CN1308291C - 治疗剂 - Google Patents

治疗剂 Download PDF

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Publication number
CN1308291C
CN1308291C CNB2003801098952A CN200380109895A CN1308291C CN 1308291 C CN1308291 C CN 1308291C CN B2003801098952 A CNB2003801098952 A CN B2003801098952A CN 200380109895 A CN200380109895 A CN 200380109895A CN 1308291 C CN1308291 C CN 1308291C
Authority
CN
China
Prior art keywords
phenyl
group
dioxo
formamyl
tetrahydrochysene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2003801098952A
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English (en)
Chinese (zh)
Other versions
CN1753862A (zh
Inventor
E·－L·林德斯特德特阿尔斯特尔马克
A·C·奥尔松
L·李
C·－J·奥雷尔
A·米尼迪斯
E·尤塞菲－萨拉克德
M·U·J·达尔斯特伦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
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Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1753862A publication Critical patent/CN1753862A/zh
Application granted granted Critical
Publication of CN1308291C publication Critical patent/CN1308291C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB2003801098952A 2002-12-21 2003-12-19 治疗剂 Expired - Fee Related CN1308291C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0229931.1 2002-12-21
GBGB0229931.1A GB0229931D0 (en) 2002-12-21 2002-12-21 Therapeutic agents

Publications (2)

Publication Number Publication Date
CN1753862A CN1753862A (zh) 2006-03-29
CN1308291C true CN1308291C (zh) 2007-04-04

Family

ID=9950253

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2003801098952A Expired - Fee Related CN1308291C (zh) 2002-12-21 2003-12-19 治疗剂

Country Status (21)

Country Link
US (1) US7462644B2 (enExample)
EP (1) EP1572626A1 (enExample)
JP (2) JP3786945B2 (enExample)
KR (1) KR20050089065A (enExample)
CN (1) CN1308291C (enExample)
AR (1) AR042632A1 (enExample)
AU (1) AU2003290309B2 (enExample)
BR (1) BR0317458A (enExample)
CA (1) CA2508851A1 (enExample)
CL (1) CL2003002683A1 (enExample)
CO (1) CO5580820A2 (enExample)
GB (1) GB0229931D0 (enExample)
IS (1) IS7946A (enExample)
MX (1) MXPA05006812A (enExample)
NO (1) NO20052914L (enExample)
PL (1) PL377144A1 (enExample)
RU (1) RU2005117792A (enExample)
TW (1) TW200508180A (enExample)
UA (1) UA80729C2 (enExample)
WO (1) WO2004056748A1 (enExample)
ZA (1) ZA200504730B (enExample)

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JP2006511572A (ja) 2006-04-06
TW200508180A (en) 2005-03-01
RU2005117792A (ru) 2006-01-27
AU2003290309B2 (en) 2007-01-18
CL2003002683A1 (es) 2005-04-08
MXPA05006812A (es) 2005-09-08
AR042632A1 (es) 2005-06-29
AU2003290309A1 (en) 2004-07-14
JP2006045240A (ja) 2006-02-16
IS7946A (is) 2005-07-19
US7462644B2 (en) 2008-12-09
NO20052914L (no) 2005-07-19
US20050131068A1 (en) 2005-06-16
EP1572626A1 (en) 2005-09-14
ZA200504730B (en) 2006-09-27
CA2508851A1 (en) 2004-07-08
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JP3786945B2 (ja) 2006-06-21
PL377144A1 (pl) 2006-01-23
KR20050089065A (ko) 2005-09-07
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BR0317458A (pt) 2005-11-16

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