1483466A CNA031463819A CN03146381A CN1483466A CN 1483466 A CN1483466 A CN 1483466A CN A031463819 A CNA031463819 A CN A031463819A CN 03146381 A CN03146381 A CN 03146381A CN 1483466 A CN1483466 A CN 1483466A
- Authority
- CN
- China
- Prior art keywords
- extract
- herba polygoni
- polygoni capitati
- water
- stem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000284 extract Substances 0.000 title claims abstract description 91
- 239000000203 mixture Substances 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title abstract description 26
- 241000764065 Persicaria capitata Species 0.000 title abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 54
- 238000000034 method Methods 0.000 claims abstract description 34
- 206010037596 Pyelonephritis Diseases 0.000 claims abstract description 8
- 238000000194 supercritical-fluid extraction Methods 0.000 claims abstract description 7
- 238000000605 extraction Methods 0.000 claims description 37
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 22
- 238000001035 drying Methods 0.000 claims description 18
- 238000001694 spray drying Methods 0.000 claims description 12
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 8
- 238000010992 reflux Methods 0.000 claims description 8
- 208000004880 Polyuria Diseases 0.000 claims description 7
- 230000035619 diuresis Effects 0.000 claims description 7
- 230000003115 biocidal effect Effects 0.000 claims description 6
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 4
- 239000001569 carbon dioxide Substances 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 230000036592 analgesia Effects 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 235000013305 food Nutrition 0.000 claims description 3
- 201000007094 prostatitis Diseases 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims 2
- 241001377695 Polygonum arenastrum Species 0.000 claims 1
- 235000006386 Polygonum aviculare Nutrition 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 66
- 239000003814 drug Substances 0.000 abstract description 18
- 230000000694 effects Effects 0.000 abstract description 17
- 238000011160 research Methods 0.000 abstract description 12
- 241000196324 Embryophyta Species 0.000 abstract description 6
- 235000019441 ethanol Nutrition 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000843 powder Substances 0.000 description 52
- 239000000047 product Substances 0.000 description 30
- 241000588653 Neisseria Species 0.000 description 22
- 241000222122 Candida albicans Species 0.000 description 21
- 229940095731 candida albicans Drugs 0.000 description 21
- 238000012360 testing method Methods 0.000 description 17
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 16
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 15
- 230000000844 anti-bacterial effect Effects 0.000 description 13
- 238000002481 ethanol extraction Methods 0.000 description 13
- 239000000469 ethanolic extract Substances 0.000 description 13
- 238000002474 experimental method Methods 0.000 description 13
- 241000894006 Bacteria Species 0.000 description 11
- 238000004062 sedimentation Methods 0.000 description 11
- 241000191967 Staphylococcus aureus Species 0.000 description 10
- -1 and reflux Substances 0.000 description 9
- 229940079593 drug Drugs 0.000 description 9
- 229930003944 flavone Natural products 0.000 description 9
- 235000011949 flavones Nutrition 0.000 description 9
- 208000015181 infectious disease Diseases 0.000 description 9
- UFLHIIWVXFIJGU-ARJAWSKDSA-N (Z)-hex-3-en-1-ol Chemical compound CC\C=C/CCO UFLHIIWVXFIJGU-ARJAWSKDSA-N 0.000 description 8
- 241000699666 Mus <mouse, genus> Species 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 8
- 229940074391 gallic acid Drugs 0.000 description 8
- 235000004515 gallic acid Nutrition 0.000 description 8
- 239000008187 granular material Substances 0.000 description 8
- 238000000338 in vitro Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000013641 positive control Substances 0.000 description 6
- 230000008961 swelling Effects 0.000 description 6
- 241000193830 Bacillus <bacterium> Species 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 5
- 241000700159 Rattus Species 0.000 description 5
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 150000002212 flavone derivatives Chemical class 0.000 description 5
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 5
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 4
- 241001478240 Coccus Species 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 230000000202 analgesic effect Effects 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- 235000008504 concentrate Nutrition 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 150000002213 flavones Chemical class 0.000 description 4
- 241000411851 herbal medicine Species 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 4
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 4
- 235000005493 rutin Nutrition 0.000 description 4
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 4
- 229960004555 rutoside Drugs 0.000 description 4
- 210000002700 urine Anatomy 0.000 description 4
- 241000588747 Klebsiella pneumoniae Species 0.000 description 3
- 241000588769 Proteus <enterobacteria> Species 0.000 description 3
- 229910000831 Steel Inorganic materials 0.000 description 3
- 241000194017 Streptococcus Species 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 102000011759 adducin Human genes 0.000 description 3
- 108010076723 adducin Proteins 0.000 description 3
- QXDMQSPYEZFLGF-UHFFFAOYSA-L calcium oxalate Chemical compound [Ca+2].[O-]C(=O)C([O-])=O QXDMQSPYEZFLGF-UHFFFAOYSA-L 0.000 description 3
- 208000001848 dysentery Diseases 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 229960000890 hydrocortisone Drugs 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000012567 medical material Substances 0.000 description 3
- 230000036407 pain Effects 0.000 description 3
- 230000003285 pharmacodynamic effect Effects 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 230000001047 pyretic effect Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000010959 steel Substances 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 208000000913 Kidney Calculi Diseases 0.000 description 2
- 206010029148 Nephrolithiasis Diseases 0.000 description 2
- 241000205407 Polygonum Species 0.000 description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000000658 coextraction Methods 0.000 description 2
- 230000001351 cycling effect Effects 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 230000001882 diuretic effect Effects 0.000 description 2
- 239000000890 drug combination Substances 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000002458 infectious effect Effects 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241001480043 Arthrodermataceae Species 0.000 description 1
- 241000606124 Bacteroides fragilis Species 0.000 description 1
- 241000186427 Cutibacterium acnes Species 0.000 description 1
- 241001464975 Cutibacterium granulosum Species 0.000 description 1
- 241001360526 Escherichia coli ATCC 25922 Species 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000191992 Peptostreptococcus Species 0.000 description 1
- 241000219050 Polygonaceae Species 0.000 description 1
- 241000192023 Sarcina Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical compound ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 1
- 241000223238 Trichophyton Species 0.000 description 1
- 241001593750 Turcica Species 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 150000003851 azoles Chemical class 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000003245 coal Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 201000003146 cystitis Diseases 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 239000003405 delayed action preparation Substances 0.000 description 1
- 230000037304 dermatophytes Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 210000004349 growth plate Anatomy 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000008921 jie er yin Substances 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000015091 medicinal tea Nutrition 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- XEEVLJKYYUVTRC-UHFFFAOYSA-N oxomalonic acid Chemical compound OC(=O)C(=O)C(O)=O XEEVLJKYYUVTRC-UHFFFAOYSA-N 0.000 description 1
- 206010034674 peritonitis Diseases 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- ZFBGNQYKWSPQDQ-UHFFFAOYSA-N piperazine;sodium Chemical compound [Na].C1CNCCN1 ZFBGNQYKWSPQDQ-UHFFFAOYSA-N 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 229940055019 propionibacterium acne Drugs 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 201000002282 venous insufficiency Diseases 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (11)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 03146381 CN1219545C (zh) | 2002-07-12 | 2003-07-11 | 头花蓼提取物及其药物组合物制剂 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN02124153 | 2002-07-12 | ||
CN02124153.8 | 2002-07-12 | ||
CN 03146381 CN1219545C (zh) | 2002-07-12 | 2003-07-11 | 头花蓼提取物及其药物组合物制剂 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1483466A true CN1483466A (zh) | 2004-03-24 |
CN1219545C CN1219545C (zh) | 2005-09-21 |
Family
ID=34195375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 03146381 Expired - Lifetime CN1219545C (zh) | 2002-07-12 | 2003-07-11 | 头花蓼提取物及其药物组合物制剂 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1219545C (zh) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100535655C (zh) * | 2006-06-22 | 2009-09-02 | 成都中医药大学 | 头花蓼药材的检测方法 |
WO2011035734A1 (zh) * | 2009-09-28 | 2011-03-31 | 贵州威门药业股份有限公司 | 热淋清浸膏及其制备方法和用途 |
CN1947749B (zh) * | 2005-10-10 | 2012-02-22 | 山东轩竹医药科技有限公司 | 一种由头花蓼和茯苓制成的药物组合物 |
CN102526218A (zh) * | 2012-01-05 | 2012-07-04 | 贵州威门药业股份有限公司 | 制备头花蓼提取物的方法和头花蓼提取物 |
CN102526219A (zh) * | 2012-01-05 | 2012-07-04 | 贵州威门药业股份有限公司 | 热淋清颗粒提取物及其制备方法和用途 |
CN103536663A (zh) * | 2013-10-30 | 2014-01-29 | 浙江百草中药饮片有限公司 | 一种头花蓼降糖提取物片剂的制备方法 |
CN103550311A (zh) * | 2013-10-30 | 2014-02-05 | 浙江百草中药饮片有限公司 | 一种头花蓼提取物及其制备方法和应用 |
CN103550310A (zh) * | 2013-10-30 | 2014-02-05 | 浙江百草中药饮片有限公司 | 一种头花蓼降糖提取物口服液的制备方法 |
CN104224943A (zh) * | 2013-06-21 | 2014-12-24 | 北大方正集团有限公司 | 用于治疗慢性前列腺炎的中药组合物、制备方法和用途 |
CN105434555A (zh) * | 2015-12-30 | 2016-03-30 | 贵州弘康药业有限公司 | 一种热淋清制剂的制作方法 |
CN116726075A (zh) * | 2023-05-10 | 2023-09-12 | 贵州医科大学 | 苗药头花蓼提取物在制备治疗草酸钙肾结石药物中的应用 |
-
2003
- 2003-07-11 CN CN 03146381 patent/CN1219545C/zh not_active Expired - Lifetime
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1947749B (zh) * | 2005-10-10 | 2012-02-22 | 山东轩竹医药科技有限公司 | 一种由头花蓼和茯苓制成的药物组合物 |
CN100535655C (zh) * | 2006-06-22 | 2009-09-02 | 成都中医药大学 | 头花蓼药材的检测方法 |
WO2011035734A1 (zh) * | 2009-09-28 | 2011-03-31 | 贵州威门药业股份有限公司 | 热淋清浸膏及其制备方法和用途 |
CN102526218A (zh) * | 2012-01-05 | 2012-07-04 | 贵州威门药业股份有限公司 | 制备头花蓼提取物的方法和头花蓼提取物 |
CN102526219A (zh) * | 2012-01-05 | 2012-07-04 | 贵州威门药业股份有限公司 | 热淋清颗粒提取物及其制备方法和用途 |
CN102526219B (zh) * | 2012-01-05 | 2013-07-31 | 贵州威门药业股份有限公司 | 热淋清颗粒提取物及其制备方法和用途 |
CN104224943A (zh) * | 2013-06-21 | 2014-12-24 | 北大方正集团有限公司 | 用于治疗慢性前列腺炎的中药组合物、制备方法和用途 |
CN103550311A (zh) * | 2013-10-30 | 2014-02-05 | 浙江百草中药饮片有限公司 | 一种头花蓼提取物及其制备方法和应用 |
CN103550310A (zh) * | 2013-10-30 | 2014-02-05 | 浙江百草中药饮片有限公司 | 一种头花蓼降糖提取物口服液的制备方法 |
CN103536663A (zh) * | 2013-10-30 | 2014-01-29 | 浙江百草中药饮片有限公司 | 一种头花蓼降糖提取物片剂的制备方法 |
CN103550311B (zh) * | 2013-10-30 | 2015-08-19 | 浙江百草中药饮片有限公司 | 一种头花蓼提取物及其制备方法和应用 |
CN103550310B (zh) * | 2013-10-30 | 2015-08-19 | 浙江百草中药饮片有限公司 | 一种头花蓼降糖提取物口服液的制备方法 |
CN103536663B (zh) * | 2013-10-30 | 2015-08-19 | 浙江百草中药饮片有限公司 | 一种头花蓼降糖提取物片剂的制备方法 |
CN105434555A (zh) * | 2015-12-30 | 2016-03-30 | 贵州弘康药业有限公司 | 一种热淋清制剂的制作方法 |
CN116726075A (zh) * | 2023-05-10 | 2023-09-12 | 贵州医科大学 | 苗药头花蓼提取物在制备治疗草酸钙肾结石药物中的应用 |
Also Published As
Publication number | Publication date |
---|---|
CN1219545C (zh) | 2005-09-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1481832A (zh) | 头花蓼提取物及其制备方法和用途 | |
CN1850249A (zh) | 一种具有止咳平喘作用的组合物及其制备方法 | |
CN1483466A (zh) | 头花蓼提取物及其药物组合物制剂 | |
CN1762967A (zh) | 甘草次酸衍生物、制备方法及其用途 | |
CN1245198C (zh) | 一种治疗糖尿病的中药组合物及其制备方法 | |
CN1698709A (zh) | 一种复方黄芩制剂 | |
CN1957999A (zh) | 一种中药组合物及其制备方法和质量控制方法 | |
CN1827130A (zh) | 丹参、丹皮有效部位制备物及复方制备方法和医疗用途 | |
CN1679807A (zh) | 一种清热通淋的中药制剂及其制备方法 | |
CN1651041A (zh) | 姬松茸水溶性小分子提取物及其制备工艺和用途 | |
CN1201805C (zh) | 一种用于放化疗减毒增效的药物组合物及其制备方法 | |
CN1939414A (zh) | 一种具有抗菌消炎作用的药物组合物 | |
CN1650996A (zh) | 一种药物组合物及其制备方法和应用 | |
CN1535700A (zh) | 一种补血药物组合物 | |
CN1251677C (zh) | 一种以20(s)-原人参二醇为有效成分的抗癌辅助药物及应用 | |
CN1772122A (zh) | 一种具有消炎、解毒功效的了哥王制剂 | |
CN1947749A (zh) | 一种由头花蓼和茯苓制成的药物组合物 | |
CN1652805A (zh) | 一种用于治疗和改善支气管呼吸困难的草药组合物 | |
CN1207030C (zh) | 一种具有抗肿瘤、抗自由基损伤和调节免疫的天然生物反应调节剂 | |
CN1602945A (zh) | 通窍鼻炎软胶囊及其制备工艺 | |
CN1566136A (zh) | 白头翁总皂苷及提取方法,以及医药用途和药物制剂 | |
CN1857609A (zh) | 一种具有滋补保健作用的中药组合物及其制备方法 | |
CN1939412A (zh) | 一种由北豆根与新鱼腥草素钠制成的药物组合物 | |
CN1562144A (zh) | 治疗肠易激综合症的中药组合物及其制备方法 | |
CN1287835C (zh) | 一种治疗冠心病、心绞痛的药物组合物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Effective date of registration: 20081113 Pledge (preservation): Pledge |
|
C56 | Change in the name or address of the patentee | ||
CP02 | Change in the address of a patent holder |
Address after: Guizhou province Guiyang city Wudang District High Road No. 23 Patentee after: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Address before: Torch Avenue, industrial zone, Guiyang hi tech Development Zone, Guizhou, China Patentee before: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20101103 Granted publication date: 20050921 Pledgee: Agricultural Bank of China branch in Guiyang City Xinhua Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: 2008520000486 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Polygonum capitatum extract and medicinal composition preparation thereof Effective date of registration: 20101103 Granted publication date: 20050921 Pledgee: Agricultural Bank of China Limited by Share Ltd. Guiyang Xinhua Branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: 2010990000950 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20121220 Granted publication date: 20050921 Pledgee: Agricultural Bank of China Limited by Share Ltd. Guiyang Xinhua Branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: 2010990000950 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Polygonum capitatum extract and medicinal composition preparation thereof Effective date of registration: 20121220 Granted publication date: 20050921 Pledgee: Agricultural Bank of China Limited by Share Ltd. Guiyang Xinhua Branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: 2012990000820 |
|
PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20130425 Granted publication date: 20050921 Pledgee: Agricultural Bank of China Limited by Share Ltd. Guiyang Xinhua Branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: 2012990000820 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Polygonum capitatum extract and medicinal composition preparation thereof Effective date of registration: 20130425 Granted publication date: 20050921 Pledgee: China Everbright Bank Limited by Share Ltd. Guiyang branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: 2013990000243 |
|
PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20130926 Granted publication date: 20050921 Pledgee: China Everbright Bank Limited by Share Ltd. Guiyang branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: 2013990000243 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Polygonum capitatum extract and medicinal composition preparation thereof Effective date of registration: 20130926 Granted publication date: 20050921 Pledgee: Agricultural Bank of China Limited by Share Ltd. Guiyang Xinhua Branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: 2013990000711 |
|
PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20140806 Granted publication date: 20050921 Pledgee: Agricultural Bank of China Limited by Share Ltd. Guiyang Xinhua Branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: 2013990000711 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Polygonum capitatum extract and medicinal composition preparation thereof Effective date of registration: 20140807 Granted publication date: 20050921 Pledgee: Agricultural Bank of China Limited by Share Ltd. Guiyang Xinhua Branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: 2014990000643 |
|
PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20101103 Granted publication date: 20050921 Pledgee: Agricultural Bank of China branch in Guiyang City Xinhua Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: 2008520000486 |
|
PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20180926 Granted publication date: 20050921 Pledgee: Agricultural Bank of China Limited by Share Ltd. Guiyang Xinhua Branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: 2014990000643 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Polygonum capitatum extract and medicinal composition preparation thereof Effective date of registration: 20180926 Granted publication date: 20050921 Pledgee: Agricultural Bank of China Limited by Share Ltd. Guiyang branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: 2018990000887 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PM01 | Change of the registration of the contract for pledge of patent right |
Change date: 20191128 Registration number: 2018990000887 Pledgee after: Agricultural Bank of China Limited by Share Ltd. Guiyang Xinhua Branch Pledgee before: Agricultural Bank of China Limited by Share Ltd. Guiyang branch |
|
PM01 | Change of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20230223 Granted publication date: 20050921 Pledgee: Agricultural Bank of China Limited by Share Ltd. Guiyang Xinhua Branch Pledgor: GUIZHOU WARMEN PHARMACEUTICAL Co.,Ltd. Registration number: 2018990000887 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
CX01 | Expiry of patent term |
Granted publication date: 20050921 |
|
CX01 | Expiry of patent term |