CN1331751A - 改进的头孢菌素的体内生产方法 - Google Patents

改进的头孢菌素的体内生产方法 Download PDF

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Publication number
CN1331751A
CN1331751A CN99814782A CN99814782A CN1331751A CN 1331751 A CN1331751 A CN 1331751A CN 99814782 A CN99814782 A CN 99814782A CN 99814782 A CN99814782 A CN 99814782A CN 1331751 A CN1331751 A CN 1331751A
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CN
China
Prior art keywords
aca
nucleotide sequence
acidylate
acid
side chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99814782A
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English (en)
Chinese (zh)
Inventor
R·A·L·博文博格
R·科克曼
E·科汉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke DSM NV
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DSM NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by DSM NV filed Critical DSM NV
Publication of CN1331751A publication Critical patent/CN1331751A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN99814782A 1998-12-22 1999-12-21 改进的头孢菌素的体内生产方法 Pending CN1331751A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98204469 1998-12-22
EP98204469.5 1998-12-22

Publications (1)

Publication Number Publication Date
CN1331751A true CN1331751A (zh) 2002-01-16

Family

ID=8234568

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99814782A Pending CN1331751A (zh) 1998-12-22 1999-12-21 改进的头孢菌素的体内生产方法

Country Status (7)

Country Link
EP (1) EP1141372A2 (ja)
JP (1) JP2002533092A (ja)
KR (1) KR20010089672A (ja)
CN (1) CN1331751A (ja)
AU (1) AU3042600A (ja)
HK (1) HK1041610A1 (ja)
WO (1) WO2000037671A2 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
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CN101555463B (zh) * 2008-04-08 2012-05-30 中国科学院上海生命科学研究院湖州工业生物技术中心 表达头孢菌素脱乙酰酶的重组大肠杆菌菌株及其构建方法
CN110214188A (zh) * 2016-08-26 2019-09-06 艾美科健株式会社 7-氨基头孢烷酸的高浓度生产重组顶头孢霉菌株的制造方法及利用其方法所制造的菌株

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US8735100B2 (en) 2009-03-17 2014-05-27 Nederlandse Organisatie Voor Toegepast -Natuurwetenschappelijk Onderzoek Tno Cellulose and ligno-cellulose active proteins
US9353387B2 (en) 2009-04-15 2016-05-31 Dsm Ip Assets B.V. Dicarboxylic acid production process
UA108853C2 (uk) 2009-07-10 2015-06-25 Спосіб ферментації галактози
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EP2388331A1 (en) 2010-05-21 2011-11-23 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Constitutive promoter
AU2011315572B2 (en) 2010-10-13 2015-09-03 Dsm Ip Assets B.V. Polypeptides with permease activity
US20140141473A1 (en) 2011-04-22 2014-05-22 Dsm Ip Assets B.V. Yeast cell capable of converting sugars including arabinose and xlose
EP2554668A1 (en) 2011-08-04 2013-02-06 DSM IP Assets B.V. A pentose sugar fermenting cell
AR087423A1 (es) 2011-08-04 2014-03-19 Dsm Ip Assets Bv Celula capaz de fermentar azucares pentosas
EP3444338A1 (en) 2012-01-23 2019-02-20 DSM IP Assets B.V. Diterpene production
MY171218A (en) 2012-10-16 2019-10-02 Dsm Ip Assets Bv Cells with improved pentose conversion
EP2772545A1 (en) 2013-03-01 2014-09-03 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Starch active proteins
US20160060660A1 (en) 2013-04-05 2016-03-03 Université Du Luxembourg Biotechnological production of itaconic acid
US9885066B2 (en) 2013-05-02 2018-02-06 Dutch Dna Biotech B.V. Organic acid pathway
MX367033B (es) 2013-05-31 2019-08-02 Dsm Ip Assets Bv Microorganismos para la produccion de diterpeno.
AU2014292150B2 (en) 2013-07-15 2019-04-04 Dsm Ip Assets B.V. Diterpene production
MX369591B (es) 2013-07-31 2019-11-13 Dsm Ip Assets Bv Recuperacion de glicosidos de esteviol.
CN107429273A (zh) 2015-02-16 2017-12-01 帝斯曼知识产权资产管理有限公司 用于在厌氧条件下生产衣康酸的方法
EP3862426A3 (en) 2015-03-16 2021-11-17 DSM IP Assets B.V. Udp-glycosyltransferases
WO2016151046A1 (en) 2015-03-23 2016-09-29 Dsm Ip Assets B.V. Udp-glycosyltransferases from solanum lycopersicum
US11344051B2 (en) 2015-04-03 2022-05-31 Dsm Ip Assets B.V. Steviol glycosides
CN107532135A (zh) 2015-04-21 2018-01-02 帝斯曼知识产权资产管理有限公司 萜类化合物的微生物生产
BR112017023262A2 (pt) 2015-05-22 2018-07-17 Dsm Ip Assets Bv célula de levedura de consumo de acetato
MY192153A (en) 2015-07-10 2022-08-02 Dsm Ip Assets Bv Steviol glycoside composition
WO2017025649A1 (en) 2015-08-13 2017-02-16 Dsm Ip Assets B.V. Steviol glycoside transport
WO2017050652A1 (en) 2015-09-25 2017-03-30 Dsm Ip Assets B.V. Asparaginase
CN108138152B (zh) 2015-10-05 2023-01-06 帝斯曼知识产权资产管理有限公司 贝壳杉烯酸羟化酶
MY186400A (en) * 2015-10-06 2021-07-22 Dsm Ip Assets Bv Eukaryotic cell with increased production of fermentation product
JP2019500041A (ja) 2015-12-30 2019-01-10 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． トリアシルグリセロールの部分的酵素加水分解
CA3009871A1 (en) 2015-12-30 2017-07-06 Dsm Ip Assets B.V. Partial enzymatic hydrolysis of triacylglycerols
EP3435771A1 (en) 2016-03-31 2019-02-06 DSM IP Assets B.V. Enzyme composition and preparation of a dairy product with improved properties
EP3435770A1 (en) 2016-03-31 2019-02-06 DSM IP Assets B.V. Production of milk with low lactose content
WO2017167849A1 (en) 2016-03-31 2017-10-05 Dsm Ip Assets B.V. Enzyme composition and preparation of a dairy product with improved properties
BR112018074490A2 (pt) 2016-06-14 2019-03-19 Dsm Ip Assets B.V. célula de levedura recombinante
CN109689864B (zh) 2016-07-13 2023-04-04 帝斯曼知识产权资产管理有限公司 苹果酸脱氢酶
BR112019002432A2 (pt) 2016-08-09 2019-06-04 Dsm Ip Assets Bv cristalização de glicosídeos de esteviol
CA3032656A1 (en) 2016-08-09 2018-02-15 Dsm Ip Assets B.V. Crystallization of steviol glycosides
US11066681B2 (en) 2016-08-26 2021-07-20 Lesaffre Et Compagnie Production of itaconic acid
WO2018073107A1 (en) 2016-10-19 2018-04-26 Dsm Ip Assets B.V. Eukaryotic cell comprising xylose isomerase
EP3532611B1 (en) 2016-10-27 2021-12-01 DSM IP Assets B.V. Geranylgeranyl pyrophosphate synthases
BR112019011525A2 (pt) 2016-12-08 2020-01-28 Dsm Ip Assets Bv ácido caurenoico hidroxilases
CA3046153A1 (en) 2016-12-21 2018-06-28 Dsm Ip Assets B.V. Lipolytic enzyme variants
WO2018114912A1 (en) 2016-12-21 2018-06-28 Dsm Ip Assets B.V. Lipolytic enzyme variants
US10918113B2 (en) 2016-12-21 2021-02-16 Dsm Ip Assets B.V. Lipolytic enzyme variants
WO2018114938A1 (en) 2016-12-21 2018-06-28 Dsm Ip Assets B.V. Lipolytic enzyme variants
WO2018114995A1 (en) 2016-12-22 2018-06-28 Dsm Ip Assets B.V. Fermentation process for producing steviol glycosides
CN111032854A (zh) 2017-06-13 2020-04-17 帝斯曼知识产权资产管理有限公司 重组酵母细胞
WO2019002264A1 (en) 2017-06-27 2019-01-03 Dsm Ip Assets B.V. UDP-glycosyltransferase
BR112020004921A2 (pt) 2017-09-26 2020-09-15 Dsm Ip Assets B.V. cepa consumidora de ácido acético
EP3533878A1 (en) 2018-02-28 2019-09-04 Dutch DNA Biotech B.V. Process for producing citramalic acid employing aspergillus
EP3809852A1 (en) 2018-06-19 2021-04-28 DSM IP Assets B.V. Lipolytic enzyme variants
EP4232568A1 (en) 2020-10-22 2023-08-30 DSM IP Assets B.V. Microorganisms for diterpene production
EP4359426A2 (en) 2021-06-24 2024-05-01 Fonterra Co-Operative Group Limited Recombinant beta-lactoglobulin
WO2023285280A1 (en) 2021-07-12 2023-01-19 Dsm Ip Assets B.V. Recombinant yeast cell
WO2023285279A1 (en) 2021-07-12 2023-01-19 Dsm Ip Assets B.V. Recombinant yeast cell
EP4370690A1 (en) 2021-07-12 2024-05-22 Danisco Us Inc Recombinant yeast cell
CN117940570A (zh) 2021-07-12 2024-04-26 丹尼斯科美国公司 重组酵母细胞
MX2024000511A (es) 2021-07-12 2024-03-11 Danisco Us Inc Celula de levadura recombinante.
WO2023079049A1 (en) 2021-11-04 2023-05-11 Dsm Ip Assets B.V. Variant polypeptide and recombinant yeast cell
EP4426824A1 (en) 2021-11-04 2024-09-11 Danisco US Inc. Recombinant yeast cell
MX2024005284A (es) 2021-11-04 2024-05-17 Danisco Us Inc Proceso para la produccion de etanol y celula de levadura recombinante.
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WO2023222614A1 (en) 2022-05-16 2023-11-23 Dsm Ip Assets B.V. Lipolytic enzyme variants

Family Cites Families (5)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101555463B (zh) * 2008-04-08 2012-05-30 中国科学院上海生命科学研究院湖州工业生物技术中心 表达头孢菌素脱乙酰酶的重组大肠杆菌菌株及其构建方法
CN110214188A (zh) * 2016-08-26 2019-09-06 艾美科健株式会社 7-氨基头孢烷酸的高浓度生产重组顶头孢霉菌株的制造方法及利用其方法所制造的菌株
CN110214188B (zh) * 2016-08-26 2023-06-06 艾美科健株式会社 7-氨基头孢烷酸的高浓度生产重组顶头孢霉菌株的制造方法及利用其方法所制造的菌株

Also Published As

Publication number Publication date
HK1041610A1 (zh) 2002-07-12
AU3042600A (en) 2000-07-12
KR20010089672A (ko) 2001-10-08
WO2000037671A2 (en) 2000-06-29
EP1141372A2 (en) 2001-10-10
WO2000037671A3 (en) 2000-09-14
JP2002533092A (ja) 2002-10-08

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