ES2191313T3 - Procedimiento para la produccion fermentativa de cefalosporinas desaciladas. - Google Patents

Procedimiento para la produccion fermentativa de cefalosporinas desaciladas.

Info

Publication number
ES2191313T3
ES2191313T3 ES98929264T ES98929264T ES2191313T3 ES 2191313 T3 ES2191313 T3 ES 2191313T3 ES 98929264 T ES98929264 T ES 98929264T ES 98929264 T ES98929264 T ES 98929264T ES 2191313 T3 ES2191313 T3 ES 2191313T3
Authority
ES
Spain
Prior art keywords
cephalosporins
disabled
procedure
fermentative production
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98929264T
Other languages
English (en)
Inventor
Maarten Nieboer
Vroom Erik De
Johannis Lugtenburg
Dirk Schipper
Adrianus Wilhelmus Vollebregt
Roelof Ary Lans Bovenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke DSM NV
Original Assignee
DSM NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM NV filed Critical DSM NV
Application granted granted Critical
Publication of ES2191313T3 publication Critical patent/ES2191313T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/933—Penicillium
    • Y10S435/935—Penicillium chrysogenum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

LA PRESENTE INVENCION DESCRIBE UN PROCEDIMIENTO DE PRODUCCION DE COMPUESTOS DE CEFALOSPORINA N - DESACILADOS, A TRAVES DE LA PRODUCCION FERMENTATIVA DE LOS DERIVADOS 7 - ACILADOS DE DICHOS COMPUESTOS.
ES98929264T 1997-04-22 1998-04-22 Procedimiento para la produccion fermentativa de cefalosporinas desaciladas. Expired - Lifetime ES2191313T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97201197 1997-04-22

Publications (1)

Publication Number Publication Date
ES2191313T3 true ES2191313T3 (es) 2003-09-01

Family

ID=8228237

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98929264T Expired - Lifetime ES2191313T3 (es) 1997-04-22 1998-04-22 Procedimiento para la produccion fermentativa de cefalosporinas desaciladas.

Country Status (17)

Country Link
US (1) US6410259B1 (es)
EP (1) EP0915988B1 (es)
JP (1) JP2000512512A (es)
KR (1) KR20000022109A (es)
CN (1) CN1145703C (es)
AT (1) ATE231919T1 (es)
AU (1) AU7909498A (es)
BR (1) BR9804854A (es)
DE (1) DE69811039T2 (es)
ES (1) ES2191313T3 (es)
ID (1) ID21520A (es)
PL (1) PL330760A1 (es)
PT (1) PT915988E (es)
RU (1) RU2208643C2 (es)
SI (1) SI0915988T1 (es)
WO (1) WO1998048035A1 (es)
ZA (1) ZA983395B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002533092A (ja) * 1998-12-22 2002-10-08 デーエスエム・ナムローゼ・フェンノートシャップ セファロスポリンの改良されたｉｎｖｉｖｏ産生
EP2123772A1 (en) 2008-04-29 2009-11-25 DSM IP Assets B.V. Beta-lactam antibiotic producing strains
CN102119213A (zh) 2008-08-05 2011-07-06 帝斯曼知识产权资产管理有限公司 生产己二酰基-7-adca的菌株
EP2392649A3 (en) 2008-08-05 2012-01-11 DSM IP Assets B.V. Adipoyl-7-ADCA producing strains
WO2010115838A1 (en) 2009-04-03 2010-10-14 Dsm Ip Assets B.V. Fermentation process
EP2585608B1 (en) 2010-06-22 2017-07-26 DSM Sinochem Pharmaceuticals Netherlands B.V. Air bubble fermentation process
CN103429596B (zh) 2011-03-03 2016-03-02 中化帝斯曼制药有限公司荷兰公司 青霉素化合物的降解
CN102757999A (zh) * 2011-04-29 2012-10-31 上海医药工业研究院 一种用于生产7-氨基头孢烷酸的发酵培养基及其发酵方法
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT83746B (pt) 1985-11-15 1988-08-17 Gist Brocades Nv Processo para a preparacao de novos biocatalisadores imobilizados e para a producao de etanol por fermentacao
IE910956A1 (en) 1990-03-23 1991-09-25 Gist Brocades Nv A method of modulating the production of secondary¹metabolites
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
RO116648B1 (ro) * 1991-10-15 2001-04-30 Merck & Co Inc Bioprocedeu pentru prepararea acidului 7-amino-3-deacetil-cefalosporanic si a acidului 7-aminocefalosporanic
BR9407104A (pt) 1993-07-30 1996-08-27 Gist Brocades Nv Processo para a preparação e recuperação de ácido 7-amino desacetoxi cefalosporânico (7-adca) vetor de ADN recombinante e célula hospedeira transformada com um vetor definido
HU219259B (en) * 1993-07-30 2001-03-28 Gist Brocades Bv Process for the efficient production of 7-adca via 2-(carboxyethylthio)acetyl-7-adca and 3-(carboxymethylthio)propionyl-7-adca, recombinant dna vectrors and transformed host cells

Also Published As

Publication number Publication date
BR9804854A (pt) 1999-09-08
WO1998048035A1 (en) 1998-10-29
ZA983395B (en) 1999-01-27
EP0915988A1 (en) 1999-05-19
AU7909498A (en) 1998-11-13
SI0915988T1 (en) 2003-06-30
US6410259B1 (en) 2002-06-25
ID21520A (id) 1999-06-24
DE69811039T2 (de) 2004-01-22
EP0915988B1 (en) 2003-01-29
CN1224469A (zh) 1999-07-28
PL330760A1 (en) 1999-05-24
CN1145703C (zh) 2004-04-14
RU2208643C2 (ru) 2003-07-20
PT915988E (pt) 2003-06-30
KR20000022109A (ko) 2000-04-25
DE69811039D1 (de) 2003-03-06
JP2000512512A (ja) 2000-09-26
ATE231919T1 (de) 2003-02-15

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