AU765935B2 - Substantially oil-free cyclosporin compositions - Google Patents

Substantially oil-free cyclosporin compositions Download PDF

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Publication number
AU765935B2
AU765935B2 AU58100/00A AU5810000A AU765935B2 AU 765935 B2 AU765935 B2 AU 765935B2 AU 58100/00 A AU58100/00 A AU 58100/00A AU 5810000 A AU5810000 A AU 5810000A AU 765935 B2 AU765935 B2 AU 765935B2
Authority
AU
Australia
Prior art keywords
composition
cyclosporin
composition according
weight
fatty acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU58100/00A
Other languages
English (en)
Other versions
AU5810000A (en
Inventor
Michael Ambuhl
Barbara Haberlin
Barbara Luckel
Armin Meinzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU5810000A publication Critical patent/AU5810000A/en
Application granted granted Critical
Publication of AU765935B2 publication Critical patent/AU765935B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Surgery (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU58100/00A 1999-05-28 2000-05-26 Substantially oil-free cyclosporin compositions Ceased AU765935B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9912476.0A GB9912476D0 (en) 1999-05-28 1999-05-28 Organic compounds
GB9912476 1999-05-28
PCT/EP2000/004829 WO2000072867A2 (en) 1999-05-28 2000-05-26 Substantially oil-free cyclosporin compositions

Publications (2)

Publication Number Publication Date
AU5810000A AU5810000A (en) 2000-12-18
AU765935B2 true AU765935B2 (en) 2003-10-02

Family

ID=10854362

Family Applications (1)

Application Number Title Priority Date Filing Date
AU58100/00A Ceased AU765935B2 (en) 1999-05-28 2000-05-26 Substantially oil-free cyclosporin compositions

Country Status (26)

Country Link
US (2) US6432445B1 (cg-RX-API-DMAC10.html)
EP (1) EP1181035B1 (cg-RX-API-DMAC10.html)
JP (1) JP2003500454A (cg-RX-API-DMAC10.html)
KR (1) KR20010111587A (cg-RX-API-DMAC10.html)
CN (1) CN1353613A (cg-RX-API-DMAC10.html)
AT (1) ATE291926T1 (cg-RX-API-DMAC10.html)
AU (1) AU765935B2 (cg-RX-API-DMAC10.html)
BR (1) BR0011030A (cg-RX-API-DMAC10.html)
CA (1) CA2371247A1 (cg-RX-API-DMAC10.html)
CZ (1) CZ20014214A3 (cg-RX-API-DMAC10.html)
DE (2) DE60019100T2 (cg-RX-API-DMAC10.html)
ES (1) ES2239605T3 (cg-RX-API-DMAC10.html)
GB (2) GB9912476D0 (cg-RX-API-DMAC10.html)
HK (1) HK1045642B (cg-RX-API-DMAC10.html)
HU (1) HUP0201372A3 (cg-RX-API-DMAC10.html)
IL (1) IL146186A0 (cg-RX-API-DMAC10.html)
MX (1) MXPA01012222A (cg-RX-API-DMAC10.html)
NO (1) NO20015785L (cg-RX-API-DMAC10.html)
NZ (1) NZ515154A (cg-RX-API-DMAC10.html)
PL (1) PL199591B1 (cg-RX-API-DMAC10.html)
PT (1) PT1181035E (cg-RX-API-DMAC10.html)
RU (1) RU2249461C2 (cg-RX-API-DMAC10.html)
SK (1) SK285471B6 (cg-RX-API-DMAC10.html)
TR (1) TR200103276T2 (cg-RX-API-DMAC10.html)
WO (1) WO2000072867A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA200109658B (cg-RX-API-DMAC10.html)

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PT988046E (pt) * 1997-01-30 2004-12-31 Novartis Ag Composicoes farmaceuticas sem oleo contendo ciclosporina a
IL143604A0 (en) 1998-12-30 2002-04-21 Dexcel Ltd Dispersable concentrate for the delivery of cyclosporin
GB9912476D0 (en) 1999-05-28 1999-07-28 Novartis Ag Organic compounds
AR033711A1 (es) * 2001-05-09 2004-01-07 Novartis Ag Composiciones farmaceuticas
US20050129718A1 (en) * 2001-12-20 2005-06-16 Sherman Bernard C. Pharmaceutical compositions comprising a cyclosporin, a hydrophilic surfactant and a lipophilic surfactant
US20040115287A1 (en) * 2002-12-17 2004-06-17 Lipocine, Inc. Hydrophobic active agent compositions and methods
CA2518265A1 (en) * 2003-03-17 2004-09-30 Albany Molecular Research, Inc. Novel cyclosporins
JP2005255677A (ja) * 2004-02-12 2005-09-22 Nof Corp シクロスポリン製剤
US20060014677A1 (en) * 2004-07-19 2006-01-19 Isotechnika International Inc. Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds
JP2008514702A (ja) * 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド 新規シクロスポリン類似体およびそれらの薬学的使用
US7378391B2 (en) * 2004-09-29 2008-05-27 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
WO2006041631A2 (en) * 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
US7825087B2 (en) * 2005-04-12 2010-11-02 Elan Pharma International Limited Nanoparticulate and controlled release compositions comprising cyclosporine
WO2006114776A1 (en) * 2005-04-27 2006-11-02 Kingspan Holdings (Irl) Limited Surfactant for phenolic foam
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
MY158809A (en) * 2010-09-22 2016-11-15 Craun Res Sdn Bhd Pharmaceutical compositions for calanolides, their derivatives and analogues, and process for producing the same
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
WO2016205423A2 (en) 2015-06-15 2016-12-22 Lipocine Inc. Composition and method for oral delivery of androgen prodrugs
CA3078723A1 (en) 2016-11-28 2018-05-31 Nachiappan Chidambaram Oral testosterone undecanoate therapy
EP3824296B1 (en) 2018-07-20 2026-04-01 Lipocine Inc. Oral pharmaceutical composition comprising testosterone tridecanoate and/or testosterone dodecanoate for treating liver diseases

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998033512A1 (en) * 1997-01-30 1998-08-06 Novartis Ag Oil-free pharmaceutical compositions containing cyclosporin a
WO1998040094A1 (en) * 1997-03-12 1998-09-17 Abbott Laboratories Hydrophilic binary systems for the administration of cyclosporine
WO2000040219A1 (en) * 1998-12-30 2000-07-13 Dexcel Ltd. Dispersible concentrate for the delivery of cyclosporin

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Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
WO1998033512A1 (en) * 1997-01-30 1998-08-06 Novartis Ag Oil-free pharmaceutical compositions containing cyclosporin a
WO1998040094A1 (en) * 1997-03-12 1998-09-17 Abbott Laboratories Hydrophilic binary systems for the administration of cyclosporine
WO2000040219A1 (en) * 1998-12-30 2000-07-13 Dexcel Ltd. Dispersible concentrate for the delivery of cyclosporin

Also Published As

Publication number Publication date
HK1045642B (en) 2005-10-28
CN1353613A (zh) 2002-06-12
TR200103276T2 (tr) 2002-05-21
AU5810000A (en) 2000-12-18
HUP0201372A2 (en) 2002-09-28
GB2367004A (en) 2002-03-27
GB9912476D0 (en) 1999-07-28
RU2249461C2 (ru) 2005-04-10
PT1181035E (pt) 2005-08-31
DE60019100T2 (de) 2006-03-23
US6432445B1 (en) 2002-08-13
HK1045642A1 (en) 2002-12-06
EP1181035A2 (en) 2002-02-27
JP2003500454A (ja) 2003-01-07
US20020188134A1 (en) 2002-12-12
US6767555B2 (en) 2004-07-27
DE60019100D1 (de) 2005-05-04
IL146186A0 (en) 2002-07-25
CA2371247A1 (en) 2000-12-07
ZA200109658B (en) 2002-08-20
DE10084671T1 (de) 2002-06-06
NO20015785D0 (no) 2001-11-27
PL199591B1 (pl) 2008-10-31
NZ515154A (en) 2003-08-29
PL351593A1 (en) 2003-05-05
WO2000072867A3 (en) 2001-04-05
GB2367004B (en) 2004-04-14
HUP0201372A3 (en) 2002-10-28
SK17222001A3 (sk) 2002-03-05
ATE291926T1 (de) 2005-04-15
ES2239605T3 (es) 2005-10-01
GB0128277D0 (en) 2002-01-16
US20020068083A1 (en) 2002-06-06
KR20010111587A (ko) 2001-12-19
CZ20014214A3 (cs) 2002-03-13
BR0011030A (pt) 2002-02-26
WO2000072867A2 (en) 2000-12-07
SK285471B6 (sk) 2007-02-01
NO20015785L (no) 2002-01-23
EP1181035B1 (en) 2005-03-30
MXPA01012222A (es) 2002-07-02

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FGA Letters patent sealed or granted (standard patent)