CN1281552A - 连续式高处理量筛选 - Google Patents

连续式高处理量筛选 Download PDF

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Publication number
CN1281552A
CN1281552A CN98812079A CN98812079A CN1281552A CN 1281552 A CN1281552 A CN 1281552A CN 98812079 A CN98812079 A CN 98812079A CN 98812079 A CN98812079 A CN 98812079A CN 1281552 A CN1281552 A CN 1281552A
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CN
China
Prior art keywords
matrix
detection
porous
substance
reagent
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Pending
Application number
CN98812079A
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English (en)
Chinese (zh)
Inventor
B·A·比特尔
M·E·舒达克
M·J·沃二巴斯
D·J·布尔恩斯
M·K·约瑟夫
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Abbott Laboratories
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Abbott Laboratories
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Publication of CN1281552A publication Critical patent/CN1281552A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Peptides Or Proteins (AREA)
  • Paper (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Image Processing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Geophysics And Detection Of Objects (AREA)
CN98812079A 1997-12-12 1998-12-11 连续式高处理量筛选 Pending CN1281552A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/990,168 1997-12-12
US08/990,168 US5976813A (en) 1997-12-12 1997-12-12 Continuous format high throughput screening

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2008100817676A Division CN101256187A (zh) 1997-12-12 1998-12-11 连续式高处理量筛选

Publications (1)

Publication Number Publication Date
CN1281552A true CN1281552A (zh) 2001-01-24

Family

ID=25535858

Family Applications (2)

Application Number Title Priority Date Filing Date
CN98812079A Pending CN1281552A (zh) 1997-12-12 1998-12-11 连续式高处理量筛选
CNA2008100817676A Pending CN101256187A (zh) 1997-12-12 1998-12-11 连续式高处理量筛选

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2008100817676A Pending CN101256187A (zh) 1997-12-12 1998-12-11 连续式高处理量筛选

Country Status (25)

Country Link
US (1) US5976813A (enExample)
EP (1) EP1038179B1 (enExample)
JP (1) JP4558197B2 (enExample)
KR (1) KR100657777B1 (enExample)
CN (2) CN1281552A (enExample)
AT (1) ATE336001T1 (enExample)
AU (1) AU759538B2 (enExample)
BG (1) BG65264B1 (enExample)
BR (1) BR9815059A (enExample)
CA (1) CA2310684C (enExample)
CY (1) CY1106220T1 (enExample)
CZ (1) CZ299740B6 (enExample)
DE (1) DE69835537T2 (enExample)
DK (1) DK1038179T3 (enExample)
ES (1) ES2270539T3 (enExample)
HU (1) HU228578B1 (enExample)
IL (1) IL135793A (enExample)
NO (1) NO326662B1 (enExample)
NZ (1) NZ504112A (enExample)
PL (1) PL194813B1 (enExample)
PT (1) PT1038179E (enExample)
SK (1) SK286095B6 (enExample)
TR (1) TR200001647T2 (enExample)
TW (1) TW555967B (enExample)
WO (1) WO1999030154A2 (enExample)

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NZ504112A (en) 2002-11-26
SK8362000A3 (en) 2000-10-09
HUP0100207A2 (hu) 2001-06-28
DE69835537D1 (de) 2006-09-21
WO1999030154A3 (en) 1999-08-12
CZ299740B6 (cs) 2008-11-05
PL194813B1 (pl) 2007-07-31
EP1038179B1 (en) 2006-08-09
EP1038179A2 (en) 2000-09-27
KR20010024709A (ko) 2001-03-26
IL135793A (en) 2005-09-25
NO326662B1 (no) 2009-01-26
WO1999030154A2 (en) 1999-06-17
US5976813A (en) 1999-11-02
SK286095B6 (sk) 2008-03-05
KR100657777B1 (ko) 2006-12-15
DK1038179T3 (da) 2006-11-20
TR200001647T2 (tr) 2001-06-21
CA2310684C (en) 2011-05-10
PT1038179E (pt) 2006-12-29
ATE336001T1 (de) 2006-09-15
AU1821699A (en) 1999-06-28
BR9815059A (pt) 2007-05-22
CN101256187A (zh) 2008-09-03
JP2001526390A (ja) 2001-12-18
HU228578B1 (en) 2013-04-29
BG104564A (en) 2001-04-30
HK1032996A1 (en) 2001-08-10
NO20002079L (no) 2000-06-09
CY1106220T1 (el) 2011-06-08
CA2310684A1 (en) 1999-06-17
ES2270539T3 (es) 2007-04-01
NO20002079D0 (no) 2000-04-19
DE69835537T2 (de) 2007-08-09
AU759538B2 (en) 2003-04-17
CZ20002078A3 (cs) 2000-09-13
TW555967B (en) 2003-10-01
PL341655A1 (en) 2001-04-23
BG65264B1 (bg) 2007-10-31
JP4558197B2 (ja) 2010-10-06
HUP0100207A3 (en) 2003-08-28
IL135793A0 (en) 2001-05-20

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