CZ299740B6 - Kontinuální systém vysoce výkonného screeningu s použitím planárních matric - Google Patents

Kontinuální systém vysoce výkonného screeningu s použitím planárních matric Download PDF

Info

Publication number
CZ299740B6
CZ299740B6 CZ20002078A CZ20002078A CZ299740B6 CZ 299740 B6 CZ299740 B6 CZ 299740B6 CZ 20002078 A CZ20002078 A CZ 20002078A CZ 20002078 A CZ20002078 A CZ 20002078A CZ 299740 B6 CZ299740 B6 CZ 299740B6
Authority
CZ
Czechia
Prior art keywords
matrix
assay
gel
substance
ligand
Prior art date
Application number
CZ20002078A
Other languages
Czech (cs)
English (en)
Other versions
CZ20002078A3 (cs
Inventor
A. Beutel@Bruce
E. Schurdak@Mark
J. Voorbach@Martin
J. Burns@David
K. Joseph@Mary
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of CZ20002078A3 publication Critical patent/CZ20002078A3/cs
Publication of CZ299740B6 publication Critical patent/CZ299740B6/cs

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/00527Sheets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00585Parallel processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00596Solid-phase processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061The surface being organic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614Delimitation of the attachment areas
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623Immobilisation or binding
    • B01J2219/0063Other, e.g. van der Waals forces, hydrogen bonding
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00639Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00659Two-dimensional arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00702Processes involving means for analysing and characterising the products
    • B01J2219/00707Processes involving means for analysing and characterising the products separated from the reactor apparatus

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Paper (AREA)
  • Peptides Or Proteins (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Geophysics And Detection Of Objects (AREA)
  • Image Processing (AREA)
CZ20002078A 1997-12-12 1998-12-11 Kontinuální systém vysoce výkonného screeningu s použitím planárních matric CZ299740B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/990,168 US5976813A (en) 1997-12-12 1997-12-12 Continuous format high throughput screening

Publications (2)

Publication Number Publication Date
CZ20002078A3 CZ20002078A3 (cs) 2000-09-13
CZ299740B6 true CZ299740B6 (cs) 2008-11-05

Family

ID=25535858

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ20002078A CZ299740B6 (cs) 1997-12-12 1998-12-11 Kontinuální systém vysoce výkonného screeningu s použitím planárních matric

Country Status (25)

Country Link
US (1) US5976813A (enExample)
EP (1) EP1038179B1 (enExample)
JP (1) JP4558197B2 (enExample)
KR (1) KR100657777B1 (enExample)
CN (2) CN101256187A (enExample)
AT (1) ATE336001T1 (enExample)
AU (1) AU759538B2 (enExample)
BG (1) BG65264B1 (enExample)
BR (1) BR9815059A (enExample)
CA (1) CA2310684C (enExample)
CY (1) CY1106220T1 (enExample)
CZ (1) CZ299740B6 (enExample)
DE (1) DE69835537T2 (enExample)
DK (1) DK1038179T3 (enExample)
ES (1) ES2270539T3 (enExample)
HU (1) HU228578B1 (enExample)
IL (1) IL135793A (enExample)
NO (1) NO326662B1 (enExample)
NZ (1) NZ504112A (enExample)
PL (1) PL194813B1 (enExample)
PT (1) PT1038179E (enExample)
SK (1) SK286095B6 (enExample)
TR (1) TR200001647T2 (enExample)
TW (1) TW555967B (enExample)
WO (1) WO1999030154A2 (enExample)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU226203B1 (en) 1996-01-26 2008-06-30 Virco B V B A Method for determining of the chemotherapy of patients who are hiv positive based on the phenotypic drug sensitivity of human hiv strains
US6790652B1 (en) * 1998-01-08 2004-09-14 Bioimage A/S Method and apparatus for high density format screening for bioactive molecules
US6410332B1 (en) * 1998-09-08 2002-06-25 Symyx Technologies, Inc. Sampling and analysis of reactions by trapping reaction components on a sorbent
WO2000014540A1 (en) * 1998-09-08 2000-03-16 Tibotec N.V. Method for the rapid screening of analytes
WO2000036405A2 (en) * 1998-12-18 2000-06-22 Symyx Technologies, Inc. Apparatus and method for characterizing libraries of different materials using x-ray scattering
US20040185432A1 (en) * 1999-01-08 2004-09-23 Bioimage A/S Method and apparatus for high density format screening for bioactive molecules
US6690399B1 (en) * 1999-05-07 2004-02-10 Tropix, Inc. Data display software for displaying assay results
US6800437B1 (en) 1999-08-06 2004-10-05 Tibotec Bvba Method of monitoring a biological system by labeling with an apo metal binding protein
US6544480B1 (en) 1999-10-26 2003-04-08 Tibotec Bvba Device and related method for dispensing small volumes of liquid
WO2001073125A2 (en) * 2000-03-24 2001-10-04 Lyles Mark B High throughput screening array containing porous material
US20030031675A1 (en) 2000-06-06 2003-02-13 Mikesell Glen E. B7-related nucleic acids and polypeptides useful for immunomodulation
US20030219825A1 (en) * 2000-06-13 2003-11-27 Haizlip Jill Elaine High throughput method for screening candidate compounds for biological activity
US7087375B1 (en) 2000-06-23 2006-08-08 Johan Lennerstrand Method for determining the mechanism of HIV RT inhibitors
US7052659B1 (en) 2000-07-18 2006-05-30 General Electric Company Sequential high throughput screening method and system
US6653124B1 (en) 2000-11-10 2003-11-25 Cytoplex Biosciences Inc. Array-based microenvironment for cell culturing, cell monitoring and drug-target validation
AUPR224600A0 (en) * 2000-12-21 2001-01-25 Polymerat Pty Ltd Novel polymers
US7244232B2 (en) * 2001-03-07 2007-07-17 Biomed Solutions, Llc Process for identifying cancerous and/or metastatic cells of a living organism
US20030060695A1 (en) * 2001-03-07 2003-03-27 Connelly Patrick R. Implantable artificial organ devices
US20020142304A1 (en) * 2001-03-09 2002-10-03 Anderson Daniel G. Uses and methods of making microarrays of polymeric biomaterials
US20080009019A1 (en) * 2001-06-13 2008-01-10 Smithkline Beecham Corporation High throughput method for screening candidate compounds for biological activity
DE10138766A1 (de) * 2001-08-07 2003-02-20 Bayer Cropscience Ag Verfahren zum Identifizieren von makrocyclischen Polyketiden
US20030032198A1 (en) * 2001-08-13 2003-02-13 Symyx Technologies, Inc. High throughput dispensing of fluids
EP1298433A1 (en) * 2001-09-28 2003-04-02 EMC microcollections GmbH Device and method for the generation of arrays of substance mixtures by diffusion
EP1487969A4 (en) * 2001-12-07 2008-07-09 Dyax Corp METHOD AND DEVICE FOR WASHING MAGNETICALLY RESPONSIVE PARTICLES
AU2002359721A1 (en) * 2001-12-19 2003-07-09 Bristol-Myers Squibb Company Pichia pastoris formate dehydrogenase and uses therefor
WO2003072752A2 (en) * 2002-02-27 2003-09-04 Miragene, Inc. Improved substrate chemistry for protein immobilization on a rigid support
US20050054118A1 (en) * 2002-02-27 2005-03-10 Lebrun Stewart J. High throughput screening method
US20040072274A1 (en) * 2002-05-09 2004-04-15 Lebrun Stewart J. System and method for visualization and digital analysis of protein and other macromolecule microarrays
EP1534755B1 (en) 2002-05-10 2011-10-12 Bio-Layer Pty Limited Generation of surface coating diversity
EP1900827A3 (en) 2002-05-21 2008-04-16 Bayer HealthCare AG Methods and compositions for the prediction, diagnosis, prognosis, prevention and treatment of malignant neoplasia
US20040028804A1 (en) * 2002-08-07 2004-02-12 Anderson Daniel G. Production of polymeric microarrays
US20040032058A1 (en) * 2002-08-13 2004-02-19 Neeper Robert K. Systems and methods for casting and handling assay matrices
USD480815S1 (en) 2002-08-13 2003-10-14 Discovery Partners International Card carrying an array of compounds
US20040091941A1 (en) * 2002-08-13 2004-05-13 Ewing William R. Spotting pattern for placement of compounds in an array
US8557743B2 (en) * 2002-09-05 2013-10-15 Dyax Corp. Display library process
US20040058327A1 (en) * 2002-09-20 2004-03-25 Pan Jeffrey Y Method for using a blank matrix in a continuous format high throughput screening process
WO2004092903A2 (en) * 2003-04-09 2004-10-28 Discovery Partners International Spot finding algorithm using image recognition software
US7025935B2 (en) * 2003-04-11 2006-04-11 Illumina, Inc. Apparatus and methods for reformatting liquid samples
US20070128603A1 (en) * 2003-05-28 2007-06-07 Bayer Healthcare Ag Diagnostic and therapeutics for diseases associated with 5-hydroxytryptamine (serotonin) receptor 7 (5-ht7)
JP2005046121A (ja) * 2003-07-31 2005-02-24 Japan Science & Technology Agency オンチップバイオアッセイ方法及びキット
US20050136536A1 (en) * 2003-09-15 2005-06-23 Anderson Daniel G. Embryonic epithelial cells
US20050069462A1 (en) * 2003-09-30 2005-03-31 International Business Machines Corporation Microfluidics Packaging
US20050069949A1 (en) * 2003-09-30 2005-03-31 International Business Machines Corporation Microfabricated Fluidic Structures
EP1892306A3 (en) 2003-10-06 2008-06-11 Bayer HealthCare AG Methods and kits for investigating cancer
US20060127963A1 (en) * 2003-11-21 2006-06-15 Lebrun Stewart J Microarray-based analysis of rheumatoid arthritis markers
WO2005054453A1 (en) 2003-12-02 2005-06-16 Basf Aktiengesellschaft 2-methyl-6-solanylbenzoquinone methyltransferase as target for herbicides
US20050124017A1 (en) * 2003-12-05 2005-06-09 Stewart Lebrun Quantitative alkaline-phosphatase precipitation reagent and methods for visualization of protein microarrays
EP1700244A4 (en) * 2003-12-12 2009-07-08 Bio Layer Pty Ltd PROCESS FOR THE PREPARATION OF SURFACES
US20090253769A1 (en) * 2004-01-21 2009-10-08 Gessica Filocamo Inhibitors of mammalian hdac 11 useful for treating hdac 11 mediated disorders
EP1564556A1 (de) * 2004-02-17 2005-08-17 DST Diagnostic Science & Technology GmbH Verfahren und Vorrichtung zur Bestimmung mehrerer Analyten mit simultaner interner Kontrolle
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
EP1773866B1 (en) 2004-07-02 2013-06-19 Bio-Layer Pty Limited Use of metal complexes
US20080206855A1 (en) * 2005-05-06 2008-08-28 Kalypsys, Inc. Automated Compound Screening Using Gel-Permeation Matrix and Pin-Based Sample Transfer
US7629115B2 (en) * 2005-05-13 2009-12-08 Honeywell International Inc. Cell-based platform for high throughput screening
WO2007053186A2 (en) 2005-05-31 2007-05-10 Labnow, Inc. Methods and compositions related to determination and use of white blood cell counts
WO2007064902A2 (en) 2005-12-02 2007-06-07 Sirtris Pharmaceuticals, Inc. Mass spectrometry assays for acetyltransferase/deacetylase activity
EP1966603A4 (en) * 2005-12-30 2009-08-19 Bio Layer Pty Ltd FIXING MOLECULES
EP2851091B1 (en) 2007-04-13 2017-12-27 Dana-Farber Cancer Institute, Inc. Methods for treating cancer resistant to ERBB therapeutics
WO2008154207A1 (en) * 2007-06-08 2008-12-18 The Burnham Institute For Medical Research Methods and compounds for regulating apoptosis
US20090272657A1 (en) * 2008-05-01 2009-11-05 Massachusetts Institute Of Technology Devices and processes for analyzing nucleic acid damage and repair using electrophoresis
WO2014018721A1 (en) * 2012-07-25 2014-01-30 Bio-Rad Laboratories, Inc. Targeted delivery of reagents through patterned transfer sheets
US9447135B2 (en) 2012-12-14 2016-09-20 University Of Kentucky Research Foundation Semi-synthetic mithramycin derivatives with anti-cancer activity
GB201318814D0 (en) 2013-10-24 2013-12-11 Petroleum & Chemical Corp Microfluidic devices and arrangements for supplying such devices with reagents and biological samples
US10024845B2 (en) 2013-12-23 2018-07-17 Basf Se Methods for determining modulators of insect transient receptor potential V (TRPV) channel
WO2019023559A1 (en) 2017-07-27 2019-01-31 University Of Southern California OTOPETRIN PROTON CHANNELS AS TARGETS FOR PHARMACEUTICAL DISCOVERY

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0063810A1 (en) * 1981-04-29 1982-11-03 Ciba-Geigy Ag New devices and kits for immunological analysis
WO1994002515A1 (en) * 1992-07-21 1994-02-03 Bunsen Rush Laboratories Inc. Oligomer library formats and methods relating thereto
WO1997016569A1 (en) * 1995-11-03 1997-05-09 Pharmacopeia, Inc. Lawn assay for compounds that affect enzyme activity or bind to target molecules

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4447526A (en) * 1981-04-20 1984-05-08 Miles Laboratories, Inc. Homogeneous specific binding assay with carrier matrix incorporating specific binding partner
US4591570A (en) * 1983-02-02 1986-05-27 Centocor, Inc. Matrix of antibody-coated spots for determination of antigens
JP2564181B2 (ja) * 1988-11-24 1996-12-18 コニカ株式会社 特定成分の分析方法
DE4208645A1 (de) * 1992-03-18 1993-09-23 Bayer Ag Optischer festphasenbiosensor auf basis fluoreszenzfarbstoffmarkierter polyionischer schichten
CA2130947C (en) * 1993-11-12 2001-02-06 Robert E. Emmons Dry elements, test devices, test kits and methods for chemiluminescent detection of analytes using peroxidase-labeled reagents
AU691296B2 (en) * 1994-05-06 1998-05-14 Pharmacopeia Drug Discovery, Inc. Combinatorial dihydrobenzopyran library
AU2986395A (en) * 1994-07-22 1996-02-22 Zeneca Limited Method for screening compound libraries

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0063810A1 (en) * 1981-04-29 1982-11-03 Ciba-Geigy Ag New devices and kits for immunological analysis
WO1994002515A1 (en) * 1992-07-21 1994-02-03 Bunsen Rush Laboratories Inc. Oligomer library formats and methods relating thereto
WO1997016569A1 (en) * 1995-11-03 1997-05-09 Pharmacopeia, Inc. Lawn assay for compounds that affect enzyme activity or bind to target molecules

Also Published As

Publication number Publication date
NZ504112A (en) 2002-11-26
PL341655A1 (en) 2001-04-23
DE69835537D1 (de) 2006-09-21
ES2270539T3 (es) 2007-04-01
IL135793A0 (en) 2001-05-20
CY1106220T1 (el) 2011-06-08
PL194813B1 (pl) 2007-07-31
US5976813A (en) 1999-11-02
EP1038179A2 (en) 2000-09-27
TW555967B (en) 2003-10-01
AU759538B2 (en) 2003-04-17
HUP0100207A3 (en) 2003-08-28
HUP0100207A2 (hu) 2001-06-28
BR9815059A (pt) 2007-05-22
HU228578B1 (en) 2013-04-29
SK8362000A3 (en) 2000-10-09
KR100657777B1 (ko) 2006-12-15
JP4558197B2 (ja) 2010-10-06
IL135793A (en) 2005-09-25
AU1821699A (en) 1999-06-28
EP1038179B1 (en) 2006-08-09
CN101256187A (zh) 2008-09-03
PT1038179E (pt) 2006-12-29
CA2310684C (en) 2011-05-10
BG65264B1 (bg) 2007-10-31
KR20010024709A (ko) 2001-03-26
HK1032996A1 (en) 2001-08-10
ATE336001T1 (de) 2006-09-15
NO326662B1 (no) 2009-01-26
NO20002079D0 (no) 2000-04-19
DK1038179T3 (da) 2006-11-20
CA2310684A1 (en) 1999-06-17
NO20002079L (no) 2000-06-09
SK286095B6 (sk) 2008-03-05
DE69835537T2 (de) 2007-08-09
CN1281552A (zh) 2001-01-24
JP2001526390A (ja) 2001-12-18
TR200001647T2 (tr) 2001-06-21
BG104564A (en) 2001-04-30
WO1999030154A2 (en) 1999-06-17
CZ20002078A3 (cs) 2000-09-13
WO1999030154A3 (en) 1999-08-12

Similar Documents

Publication Publication Date Title
CZ299740B6 (cs) Kontinuální systém vysoce výkonného screeningu s použitím planárních matric
RU2217498C2 (ru) Способ специфического детектирования одного или более аналитов в образце (варианты), способ идентификации или величины по меньшей мере одного типа клетки или организма в образце, способ детектирования присутствия или величины по меньшей мере одного аналита в типе клетки или организма, способ отслеживания клетки или организма, способ идентификации или определения характеристик потенциального фармацевтического агента
US20030166015A1 (en) Multiplexed analysis of cell-substrate interactions
CA2734029A1 (en) Methods for determining the concentration of an analyte in solution
CA2291621A1 (en) High-throughput assay
US6756014B2 (en) Biochemical sensor and biochemical testing system using the same
US20040043398A1 (en) Use of the multipin platform as anchor device
CA2459055A1 (en) A screening system for identifying drug-drug interactions and methods of use thereof
AU2002323317A1 (en) A screening system for identifying drug-drug interactions and methods of use thereof
US9588106B2 (en) Methods and compositions for measuring cell permeability
EP1852186A1 (en) Method and means for multiparametric assays being compartmentalized
PT2282206E (pt) Método e aparelho para testar vários analitos simultaneamente com um controlo interno
MXPA00005800A (en) Continuous format high throughput screening
HK1032996B (en) Continuous format high throughput screening using planar matrices
EP1298433A1 (en) Device and method for the generation of arrays of substance mixtures by diffusion
WO2003076900A2 (en) Multiplexed analysis of cell-substrate interactions
WO2007024014A1 (ja) 分子間相互作用測定方法及びこの方法を用いた測定装置

Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20171211