CN1353613A - 药物组合物 - Google Patents

药物组合物 Download PDF

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Publication number
CN1353613A
CN1353613A CN00808183A CN00808183A CN1353613A CN 1353613 A CN1353613 A CN 1353613A CN 00808183 A CN00808183 A CN 00808183A CN 00808183 A CN00808183 A CN 00808183A CN 1353613 A CN1353613 A CN 1353613A
Authority
CN
China
Prior art keywords
compositions
cyclosporin
weight
ethanol
formerly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00808183A
Other languages
English (en)
Chinese (zh)
Inventor
M·阿姆布尔
B·卢凯尔
B·哈博林
A·梅恩泽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN1353613A publication Critical patent/CN1353613A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Surgery (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Fats And Perfumes (AREA)
CN00808183A 1999-05-28 2000-05-26 药物组合物 Pending CN1353613A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9912476.0 1999-05-28
GBGB9912476.0A GB9912476D0 (en) 1999-05-28 1999-05-28 Organic compounds

Publications (1)

Publication Number Publication Date
CN1353613A true CN1353613A (zh) 2002-06-12

Family

ID=10854362

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00808183A Pending CN1353613A (zh) 1999-05-28 2000-05-26 药物组合物

Country Status (26)

Country Link
US (2) US6432445B1 (cg-RX-API-DMAC7.html)
EP (1) EP1181035B1 (cg-RX-API-DMAC7.html)
JP (1) JP2003500454A (cg-RX-API-DMAC7.html)
KR (1) KR20010111587A (cg-RX-API-DMAC7.html)
CN (1) CN1353613A (cg-RX-API-DMAC7.html)
AT (1) ATE291926T1 (cg-RX-API-DMAC7.html)
AU (1) AU765935B2 (cg-RX-API-DMAC7.html)
BR (1) BR0011030A (cg-RX-API-DMAC7.html)
CA (1) CA2371247A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ20014214A3 (cg-RX-API-DMAC7.html)
DE (2) DE10084671T1 (cg-RX-API-DMAC7.html)
ES (1) ES2239605T3 (cg-RX-API-DMAC7.html)
GB (2) GB9912476D0 (cg-RX-API-DMAC7.html)
HK (1) HK1045642B (cg-RX-API-DMAC7.html)
HU (1) HUP0201372A3 (cg-RX-API-DMAC7.html)
IL (1) IL146186A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA01012222A (cg-RX-API-DMAC7.html)
NO (1) NO20015785L (cg-RX-API-DMAC7.html)
NZ (1) NZ515154A (cg-RX-API-DMAC7.html)
PL (1) PL199591B1 (cg-RX-API-DMAC7.html)
PT (1) PT1181035E (cg-RX-API-DMAC7.html)
RU (1) RU2249461C2 (cg-RX-API-DMAC7.html)
SK (1) SK285471B6 (cg-RX-API-DMAC7.html)
TR (1) TR200103276T2 (cg-RX-API-DMAC7.html)
WO (1) WO2000072867A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200109658B (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101184800B (zh) * 2005-04-27 2011-04-27 金斯潘控股有限公司 用于酚醛泡沫体的表面活性剂

Families Citing this family (26)

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SK285019B6 (sk) * 1997-01-30 2006-04-06 Novartis Ag Tvrdá želatínová tobolka
ATE404172T1 (de) 1998-12-30 2008-08-15 Dexcel Ltd Dispergierbares konzentrat zur verabreichung von cyclosporin
GB9912476D0 (en) * 1999-05-28 1999-07-28 Novartis Ag Organic compounds
AR033711A1 (es) * 2001-05-09 2004-01-07 Novartis Ag Composiciones farmaceuticas
CA2471241A1 (en) * 2001-12-20 2003-07-03 Bernard Charles Sherman Pharmaceutical compositions comprising a cyclosporin, a hydrophilic surfactant and a lipophilic surfactant
US20040115287A1 (en) * 2002-12-17 2004-06-17 Lipocine, Inc. Hydrophobic active agent compositions and methods
US7538084B2 (en) * 2003-03-17 2009-05-26 Amr Technology, Inc. Cyclosporins
JP2005255677A (ja) * 2004-02-12 2005-09-22 Nof Corp シクロスポリン製剤
US20060014677A1 (en) * 2004-07-19 2006-01-19 Isotechnika International Inc. Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds
JP2008514701A (ja) * 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキン類似体およびそれらの薬学的使用
JP2008514702A (ja) * 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド 新規シクロスポリン類似体およびそれらの薬学的使用
JP2008515886A (ja) * 2004-10-06 2008-05-15 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキンおよびそれらの医用薬剤としての有用性
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US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
MY158809A (en) * 2010-09-22 2016-11-15 Craun Res Sdn Bhd Pharmaceutical compositions for calanolides, their derivatives and analogues, and process for producing the same
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
US20160361322A1 (en) 2015-06-15 2016-12-15 Lipocine Inc. Composition and method for oral delivery of androgen prodrugs
US11559530B2 (en) 2016-11-28 2023-01-24 Lipocine Inc. Oral testosterone undecanoate therapy
WO2020018974A1 (en) 2018-07-20 2020-01-23 Lipocine Inc. Liver disease

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ATE404172T1 (de) * 1998-12-30 2008-08-15 Dexcel Ltd Dispergierbares konzentrat zur verabreichung von cyclosporin
GB9912476D0 (en) * 1999-05-28 1999-07-28 Novartis Ag Organic compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101184800B (zh) * 2005-04-27 2011-04-27 金斯潘控股有限公司 用于酚醛泡沫体的表面活性剂

Also Published As

Publication number Publication date
US6767555B2 (en) 2004-07-27
JP2003500454A (ja) 2003-01-07
AU765935B2 (en) 2003-10-02
NO20015785L (no) 2002-01-23
ZA200109658B (en) 2002-08-20
HUP0201372A2 (en) 2002-09-28
EP1181035B1 (en) 2005-03-30
HK1045642B (en) 2005-10-28
KR20010111587A (ko) 2001-12-19
NO20015785D0 (no) 2001-11-27
GB0128277D0 (en) 2002-01-16
BR0011030A (pt) 2002-02-26
GB9912476D0 (en) 1999-07-28
DE60019100T2 (de) 2006-03-23
HUP0201372A3 (en) 2002-10-28
TR200103276T2 (tr) 2002-05-21
RU2249461C2 (ru) 2005-04-10
SK285471B6 (sk) 2007-02-01
AU5810000A (en) 2000-12-18
GB2367004A (en) 2002-03-27
WO2000072867A3 (en) 2001-04-05
EP1181035A2 (en) 2002-02-27
HK1045642A1 (en) 2002-12-06
ES2239605T3 (es) 2005-10-01
US20020188134A1 (en) 2002-12-12
NZ515154A (en) 2003-08-29
IL146186A0 (en) 2002-07-25
DE10084671T1 (de) 2002-06-06
US20020068083A1 (en) 2002-06-06
ATE291926T1 (de) 2005-04-15
PT1181035E (pt) 2005-08-31
MXPA01012222A (es) 2002-07-02
CA2371247A1 (en) 2000-12-07
PL199591B1 (pl) 2008-10-31
PL351593A1 (en) 2003-05-05
DE60019100D1 (de) 2005-05-04
WO2000072867A2 (en) 2000-12-07
SK17222001A3 (sk) 2002-03-05
CZ20014214A3 (cs) 2002-03-13
GB2367004B (en) 2004-04-14
US6432445B1 (en) 2002-08-13

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