CN1446054A - 新型组合物与用途 - Google Patents
新型组合物与用途 Download PDFInfo
- Publication number
- CN1446054A CN1446054A CN01813705A CN01813705A CN1446054A CN 1446054 A CN1446054 A CN 1446054A CN 01813705 A CN01813705 A CN 01813705A CN 01813705 A CN01813705 A CN 01813705A CN 1446054 A CN1446054 A CN 1446054A
- Authority
- CN
- China
- Prior art keywords
- composition
- carbohydrate
- maltodextrin
- purposes
- glucose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 108
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 63
- 239000002253 acid Substances 0.000 claims abstract description 29
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 27
- 239000008103 glucose Substances 0.000 claims abstract description 24
- 229920000642 polymer Polymers 0.000 claims abstract description 22
- 230000006378 damage Effects 0.000 claims abstract description 10
- 238000004519 manufacturing process Methods 0.000 claims abstract description 3
- 229920002774 Maltodextrin Polymers 0.000 claims description 62
- 239000005913 Maltodextrin Substances 0.000 claims description 60
- 229940035034 maltodextrin Drugs 0.000 claims description 60
- 235000013361 beverage Nutrition 0.000 claims description 28
- 235000011496 sports drink Nutrition 0.000 claims description 21
- 239000000047 product Substances 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 8
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 7
- 239000011575 calcium Substances 0.000 claims description 7
- 229910052791 calcium Inorganic materials 0.000 claims description 7
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 239000013589 supplement Substances 0.000 claims description 2
- 102000004139 alpha-Amylases Human genes 0.000 abstract description 12
- 108090000637 alpha-Amylases Proteins 0.000 abstract description 12
- 229940024171 alpha-amylase Drugs 0.000 abstract description 12
- 230000002265 prevention Effects 0.000 abstract 1
- 235000014633 carbohydrates Nutrition 0.000 description 53
- 102000004190 Enzymes Human genes 0.000 description 39
- 108090000790 Enzymes Proteins 0.000 description 39
- 229940088598 enzyme Drugs 0.000 description 39
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 27
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 24
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 24
- 239000000243 solution Substances 0.000 description 19
- 230000007062 hydrolysis Effects 0.000 description 12
- 238000006460 hydrolysis reaction Methods 0.000 description 12
- 238000002360 preparation method Methods 0.000 description 12
- LPQOADBMXVRBNX-UHFFFAOYSA-N ac1ldcw0 Chemical group Cl.C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3CCSC1=C32 LPQOADBMXVRBNX-UHFFFAOYSA-N 0.000 description 11
- 229930006000 Sucrose Natural products 0.000 description 10
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 10
- 239000000523 sample Substances 0.000 description 10
- 239000005720 sucrose Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 230000002378 acidificating effect Effects 0.000 description 9
- 150000002016 disaccharides Chemical class 0.000 description 9
- 210000000214 mouth Anatomy 0.000 description 9
- 238000011160 research Methods 0.000 description 9
- 235000000346 sugar Nutrition 0.000 description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 8
- 210000003298 dental enamel Anatomy 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 235000011121 sodium hydroxide Nutrition 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 208000002064 Dental Plaque Diseases 0.000 description 7
- 150000007513 acids Chemical class 0.000 description 7
- 229960004106 citric acid Drugs 0.000 description 7
- 235000015165 citric acid Nutrition 0.000 description 7
- 210000003296 saliva Anatomy 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 6
- 230000001013 cariogenic effect Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 235000015897 energy drink Nutrition 0.000 description 6
- 230000003628 erosive effect Effects 0.000 description 6
- 238000004128 high performance liquid chromatography Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 229920002472 Starch Polymers 0.000 description 5
- 208000002925 dental caries Diseases 0.000 description 5
- -1 fruit acids Chemical class 0.000 description 5
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 235000010323 ascorbic acid Nutrition 0.000 description 4
- 229960005070 ascorbic acid Drugs 0.000 description 4
- 239000011668 ascorbic acid Substances 0.000 description 4
- 239000008121 dextrose Substances 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 239000001630 malic acid Substances 0.000 description 4
- 235000011090 malic acid Nutrition 0.000 description 4
- 238000006116 polymerization reaction Methods 0.000 description 4
- 239000006188 syrup Substances 0.000 description 4
- 235000020357 syrup Nutrition 0.000 description 4
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 3
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 3
- 229960004543 anhydrous citric acid Drugs 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 235000008504 concentrate Nutrition 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 235000015203 fruit juice Nutrition 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 2
- 108010011485 Aspartame Proteins 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000167880 Hirundinidae Species 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000000605 aspartame Substances 0.000 description 2
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 2
- 235000010357 aspartame Nutrition 0.000 description 2
- 229960003438 aspartame Drugs 0.000 description 2
- 229920005601 base polymer Polymers 0.000 description 2
- OENHQHLEOONYIE-UKMVMLAPSA-N beta-Carotene Chemical compound CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 239000004302 potassium sorbate Substances 0.000 description 2
- 235000010241 potassium sorbate Nutrition 0.000 description 2
- 229940069338 potassium sorbate Drugs 0.000 description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 2
- 239000004299 sodium benzoate Substances 0.000 description 2
- 235000010234 sodium benzoate Nutrition 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- HNSDLXPSAYFUHK-UHFFFAOYSA-N 1,4-bis(2-ethylhexyl) sulfosuccinate Chemical compound CCCCC(CC)COC(=O)CC(S(O)(=O)=O)C(=O)OCC(CC)CCCC HNSDLXPSAYFUHK-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical group [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 208000008617 Tooth Demineralization Diseases 0.000 description 1
- 206010072665 Tooth demineralisation Diseases 0.000 description 1
- 206010044038 Tooth erosion Diseases 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- QVMHUALAQYRRBM-UHFFFAOYSA-N [P].[P] Chemical compound [P].[P] QVMHUALAQYRRBM-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229940092124 calcium citrate malate Drugs 0.000 description 1
- 229940043430 calcium compound Drugs 0.000 description 1
- 150000001674 calcium compounds Chemical class 0.000 description 1
- MPCMQXRREZMSPJ-UHFFFAOYSA-L calcium;2-hydroxybutanedioate;2-hydroxypropane-1,2,3-tricarboxylic acid;pentahydrate Chemical compound O.O.O.O.O.[Ca+2].[O-]C(=O)C(O)CC([O-])=O.OC(=O)CC(O)(C(O)=O)CC(O)=O MPCMQXRREZMSPJ-UHFFFAOYSA-L 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 229960002303 citric acid monohydrate Drugs 0.000 description 1
- 235000013353 coffee beverage Nutrition 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229940099112 cornstarch Drugs 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000005115 demineralization Methods 0.000 description 1
- 230000002328 demineralizing effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 150000002303 glucose derivatives Chemical class 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 208000036595 non-bacterial tooth erosion Diseases 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 230000032696 parturition Effects 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 238000003918 potentiometric titration Methods 0.000 description 1
- 238000004382 potting Methods 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/42—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/38—Sucrose-free products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
用于减少或防止被蚀斑酸产生所引起的牙齿损坏的口服用含碳水化合物的组合物具有4.5或低于4.5的有效pH并含有至少1.0wt%的作为碳水化合物源的α-淀粉酶可消化的、α-(1,4)-连接的葡萄糖聚合物,在该组合物中单-和二-糖类的浓度不大于2.0wt%。
Description
本发明涉及口服的含碳水化合物的组合物,如饮料和甜食组合物,并涉及α-(1,4)-连接的葡萄糖聚合物在此类组合物中使用以减轻或防止与食用糖类有关的牙齿损坏的用途。
龋齿和牙侵蚀是由酸对于牙表面釉质的作用所引起的。牙侵蚀通常与酸类如水果酸类的直接食用有关,而龋齿与糖类的食用有关。引起龋齿的酸,是由覆盖在牙釉质表面的口腔牙斑菌对糖类发酵而产生的。具体的问题是由于含有用作能量源的碳水化合物的产品(例如所谓能量补充型饮料或运动饮料)的频繁食用引起的。在补充能量的口服产品如运动饮料中,碳水化合物的最常见来源是单糖和二糖类,例如葡萄糖(右旋糖)、蔗糖和麦芽糖。葡萄糖的较长链聚合物如麦芽糖糊精也可作为能量源用于此类产品中。已经发现,单-和二-糖类以及麦芽糖糊精在疾病的大鼠模型中容易通过牙斑菌发酵而产生酸类(0renby and Mistry,1996,Caries Research 30,289)。由口腔牙斑菌对糖类发酵所产生的酸降低了蚀斑液(plaque fluid)的pH。随着pH下降,蚀斑液较少地被钙羟磷灰石(釉质的矿质成分)所饱和。“临界pH”-低于它,蚀斑液没有被磷灰石饱和-被认为是5.5左右。这取决于个人的唾液组成和在口腔内的位置。(Meurman and ten Cate,1996 EurJ Oral Sci 104,199-206)。
麦芽糖糊精是也称为葡萄糖聚合物的碳水化合物。它们通常通过水解作用从淀粉,例如玉米淀粉,衍生而来。它们主要包括长度为三个或更多个右旋糖单元的聚合物,但也可含有少量百分数,典型地至多大约10wt%的单糖或二糖。从淀粉制备麦芽糖糊精可获得一定范围的聚合物链长度。淀粉的解聚程度以糖化率(D.E)表示,它是所存在的以右旋糖表示的总还原糖的量,并按照总干燥物质的百分比计算。葡萄糖(右旋糖)具有100的D.E.。葡萄糖浆通常具有20或20以上的D.E.,而麦芽糖糊精通常具有低于20的D.E.。D.E.值越高,它所含的还原糖的量越多,因此碳水化合物源物质更容易被口腔细菌发酵。具有在1-20范围内D.E.值的麦芽糖糊精,能够以低的单-和二-糖类%含量从市场上购到,下面详细描述。
淀粉的工业水解能够加以控制以提供具有各种D.E.和具有低的单-和二-糖类的百分含量的麦芽糖糊精。例如,Cerestar(TratfordPark,Manchester M17 1PA,UK)提供了D.E.值范围为5-18.5的麦芽糖糊精,Staley(A.E.Staley Manufacturing Company,2200E.Eldorado Street,Decatur,IL 62525 USA)提供了具有1-18D.E.值的麦芽糖糊精。限制了单-和二-糖类的%含量的低D.E.葡萄糖浆也可商购得到。
糖分布 | (%) | |||
单-糖 | 二-糖 | 三-糖 | 更高级 | |
Staley Star-Dri Maltodextrin 5(D.E.5) | 0.9 | 0.9 | 1.0 | 97.2 |
Staley Star-Dri Maltodextrin 10(D.E.10) | 0.6 | 2.8 | 4.4 | 92.2 |
Staley Star-Dri Maltodextrin 15(D.E.15) | 1.3 | 4.1 | 6.0 | 88.6 |
Cerestar C-Pur 01910 Maltodextrin(D.E.14) | 1 | 3 | 6 | 90 |
Cerestar C-Sweet 01411 Glucose Syrup(D.E.29) | 4 | 11 | 16.5 | 68.5 |
碳水化合物的多糖源,如麦芽糖糊精和葡萄糖浆,在口腔中经酶α-淀粉酶的作用而快速转化成葡萄糖。α淀粉酶使非生龋齿多糖的α-(1,4)键发生水解而形成可生龋齿的单糖和二糖如葡萄糖和麦芽糖。虽然有一些证据表明在牙斑中存在可产生α-淀粉酶的细菌,但是α-淀粉酶活性的大部分是唾液来源(Scannapieco等人,1993,Critical Reviews in Oral Biology and Medicine 4,301-307)。
α-淀粉酶能够基本上将葡萄糖的非生龋齿的长链聚合物转化成生龋齿的底物,后者然后通过牙斑菌代谢,产生了作为副产物的有机酸。Al-Khatib等人已经在1997,Caries Research 31,316,abstracts106 & 107中对麦芽糖糊精在人模型的生龋齿可能性进行了评价。发现麦芽糖糊精具有比蔗糖更低的生酸可能性,但是也发现其在口腔内的生龋齿试验中具有脱矿物活性。
这与文献的结论一致,即麦芽糖糊精和糖类对齿列不利。
欧洲专利申请EP 0264 117涉及提供调节型饮料的问题,该饮料能够在人们的体育活动中保持血液中的血糖水平,替代所损失的体液和盐类以及抑制由发酵性糖类引起的对齿列的损坏。EP 0 264 117描述调节型饮料粉末组合物,它包括60-85wt%长链葡萄糖聚合物作为碳水化合物源,其中组合物的pH被调节在pH5.2和5.8之间。根据EP 0264 117,该长链葡萄糖聚合物优选含有低于10wt%的单糖和二糖。然而,对齿列的任何影响的证据都没有给出,可以预见唾液淀粉酶将从此类组合物产生可发酵性糖。
瑞典专利出版物SE 8904190公开了供能量需求型身体活动中使用的口服食用组合物,它包括麦芽糖糊精作为主能量源并补充了作为龋齿(caries)防止物质的木糖醇。SE 8904190涉及提供以低分子量碳水化合物源例如右旋糖和蔗糖为基础的缓慢吸收型饮料产品以及龋齿形成的问题,该龋齿形成归因于这些碳水化合物物质源用作了口腔内细菌群落的培养基。SE 8904190的麦芽糖糊精组合物是根据链长度为至多10个葡萄糖单元的单-、二-和低聚糖含量来定义,剩余部分(55-70wt%)是长度超过10个葡萄糖单元的低聚糖。单糖和二糖含量的范围是2.1-4.0wt%。麦芽糖糊精组合物的优选的单糖和二糖含量是3.0wt%。SE 8904190组合物的pH没有被限定。虽然SE 8904190声称该碳水化合物源不应该是生龋齿性细菌的良好培养基,但是,值得注意的是,在说明书中的唯一实例,运动饮料组合物,包含51.8wt%的麦芽糖糊精和38wt%的生龋齿的单糖果糖。由于α-淀粉酶和口腔细菌的作用,在SE 8904190中公开的组合物不可避免地具有蚀斑酸产生和牙齿脱矿物化的可能性。
本发明提供了用于口服的非生龋齿的、含碳水化合物的组合物,它包括葡萄糖的α-(1,4)-连接聚合物如麦芽糖糊精作为碳水化合物的主要物质源。本发明组合物的使用克服了由口腔细菌在嘴内产生的蚀斑酸(plaque acid)所引起的对牙齿的潜在损害的问题。为了免除疑惑,本文涉及到的葡萄糖的α-(1,4)-连接聚合物包括具有α-(1,6)连接键和α-(1,4)连接键的聚合物。
现已发现,使用以葡萄糖的α-(1,4)-连接聚合物如麦芽糖糊精作为主要碳水化合物源在低pH下配制的组合物,能够抑制蚀斑酸产生。虽然不希望受理论的束缚,但是可以推测,在低的pH下,α-淀粉酶酶不能将该α-(1,4)键水解和将该葡萄糖聚合物转化成容易发酵的单-和二-糖类。因此组合物可以配制成含有产生能量的碳水化合物,所述碳水化合物具有最小程度的因蚀斑酸产生而导致的牙损坏。
本发明提供了含有碳水化合物的组合物在制备用于减少或防止由蚀斑酸产生引起的牙齿损坏的口服组合物中的用途,所述组合物具有4.5或更低的有效pH,包括至少1.0wt%的α-淀粉酶可消化的、α-(1,4)-连接的葡萄糖聚合物作为碳水化合物源,组合物中单-和二-糖类的浓度不大于2.0wt%。
在本发明的上下文中,有效的pH被定义为在组合物的服用过程中,在组合物接触到口腔内唾液的同时引起产生4.5或4.5以下的瞬时口腔内pH值的该组合物的那一pH。业已发现,将组合物配制成低于pH4.5的pH是有效的,而且为了获得最大的益处,有效的pH应该低于4.0。典型地,本发明组合物具有不低于2.0的有效pH。
用于本发明中的碳水化合物源适宜是具有低DE值(典型为15或更低)的麦芽糖糊精,以使得单-和二-糖类的浓度最大程度地减少。对于应用到组合物中的碳水化合物的浓度没有特别的上限,而是由制备的实际情况和其它感官方面的考虑因素来决定,只要单-和二糖在组合物中的浓度最大程度地减少就行。作为一个近似的参考,单-和二-糖类在组合物中的浓度优选是不大于1.5wt%,更理想的是不大于1.0%或甚至0.5wt%。
本发明适用于口服或饮用的各种含有碳水化合物的产品,尤其适用于饮料和糖果产品。组合物可以是液体、固体或半固体形式。术语“饮料”包括立即可饮的液体组合物以及供稀释或溶解用的浓缩物和粉末配制品。本发明能够以各种饮料形式使用,例如以有或没有果汁或水果榨出物的浓缩物,不含气体的饮料或者碳酸饮料形式使用,尤其适用于饮料如运动和能量型饮料或者添加维生素的饮料。
组合物可以是不甜的或者用强甜味剂例如糖精、天冬氨酰基苯基丙氨酰基甲酯或现有技术中已知的其它非糖的甜味剂来增加甜味。组合物也可含有其它的普通添加剂如苯甲酸钠、山梨酸、焦亚硫酸钠、抗坏血酸、调味料、色料、稳定剂,例如食用水胶体和二氧化碳。
本发明特别适用于以大约6%的碳水化合物,例如以4.0-8.0%范围内的碳水化合物所配制的运动饮料,和适用于用较高含量的碳水化合物,例如大约15-25%的碳水化合物制得的能量提供型产品。如果含有可发酵的单-或二-糖类碳水化合物源的果汁或类似物质是该组合物的一个组分,那么这将提供单-和二糖在组合物中的浓度而且适当的配给量将是所需要的。
根据本发明配制的含有葡萄糖的α-(1,4)-连接聚合物作为碳水化合物能量的主要来源物的高能量组合物,例如具有超过约15wt%碳水化合物,尤其超过20wt%碳水化合物的组合物,被认为是新型的,其本身构成了本发明的一部分。
酸性组分本身在组合物中的引入,使得组合物本身潜在性地不利,这归因于认为通过成酸性食物从牙齿中更快速地(与钙被正常的再矿化过程所置换的速度相比)浸出钙所引起的牙侵蚀的可能性。Lussi等人(1995,Caries Res 29,349-354)将饮料的pH和可滴定酸度与它的腐蚀可能性相关联;酸在饮料中的浓度越高,对牙齿的损坏越大。
现有技术中已知有许多方法来减轻食物酸化剂的腐蚀可能性。WO92/05711公开了防止因为饮用包括0.02%-0.15%钙的酸饮料(具有低于5.5的pH)而引起牙釉质发生腐蚀的方法,所述钙是按照1∶0.5-1∶4.5的柠檬酸盐与苹果酸盐摩尔比率的柠檬酸苹果酸钙复合物形式。WO97/30601和WO 99/08550公开了含有钙化合物和酸化剂的减少牙齿腐蚀性能的一种组合物,特征在于钙是以0.3-0.8摩尔每摩尔酸化剂的范围存在和组合物的pH是3.5到4.5。WO 00/13531公开了通常被用作增稠剂、稳定剂和乳化剂的粘度改性聚合物材料用于食用的酸性组合物中以减轻或抑制与酸的食用有关的牙齿损坏的用途。
当与以钙和/或粘度改性聚合物材料的添加为基础的控制牙侵蚀的已知方法相结合使用时,本发明特别适合用于口服的酸性、含碳水化合物的产品,如酸性运动饮料和能量饮料、用果汁制得的酸性饮料,也适用于口服的其它酸性产品。上述参考文献的教导因此被引入供参考。
酸性组合物可以含有有机和/或无机酸而且可以补充维生素如B维生素类和抗坏血酸。酸性溶液也可含有钠离子,尤其在运动饮料的配制品中。优选的酸化剂包括可饮用的酸类例如柠檬酸、苹果酸、乳酸、磷磷、乙酸和酒石酸。本发明特别适用于含有天然或添加的柠檬酸的饮用产品。组合物中酸化剂浓度将由产品的类型、所需要的有效pH、所需要的感官特性和所选择的酸源的酸性来确定。组合物的酸性以可滴定酸度来表示,后者是在溶液中存在的酸的百分重量的量度,这是从为了中和所存在的酸性物质所需要的氢氧化钠的量计算出的。在实践中,可滴定酸度是在20摄氏度的温度下用已知浓度的标准氢氧化钠溶液以电位滴定法测量的。典型的饮料是具有在0.01-4%w/w范围内、适宜地在0.1-2%w/w范围内的可滴定酸度和典型的水果味的即饮型饮料。典型地,在本发明的组合物中的酸浓度,例如在水果味的产品中的酸浓度将在0.01%w/w到4%w/w范围内,合适地在0.1%w/w到2.5%w/w范围内。以柠檬酸和/或苹果酸作为酸化剂为基础的典型的即饮型水果味饮料将具有在0.01%w/w到2%w/w,优选0.01%w/w到1.0%w/w的饮料组合物范围内的酸浓度。在供稀释用的浓缩物中,典型的柠檬酸/苹果酸浓度范围是组合物的0.1%w/w到4%w/w。可以使用可饮用酸类的混合物,例如,选自柠檬酸、苹果酸、磷酸和乳酸的酸类和在现有技术中已知的其它合适的食品级赋形剂的混合物。
本发明组合物的有效pH将根据产品的类型,酸含量和所需的感官特性来变化。组合物的典型有效的pH是pH2.4到pH4.0,更优选pH2.7到pH4.0,尤其对于含有水果酸类的饮料。可以认识到,对于液体组合物如饮料而言,有效的pH将非常接近组合物的实际pH。
本发明组合物可按照常规方法通过混合各成分来制备。在与其它组分混合之前,固体成分可以溶于水中或如果需要的话溶于热水中。典型地,在装入瓶子或罐或其它封闭容器中之前,对饮料组合物进行巴氏杀菌或在填充之后进行“罐封后巴氏杀菌”。
本发明通过下面的实施例来说明:
实施例1-pH对于14DE麦芽糖糊精的α淀粉酶水解的影响
为了试验本发明:降低的pH将抑制唾液α淀粉酶使葡萄糖聚合物的α-(1,4)连接键发生水解的能力,下面将详细描述的14DE麦芽糖糊精溶液在有或没有唾液α淀粉酶存在下于37℃培养。淀粉酶可以从Sigma-Aldrich Company Ltd,Poole,Dorset,UK商购。一个单位的α淀粉酶活性被定义为于20摄氏度在pH6.9时,3分钟内从淀粉中释放1.0mg麦芽糖的量。培养物的pH可通过添加氢氧化钠/盐酸来调节。在添加酶之后即刻(0分钟)和在3分、10分钟之后,从培养箱中取出样品。这些样品立即在0.1M氢氧化钠中稀释1/200。
溶液的组成 | |
14DE Maltodextrin(Cerestar C-Pur 01910) | 10%w/v |
氯化钠 | 0.1%w/v |
柠檬酸 | 20mmolar |
人α淀粉酶(Sigma type XIII-A) | 25单位/ml |
结果
随后,通过HPLC来确定麦芽糖糊精/酶培养物中碳水化合物类物质的组成。
HPLC的有关细节如下:
色谱柱:DIONEX柱子,CarboPac PA-100
温度:25℃
流速:1.0 ml/分钟
试验时间:30分钟
流动相:100% 0.1M NaOH至100% 0.1M NaOH 0.25M乙酸钠
结果用作为总碳水化合物的一部分的碳水化合物类的%来表示。
时间:0分钟
时间:3分钟
时间:10分钟
组成 | 无酶pH7.0(in%) | 有酶pH7(in%) | 有酶pH5(in%) | 有酶pH4.5(in%) | 有酶pH4(in%) | 有酶pH3.5(in%) | 有酶pH3(in%) |
DP1 | 0.6 | 0.6 | 1.0 | 0.9 | 0.8 | 0.8 | 0.8 |
DP2 | 2.0 | 2.2 | 0.9 | 0.9 | 1.0 | 1.5 | 1.8 |
DP3 | 2.5 | 2.7 | 1.3 | 1.3 | 1.4 | 1.7 | 2.2 |
DP4 | 1.7 | 2.0 | 1.5 | 1.4 | 1.4 | 1.5 | 1.8 |
DP5 | 6.2 | 5.8 | 5.1 | 5.0 | 5.3 | 5.7 | 6.7 |
DP6 | 6.5 | 5.8 | 4.1 | 4.2 | 4.5 | 5.0 | 6.2 |
DP7 | 5.8 | 5.3 | 4.4 | 4.4 | 4.6 | 5.0 | 6.0 |
其它 | 74.8 | 75.6 | 81.5 | 81.9 | 80.9 | 78.8 | 74.5 |
组成 | 无酶pH7.0(in%) | 有酶pH7(in%) | 有酶pH5(in%) | 有酶pH4.5(in%) | 有酶pH4(in%) | 有酶pH3.5(in%) | 有酶pH3(in%) |
DP1 | 0.6 | 1.1 | 1.3 | 1.0 | 0.9 | 0.8 | 0.7 |
DP2 | 1.9 | 3.9 | 1.2 | 1.1 | 1.1 | 1.2 | 1.5 |
DP3 | 2.3 | 4.6 | 1.8 | 1.5 | 1.5 | 1.7 | 1.9 |
DP4 | 1.6 | 2.3 | 1.7 | 1.6 | 1.5 | 1.5 | 1.5 |
DP5 | 6.1 | 4.2 | 4.8 | 5.1 | 5.6 | 5.8 | 5.8 |
DP6 | 6.3 | 3.5 | 3.6 | 4.1 | 4.8 | 5.1 | 5.5 |
DP7 | 5.7 | 3.4 | 4.1 | 4.4 | 4.9 | 5.0 | 5.1 |
其它 | 75.4 | 77.1 | 81.6 | 81.1 | 79.6 | 78.9 | 78.2 |
组成 | 无酶pH7.0(in%) | 有酶pH7(in%) | 有酶pH5(in%) | 有酶pH4.5(in%) | 有酶pH4(in%) | 有酶pH3.5(in%) | 有酶pH3(in%) |
DP1 | 0.6 | 2.6 | 1.7 | 1.3 | 0.9 | 0.9 | 0.7 |
DP2 | 1.8 | 6.4 | 1.7 | 1.2 | 1.1 | 1.4 | 1.5 |
DP3 | 2.1 | 7.0 | 2.5 | 1.8 | 1.5 | 1.5 | 1.9 |
DP4 | 1.5 | 3.3 | 1.9 | 1.7 | 1.5 | 1.5 | 1.5 |
DP5 | 5.7 | 2.2 | 3.6 | 4.4 | 5.6 | 5.6 | 5.8 |
DP6 | 5.8 | 0.9 | 2.4 | 3.3 | 5.2 | 4.8 | 5.4 |
DP7 | 5.2 | 0.9 | 2.9 | 3.8 | 4.9 | 4.8 | 5.1 |
其它 | 77.5 | 76.6 | 83.4 | 82.6 | 79.4 | 79.5 | 78.0 |
[DP表示聚合度;DP1表示单糖,DP2二糖,等等。“其它”指通过差值计算的其它碳水化合物物质。]
pH降至4.5将抑制α-(1,4)连接键的水解。高于pH 4.5,高级糖类聚合物(DP>5)会减少而单-,二-和三糖类(DP1-3)会增加。在pH7.0下观察到麦芽糖糊精的显著水解。
实施例2-pH对于5DE麦芽糖糊精的α淀粉酶水解的影响
为了试验本发明:降低的pH将抑制唾液α淀粉酶使葡萄糖聚合物的α-(1,4)连接键发生水解的能力,下面将详细描述的5DE麦芽糖糊精溶液按照与实施例1中所述类似方式在有或没有唾液α淀粉酶存在时于37℃培养。pH可通过添加氢氧化钠/盐酸来调节。在添加之后酶即刻(0分钟)和在10分钟之后,从培养箱中取出样品。这些样品立即在0.1M氢氧化钠中稀释1/200。
溶液的组成 | |
5DE Mal todextrin(Staley Star-Dri) | 18.75%w/v(18%碳水化合物) |
氯化钠 | 0.1%w/v |
柠檬酸 | 20mmolar |
人α淀粉酶(Sigma type XIII-A) | 25单位/ml,当添加时 |
结果
随后,通过HPLC来确定麦芽糖糊精/酶培养物中碳水化合物类物质的组成。HPLC详细情况与实施例1中相同。
结果用作为总碳水化合物的一部分的碳水化合物类的%来表示。
时间:0分钟
时间:10分钟
组成 | 无酶pH7.0(in%) | 有酶pH7(in%) | 有酶pH5(in%) | 有酶pH4.5(in%) | 有酶pH4(in%) | 有酶pH3.5(in%) |
DP1 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
DP2 | 0.9 | 0.8 | 0.7 | 0.6 | 0.6 | 0.6 |
DP3 | 1.1 | 1.1 | 0.9 | 0.8 | 0.7 | 0.7 |
DP4 | 1.2 | 1.1 | 1.0 | 0.9 | 0.8 | 0.8 |
DP5 | 2.9 | 2.8 | 2.8 | 2.7 | 2.6 | 2.6 |
DP6 | 3.5 | 2.9 | 2.9 | 2.7 | 2.6 | 2.5 |
DP7 | 3.6 | 3.2 | 3.2 | 3.1 | 3.0 | 3.0 |
其它 | 85.8 | 87.1 | 87.6 | 88.2 | 88.7 | 88.9 |
组成 | 无酶pH7.0(in%) | 有酶pH7(in%) | 有酶pH5(in%) | 有酶pH4.5(in%) | 有酶pH4(in%) | 有酶pH3.5(in%) |
DP1 | 0.9 | 2.7 | 1.5 | 1.2 | 1.0 | 1.0 |
DP2 | 0.9 | 4.9 | 1.8 | 1.0 | 0.7 | 0.5 |
DP3 | 1.0 | 6.1 | 2.6 | 1.4 | 0.8 | 0.6 |
DP4 | 1.1 | 3.2 | 1.3 | 1.0 | 0.9 | 0.8 |
DP5 | 2.9 | 2.6 | 2.8 | 2.7 | 2.7 | 2.5 |
DP6 | 3.4 | 1.8 | 2.5 | 1.5 | 2.7 | 2.4 |
DP7 | 3.5 | 2.0 | 2.9 | 3.0 | 3.0 | 2.9 |
其它 | 86.4 | 76.8 | 84.6 | 88.2 | 88.4 | 89.3 |
[DP表示聚合度;DP1表示单糖,DP2二糖,等等。“其它”指通过差值计算的其它碳水化合物物质。]
pH降至4.5将抑制α-(1,4)连接键的水解。高于pH4.5,高级糖类聚合物(DP>5)会减少而单-,二-和三糖类(DP1-3)会增加。再一次,在pH7.0时观察到显著的水解。
实施例3-运动饮料组合物
根据下面的详细配方制备运动饮料组合物。各自加入具有在6-14范围内D.E.值的四种不同麦芽糖糊精,得到6.4wt%的碳水化合物浓度。各试验组合物的总体积是1升,pH是3.8。钠浓度是大约55mg/100ml。
运动饮料的组成 | 重量(g),在1升中 |
硫酸氢钠(50%溶液) | 1.9105ml |
无水的柠檬酸 | 3.0 |
Colour Orange Emulsion 61.461 | 1.84 |
山梨酸钾 | 0.3886 |
阿斯巴特 | 0.2215 |
合成糖精 | 0.0709 |
抗坏血酸 | 0.2336 |
柠檬酸三钠二水合物 | 1.300 |
Orange Flavour 10174-34 | 0.270 |
Cloudifier Emulsion 61.459 | 0.470 |
碳酸钙(Sturcal F) | 0.930 |
麦芽糖糊精 | 66.66 |
水 | 加至11 |
所使用的四种麦芽糖糊精的组成通过HPLC确定(参见下面)。
组成 | 麦芽糖糊精1(in%)DE=6 | 麦芽糖糊精2(in%)DE=10 | 麦芽糖糊精3(in%)DE=14-16 | 麦芽糖糊精4(in%)DE=14 |
DP1 | 0.8 | 1.0 | 1.1 | 0.3 |
DP2 | 1.0 | 1.9 | 4.0 | 2.9 |
DP3 | 1.3 | 2.9 | 4.7 | 3.1 |
DP4 | 1.5 | 2.4 | 3.8 | 2.5 |
DP5 | 1.5 | 2.4 | 4.0 | 2.6 |
DP6 | 1.6 | 3.7 | 4.3 | 3.3 |
DP7 | 1.9 | 4.4 | 4.6 | 3.6 |
其它 | 90.4 | 81.3 | 73.5 | 81.7 |
[DP表示聚合度;DP1表示单糖,DP2二糖,等等。“其它”指通过差值计算的其它碳水化合物物质。]
蚀斑pH研究
为了评价本发明对于(抑制)牙斑菌从配制剂产生酸的能力而言的用处,利用蚀斑pH研究方法分析了含有麦芽糖糊精的运动饮料。这在七段(seven leg)研究中牵涉到14名志愿者,它还包括空白(没有碳水化合物的运动饮料配制品)以及蔗糖和山梨糖醇正性和负性的对照段(溶于水中的10%溶液)。在每个试验日中,通过使用无菌的不锈钢直探针从受试者牙齿的四个部位的颊面上取蚀斑的样品。这会形成该基线蚀斑样品(时间0)。样品与20微升的蒸馏水混合,用微电极测量pH。然后,受试者用15ml的运动饮料或对照物彻底地漱洗他们的口腔达1分钟。接下来,受试者吞咽饮料。随后在2和5分钟后以及其后在至多30分钟内以5分钟间隔,测定蚀斑的pH。不含任何碳水化合物的运动饮料配制品用作空白。获得全部数据之后进行统计分析(Turkey′sSignificant Difference Test and Splined Stephan Curves)。该方法已经由Toumba和Duggal,1999(British Dental Journal 186,626-629)进行了描述。
结果
下表显示,四种不同的含麦芽糖糊精的组合物的pH从来都没有降低到6.15以下,而蔗糖对照组合物的pH下降到5.42。“牙齿友好性”的标准是pH没有降低到pH5.5以下,低于该值时釉质开始溶解。该麦芽糖糊精配制品不引起蚀斑pH降低至釉质发生破坏的水平。不含碳水化合物的运动饮料配制品和山梨糖醇对照组合物降低蚀斑pH到低于试验溶液。数据的分析显示,在从蔗糖的pH降和四种含有麦芽糖糊精的组合物的pH降之间有统计学上显著性差异。在四种含有麦芽糖糊精的组合物之间没有差异。结果证明,可以配制含有较大量无明显生龋可能性的低D.E.麦芽糖糊精的饮料。
A:麦芽糖糊精1 B:麦芽糖糊精2 C:麦芽糖糊精3 D:麦芽糖糊精4 E:没有麦芽糖糊精 F:10% w/v蔗糖 G:10% w/v山梨糖醇
在某个时间(分钟)的平均pH | 最低pH(在任何时间) | |||||||||
0 | 2 | 5 | 10 | 15 | 20 | 25 | 30 | 平均 | SD | |
A | 6.91 | 6.91 | 6.46 | 6.43 | 6.57 | 6.73 | 6.86 | 6.86 | 6.20 | 0.342 |
B | 6.91 | 6.91 | 6.33 | 6.47 | 6.61 | 6.61 | 6.89 | 6.86 | 6.26 | 0.342 |
C | 6.98 | 6.98 | 6.48 | 6.50 | 6.69 | 6.72 | 6.84 | 6.94 | 6.28 | 0.393 |
D | 6.95 | 6.95 | 6.20 | 6.46 | 6.50 | 6.60 | 6.77 | 6.91 | 6.15 | 0.335 |
E | 6.86 | 6.86 | 6.68 | 6.90 | 6.96 | 7.02 | 7.08 | 6.94 | 6.61 | 0.299 |
F | 6.86 | 6.86 | 6.13 | 5.67 | 5.73 | 5.99 | 6.39 | 6.34 | 5.42 | 0.181 |
G | 6.96 | 6.96 | 7.02 | 6.96 | 7.00 | 6.89 | 6.93 | 6.96 | 6.73 | 0.348 |
实施例4-能量/运动饮料组合物
根据下面详细描述的配方制备能量/运动饮料组合物。使用6-24%碳水化合物制备三种不同的5D.E.麦芽糖糊精溶液。试验组合物具有0.3%w/w柠檬酸一水化物的产物酸性,产物pH是3.2。
能量饮料的组成(%w/v) | 溶液1(S1) | 溶液2(S2) | 溶液3(S3) |
无水的柠檬酸 | 0.262 | 0.262 | 0.262 |
山梨酸钾 | 0.03 | 0.03 | 0.03 |
苯甲酸钠 | 0.0072 | 0.0072 | 0.0072 |
柠檬酸三钠二水合物 | 0.06 | 0.06 | 0.06 |
麦芽糖糊精(Staley Star-Dri 5D.E.) | 6.25 | 12.5 | 25.0 |
水 | 补充至100 | 补充至100 | 补充至100 |
麦芽糖糊精(Staley Star-Dri 5D.E.)是95%碳水化合物。
所使用的三种麦芽糖糊精溶液的组成通过HPLC确定(参见下面)。
组成 | 溶液1(g/L) | 溶液2(g/L) | 溶液3(g/L) |
DP1 | 0.766 | 1.555 | 1.840 |
DP2 | 0.809 | 1.648 | 2.307 |
[DP表示聚合度;DP1表示单糖,DP2表示二糖。]
蚀斑pH研究
为了评价本发明对于(抑制)牙斑菌从配制剂产生酸的能力而言的用处,利用蚀斑pH研究方法分析了含有麦芽糖糊精的能量/运动饮料。这按照与实施例3中所述的类似的方式进行。这牵涉到在五段研究中的9名志愿者,这些研究还包括酸化蔗糖和酸化山梨糖醇正性和负性对照段(10%溶液溶于同样的基本组合物中,作为试验麦芽糖糊精溶液)。在每个试验日中,通过使用无菌的不锈钢直探针从受试者牙齿颊面上取蚀斑样品。这会形成该基线蚀斑样品(时间0)。样品与30微升的蒸馏水混合,用微电极测量pH。然后,受试者用15ml的能量/运动饮料或对照物彻底地漱洗他们的口腔达1分钟。之后,受试者吞咽饮料。继之在6分钟40秒、10分钟、15分钟、25分钟和30分钟测定蚀斑的pH。
结果
下表显示,三种含麦芽糖糊精的组合物的pH从来都没有降低到5.5以下,而蔗糖对照组合物的pH下降到5.28。“牙齿友好性”的标准是pH没有降低到pH5.5以下,低于该值时釉质开始溶解。该麦芽糖糊精配制品不引起蚀斑pH降低至釉质发生破坏的水平。该山梨糖醇对照组合物降低蚀斑pH到低于试验溶液。
在某个时间(分钟:秒)的平均pH | ||||||
0 | 6:40 | 10 | 15 | 25 | 30 | |
S1 | 6.62 | 6.00 | 6.33 | 6.51 | 6.53 | 6.62 |
S2 | 6.35 | 5.57 | 5.92 | 6.20 | 6.29 | 6.18 |
S3 | 6.84 | 5.74 | 6.09 | 6.25 | 6.42 | 6.54 |
S4 | 6.57 | 5.28 | 5.57 | 5.85 | 6.09 | 6.16 |
S5 | 6.45 | 6.05 | 6.36 | 6.40 | 6.40 | 6.45 |
[S4:酸化10%w/v蔗糖 S5:酸化10%w/v山梨糖醇]
结果证明,饮料可被配制成含有较大量的低D.E.麦芽糖糊精,其具有最小的生龋齿的可能性。
实施例5-粉末状的运动饮料组合物
根据各种成分的下面列表制备粉末状的运动饮料配制料,这些成分典型地通过使用带形混合器进行干混直至获得均匀混合物为止。该产物然后填充到合适的包装物品如小袋,瓶或桶中。
成分 | Kg |
麦芽糖糊精(Ceres tar C-Pur 01910) | 87.2 |
阿斯巴特 | 0.2 |
合成糖精 | 0.1 |
碳酸钙 | 1.24 |
无水的柠檬酸 | 6.84 |
抗坏血酸 | 0.32 |
柠檬酸三钠二水合物 | 2.83 |
橙香精 | 0.54 |
β胡罗卜素(1%冷水可溶解的) | 0.73 |
总量 | 100 |
将75g的粉末溶于水中达到1升的最终容积,制备出橙黄色运动饮料。该饮料具有大约4的pH。
Claims (13)
1.一种具有4.5或更低的有效pH并包括至少1.0wt%的作为碳水化合物源的α-淀粉酶可消化的、α-(1,4)-连接的葡萄糖聚合物的含有碳水化合物的组合物,在该组合物中单-和二-糖类的浓度不大于2.0wt%,用于口服组合物的制造中以减少或防止由蚀斑酸产生引起的牙齿损坏的用途。
2.根据权利要求1的组合物的用途,其中葡萄糖的α-(1,4)-连接的聚合物是麦芽糖糊精。
3.根据权利要求2的组合物的用途,其中葡萄糖的α-(1,4)-连接的聚合物是具有15或15以下的糖化率(DE)的麦芽糖糊精。
4.根据权利要求1-3中任何一项的组合物的用途,其中单-和二-糖类的浓度是不大于1.0wt%。
5.根据权利要求1到4中任何一项的组合物的用途,具有在2.0到4.0范围内的有效pH。
6.根据权利要求1到5中任何一项的组合物的用途,该组合物是饮料。
7.根据权利要求1到5中任何一项的组合物的用途,该组合物是糖果产品。
8.根据权利要求6的组合物的用途,该组合物是含有4.0-8.0wt%的碳水化合物的运动饮料。
9.根据权利要求6或7的组合物的用途,它是含有15-25wt%碳水化合物的能量补充型产品。
10.根据权利要求6的组合物的用途,该组合物具有在2.4到4.0范围内的有效pH。
11.根据前述任一项权利要求的组合物的用途,进一步包括钙和/或粘度改性材料。
12.一种具有4.5或低于4.5的有效pH并且包括至少20.0wt%的作为碳水化合物源的α-淀粉酶可消化的、α-(1,4)-连接的葡萄糖聚合物的口服用的含碳水化合物的组合物,在该组合物中单-和二-糖类的浓度是不大于2.0wt%。
13.根据权利要求12的组合物,它是饮料。
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GBGB0018849.0A GB0018849D0 (en) | 2000-08-01 | 2000-08-01 | Novel composition and use |
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CN1446054A true CN1446054A (zh) | 2003-10-01 |
CN1240322C CN1240322C (zh) | 2006-02-08 |
Family
ID=9896751
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB018137059A Expired - Fee Related CN1240322C (zh) | 2000-08-01 | 2001-07-26 | 新型组合物与用途 |
Country Status (27)
Country | Link |
---|---|
US (1) | US20030175215A1 (zh) |
EP (1) | EP1313379B1 (zh) |
JP (1) | JP2004505027A (zh) |
KR (1) | KR100804928B1 (zh) |
CN (1) | CN1240322C (zh) |
AR (1) | AR033550A1 (zh) |
AT (1) | ATE270052T1 (zh) |
AU (2) | AU8975701A (zh) |
BR (1) | BR0112900A (zh) |
CA (1) | CA2416927C (zh) |
CZ (1) | CZ301463B6 (zh) |
DE (1) | DE60104128T2 (zh) |
DK (1) | DK1313379T3 (zh) |
ES (1) | ES2223005T3 (zh) |
GB (1) | GB0018849D0 (zh) |
HK (1) | HK1057848A1 (zh) |
HU (1) | HUP0303936A3 (zh) |
MX (1) | MXPA03000987A (zh) |
MY (1) | MY139947A (zh) |
NZ (1) | NZ523736A (zh) |
PL (1) | PL201806B1 (zh) |
PT (1) | PT1313379E (zh) |
SI (1) | SI1313379T1 (zh) |
TR (1) | TR200401819T4 (zh) |
TW (1) | TWI243024B (zh) |
WO (1) | WO2002009537A2 (zh) |
ZA (1) | ZA200300652B (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0018849D0 (en) * | 2000-08-01 | 2000-09-20 | Smithkline Beecham Plc | Novel composition and use |
AU2003259532A1 (en) * | 2003-07-31 | 2005-02-14 | Matthew Anthony Hartigan | Ready-to-drink formulation containing an active ingredient |
FR2867355B1 (fr) * | 2004-03-11 | 2006-06-23 | Christophe Hausswirth | Nouvelle preparation pulverulente destinee aux sportifs et aux personnes accomplissant des efforts physiques |
US20070003670A1 (en) * | 2005-06-29 | 2007-01-04 | Rod Jendrysik | Sports drink acid blend to reduce or eliminate aftertaste |
JP2009532065A (ja) * | 2006-04-05 | 2009-09-10 | キャドバリー アダムス ユーエスエー エルエルシー | 酸含有チューインガム中のリン酸カルシウム錯体 |
KR20140092313A (ko) * | 2011-09-23 | 2014-07-23 | 내츄럴 바이오테크놀로지 에스피알엘 | 음료수 및 소스를 위한 살균 조성물 |
EP2983514A4 (en) | 2013-03-15 | 2017-03-15 | Cargill, Incorporated | Carbohydrate compositions |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US853237A (en) * | 1906-08-07 | 1907-05-14 | George S Gray | Nut-lock. |
JPS5799171A (en) * | 1980-12-12 | 1982-06-19 | Meiji Seika Kaisha Ltd | Preparation of novel sweetening agent containing sorbitol and mannitol |
US4631195A (en) * | 1982-07-06 | 1986-12-23 | Colliopoulos John A | Sweetening composition |
US4971806A (en) * | 1984-01-31 | 1990-11-20 | Warner-Lambert Company | Multi-layered chewing gum composition having different rates of flavor release |
US4753805A (en) * | 1984-01-31 | 1988-06-28 | Warner-Lambert Company | Tabletted chewing gum composition and method of preparation |
KR860000528B1 (ko) * | 1984-06-15 | 1986-05-08 | 김봉노 | 국자의 제조방법 |
DE3771995D1 (de) * | 1986-10-16 | 1991-09-12 | Sinebrychoff Ab | Fitness-getraenkepulver |
FI89761C (fi) * | 1986-10-16 | 1993-11-25 | Sinebrychoff Ab | Anvaendning av aeppelsyra foer framstaellning av motionsdryckpulver |
US5370881A (en) * | 1987-04-20 | 1994-12-06 | Fuisz Technologies Ltd. | Water-soluble delivery systems for hydrophobic liquids |
ES2055251T3 (es) * | 1989-08-31 | 1994-08-16 | Paul Resmer | Alimento liquido y estable con contenido de harina de guar, e ingerible con sonda. |
US5032411A (en) * | 1990-02-27 | 1991-07-16 | University Of Texas System Board Of Regents | Beverage compositions for human consumption |
US5236719A (en) * | 1991-09-27 | 1993-08-17 | Wm. Wrigley Jr. Company | Chewing gum and other comestibles containing purified indigestible dextrin |
US5294606A (en) * | 1992-11-24 | 1994-03-15 | Reliv' International Inc. | Isotonic energy composition and method to use same |
JP3936752B2 (ja) * | 1994-03-01 | 2007-06-27 | 株式会社林原生物化学研究所 | 結晶マルトテトラオシルグルコシドとその製造方法並びに用途 |
JP3678451B2 (ja) * | 1995-02-10 | 2005-08-03 | 株式会社林原生物化学研究所 | う蝕抑制剤とその製造方法並びに用途 |
GB9603518D0 (en) * | 1996-02-20 | 1996-04-17 | Smithkline Beecham Plc | Novel process |
US5804165A (en) * | 1996-07-24 | 1998-09-08 | Arnold; Michael J. | Antiplaque oral composition |
JPH1087461A (ja) * | 1996-09-14 | 1998-04-07 | Showa Sangyo Co Ltd | 脱灰抑制剤およびそれを含む飲食物、口腔洗浄剤 |
GB9717598D0 (en) * | 1997-08-19 | 1997-10-22 | Smithkline Beecham Plc | Novel composition and use |
GB9819530D0 (en) * | 1998-09-09 | 1998-10-28 | Smithkline Beecham Plc | Novel compositions and use |
GB0018849D0 (en) * | 2000-08-01 | 2000-09-20 | Smithkline Beecham Plc | Novel composition and use |
-
2000
- 2000-08-01 GB GBGB0018849.0A patent/GB0018849D0/en not_active Ceased
-
2001
- 2001-07-26 AT AT01969521T patent/ATE270052T1/de active
- 2001-07-26 MX MXPA03000987A patent/MXPA03000987A/es active IP Right Grant
- 2001-07-26 PT PT01969521T patent/PT1313379E/pt unknown
- 2001-07-26 JP JP2002515098A patent/JP2004505027A/ja active Pending
- 2001-07-26 CN CNB018137059A patent/CN1240322C/zh not_active Expired - Fee Related
- 2001-07-26 KR KR1020037001410A patent/KR100804928B1/ko not_active IP Right Cessation
- 2001-07-26 AU AU8975701A patent/AU8975701A/xx active Pending
- 2001-07-26 ES ES01969521T patent/ES2223005T3/es not_active Expired - Lifetime
- 2001-07-26 SI SI200130170T patent/SI1313379T1/xx unknown
- 2001-07-26 EP EP01969521A patent/EP1313379B1/en not_active Expired - Lifetime
- 2001-07-26 WO PCT/EP2001/008638 patent/WO2002009537A2/en active IP Right Grant
- 2001-07-26 US US10/343,556 patent/US20030175215A1/en not_active Abandoned
- 2001-07-26 HU HU0303936A patent/HUP0303936A3/hu unknown
- 2001-07-26 AU AU2001289757A patent/AU2001289757B2/en not_active Ceased
- 2001-07-26 NZ NZ523736A patent/NZ523736A/en not_active IP Right Cessation
- 2001-07-26 BR BR0112900-7A patent/BR0112900A/pt not_active IP Right Cessation
- 2001-07-26 CZ CZ20030298A patent/CZ301463B6/cs not_active IP Right Cessation
- 2001-07-26 TR TR2004/01819T patent/TR200401819T4/xx unknown
- 2001-07-26 DK DK01969521T patent/DK1313379T3/da active
- 2001-07-26 DE DE60104128T patent/DE60104128T2/de not_active Expired - Lifetime
- 2001-07-26 PL PL365184A patent/PL201806B1/pl not_active IP Right Cessation
- 2001-07-26 CA CA002416927A patent/CA2416927C/en not_active Expired - Fee Related
- 2001-07-30 AR ARP010103631A patent/AR033550A1/es unknown
- 2001-07-31 TW TW090118637A patent/TWI243024B/zh not_active IP Right Cessation
- 2001-07-31 MY MYPI20013615A patent/MY139947A/en unknown
-
2003
- 2003-01-23 ZA ZA200300652A patent/ZA200300652B/en unknown
- 2003-11-28 HK HK03108722A patent/HK1057848A1/xx not_active IP Right Cessation
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