CN1404876A - 抗ctla－4抗体的应用 - Google Patents
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Families Citing this family (66)
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|---|---|---|---|---|
| US7109003B2 (en) | 1998-12-23 | 2006-09-19 | Abgenix, Inc. | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 |
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| AU2016364889B2 (en) | 2015-12-02 | 2024-01-04 | Agenus Inc. | Antibodies and methods of use thereof |
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| WO2017173334A1 (en) | 2016-04-01 | 2017-10-05 | Checkmate Pharmaceuticals, Inc. | Fc receptor-mediated drug delivery |
| EA039322B1 (ru) * | 2016-04-15 | 2022-01-13 | Эйдженус Инк. | Антитела против ctla-4 и способы их применения |
| WO2018035710A1 (en) | 2016-08-23 | 2018-03-01 | Akeso Biopharma, Inc. | Anti-ctla4 antibodies |
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| WO2019160866A2 (en) | 2018-02-13 | 2019-08-22 | Checkmate Pharmaceuticals, Inc. | Compositions and methods for tumor immunotherapy |
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| EP4229222A2 (en) | 2020-10-19 | 2023-08-23 | Dana-Farber Cancer Institute, Inc. | Germline biomarkers of clinical response and benefit to immune checkpoint inhibitor therapy |
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Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5994362A (en) * | 1992-03-11 | 1999-11-30 | Merck & Co., Inc. | Method of treatment for prostatic cancer |
| US5811097A (en) * | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| ZA98533B (en) * | 1997-01-31 | 1999-07-22 | Bristol Myers Squibb Co | Soluble CTLA4 mutant molecules and uses thereof. |
| EP2112166B1 (en) * | 1998-12-23 | 2018-11-21 | Pfizer Inc. | Human monoclonal antibodies to ctla-4 |
| US6682736B1 (en) * | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
| ATE354655T1 (de) * | 1999-08-24 | 2007-03-15 | Medarex Inc | Humane antikörper gegen ctla-4 und deren verwendungen |
| US7605238B2 (en) * | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| US7183376B2 (en) * | 2000-06-23 | 2007-02-27 | Maxygen, Inc. | Variant B7 co-stimulatory molecules |
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2002
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- 2002-05-17 JP JP2002142978A patent/JP2002371013A/ja active Pending
- 2002-05-17 CA CA002382443A patent/CA2382443A1/en not_active Abandoned
- 2002-05-21 CZ CZ20021760A patent/CZ20021760A3/cs unknown
- 2002-05-21 ZA ZA200204020A patent/ZA200204020B/xx unknown
- 2002-05-21 AU AU42421/02A patent/AU4242102A/en not_active Abandoned
- 2002-05-22 MY MYPI20021892A patent/MY136095A/en unknown
- 2002-05-22 KR KR10-2002-0028317A patent/KR100531707B1/ko not_active Expired - Fee Related
- 2002-05-22 US US10/153,382 patent/US20030086930A1/en not_active Abandoned
- 2002-05-23 PL PL02354112A patent/PL354112A1/xx not_active Application Discontinuation
- 2002-05-23 HU HU0201737A patent/HUP0201737A2/hu unknown
- 2002-05-23 CN CN02120349A patent/CN1404876A/zh active Pending
- 2002-05-23 EP EP02253652A patent/EP1262193A1/en not_active Withdrawn
- 2002-05-23 SK SK724-2002A patent/SK7242002A3/sk not_active Application Discontinuation
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101909693A (zh) * | 2008-01-08 | 2010-12-08 | 百时美施贵宝公司 | 用于治疗增殖性疾病的抗-ctla4抗体与微管蛋白调节剂的组合 |
| CN111330017A (zh) * | 2012-08-23 | 2020-06-26 | 艾更斯司股份有限公司 | 结合158p1d7蛋白的抗体药物偶联物(adc) |
| CN105636986A (zh) * | 2013-10-18 | 2016-06-01 | 瑞泽恩制药公司 | 包含vegf拮抗剂和抗-ctla-4抗体的组合的方法和组合物 |
| CN105636986B (zh) * | 2013-10-18 | 2020-05-12 | 瑞泽恩制药公司 | 包含vegf拮抗剂和抗-ctla-4抗体的组合的方法和组合物 |
| CN108271359A (zh) * | 2015-02-13 | 2018-07-10 | 索伦托治疗有限公司 | 结合ctla4的抗体治疗剂 |
| CN108348601A (zh) * | 2015-07-22 | 2018-07-31 | 索伦托治疗有限公司 | 与lag3结合的抗体治疗剂 |
| CN108348601B (zh) * | 2015-07-22 | 2022-05-17 | 索伦托药业有限公司 | 与lag3结合的抗体治疗剂 |
| CN109906088A (zh) * | 2016-08-26 | 2019-06-18 | 奥野哲治 | 微血管血流减少剂及其应用 |
| CN110092826A (zh) * | 2019-02-28 | 2019-08-06 | 天津大学 | CTLA-4类似物CFN13及CFN13-Fc基因和蛋白 |
| CN110092826B (zh) * | 2019-02-28 | 2022-04-15 | 天津大学 | CTLA-4类似物CFN13及CFN13-Fc基因和蛋白 |
| WO2021238932A1 (zh) * | 2020-05-26 | 2021-12-02 | 百奥泰生物制药股份有限公司 | 多特异性抗体及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1262193A1 (en) | 2002-12-04 |
| AU4242102A (en) | 2002-11-28 |
| IL149701A0 (en) | 2002-11-10 |
| SK7242002A3 (en) | 2003-07-01 |
| CZ20021760A3 (cs) | 2003-05-14 |
| JP2002371013A (ja) | 2002-12-26 |
| HUP0201737A2 (hu) | 2003-02-28 |
| MY136095A (en) | 2008-08-29 |
| CA2382443A1 (en) | 2002-11-23 |
| KR100531707B1 (ko) | 2005-11-30 |
| ZA200204020B (en) | 2003-11-21 |
| KR20020090873A (ko) | 2002-12-05 |
| PL354112A1 (en) | 2002-12-02 |
| HU0201737D0 (enrdf_load_stackoverflow) | 2002-07-29 |
| US20030086930A1 (en) | 2003-05-08 |
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