CN1353613A - 药物组合物 - Google Patents

药物组合物 Download PDF

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Publication number
CN1353613A
CN1353613A CN00808183A CN00808183A CN1353613A CN 1353613 A CN1353613 A CN 1353613A CN 00808183 A CN00808183 A CN 00808183A CN 00808183 A CN00808183 A CN 00808183A CN 1353613 A CN1353613 A CN 1353613A
Authority
CN
China
Prior art keywords
compositions
cyclosporin
weight
ethanol
formerly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00808183A
Other languages
English (en)
Chinese (zh)
Inventor
M·阿姆布尔
B·卢凯尔
B·哈博林
A·梅恩泽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN1353613A publication Critical patent/CN1353613A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Surgery (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN00808183A 1999-05-28 2000-05-26 药物组合物 Pending CN1353613A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9912476.0A GB9912476D0 (en) 1999-05-28 1999-05-28 Organic compounds
GB9912476.0 1999-05-28

Publications (1)

Publication Number Publication Date
CN1353613A true CN1353613A (zh) 2002-06-12

Family

ID=10854362

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00808183A Pending CN1353613A (zh) 1999-05-28 2000-05-26 药物组合物

Country Status (26)

Country Link
US (2) US6432445B1 (cg-RX-API-DMAC10.html)
EP (1) EP1181035B1 (cg-RX-API-DMAC10.html)
JP (1) JP2003500454A (cg-RX-API-DMAC10.html)
KR (1) KR20010111587A (cg-RX-API-DMAC10.html)
CN (1) CN1353613A (cg-RX-API-DMAC10.html)
AT (1) ATE291926T1 (cg-RX-API-DMAC10.html)
AU (1) AU765935B2 (cg-RX-API-DMAC10.html)
BR (1) BR0011030A (cg-RX-API-DMAC10.html)
CA (1) CA2371247A1 (cg-RX-API-DMAC10.html)
CZ (1) CZ20014214A3 (cg-RX-API-DMAC10.html)
DE (2) DE60019100T2 (cg-RX-API-DMAC10.html)
ES (1) ES2239605T3 (cg-RX-API-DMAC10.html)
GB (2) GB9912476D0 (cg-RX-API-DMAC10.html)
HK (1) HK1045642B (cg-RX-API-DMAC10.html)
HU (1) HUP0201372A3 (cg-RX-API-DMAC10.html)
IL (1) IL146186A0 (cg-RX-API-DMAC10.html)
MX (1) MXPA01012222A (cg-RX-API-DMAC10.html)
NO (1) NO20015785L (cg-RX-API-DMAC10.html)
NZ (1) NZ515154A (cg-RX-API-DMAC10.html)
PL (1) PL199591B1 (cg-RX-API-DMAC10.html)
PT (1) PT1181035E (cg-RX-API-DMAC10.html)
RU (1) RU2249461C2 (cg-RX-API-DMAC10.html)
SK (1) SK285471B6 (cg-RX-API-DMAC10.html)
TR (1) TR200103276T2 (cg-RX-API-DMAC10.html)
WO (1) WO2000072867A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA200109658B (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101184800B (zh) * 2005-04-27 2011-04-27 金斯潘控股有限公司 用于酚醛泡沫体的表面活性剂

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT988046E (pt) * 1997-01-30 2004-12-31 Novartis Ag Composicoes farmaceuticas sem oleo contendo ciclosporina a
IL143604A0 (en) 1998-12-30 2002-04-21 Dexcel Ltd Dispersable concentrate for the delivery of cyclosporin
GB9912476D0 (en) 1999-05-28 1999-07-28 Novartis Ag Organic compounds
AR033711A1 (es) * 2001-05-09 2004-01-07 Novartis Ag Composiciones farmaceuticas
US20050129718A1 (en) * 2001-12-20 2005-06-16 Sherman Bernard C. Pharmaceutical compositions comprising a cyclosporin, a hydrophilic surfactant and a lipophilic surfactant
US20040115287A1 (en) * 2002-12-17 2004-06-17 Lipocine, Inc. Hydrophobic active agent compositions and methods
CA2518265A1 (en) * 2003-03-17 2004-09-30 Albany Molecular Research, Inc. Novel cyclosporins
JP2005255677A (ja) * 2004-02-12 2005-09-22 Nof Corp シクロスポリン製剤
US20060014677A1 (en) * 2004-07-19 2006-01-19 Isotechnika International Inc. Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds
JP2008514702A (ja) * 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド 新規シクロスポリン類似体およびそれらの薬学的使用
US7378391B2 (en) * 2004-09-29 2008-05-27 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
WO2006041631A2 (en) * 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
US7825087B2 (en) * 2005-04-12 2010-11-02 Elan Pharma International Limited Nanoparticulate and controlled release compositions comprising cyclosporine
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
MY158809A (en) * 2010-09-22 2016-11-15 Craun Res Sdn Bhd Pharmaceutical compositions for calanolides, their derivatives and analogues, and process for producing the same
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
WO2016205423A2 (en) 2015-06-15 2016-12-22 Lipocine Inc. Composition and method for oral delivery of androgen prodrugs
CA3078723A1 (en) 2016-11-28 2018-05-31 Nachiappan Chidambaram Oral testosterone undecanoate therapy
EP3824296B1 (en) 2018-07-20 2026-04-01 Lipocine Inc. Oral pharmaceutical composition comprising testosterone tridecanoate and/or testosterone dodecanoate for treating liver diseases

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7012460A (cg-RX-API-DMAC10.html) 1970-08-22 1972-02-24
DE3225706C2 (de) 1982-07-09 1984-04-26 A. Nattermann & Cie GmbH, 5000 Köln Flüssige Wirkstofformulierungen in Form von Konzentraten für Mikroemulsionen
DE3315805A1 (de) 1983-04-30 1984-11-08 Bayer Ag, 5090 Leverkusen Wirkstoffzubereitungen
GB8903804D0 (en) 1989-02-20 1989-04-05 Sandoz Ltd Improvements in or relating to organic compounds
US5639724A (en) * 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
FR2609631A1 (fr) 1987-01-15 1988-07-22 Sanofi Sa Compositions liquides stables a base de bithionol
US6007840A (en) 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
US5342625A (en) 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
GB2222770B (en) 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
DE3908047A1 (de) 1989-03-13 1990-09-20 Desitin Arzneimittel Gmbh Hochdisperse pharmazeutische zusammensetzung
US5283229A (en) 1989-12-11 1994-02-01 Isp Investments Inc. Delivery system for agricultural chemicals
US5266590A (en) 1989-12-11 1993-11-30 Isp Investments Inc. Cold stabilization of aqueous microemulsions of a water-insoluble agriculturally active compound
US5389688A (en) 1989-12-11 1995-02-14 Isp Investments Inc. Water based microemulsion formulations
US5110606A (en) 1990-11-13 1992-05-05 Affinity Biotech, Inc. Non-aqueous microemulsions for drug delivery
CA2097707A1 (en) 1991-02-12 1992-08-13 Kolazi S. Narayanan Stabilization of microemulsions using hydrophobic acid buffers
US5300529A (en) 1991-02-12 1994-04-05 Isp Investments Inc. Stable, clear, efficacious aqueous microemulsion compositions containing a high loading of a water-insoluble, agriculturally active chemical
US6022853A (en) * 1991-08-30 2000-02-08 Creative Biomolecules, Inc. Morphogen-enriched dietary composition
GB9225540D0 (en) 1992-12-07 1993-01-27 Ici Plc Cleaning compositions
JPH06293633A (ja) 1993-04-05 1994-10-21 Shin Etsu Chem Co Ltd 水性腸溶性エマルジョンの製造方法
CH686761A5 (de) 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
GB2278780B (en) 1993-05-27 1998-10-14 Sandoz Ltd Macrolide formulations
FR2710535B1 (fr) 1993-09-30 1995-11-24 Gattefosse Ets Sa Composition à usage pharmaceutique ou cosmétique apte à former une microémulsion.
DE4337041A1 (de) 1993-10-29 1995-05-04 Henkel Kgaa Verfahren zur Herstellung in Öl-in-Wasser-Emulsionen
WO1995022343A1 (en) 1994-02-17 1995-08-24 Shiseido Company, Ltd. Cyclosporin-containing emulsion composition
MY129435A (en) 1994-10-26 2007-04-30 Novartis Ag Pharmaceutical microemulsion preconcentrates
US5691289A (en) 1994-11-17 1997-11-25 Kay Chemical Company Cleaning compositions and methods of using the same
HU215966B (hu) 1994-11-21 1999-07-28 BIOGAL Gyógyszergyár Rt. Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum
EP0825849A1 (en) 1995-05-19 1998-03-04 Abbott Laboratories Self-emulsifying formulations of lipophilic drugs
SE9503143D0 (sv) 1995-09-12 1995-09-12 Astra Ab New preparation
DE19537836A1 (de) 1995-10-11 1997-04-17 Henkel Kgaa Aerosolemulsionen
KR970064620A (ko) 1996-03-05 1997-10-13 임성기 사이클로스포린-함유 외용약제 조성물
DE19615271A1 (de) 1996-04-18 1997-10-23 Huels Chemische Werke Ag Tensidhaltige Reinigungsmittel in Form einer Mikroemulsion
KR980008239A (ko) 1996-07-26 1998-04-30 김충환 사이클로스포린-함유 약학적 조성물
PT988046E (pt) * 1997-01-30 2004-12-31 Novartis Ag Composicoes farmaceuticas sem oleo contendo ciclosporina a
HU228855B1 (en) * 1997-03-12 2013-06-28 Abbott Lab Hydrophilic binary systems for the administration of cyclosporine
WO1998040051A1 (en) 1997-03-12 1998-09-17 Abbott Laboratories Lipophilic binary systems for the administration of lipophilic compounds
US6028067A (en) 1997-12-05 2000-02-22 Chong Kun Dang Corp. Cyclosporin-containing microemulsion preconcentrate composition
US6063762A (en) 1997-12-05 2000-05-16 Chong Kun Dang Corp. Cyclosporin-containing microemulsion preconcentrate composition
WO1999029335A1 (en) 1997-12-05 1999-06-17 Chong Kun Dang Corp. Pharmaceutical composition containing cyclosporin
US6284268B1 (en) 1997-12-10 2001-09-04 Cyclosporine Therapeutics Limited Pharmaceutical compositions containing an omega-3 fatty acid oil
NZ329929A (en) * 1998-03-09 1999-10-28 Bernard Charles Sherman Pharmaceutical emulsion preconcentrate containing cyclosporin in a solvent system containing glycerides, propylene or polyethylene glycol, a surfactant and a co-surfactant
IL143604A0 (en) * 1998-12-30 2002-04-21 Dexcel Ltd Dispersable concentrate for the delivery of cyclosporin
GB9912476D0 (en) * 1999-05-28 1999-07-28 Novartis Ag Organic compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101184800B (zh) * 2005-04-27 2011-04-27 金斯潘控股有限公司 用于酚醛泡沫体的表面活性剂

Also Published As

Publication number Publication date
HK1045642B (en) 2005-10-28
TR200103276T2 (tr) 2002-05-21
AU5810000A (en) 2000-12-18
HUP0201372A2 (en) 2002-09-28
GB2367004A (en) 2002-03-27
GB9912476D0 (en) 1999-07-28
RU2249461C2 (ru) 2005-04-10
PT1181035E (pt) 2005-08-31
DE60019100T2 (de) 2006-03-23
US6432445B1 (en) 2002-08-13
HK1045642A1 (en) 2002-12-06
EP1181035A2 (en) 2002-02-27
JP2003500454A (ja) 2003-01-07
US20020188134A1 (en) 2002-12-12
US6767555B2 (en) 2004-07-27
DE60019100D1 (de) 2005-05-04
IL146186A0 (en) 2002-07-25
CA2371247A1 (en) 2000-12-07
ZA200109658B (en) 2002-08-20
DE10084671T1 (de) 2002-06-06
NO20015785D0 (no) 2001-11-27
PL199591B1 (pl) 2008-10-31
NZ515154A (en) 2003-08-29
AU765935B2 (en) 2003-10-02
PL351593A1 (en) 2003-05-05
WO2000072867A3 (en) 2001-04-05
GB2367004B (en) 2004-04-14
HUP0201372A3 (en) 2002-10-28
SK17222001A3 (sk) 2002-03-05
ATE291926T1 (de) 2005-04-15
ES2239605T3 (es) 2005-10-01
GB0128277D0 (en) 2002-01-16
US20020068083A1 (en) 2002-06-06
KR20010111587A (ko) 2001-12-19
CZ20014214A3 (cs) 2002-03-13
BR0011030A (pt) 2002-02-26
WO2000072867A2 (en) 2000-12-07
SK285471B6 (sk) 2007-02-01
NO20015785L (no) 2002-01-23
EP1181035B1 (en) 2005-03-30
MXPA01012222A (es) 2002-07-02

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