UA80729C2 - Substituted (2s)-2-ethoxy-3-phenylpropanoic acids - Google Patents
Substituted (2s)-2-ethoxy-3-phenylpropanoic acids Download PDFInfo
- Publication number
- UA80729C2 UA80729C2 UAA200505596A UA2005005596A UA80729C2 UA 80729 C2 UA80729 C2 UA 80729C2 UA A200505596 A UAA200505596 A UA A200505596A UA 2005005596 A UA2005005596 A UA 2005005596A UA 80729 C2 UA80729 C2 UA 80729C2
- Authority
- UA
- Ukraine
- Prior art keywords
- phenyl
- methylthio
- tetrahydro
- dioxo
- carbamoyl
- Prior art date
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- VOYUMMCXVQRKIY-JTQLQIEISA-N (2s)-2-ethoxy-3-phenylpropanoic acid Chemical class CCO[C@H](C(O)=O)CC1=CC=CC=C1 VOYUMMCXVQRKIY-JTQLQIEISA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 145
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 7
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 7
- 150000002632 lipids Chemical class 0.000 claims abstract description 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 57
- -1 trifluoromethoxyl Chemical group 0.000 claims description 48
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 42
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 36
- 239000002253 acid Substances 0.000 claims description 25
- 238000011282 treatment Methods 0.000 claims description 20
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- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims description 4
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- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims description 3
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- XYOVOXDWRFGKEX-UHFFFAOYSA-N azepine Chemical compound N1C=CC=CC=C1 XYOVOXDWRFGKEX-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
- C07C235/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| GBGB0229931.1A GB0229931D0 (en) | 2002-12-21 | 2002-12-21 | Therapeutic agents |
| PCT/GB2003/005602 WO2004056748A1 (en) | 2002-12-21 | 2003-12-19 | Therapeutic agents |
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| UA80729C2 true UA80729C2 (en) | 2007-10-25 |
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| UAA200505596A UA80729C2 (en) | 2002-12-21 | 2003-12-19 | Substituted (2s)-2-ethoxy-3-phenylpropanoic acids |
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| EP (1) | EP1572626A1 (enExample) |
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| IS (1) | IS7946A (enExample) |
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| NO (1) | NO20052914L (enExample) |
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| RU (1) | RU2005117792A (enExample) |
| TW (1) | TW200508180A (enExample) |
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| CN100503599C (zh) | 2002-03-13 | 2009-06-24 | 詹森药业有限公司 | 作为组蛋白脱乙酰酶的新颖抑制剂的羰基氨基衍生物 |
| KR20040094672A (ko) | 2002-03-13 | 2004-11-10 | 얀센 파마슈티카 엔.브이. | 히스톤 디아세틸라제의 신규한 저해제로서의설포닐아미노-유도체 |
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| HRP20040804A2 (en) | 2002-03-13 | 2005-02-28 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase |
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| BRPI0406761A (pt) | 2003-01-14 | 2005-12-20 | Arena Pharm Inc | Derivados de arila e heteroarila 1,2,3-trissubstituìdos como moduladores do metabolismo e a profilaxia e tratamento de distúrbios relacionados a estes tais como diabetes e hiper-glicemia |
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| EP1811991B1 (en) * | 2004-11-10 | 2018-11-07 | Genzyme Corporation | Treatment of type 2 diabetes using inhibitors of glycosphingolipid synthesis |
| MY148521A (en) | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
| EP1885710B1 (en) | 2005-05-18 | 2015-08-19 | Janssen Pharmaceutica N.V. | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
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2003
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- 2003-12-19 KR KR1020057011714A patent/KR20050089065A/ko not_active Withdrawn
- 2003-12-19 EP EP03782668A patent/EP1572626A1/en not_active Withdrawn
- 2003-12-19 WO PCT/GB2003/005602 patent/WO2004056748A1/en not_active Ceased
- 2003-12-19 UA UAA200505596A patent/UA80729C2/uk unknown
- 2003-12-19 US US10/499,893 patent/US7462644B2/en not_active Expired - Fee Related
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| RU2005117792A (ru) | 2006-01-27 |
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| MXPA05006812A (es) | 2005-09-08 |
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| IS7946A (is) | 2005-07-19 |
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| JP2006511572A (ja) | 2006-04-06 |
| NO20052914D0 (no) | 2005-06-15 |
| BR0317458A (pt) | 2005-11-16 |
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| NO20052914L (no) | 2005-07-19 |
| US7462644B2 (en) | 2008-12-09 |
| US20050131068A1 (en) | 2005-06-16 |
| EP1572626A1 (en) | 2005-09-14 |
| CA2508851A1 (en) | 2004-07-08 |
| ZA200504730B (en) | 2006-09-27 |
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