CN1476431A - 制备编端霉素衍生物的方法 - Google Patents
制备编端霉素衍生物的方法 Download PDFInfo
- Publication number
- CN1476431A CN1476431A CNA018193862A CN01819386A CN1476431A CN 1476431 A CN1476431 A CN 1476431A CN A018193862 A CNA018193862 A CN A018193862A CN 01819386 A CN01819386 A CN 01819386A CN 1476431 A CN1476431 A CN 1476431A
- Authority
- CN
- China
- Prior art keywords
- compound
- molecular formula
- acid
- reaction
- condition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/42—Nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrrole Compounds (AREA)
Abstract
Description
Claims (15)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0029004.9 | 2000-11-28 | ||
GBGB0029004.9A GB0029004D0 (en) | 2000-11-28 | 2000-11-28 | Process for preparing distamycin derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1476431A true CN1476431A (zh) | 2004-02-18 |
CN1190418C CN1190418C (zh) | 2005-02-23 |
Family
ID=9904031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB018193862A Expired - Fee Related CN1190418C (zh) | 2000-11-28 | 2001-11-07 | 制备偏端霉素衍生物的方法 |
Country Status (31)
Country | Link |
---|---|
US (1) | US6906199B2 (zh) |
EP (1) | EP1347958B1 (zh) |
JP (1) | JP4574944B2 (zh) |
KR (1) | KR100847234B1 (zh) |
CN (1) | CN1190418C (zh) |
AR (1) | AR035073A1 (zh) |
AT (1) | ATE287395T1 (zh) |
AU (2) | AU2069602A (zh) |
BR (1) | BR0115351A (zh) |
CA (1) | CA2427177C (zh) |
CZ (1) | CZ303461B6 (zh) |
DE (1) | DE60108528T2 (zh) |
EA (1) | EA005399B1 (zh) |
EE (1) | EE05218B1 (zh) |
ES (1) | ES2236365T3 (zh) |
GB (1) | GB0029004D0 (zh) |
HK (1) | HK1060732A1 (zh) |
HU (1) | HU229670B1 (zh) |
IL (2) | IL155385A0 (zh) |
MX (1) | MXPA03004679A (zh) |
MY (1) | MY134563A (zh) |
NO (1) | NO324601B1 (zh) |
NZ (1) | NZ525230A (zh) |
PE (1) | PE20020551A1 (zh) |
PL (1) | PL205821B1 (zh) |
PT (1) | PT1347958E (zh) |
SI (1) | SI1347958T1 (zh) |
SK (1) | SK286610B6 (zh) |
TW (1) | TWI287002B (zh) |
WO (1) | WO2002044147A1 (zh) |
ZA (1) | ZA200302771B (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100842363B1 (ko) * | 2007-04-05 | 2008-07-02 | 김춘동 | 튜브 짜개 |
BR112015022224A2 (pt) * | 2013-03-15 | 2017-07-18 | Genzyme Corp | poliamidas de amina funcional |
JP2015080906A (ja) * | 2013-10-23 | 2015-04-27 | セイコーエプソン株式会社 | 液体収容容器、液体噴射装置 |
WO2023149487A1 (ja) * | 2022-02-02 | 2023-08-10 | 国立大学法人千葉大学 | ピロール・イミダゾールポリアミドの製造方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8612218D0 (en) | 1986-05-20 | 1986-06-25 | Erba Farmitalia | Site specific alkylating agents |
IL84114A (en) | 1986-10-07 | 1994-01-25 | Boehringer Mannheim Italia | Anti-neoplastic pharmaceutical compositions containing HSG together with an anti-tumor drug |
GB8906709D0 (en) | 1989-03-23 | 1989-05-10 | Creighton Andrew M | Acryloyl substituted pyrrole derivatives |
JP2919867B2 (ja) | 1989-09-27 | 1999-07-19 | 千寿製薬株式会社 | 抗腫瘍剤 |
IT1272234B (it) | 1994-05-02 | 1997-06-16 | Consiglio Nazionale Ricerche | Derivati glutationici delle antracicline e procedimento per ottenerli. |
GB9416005D0 (en) | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Peptidic compounds analogous to distamycin a and process for their preparation |
US5880097A (en) | 1996-01-04 | 1999-03-09 | Terrapin Techologies, Inc. | Tethered prodrugs |
KR100469778B1 (ko) * | 1996-05-14 | 2005-05-16 | 파머시아 앤 업잔 에스.피.에이. | 디스타마이신유도체,이의제조방법,및항종양성및항바이러스성제제로서의이들의용도 |
GB9610079D0 (en) | 1996-05-14 | 1996-07-17 | Pharmacia Spa | Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents |
GB9615692D0 (en) * | 1996-07-25 | 1996-09-04 | Pharmacia Spa | Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
GB9623522D0 (en) | 1996-11-11 | 1997-01-08 | Pharmacia & Upjohn Spa | Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents |
GB9727524D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Synergistic antitumor composition containing a biologically active ureido compound |
GB9806692D0 (en) | 1998-03-27 | 1998-05-27 | Pharmacia & Upjohn Spa | Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents |
GB9806689D0 (en) | 1998-03-27 | 1998-05-27 | Pharmacia & Upjohn Spa | Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents |
GB9816653D0 (en) | 1998-07-30 | 1998-09-30 | Pharmacia & Upjohn Spa | Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents |
GB9816652D0 (en) | 1998-07-30 | 1998-09-30 | Pharmacia & Upjohn Spa | Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents |
-
2000
- 2000-11-28 GB GBGB0029004.9A patent/GB0029004D0/en not_active Ceased
-
2001
- 2001-11-07 BR BR0115351-0A patent/BR0115351A/pt active Search and Examination
- 2001-11-07 AU AU2069602A patent/AU2069602A/xx active Pending
- 2001-11-07 HU HU0302158A patent/HU229670B1/hu not_active IP Right Cessation
- 2001-11-07 IL IL15538501A patent/IL155385A0/xx active IP Right Grant
- 2001-11-07 MX MXPA03004679A patent/MXPA03004679A/es active IP Right Grant
- 2001-11-07 NZ NZ525230A patent/NZ525230A/en not_active IP Right Cessation
- 2001-11-07 SK SK832-2003A patent/SK286610B6/sk not_active IP Right Cessation
- 2001-11-07 WO PCT/EP2001/013050 patent/WO2002044147A1/en active IP Right Grant
- 2001-11-07 ZA ZA200302771A patent/ZA200302771B/en unknown
- 2001-11-07 EA EA200300617A patent/EA005399B1/ru not_active IP Right Cessation
- 2001-11-07 ES ES01998537T patent/ES2236365T3/es not_active Expired - Lifetime
- 2001-11-07 CN CNB018193862A patent/CN1190418C/zh not_active Expired - Fee Related
- 2001-11-07 PT PT01998537T patent/PT1347958E/pt unknown
- 2001-11-07 DE DE60108528T patent/DE60108528T2/de not_active Expired - Lifetime
- 2001-11-07 AU AU2002220696A patent/AU2002220696B2/en not_active Ceased
- 2001-11-07 EP EP01998537A patent/EP1347958B1/en not_active Expired - Lifetime
- 2001-11-07 US US10/415,091 patent/US6906199B2/en not_active Expired - Fee Related
- 2001-11-07 SI SI200130298T patent/SI1347958T1/xx unknown
- 2001-11-07 CZ CZ20031132A patent/CZ303461B6/cs not_active IP Right Cessation
- 2001-11-07 AT AT01998537T patent/ATE287395T1/de active
- 2001-11-07 CA CA002427177A patent/CA2427177C/en not_active Expired - Fee Related
- 2001-11-07 KR KR1020037007081A patent/KR100847234B1/ko not_active IP Right Cessation
- 2001-11-07 PL PL362179A patent/PL205821B1/pl unknown
- 2001-11-07 JP JP2002546517A patent/JP4574944B2/ja not_active Expired - Fee Related
- 2001-11-07 EE EEP200300204A patent/EE05218B1/xx not_active IP Right Cessation
- 2001-11-21 TW TW090128821A patent/TWI287002B/zh not_active IP Right Cessation
- 2001-11-26 AR ARP010105477A patent/AR035073A1/es not_active Application Discontinuation
- 2001-11-26 PE PE2001001178A patent/PE20020551A1/es not_active Application Discontinuation
- 2001-11-27 MY MYPI20015410A patent/MY134563A/en unknown
-
2003
- 2003-04-10 IL IL155385A patent/IL155385A/en not_active IP Right Cessation
- 2003-05-21 NO NO20032297A patent/NO324601B1/no not_active IP Right Cessation
-
2004
- 2004-05-25 HK HK04103702A patent/HK1060732A1/xx not_active IP Right Cessation
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: NERVIANO MEDICAL SCIENCES S R Free format text: FORMER OWNER: PHARMACIA ITALIA S.P.A. Effective date: 20061215 |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20061215 Address after: Milan Italy Patentee after: Nerviano Medical Sciences SRL Address before: Milan Italy Patentee before: Pharmacia & Up John S. P. A. |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20050223 Termination date: 20161107 |